Research Topics
| Kandice Kottke-MarchantSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
| Collaborators
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Detail Information
Publications
Importance of platelets and platelet response in acute coronary syndromesKandice Kottke-Marchant
Pathology and Laboratory Medicine Institute, Department of Clinical Pathology, Cleveland Clinic, 9500 Euclid Avenue, L21, Cleveland, OH 44195, USA
Cleve Clin J Med 76:S2-7. 2009..Standard testing protocols for platelet aggregation are needed to achieve consistency among studies...
The laboratory diagnosis of platelet disordersKandice Kottke-Marchant
Department of Clinical Pathology, The Cleveland Clinic Foundation, L30, 9500 Euclid Ave, Cleveland, OH 44195, USA
Arch Pathol Lab Med 126:133-46. 2002..To provide both a detailed description of the laboratory tests available in the diagnosis of platelet disorders and a testing algorithm, based on platelet count, that can be used to direct the evaluation of platelet disorders...- Genetic polymorphisms associated with venous and arterial thrombosis: an overviewKandice Kottke-Marchant
Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Arch Pathol Lab Med 126:295-304. 2002..To provide an overview of genetic polymorphisms associated with thrombotic cardiovascular disease... - A positive in vitro assay is required to diagnose heparin-induced thrombocytopeniaKandace Kottke-Marchant
Section of Hemostasis and Thrombosis, Department of Clinical Pathology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, L30, Cleveland, OH 44195, USA
Med Clin North Am 87:1215-24. 2003..The platelet count on postoperative day 1 is 160,000/microL and on postoperative day 6 is 60,000/microL. Heparin-induced thrombocytopenia (HIT) is suspected and HIT assays are ordered... - Antithrombin deficiency: issues in laboratory diagnosisKandice Kottke-Marchant
Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
Arch Pathol Lab Med 126:1326-36. 2002..These recommendations specify whom, how, and when to test... - Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptorKandice Kottke-Marchant
Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
Arch Pathol Lab Med 126:1337-48. 2002..The role of related proteins, such as thrombomodulin and endothelial protein C receptor, is also reviewed. Data Sources.-Review of the published medical literature... 
Platelet and endothelial adhesion on fluorosurfactant polymers designed for vascular graft modificationChad Tang
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biomed Mater Res A 88:348-58. 2009..These results illustrate the potential for ligands presented in a FSP surface modification to selectively adhere ECs with limited platelet attachment...- Biomimetic fluorocarbon surfactant polymers reduce platelet adhesion on PTFE/ePTFE surfacesShuwu Wang
NanoMimetics, Inc, 1768 E 25th Street, Cleveland, OH 44114, USA
J Biomater Sci Polym Ed 20:619-35. 2009.... - Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptidesJunmin Zhu
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Bioconjug Chem 20:333-9. 2009..Furthermore, cRGD-PEGDA is an attractive candidate for the future development of tissue engineering scaffolds with optimum cell adhesive strength and ligand density... - Endothelial cell attachment and shear response on biomimetic polymer-coated vascular graftsLynn A Dudash
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biomed Mater Res A 100:2204-10. 2012..This shear stable EC layer is necessary for in vivo endothelialization of the graft material, which shows promise to increase the patency of synthetic small diameter vascular grafts... - A biomimetic peptide fluorosurfactant polymer for endothelialization of ePTFE with limited platelet adhesionCoby C Larsen
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Wickenden 309, Cleveland, OH 44106, USA
Biomaterials 28:3537-48. 2007..This EC-selectivity could potentially facilitate rapid in vivo endothelialization and healing without thrombosis for small-diameter ePTFE vascular grafts... - The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotypeJeffrey A Beamish
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
Biomaterials 30:4127-35. 2009.... - The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineeringJeffrey A Beamish
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Wickenden 309, Cleveland, Ohio 44106, USA
J Biomed Mater Res A 92:441-50. 2010.... - Affinity manipulation of surface-conjugated RGD peptide to modulate binding of liposomes to activated plateletsGuofeng Huang
Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, 10900 Euclid Avenue, Cleveland, OH 44106 7207, USA
Biomaterials 29:1676-85. 2008..Hence, the results establish the feasibility of modulating the platelet-targeting and binding ability of vascularly targeted liposomes by manipulating the affinity of surface-modifying ligands... - The effect of RGD fluorosurfactant polymer modification of ePTFE on endothelial cell adhesion, growth, and functionCoby C Larsen
