STEVEN LIETMAN

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint The effect of recombinant human osteogenic protein-1 (bone morphogenetic protein-7) impregnation on allografts in a canine intercalary bone defect
    Dennis M Cullinane
    Department of Orthopaedic Surgery, Johns Hopkins Outpatient Center, Johns Hopkins University, 601 North Caroline Street, Suite 5251, Baltimore, Maryland 21287 0882, USA
    J Orthop Res 20:1240-5. 2002
  2. ncbi request reprint The effect of recombinant human osteogenic protein-1 on allograft incorporation
    S A Lietman
    Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Bone Joint Surg Br 87:1292-7. 2005
  3. ncbi request reprint A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia
    Steven A Lietman
    Department of Orthopaedic Surgery A41, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195
    J Bone Joint Surg Am 87:2489-94. 2005
  4. pmc Preimplantation genetic diagnosis for severe albright hereditary osteodystrophy
    Steven A Lietman
    Department of Orthopedic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 93:901-4. 2008
  5. ncbi request reprint Fibrous dysplasia
    Steven A Lietman
    Musculoskeletal Tumor Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Pediatr Endocrinol Rev 10:389-96. 2013
  6. pmc The role of SH3BP2 in the pathophysiology of cherubism
    ERNST J REICHENBERGER
    Department of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT, USA
    Orphanet J Rare Dis 7:S5. 2012
  7. pmc Cherubism: best clinical practice
    Maria E Papadaki
    Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA
    Orphanet J Rare Dis 7:S6. 2012
  8. pmc Hypercalcemia in children and adolescents
    Steven A Lietman
    Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Curr Opin Pediatr 22:508-15. 2010
  9. doi request reprint Soft-tissue sarcomas: Overview of management, with a focus on surgical treatment considerations
    Steven A Lietman
    Director, Musculoskeletal Tumor Center, Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, A41, Cleveland, OH 44195, USA
    Cleve Clin J Med 77:S13-7. 2010
  10. pmc A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia
    Steven A Lietman
    Departments of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute and Foundation, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 94:4372-9. 2009

Research Grants

  1. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2010
  2. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
  3. Molecular Mechanisms in Bone Resorption
    STEVEN LIETMAN; Fiscal Year: 2009

