Justin D Lathia

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Deadly teamwork: neural cancer stem cells and the tumor microenvironment
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44118, USA
    Cell Stem Cell 8:482-5. 2011
  2. ncbi Laminin alpha 2 enables glioblastoma stem cell growth
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Neurol 72:766-78. 2012
  3. ncbi Holding on to stemness
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Cell Biol 14:450-2. 2012
  4. ncbi Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
    J D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Death Dis 2:e200. 2011
  5. ncbi Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stem Cell Rev 7:227-37. 2011
  6. ncbi Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 6:e24807. 2011
  7. ncbi Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
  8. ncbi Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
    Youngmi Kim
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Dev 26:1247-62. 2012
  9. ncbi Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
    Olga A Guryanova
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cancer Cell 19:498-511. 2011
  10. ncbi The malignant social network: cell-cell adhesion and communication in cancer stem cells
    James S Hale
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Cell Adh Migr 6:346-55. 2012

Collaborators

Detail Information

Publications18

  1. ncbi Deadly teamwork: neural cancer stem cells and the tumor microenvironment
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44118, USA
    Cell Stem Cell 8:482-5. 2011
    ..The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy...
  2. ncbi Laminin alpha 2 enables glioblastoma stem cell growth
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Neurol 72:766-78. 2012
    ..Extracellular matrix (ECM) cues instruct neural stem/progenitor cell-niche interactions, and the objective of our study was to elucidate its composition and contribution to GSC maintenance in the perivascular niche...
  3. ncbi Holding on to stemness
    Justin D Lathia
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Cell Biol 14:450-2. 2012
    ..Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche...
  4. ncbi Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions
    J D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Death Dis 2:e200. 2011
    ....
  5. ncbi Seeing is believing: are cancer stem cells the Loch Ness monster of tumor biology?
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stem Cell Rev 7:227-37. 2011
    ..What remains clear is that a population of cells is present in many tumors which are resistant to conventional therapies and must be considered in the design of the next generation of cancer treatments...
  6. ncbi Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 6:e24807. 2011
    ....
  7. ncbi Integrin alpha 6 regulates glioblastoma stem cells
    Justin D Lathia
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Stem Cell 6:421-32. 2010
    ..Our results provide evidence that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy...
  8. ncbi Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
    Youngmi Kim
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Genes Dev 26:1247-62. 2012
    ..Our results may explain mixed clinical responses of anti-PDGFR-based approaches and suggest the need for integration of models of cancer as an organ system into development of cancer therapies...
  9. ncbi Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3
    Olga A Guryanova
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cancer Cell 19:498-511. 2011
    ..These data demonstrate that BMX represents a GSC therapeutic target and reinforces the importance of STAT3 signaling in stem-like cancer phenotypes...
  10. ncbi The malignant social network: cell-cell adhesion and communication in cancer stem cells
    James S Hale
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Cell Adh Migr 6:346-55. 2012
    ..In this review, we will discuss our current understanding of cell-cell adhesion mechanisms used by CSCs and how these local interactions have global consequences for tumor biology...
  11. ncbi Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells
    Meizhang Li
    Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Glia 59:108-18. 2011
    ..In addition, AMD3100 treatment of pregnant mice reduced the generation of neurospheres from E12.5 embryos. Our data suggest that CXCR4 is a potential cell surface marker for early embryonic NSCs and modulates growth-factor signaling...
  12. ncbi Endothelial expression of TNF receptor-1 generates a proapoptotic signal inhibited by integrin α6β1 in glioblastoma
    Ping Huang
    Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio, USA
    Cancer Res 72:1428-37. 2012
    ..Together, our findings indicate that the laminin receptor integrin α6β1 promotes the survival of brain ECs by inhibiting prodeath signaling by TNF-R1, in part by inducing cFLIP expression...
  13. ncbi Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2
    Christine E Eyler
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 146:53-66. 2011
    ..These data provide insight into how GSCs are mechanistically distinct from their less tumorigenic counterparts and suggest that NOS2 inhibition may be an efficacious approach to treating this devastating disease...
  14. ncbi Targeting A20 decreases glioma stem cell survival and tumor growth
    Anita B Hjelmeland
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS Biol 8:e1000319. 2010
    ..A20 anticancer therapies should therefore be viewed with caution as effects will likely differ depending on the tumor type...
  15. ncbi Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth
    Lin Cheng
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 153:139-52. 2013
    ..Thus, GSCs contribute to vascular pericytes that may actively remodel perivascular niches. Therapeutic targeting of GSC-derived pericytes may effectively block tumor progression and improve antiangiogenic therapy...
  16. ncbi Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair
    Meizhang Li
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Trends Neurosci 35:619-28. 2012
    ..These observations suggest that the CXCL12-CXCR4 axis maintains NSCs and serves as an emergent salvage signal for initiating endogenous stem cell-based tissue repair...
  17. ncbi Twisted tango: brain tumor neurovascular interactions
    Anita B Hjelmeland
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 14:1375-81. 2011
    ..Interrogating the codependence of BTSCs and the perivascular niche may directly inform clinical approaches for brain tumor therapy through targeting of highly angiogenic and tumorigenic cellular subsets...
  18. ncbi Growth factor receptors define cancer hierarchies
    Monica Venere
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cancer Cell 23:135-7. 2013
    ..Two papers in Cancer Cell, one in this issue (Day and colleagues) and one in a recent issue (Binda and colleagues), describe how Eph receptor tyrosine kinases critically define and regulate the growth of cancer stem cells...