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Wickenden 309, Cleveland, OH 44106, USA
Biomaterials 27:4846-55. 2006..Our results indicate successful synthesis and surface modification with PFSP; this is a simple, quantitative, and effective approach to modifying ePTFE to encourage endothelial cell attachment, growth, and function... - Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectinSharon Sagnella
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA
Tissue Eng 11:226-36. 2005..These results indicate that the HBP surfaces promote initial HPAEC adhesion and spreading, but not long-term survival... - Aspirin resistance and a single geneBrian K Jefferson
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 95:805-8. 2005..Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1... - Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineeringJeffrey A Beamish
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
Tissue Eng Part B Rev 16:467-91. 2010..The application of an improved molecular understanding of SMC biology will facilitate the design of more potent cell-instructive scaffold systems to regulate SMC behavior... - Pilot candidate gene analysis of patients ≥ 60 years old with aortic stenosis involving a tricuspid aortic valveStephen G Ellis
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
Am J Cardiol 110:88-92. 2012..Given the concerns regarding the problem of multiple statistical testing, validation studies are required to further assess these correlations... - Simultaneous deep venous thrombosis and acquired factor VIII inhibitorSteven R Deitcher
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Clin Appl Thromb Hemost 8:375-9. 2002..The diagnostic and therapeutic challenges posed by these cases as well as a proposed mechanism by which pathologic thrombosis can develop in a patient with a life-threatening bleeding disorder are discussed... - The effects of heparin releasing hydrogels on vascular smooth muscle cell phenotypeJeffrey A Beamish
Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Wickenden 205, Cleveland, OH 44106, USA
Biomaterials 30:6286-94. 2009..These results indicate that RGD-modified, heparin releasing PEGDA gels can act as cell-instructive scaffolds that promote contractile SMC phenotype... - LightTyper platform for high-throughput clinical genotypingGurunathan Murugesan
The Cleveland Clinic Foundation, Department of Clinical Pathology, OH 44195, USA
Expert Rev Mol Diagn 5:457-71. 2005..The initial experience presented here suggests the potential use of the LightTyper for high-throughput clinical genotyping... - Detection of a novel point mutation of the prothrombin gene at position 20209Ilka Warshawsky
Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
Diagn Mol Pathol 11:152-6. 2002.... - Lack of effect of enteric coating on aspirin-induced inhibition of platelet aggregation in healthy volunteersJuhana Karha
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am Heart J 151:976.e7-11. 2006..Furthermore, point-of-care platelet assessment correlated well with the gold standard of laboratory-based optical platelet aggregometry... - Molecular genetic testing of polymorphisms associated with venous thrombosis: a review of molecular technologiesBo Xu
Department of Clinical Pathology, The Cleveland Clinic Foundation. Cleveland, OH 44195, USA
Diagn Mol Pathol 14:193-202. 2005..The choice of a technology for each individual laboratory would primarily depend on the specific requirements for the assay's accuracy, reliability, speed, throughput, and cost-effectiveness... - The role of aspirin in the prevention of thrombotic complications of thalidomide and anthracycline-based chemotherapy for multiple myelomaRachid Baz
Cleveland Clinic Myeloma Research Program, Cleveland Clinic Foundation, OH 44195, USA
Mayo Clin Proc 80:1568-74. 2005..001). CONCLUSION: Daily low-dose aspirin (81 mg orally) given to patients with newly diagnosed and relapsed/refractory multiple myeloma who were receiving DVd-T reduced the incidence of VTEs without an increase in bleeding complications... - Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokinesGurunathan Murugesan
Department of Clinical Pathology L30, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Mol Cell Cardiol 35:1375-84. 2003.... - Ximelagatran, a new oral anticoagulant--how will it affect laboratory practice? A laboratory perspectiveKandice Kottke-Marchant
Cleveland Clinic Foundation, USA
Lab Hematol 10:173-5. 2004 - RGD-modified liposomes targeted to activated platelets as a potential vascular drug delivery systemAnirban Sen Gupta
Department of Biomedical Engineering, Wickenden Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7207, USA
Thromb Haemost 93:106-14. 2005..Furthermore, the approach can be extended to the development of liposomes for other vascular targets, for application in drug delivery or gene therapy... - A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular diseasePatricia A Gum
