Research Topics
Genomes and Genes | STEVEN LIETMANSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
The effect of recombinant human osteogenic protein-1 (bone morphogenetic protein-7) impregnation on allografts in a canine intercalary bone defectDennis M Cullinane
Department of Orthopaedic Surgery, Johns Hopkins Outpatient Center, Johns Hopkins University, 601 North Caroline Street, Suite 5251, Baltimore, Maryland 21287-0882, USA
J Orthop Res 20:1240-5. 2002..These findings indicate that rhOP- I increases intercalary allograft remodeling without deleterious effects in mechanical and functional strength...- The effect of recombinant human osteogenic protein-1 on allograft incorporationS A Lietman
Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
J Bone Joint Surg Br 87:1292-7. 2005..These results indicate a benefit from the use of an rhOP-1 implant in the healing of bone allografts. The effect was independent of the position of the implant. There may be a beneficial clinical application for this treatment... - A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasiaSteven A Lietman
Department of Orthopaedic Surgery A41, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195
J Bone Joint Surg Am 87:2489-94. 2005..We therefore used PNA-clamping to detect low copy numbers of mutant GNAS alleles in DNA from peripheral blood cells from patients with McCune-Albright syndrome and fibrous dysplasia... 
Preimplantation genetic diagnosis for severe albright hereditary osteodystrophySteven A Lietman
Department of Orthopedic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Clin Endocrinol Metab 93:901-4. 2008..Phocomelia in a patient with Albright hereditary osteodystrophy (AHO) has also not been previously described...- The role of SH3BP2 in the pathophysiology of cherubismERNST J REICHENBERGER
Department of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT, USA
Orphanet J Rare Dis 7:S5. 2012..The data suggest that the underlying cause for cherubism is a systemic autoinflammatory response to physiologic challenges despite the localized appearance of bone resorption and fibrous expansion to the jaws in humans... - Cherubism: best clinical practiceMaria E Papadaki
Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Harvard School of Dental Medicine, Boston, MA, USA
Orphanet J Rare Dis 7:S6. 2012..Surgical procedures are usually performed when the disease becomes quiescent. Aggressive lesions that cause severe functional problems such as airway obstruction justify early surgical intervention... 
Preimplantation genetic diagnosis for hereditary endocrine diseaseSteven A Lietman
Department of Orthopedic Surgery, Cleveland Clinic Foundation Department of Biomedical Engineering, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Endocr Pract 17:28-32. 2011..To describe the process of preimplantation genetic diagnosis (PGD), which allows the selection of embryos without mutations for implantation, with specific application for mutations in GNAS...- SH3BP2 mutations potentiate osteoclastogenesis via PLCĪ³Steven A Lietman
Department of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
J Orthop Res 28:1425-30. 2010..The consequent activation of calcineurin and NFAT proteins induces the excessive osteoclastic phenotype of cherubism... - Hypercalcemia in children and adolescentsSteven A Lietman
Orthopaedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Curr Opin Pediatr 22:508-15. 2010..In this review, we define hypercalcemia levels, common causes for hypercalcemia in children, and treatment in order to aid the practicing pediatrician... - Bone sarcomas: Overview of management, with a focus on surgical treatment considerationsSteven A Lietman
Director, Musculoskeletal Tumor Center, Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, A41, Cleveland, OH 44195, USA
Cleve Clin J Med 77:S8-12. 2010..Post-therapy follow-up at frequent and regular intervals is critical to assess for recurrence and lung metastasis... - Soft-tissue sarcomas: Overview of management, with a focus on surgical treatment considerationsSteven A Lietman
Director, Musculoskeletal Tumor Center, Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, A41, Cleveland, OH 44195, USA
Cleve Clin J Med 77:S13-7. 2010..Resections with wide margins are generally associated with a low (< 10%) risk of recurrence... - A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemiaSteven A Lietman
Departments of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute and Foundation, Cleveland, Ohio 44195, USA
J Clin Endocrinol Metab 94:4372-9. 2009..Mutations that inactivate one allele of the gene encoding the calcium sensing receptor (CaSR) cause autosomal dominant familial hypocalciuric hypercalcemia (FHH), whereas homozygous mutations cause neonatal severe hyperparathyroidism... - A novel surgical approach for complex destructive acetabular malignanciesSteven A Lietman
The Department of Orthopaedic Surgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Surg Oncol 99:379-81. 2009.... - SH3BP2 is an activator of NFAT activity and osteoclastogenesisSteven A Lietman
Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Biochem Biophys Res Commun 371:644-8. 2008..7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and 2, thus providing a mechanistic pathway for the rapid translocation of NFATc1 into the nucleus and increased osteoclastogenesis in cherubism... - SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubismSteven A Lietman
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
Clin Orthop Relat Res 459:22-7. 2007..Although many multinucleated giant cell lesions of bone share histologic features, the primary genetic defect in cherubism and these other giant cell lesions appears different... - Identification of a novel mutation of SH3BP2 in cherubism and demonstration that SH3BP2 mutations lead to increased NFAT activationSteven A Lietman
The Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
Hum Mutat 27:717-8. 2006..R415Q (c.1244G>A), p.D420E (c.1259G>A), and p.P418R (c.1253C>G)) increased activity of NFAT (nuclear factor of activated T-cells), an osteoclastogenic mediator, indicating that cherubism results from gain of function mutations in SH3BP2... - Cortical scalloping and cortical penetration by small eccentric chondroid lesions in the long tubular bones: not a sign of malignancy?Kimmie L Bui
Department of Radiology, Cleveland Clinic, c o Joan Edgehouse, Cleveland, OH 44195, USA
Skeletal Radiol 38:791-6. 2009..The objective of this study was to evaluate by cross-sectional imaging the prevalence and degree of cortical scalloping by small eccentric chondromas correlated with histologic diagnosis and patient history... - Clinical presentation and imaging of bone and soft-tissue sarcomasHakan Ilaslan
Department of Diagnostic Radiology, Cleveland Clinic, 9500 Euclid Avenue, A21, Cleveland, OH 44195, USA
Cleve Clin J Med 77:S2-7. 2010..In contrast, radiographs are rarely helpful for evaluation of soft-tissue lesions, which almost always require MRI assessment... - A 20-year retrospective review of surgically treated liposarcoma at the Cleveland ClinicSteven A Lietman
The Cleveland Clinic, Cleveland, OH 44195, USA
Orthopedics 30:227-34. 2007..The 5-year disease-specific survival for extremity tumors was 92% (95% confidence interval [CI]; range: 84%-100%), while general 5-year survival for extremity tumors was 66% (95% Cl; range: 48%-85%)... - Genetic and molecular aspects of McCune-Albright syndromeSteven A Lietman
Department of Orthopaedic Surgery, Cleveland Clinic Lerner Research Institute, ND20, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Pediatr Endocrinol Rev 4:380-5. 2007.... - Chronic bilateral thigh and knee discomfort in an 18-year-old manJesse E Templeton
Clin Orthop Relat Res 466:507-13. 2008
Research Grants
- Molecular Mechanisms in Bone ResorptionSteven A Lietman; Fiscal Year: 2010..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..
- Molecular Mechanisms of Ectopic Bone FormationSTEVEN LIETMAN; Fiscal Year: 2006..abstract_text> ..
- Molecular Mechanisms in Bone ResorptionSTEVEN LIETMAN; Fiscal Year: 2009..New information about mechanisms of bone resorption may facilitate the development of novel strategies to decrease bone resorption and may lead to new treatments for osteoporosis. ..