Collaborators

Detail Information

Publications22

  1. ncbi request reprint The effect of recombinant human osteogenic protein-1 (bone morphogenetic protein-7) impregnation on allografts in a canine intercalary bone defect
    Dennis M Cullinane
    Department of Orthopaedic Surgery, Johns Hopkins Outpatient Center, Johns Hopkins University, 601 North Caroline Street, Suite 5251, Baltimore, Maryland 21287 0882, USA
    J Orthop Res 20:1240-5. 2002
    ..These findings indicate that rhOP- I increases intercalary allograft remodeling without deleterious effects in mechanical and functional strength...
  2. ncbi request reprint The effect of recombinant human osteogenic protein-1 on allograft incorporation
    S A Lietman
    Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Bone Joint Surg Br 87:1292-7. 2005
    ..These results indicate a benefit from the use of an rhOP-1 implant in the healing of bone allografts. The effect was independent of the position of the implant. There may be a beneficial clinical application for this treatment...
  3. ncbi request reprint A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia
    Steven A Lietman
    Department of Orthopaedic Surgery A41, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195
    J Bone Joint Surg Am 87:2489-94. 2005
    ..We therefore used PNA-clamping to detect low copy numbers of mutant GNAS alleles in DNA from peripheral blood cells from patients with McCune-Albright syndrome and fibrous dysplasia...
  4. pmc Preimplantation genetic diagnosis for severe albright hereditary osteodystrophy
    Steven A Lietman
    Department of Orthopedic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 93:901-4. 2008
    ..Phocomelia in a patient with Albright hereditary osteodystrophy (AHO) has also not been previously described...
  5. ncbi request reprint Fibrous dysplasia
    Steven A Lietman
    Musculoskeletal Tumor Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Pediatr Endocrinol Rev 10:389-96. 2013
    ..In summary fibrous dysplasia is a developmental abnormality of bone with a known molecular etiology; Further knowledge about the molecular pathology of fibrous dysplasia may lead to improved conservative therapies in the near future...
  6. pmc The role of SH3BP2 in the pathophysiology of cherubism
    ERNST J REICHENBERGER
    Department of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT, USA
    Orphanet J Rare Dis 7:S5. 2012
    ..The data suggest that the underlying cause for cherubism is a systemic autoinflammatory response to physiologic challenges despite the localized appearance of bone resorption and fibrous expansion to the jaws in humans...
  7. pmc Cherubism: best clinical practice
    Maria E Papadaki
    Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA
    Orphanet J Rare Dis 7:S6. 2012
    ..Surgical procedures are usually performed when the disease becomes quiescent. Aggressive lesions that cause severe functional problems such as airway obstruction justify early surgical intervention...
  8. pmc Hypercalcemia in children and adolescents
    Steven A Lietman
    Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Curr Opin Pediatr 22:508-15. 2010
    ..In this review, we define hypercalcemia levels, common causes for hypercalcemia in children, and treatment in order to aid the practicing pediatrician...
  9. doi request reprint Soft-tissue sarcomas: Overview of management, with a focus on surgical treatment considerations
    Steven A Lietman
    Director, Musculoskeletal Tumor Center, Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, A41, Cleveland, OH 44195, USA
    Cleve Clin J Med 77:S13-7. 2010
    ..Resections with wide margins are generally associated with a low (< 10%) risk of recurrence...
  10. pmc A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia
    Steven A Lietman
    Departments of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute and Foundation, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 94:4372-9. 2009
    ..Mutations that inactivate one allele of the gene encoding the calcium sensing receptor (CaSR) cause autosomal dominant familial hypocalciuric hypercalcemia (FHH), whereas homozygous mutations cause neonatal severe hyperparathyroidism...
  11. pmc SH3BP2 mutations potentiate osteoclastogenesis via PLCĪ³
    Steven A Lietman
    Department of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Orthop Res 28:1425-30. 2010
    ..The consequent activation of calcineurin and NFAT proteins induces the excessive osteoclastic phenotype of cherubism...
  12. doi request reprint A novel surgical approach for complex destructive acetabular malignancies
    Steven A Lietman
    The Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Surg Oncol 99:379-81. 2009
    ....
  13. pmc SH3BP2 is an activator of NFAT activity and osteoclastogenesis
    Steven A Lietman
    Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochem Biophys Res Commun 371:644-8. 2008
    ..7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and 2, thus providing a mechanistic pathway for the rapid translocation of NFATc1 into the nucleus and increased osteoclastogenesis in cherubism...
  14. doi request reprint Preimplantation genetic diagnosis for hereditary endocrine disease
    Steven A Lietman
    Department of Orthopedic Surgery, Cleveland Clinic Foundation Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Endocr Pract 17:28-32. 2011
    ..To describe the process of preimplantation genetic diagnosis (PGD), which allows the selection of embryos without mutations for implantation, with specific application for mutations in GNAS...
  15. ncbi request reprint SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism
    Steven A Lietman
    Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Orthop Relat Res 459:22-7. 2007
    ..Although many multinucleated giant cell lesions of bone share histologic features, the primary genetic defect in cherubism and these other giant cell lesions appears different...
  16. ncbi request reprint Identification of a novel mutation of SH3BP2 in cherubism and demonstration that SH3BP2 mutations lead to increased NFAT activation
    Steven A Lietman
    The Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Hum Mutat 27:717-8. 2006
    ..R415Q (c.1244G>A), p.D420E (c.1259G>A), and p.P418R (c.1253C>G)) increased activity of NFAT (nuclear factor of activated T-cells), an osteoclastogenic mediator, indicating that cherubism results from gain of function mutations in SH3BP2...
  17. doi request reprint Bone sarcomas: Overview of management, with a focus on surgical treatment considerations
    Steven A Lietman
    Director, Musculoskeletal Tumor Center, Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, A41, Cleveland, OH 44195, USA
    Cleve Clin J Med 77:S8-12. 2010
    ..Post-therapy follow-up at frequent and regular intervals is critical to assess for recurrence and lung metastasis...
  18. doi request reprint Clinical presentation and imaging of bone and soft-tissue sarcomas
    Hakan Ilaslan
    Department of Diagnostic Radiology, Cleveland Clinic, 9500 Euclid Avenue, A21, Cleveland, OH 44195, USA
    Cleve Clin J Med 77:S2-7. 2010
    ..In contrast, radiographs are rarely helpful for evaluation of soft-tissue lesions, which almost always require MRI assessment...
  19. doi request reprint Cortical scalloping and cortical penetration by small eccentric chondroid lesions in the long tubular bones: not a sign of malignancy?
    Kimmie L Bui
    Department of Radiology, Cleveland Clinic, c o Joan Edgehouse, Cleveland, OH 44195, USA
    Skeletal Radiol 38:791-6. 2009
    ..The objective of this study was to evaluate by cross-sectional imaging the prevalence and degree of cortical scalloping by small eccentric chondromas correlated with histologic diagnosis and patient history...
  20. ncbi request reprint Genetic and molecular aspects of McCune-Albright syndrome
    Steven A Lietman
    Department of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute, ND20, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Pediatr Endocrinol Rev 4:380-5. 2007
    ....
  21. ncbi request reprint A 20-year retrospective review of surgically treated liposarcoma at the Cleveland Clinic
    Steven A Lietman
    The Cleveland Clinic, Cleveland, OH 44195, USA
    Orthopedics 30:227-34. 2007
    ..The 5-year disease-specific survival for extremity tumors was 92% (95% confidence interval [CI]; range: 84%-100%), while general 5-year survival for extremity tumors was 66% (95% Cl; range: 48%-85%)...
  22. pmc Chronic bilateral thigh and knee discomfort in an 18-year-old man
    Jesse E Templeton
    Clin Orthop Relat Res 466:507-13. 2008

Research Grants5

  1. Molecular Mechanisms in Bone Resorption
    Steven A Lietman; Fiscal Year: 2010
    ..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
  2. Molecular Mechanisms of Ectopic Bone Formation
    STEVEN LIETMAN; Fiscal Year: 2006
    ..abstract_text> ..
  3. Molecular Mechanisms in Bone Resorption
    STEVEN LIETMAN; Fiscal Year: 2009
    ..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..