VERONIQUE M LEFEBVRE

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis
    Pallavi Bhattaram
    Department of Cellular and Molecular Medicine, Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195
    J Cell Biol 207:657-71. 2014
  2. pmc The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties
    Peter Dy
    Department of Cell Biology and Orthopaedic Research Center Cleveland Clinic, Cleveland, OH, USA
    Nucleic Acids Res 36:3101-17. 2008
  3. pmc A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration
    Timothy J Mead
    Department of Cellular and Molecular Medicine, and Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Nucleic Acids Res 41:4459-69. 2013
  4. pmc Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions
    Bogdan Dumitriu
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America
    PLoS ONE 5:e12088. 2010
  5. ncbi request reprint Transcriptional control of chondrocyte fate and differentiation
    Veronique Lefebvre
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Birth Defects Res C Embryo Today 75:200-12. 2005
  6. pmc The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators
    Veronique Lefebvre
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 42:429-32. 2010
  7. pmc Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors
    Veronique Lefebvre
    Department of Cell Biology, Lerner Research Institute and Orthopaedic Research Center, Cleveland Clinic, 9500 Euclid Avenue NC10, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 39:2195-214. 2007
  8. pmc Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    Patrick Smits
    Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
    J Cell Biol 164:747-58. 2004
  9. pmc L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer
    Yu Han
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell Biol 28:4999-5013. 2008
  10. ncbi request reprint Toward understanding the functions of the two highly related Sox5 and Sox6 genes
    Veronique Lefebvre
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, ND 20, Cleveland, OH 44195, USA
    J Bone Miner Metab 20:121-30. 2002

Research Grants

  1. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010

Collaborators

  • Jan Jensen
  • Solomon Afelik
  • Gregory D Jay
  • Peter Dy
  • Bogdan Dumitriu
  • Patrick Smits
  • Alfredo Penzo-Méndez
  • Pallavi Bhattaram
  • Yu Han
  • Timothy J Mead
  • David K Rhee
  • Abhilash Gadi
  • Makoto M Taketo
  • Kenji Kato
  • Kaustav Bandyopadhyay
  • Qiuqing Wang
  • Amber Silvester
  • Carol A De La Motte
  • Nayeem Quayum
  • David M Kingsley
  • Yuanshuai Huang
  • Carlos E Pedraza
  • Wendy B Macklin
  • Hongzhe Wang
  • Bhattaram Pallavi
  • Ursula Klingmuller
  • Srujana Cherukuri
  • Jane P Petschek
  • Paul L Fox
  • Michael R Patrick
  • Hongwei Wang
  • John D Carpten
  • Yaoqin Gong
  • MacArthur Baker
  • Matthew L Warman
  • Matthew Stewart
  • Jose Marcelino
  • Srijeet Mitra

Detail Information

Publications18

  1. doi request reprint SOXC proteins amplify canonical WNT signaling to secure nonchondrocytic fates in skeletogenesis
    Pallavi Bhattaram
    Department of Cellular and Molecular Medicine, Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195
    J Cell Biol 207:657-71. 2014
    ..This synergy may determine cell fate in many processes besides skeletogenesis. ..
  2. pmc The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties
    Peter Dy
    Department of Cell Biology and Orthopaedic Research Center Cleveland Clinic, Cleveland, OH, USA
    Nucleic Acids Res 36:3101-17. 2008
    ..We conclude that the three SoxC proteins have conserved overlapping expression patterns and molecular properties, and might therefore act in concert to fulfill essential roles in vivo...
  3. pmc A far-upstream (-70 kb) enhancer mediates Sox9 auto-regulation in somatic tissues during development and adult regeneration
    Timothy J Mead
    Department of Cellular and Molecular Medicine, and Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Nucleic Acids Res 41:4459-69. 2013
    ..They provide thereby novel insights on molecular mechanisms controlling developmental and disease processes and suggest new strategies to improve disease treatments...
  4. pmc Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions
    Bogdan Dumitriu
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, United States of America
    PLoS ONE 5:e12088. 2010
    ..We used here Sox6 conditional null mice and molecular assays to address these questions...
  5. ncbi request reprint Transcriptional control of chondrocyte fate and differentiation
    Veronique Lefebvre
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Birth Defects Res C Embryo Today 75:200-12. 2005
    ..1 and Nkx3.2, Sox9, Sox5 and Sox6, Runx2 and Runx3, and c-Maf...
  6. pmc The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators
    Veronique Lefebvre
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 42:429-32. 2010
    ..While their biological and molecular functions remain incompletely understood, the SoxD proteins have thus already proven that they critically modulate cell fate in major lineages...
  7. pmc Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors
    Veronique Lefebvre
    Department of Cell Biology, Lerner Research Institute and Orthopaedic Research Center, Cleveland Clinic, 9500 Euclid Avenue NC10, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 39:2195-214. 2007
    ..We review their specific molecular properties and in vivo roles, stress recent advances in the field, and suggest directions for future investigations...
  8. pmc Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    Patrick Smits
    Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
    J Cell Biol 164:747-58. 2004
    ..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones...
  9. pmc L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer
    Yu Han
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell Biol 28:4999-5013. 2008
    ..This study thus uncovers critical cis-acting elements and transcription factors driving Agc1 expression in cartilage and increases understanding of the mode of action of the chondrogenic Sox trio...
  10. ncbi request reprint Toward understanding the functions of the two highly related Sox5 and Sox6 genes
    Veronique Lefebvre
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, ND 20, Cleveland, OH 44195, USA
    J Bone Miner Metab 20:121-30. 2002
  11. ncbi request reprint Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs
    Patrick Smits
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Development 130:1135-48. 2003
    ..Through these roles and essential roles in cartilage formation, they are central transcriptional regulators of vertebral column development...
  12. ncbi request reprint Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development
    Bogdan Dumitriu
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
    Blood 108:1198-207. 2006
    ..Sox6 thus enhances erythroid cell development at multiple levels and thereby ensures adequate production and quality of red blood cells...
  13. pmc The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    ..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
  14. pmc Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage
    Peter Dy
    Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NC 10, Cleveland, OH 44195, USA
    Dev Biol 341:346-59. 2010
    ..Together, these data suggest that synovial joint morphogenesis relies on essential roles for Sox5/6 in promoting both growth plate and articular chondrocyte differentiation...
  15. pmc Vertebrate skeletogenesis
    Veronique Lefebvre
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Curr Top Dev Biol 90:291-317. 2010
    ..Upon discussing current knowledge and gaps in knowledge in the control of skeletogenesis, we highlight ultimate research goals and propose research priorities and approaches for future endeavors...
  16. ncbi request reprint Generation of mice harboring a Sox6 conditional null allele
    Bogdan Dumitriu
    Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genesis 44:219-24. 2006
    ..Sox6(fl+/fl+) mice are indistinguishable from wildtype mice, and Sox6(fl-/fl-) mice from Sox6(-/-) mice. These Sox6 conditional null mice will thus be valuable for further uncovering the roles of Sox6 in various processes in vivo...
  17. doi request reprint Generation of mice harboring a Sox5 conditional null allele
    Peter Dy
    Department of Cell Biology and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genesis 46:294-9. 2008
    ..This Sox5 conditional null allele will be valuable in further uncovering the in vivo roles of L-Sox5...
  18. ncbi request reprint Generation of mice harboring a Sox4 conditional null allele
    Alfredo Penzo-Méndez
    Department of Cell Biology and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genesis 45:776-80. 2007
    ..This Sox4 conditional null allele will thus be a valuable tool to further uncovering Sox4 functions in various processes in vivo...

Research Grants1

  1. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....