VERONIQUE M LEFEBVRE

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors
    Veronique Lefebvre
    Department of Cell Biology, Lerner Research Institute and Orthopaedic Research Center, Cleveland Clinic, 9500 Euclid Avenue NC10, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 39:2195-214. 2007
  2. ncbi The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators
    Veronique Lefebvre
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 42:429-32. 2010
  3. ncbi Transcriptional control of chondrocyte fate and differentiation
    Veronique Lefebvre
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Birth Defects Res C Embryo Today 75:200-12. 2005
  4. ncbi Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    Patrick Smits
    Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
    J Cell Biol 164:747-58. 2004
  5. ncbi L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer
    Yu Han
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell Biol 28:4999-5013. 2008
  6. ncbi Toward understanding the functions of the two highly related Sox5 and Sox6 genes
    Veronique Lefebvre
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, ND 20, Cleveland, OH 44195, USA
    J Bone Miner Metab 20:121-30. 2002
  7. ncbi Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development
    Bogdan Dumitriu
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
    Blood 108:1198-207. 2006
  8. ncbi The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
  9. ncbi Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs
    Patrick Smits
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Development 130:1135-48. 2003
  10. ncbi Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage
    Peter Dy
    Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NC 10, Cleveland, OH 44195, USA
    Dev Biol 341:346-59. 2010

Research Grants

  1. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
  2. ROLES OF SOX C GENES IN SKELETOGENESIS
    Veronique Lefebvre; Fiscal Year: 2007
  3. GENETIC ANALYSIS OF CHONDROGENESIS
    Veronique Lefebvre; Fiscal Year: 2007
  4. GENETIC BASIS OF CHONDROGENESIS
    Veronique Lefebvre; Fiscal Year: 2003
  5. Transcriptional Control of Sox9
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010

Collaborators

  • Gregory D Jay
  • Peter Dy
  • Patrick Smits
  • Bogdan Dumitriu
  • Yu Han
  • Alfredo Penzo-Méndez
  • David K Rhee
  • David M Kingsley
  • Carol A De La Motte
  • Amber Silvester
  • Hongzhe Wang
  • Carlos E Pedraza
  • Wendy B Macklin
  • Bhattaram Pallavi
  • Jane P Petschek
  • Srujana Cherukuri
  • Ursula Klingmuller
  • Michael R Patrick
  • Paul L Fox
  • Matthew Stewart
  • Hongwei Wang
  • John D Carpten
  • Yaoqin Gong
  • Jose Marcelino
  • Matthew L Warman
  • MacArthur Baker
  • Srijeet Mitra

Detail Information

Publications15

  1. ncbi Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors
    Veronique Lefebvre
    Department of Cell Biology, Lerner Research Institute and Orthopaedic Research Center, Cleveland Clinic, 9500 Euclid Avenue NC10, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 39:2195-214. 2007
    ..We review their specific molecular properties and in vivo roles, stress recent advances in the field, and suggest directions for future investigations...
  2. ncbi The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators
    Veronique Lefebvre
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 42:429-32. 2010
    ..While their biological and molecular functions remain incompletely understood, the SoxD proteins have thus already proven that they critically modulate cell fate in major lineages...
  3. ncbi Transcriptional control of chondrocyte fate and differentiation
    Veronique Lefebvre
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Birth Defects Res C Embryo Today 75:200-12. 2005
    ..1 and Nkx3.2, Sox9, Sox5 and Sox6, Runx2 and Runx3, and c-Maf...
  4. ncbi Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    Patrick Smits
    Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
    J Cell Biol 164:747-58. 2004
    ..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones...
  5. ncbi L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer
    Yu Han
    Department of Cell Biology and Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell Biol 28:4999-5013. 2008
    ..This study thus uncovers critical cis-acting elements and transcription factors driving Agc1 expression in cartilage and increases understanding of the mode of action of the chondrogenic Sox trio...
  6. ncbi Toward understanding the functions of the two highly related Sox5 and Sox6 genes
    Veronique Lefebvre
    Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, ND 20, Cleveland, OH 44195, USA
    J Bone Miner Metab 20:121-30. 2002
  7. ncbi Sox6 cell-autonomously stimulates erythroid cell survival, proliferation, and terminal maturation and is thereby an important enhancer of definitive erythropoiesis during mouse development
    Bogdan Dumitriu
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
    Blood 108:1198-207. 2006
    ..Sox6 thus enhances erythroid cell development at multiple levels and thereby ensures adequate production and quality of red blood cells...
  8. ncbi The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
    David K Rhee
    Department of Genetics, Center for Human Genetics, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Invest 115:622-31. 2005
    ..We conclude that lubricin has multiple functions in articulating joints and tendons that include the protection of surfaces and the control of synovial cell growth...
  9. ncbi Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs
    Patrick Smits
    Department of Biomedical Engineering and Orthopaedic Research Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Development 130:1135-48. 2003
    ..Through these roles and essential roles in cartilage formation, they are central transcriptional regulators of vertebral column development...
  10. ncbi Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage
    Peter Dy
    Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue NC 10, Cleveland, OH 44195, USA
    Dev Biol 341:346-59. 2010
    ..Together, these data suggest that synovial joint morphogenesis relies on essential roles for Sox5/6 in promoting both growth plate and articular chondrocyte differentiation...
  11. ncbi Vertebrate skeletogenesis
    Veronique Lefebvre
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Curr Top Dev Biol 90:291-317. 2010
    ..Upon discussing current knowledge and gaps in knowledge in the control of skeletogenesis, we highlight ultimate research goals and propose research priorities and approaches for future endeavors...
  12. ncbi Generation of mice harboring a Sox6 conditional null allele
    Bogdan Dumitriu
    Department of Biomedical Engineering and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genesis 44:219-24. 2006
    ..Sox6(fl+/fl+) mice are indistinguishable from wildtype mice, and Sox6(fl-/fl-) mice from Sox6(-/-) mice. These Sox6 conditional null mice will thus be valuable for further uncovering the roles of Sox6 in various processes in vivo...
  13. ncbi The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping expression patterns and molecular properties
    Peter Dy
    Department of Cell Biology and Orthopaedic Research Center Cleveland Clinic, Cleveland, OH, USA
    Nucleic Acids Res 36:3101-17. 2008
    ..We conclude that the three SoxC proteins have conserved overlapping expression patterns and molecular properties, and might therefore act in concert to fulfill essential roles in vivo...
  14. ncbi Generation of mice harboring a Sox5 conditional null allele
    Peter Dy
    Department of Cell Biology and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genesis 46:294-9. 2008
    ..This Sox5 conditional null allele will be valuable in further uncovering the in vivo roles of L-Sox5...
  15. ncbi Generation of mice harboring a Sox4 conditional null allele
    Alfredo Penzo-Méndez
    Department of Cell Biology and Orthopaedic Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genesis 45:776-80. 2007
    ..This Sox4 conditional null allele will thus be a valuable tool to further uncovering Sox4 functions in various processes in vivo...

Research Grants14

  1. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....
  2. ROLES OF SOX C GENES IN SKELETOGENESIS
    Veronique Lefebvre; Fiscal Year: 2007
    ....
  3. GENETIC ANALYSIS OF CHONDROGENESIS
    Veronique Lefebvre; Fiscal Year: 2007
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  4. GENETIC BASIS OF CHONDROGENESIS
    Veronique Lefebvre; Fiscal Year: 2003
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  5. Transcriptional Control of Sox9
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....