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 41:961-5. 2003..06, p = 0.009). CONCLUSIONS: This study demonstrates the natural history of aspirin resistance in a stable population, documenting a greater than threefold increase in the risk of major adverse events associated with aspirin resistance... - Elevated fibrinogen and homocysteine levels enhance the risk of mortality in patients from a high-risk preventive cardiology clinicMonica Acevedo
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Arterioscler Thromb Vasc Biol 22:1042-5. 2002..Although no significant interaction between Fib and tHcy was demonstrated, both provided independent information after adjustment for traditional risk factors... - Coagulation analyzersKandice Kottke-Marchant
Department of Clinical Pathology, Cleveland Clinic Foundation, USA
CAP Today 17:18-22, 26-8, 30-3. 2003 - Differences in warfarin dosing decisions based on international normalized ratio measurements with two point-of-care testing devices and a reference laboratory measurementKenneth M Shermock
Department of Pharmacy, The Cleveland Clinic Foundation, Ohio 44195, USA
Pharmacotherapy 22:1397-404. 2002.... - Pseudo-protein S deficiency due to activated protein C resistanceSteven R Deitcher
Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Thromb Res 112:349-53. 2003 - Biometric surfactant polymers designed for shear-stable endothelialization on biomaterialsSharon Sagnella
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biomed Mater Res A 67:689-701. 2003..Furthermore, improved shear stability increases with increasing peptide density and is related to the EC's ability to reorganize its cytoskeleton... - Endothelial cell formation of focal adhesions on hydrophilic plasma polymersSharon L Sanborn
Department of Clinical Pathology, Cleveland Clinic Foundation, OH 44195, USA
Biomaterials 23:1-8. 2002..These results suggest that EC can form cytoskeletal structures necessary for cell survival on plasma polymers, especially on more hydrophilic NVP, which could be exploited as interface material for seeding endothelial cells... - Integrin-dependent interaction of human vascular endothelial cells on biomimetic peptide surfactant polymersGurunathan Murugesan
Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Cell Commun Adhes 9:59-73. 2002.... - Human microvascular endothelial cell growth and migration on biomimetic surfactant polymersSharon M Sagnella
Department of Biomedical Engineering, Case Western Reserve Univeristy, Cleveland, OH 44106, USA
Biomaterials 25:1249-59. 2004..2%+/-0.07/h on the 100% RGD surface. Our results show that surface peptide density affects cellular functions such as growth and migration, with the highest peptide density supporting the most proliferation but the slowest migration... - Extracellular matrix-like surfactant polymers containing arginine-glycine-aspartic acid (RGD) peptidesEric H Anderson
Department of Macromolecular Science, Wickenden 201, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-7207, USA
Macromol Biosci 4:766-75. 2004..Molecular model of a peptide surfactant polymer, consisting of poly(vinyl amine) backbone with peptide, dextran oligosaccharide and hexyl branches coupled to the polymer chain... - Correlation of point-of-care ecarin clotting time versus activated clotting time with bivalirudin concentrationsLeslie Cho
Department of Cardiology, Loyola University Medical Center, Maywood, Illinois, USA
Am J Cardiol 91:1110-3. 2003 - Effect of fondaparinux on coagulation assays: results of College of American Pathologists proficiency testingAgata Smogorzewska
Department of Pathology and Laboratory Medicine, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
Arch Pathol Lab Med 130:1605-11. 2006..A fondaparinux standard curve should be used for reporting fondaparinux levels using an anti-factor Xa assay... - A review of the technical, diagnostic, and epidemiologic considerations for protein S assaysAndrew J Goodwin
Department of Pathology, University of Vermont, Burlington 05405, USA
Arch Pathol Lab Med 126:1349-66. 2002..These 2 problems point out the need for better standardized assays and rigorous studies of the diagnostic utility of these assays... - Recommendations for evaluation of coagulation analyzersChris Gardiner
University College London Hospitals, London, UK
Lab Hematol 12:32-8. 2006 - Hypersensitivity of platelets to adenosine diphosphate in patients with stable cardiovascular disease predicts major adverse events despite antiplatelet therapyDouglas J Christie
Dade Behring Inc, Newark, DE 19702, USA
Platelets 19:104-10. 2008.... - The Ultegra rapid platelet-function assay: comparison to standard platelet function assays in patients undergoing percutaneous coronary intervention with abciximab therapyGuy L Wheeler
Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA
Am Heart J 143:602-11. 2002..Ultegra RPFA measurements are not operator-dependent and are not influenced by concomitant medications, hematologic parameters, or demographics...