Justin D Lathia
Affiliation: Cleveland Clinic Foundation
Lathia J, Heddleston J, Venere M, Rich J. Deadly teamwork: neural cancer stem cells and the tumor microenvironment. Cell Stem Cell. 2011;8:482-5 pubmed publisher
..The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy. ..
Thiagarajan P, Zheng Q, Bhagrath M, Mulkearns Hubert E, Myers M, Lathia J, et al
. STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance. Endocr Relat Cancer. 2017;24:415-426 pubmed publisher
..Our data demonstrate that LEPRb-induced STAT3 activation is essential for the induction and maintenance of TNBC CSCs. ..
Mulkearns Hubert E, Torre Healy L, Silver D, Eurich J, Bayık D, Serbinowski E, et al
. Development of a Cx46 Targeting Strategy for Cancer Stem Cells. Cell Rep. 2019;27:1062-1072.e5 pubmed publisher
..Furthermore, these results demonstrate the importance of targeting cell-cell communication as an anti-cancer therapy. ..
Lathia J. Drak, Drak, Goose: A New Signaling Axis in Glioblastoma. Cancer Res. 2019;79:1036-1037 pubmed publisher
..Functional studies revealed that targeting this signaling axis attenuated mitosis and cytokinesis, providing a new pathway for therapeutic development in GBM.See related article by Chen et al., p. 1085. ..
Saygin C, Matei D, Majeti R, Reizes O, Lathia J. Targeting Cancer Stemness in the Clinic: From Hype to Hope. Cell Stem Cell. 2019;24:25-40 pubmed publisher
..We discuss barriers to translating cues from pre-clinical models into clinical applications and propose new strategies for rational design of future anti-CSC trials. ..
Lathia J, Gallagher J, Myers J, Li M, Vasanji A, McLendon R, et al
. Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS ONE. 2011;6:e24807 pubmed publisher
Alvarado A, Lathia J. Taking a Toll on Self-Renewal: TLR-Mediated Innate Immune Signaling in Stem Cells. Trends Neurosci. 2016;39:463-471 pubmed publisher
..In this review we discuss how innate immune signaling interfaces with stem cell maintenance in the normal and neoplastic brain. ..
Thiagarajan P, Sinyuk M, Turaga S, Mulkearns Hubert E, Hale J, Rao V, et al
. Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nat Commun. 2018;9:578 pubmed publisher
..These findings challenge the paradigm that connexins are tumor suppressors in TNBC and reveal a unique function for Cx26 in regulating the core self-renewal signaling that controls CSC maintenance. ..
Lathia J, Hitomi M, Gallagher J, Gadani S, Adkins J, Vasanji A, et al
. Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Cell Death Dis. 2011;2:e200 pubmed publisher