Kandice Kottke-Marchant

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Importance of platelets and platelet response in acute coronary syndromes
    Kandice Kottke-Marchant
    Pathology and Laboratory Medicine Institute, Department of Clinical Pathology, Cleveland Clinic, 9500 Euclid Avenue, L21, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:S2-7. 2009
  2. ncbi request reprint The laboratory diagnosis of platelet disorders
    Kandice Kottke-Marchant
    Department of Clinical Pathology, The Cleveland Clinic Foundation, L30, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 126:133-46. 2002
  3. ncbi request reprint Genetic polymorphisms associated with venous and arterial thrombosis: an overview
    Kandice Kottke-Marchant
    Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 126:295-304. 2002
  4. ncbi request reprint A positive in vitro assay is required to diagnose heparin-induced thrombocytopenia
    Kandace Kottke-Marchant
    Section of Hemostasis and Thrombosis, Department of Clinical Pathology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, L30, Cleveland, OH 44195, USA
    Med Clin North Am 87:1215-24. 2003
  5. ncbi request reprint Antithrombin deficiency: issues in laboratory diagnosis
    Kandice Kottke-Marchant
    Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Arch Pathol Lab Med 126:1326-36. 2002
  6. ncbi request reprint Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptor
    Kandice Kottke-Marchant
    Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Arch Pathol Lab Med 126:1337-48. 2002
  7. pmc Platelet and endothelial adhesion on fluorosurfactant polymers designed for vascular graft modification
    Chad Tang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 88:348-58. 2009
  8. pmc Biomimetic fluorocarbon surfactant polymers reduce platelet adhesion on PTFE/ePTFE surfaces
    Shuwu Wang
    NanoMimetics, Inc, 1768 E 25th Street, Cleveland, OH 44114, USA
    J Biomater Sci Polym Ed 20:619-35. 2009
  9. pmc Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptides
    Junmin Zhu
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Bioconjug Chem 20:333-9. 2009
  10. pmc Endothelial cell attachment and shear response on biomimetic polymer-coated vascular grafts
    Lynn A Dudash
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 100:2204-10. 2012

Collaborators

Detail Information

Publications45

  1. doi request reprint Importance of platelets and platelet response in acute coronary syndromes
    Kandice Kottke-Marchant
    Pathology and Laboratory Medicine Institute, Department of Clinical Pathology, Cleveland Clinic, 9500 Euclid Avenue, L21, Cleveland, OH 44195, USA
    Cleve Clin J Med 76:S2-7. 2009
    ..Standard testing protocols for platelet aggregation are needed to achieve consistency among studies...
  2. ncbi request reprint The laboratory diagnosis of platelet disorders
    Kandice Kottke-Marchant
    Department of Clinical Pathology, The Cleveland Clinic Foundation, L30, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 126:133-46. 2002
    ..To provide both a detailed description of the laboratory tests available in the diagnosis of platelet disorders and a testing algorithm, based on platelet count, that can be used to direct the evaluation of platelet disorders...
  3. ncbi request reprint Genetic polymorphisms associated with venous and arterial thrombosis: an overview
    Kandice Kottke-Marchant
    Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arch Pathol Lab Med 126:295-304. 2002
    ..To provide an overview of genetic polymorphisms associated with thrombotic cardiovascular disease...
  4. ncbi request reprint A positive in vitro assay is required to diagnose heparin-induced thrombocytopenia
    Kandace Kottke-Marchant
    Section of Hemostasis and Thrombosis, Department of Clinical Pathology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, L30, Cleveland, OH 44195, USA
    Med Clin North Am 87:1215-24. 2003
    ..The platelet count on postoperative day 1 is 160,000/microL and on postoperative day 6 is 60,000/microL. Heparin-induced thrombocytopenia (HIT) is suspected and HIT assays are ordered...
  5. ncbi request reprint Antithrombin deficiency: issues in laboratory diagnosis
    Kandice Kottke-Marchant
    Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Arch Pathol Lab Med 126:1326-36. 2002
    ..These recommendations specify whom, how, and when to test...
  6. ncbi request reprint Laboratory issues in diagnosing abnormalities of protein C, thrombomodulin, and endothelial cell protein C receptor
    Kandice Kottke-Marchant
    Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Arch Pathol Lab Med 126:1337-48. 2002
    ..The role of related proteins, such as thrombomodulin and endothelial protein C receptor, is also reviewed. Data Sources.-Review of the published medical literature...
  7. pmc Platelet and endothelial adhesion on fluorosurfactant polymers designed for vascular graft modification
    Chad Tang
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 88:348-58. 2009
    ..These results illustrate the potential for ligands presented in a FSP surface modification to selectively adhere ECs with limited platelet attachment...
  8. pmc Biomimetic fluorocarbon surfactant polymers reduce platelet adhesion on PTFE/ePTFE surfaces
    Shuwu Wang
    NanoMimetics, Inc, 1768 E 25th Street, Cleveland, OH 44114, USA
    J Biomater Sci Polym Ed 20:619-35. 2009
    ....
  9. pmc Design and synthesis of biomimetic hydrogel scaffolds with controlled organization of cyclic RGD peptides
    Junmin Zhu
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Bioconjug Chem 20:333-9. 2009
    ..Furthermore, cRGD-PEGDA is an attractive candidate for the future development of tissue engineering scaffolds with optimum cell adhesive strength and ligand density...
  10. pmc Endothelial cell attachment and shear response on biomimetic polymer-coated vascular grafts
    Lynn A Dudash
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 100:2204-10. 2012
    ..This shear stable EC layer is necessary for in vivo endothelialization of the graft material, which shows promise to increase the patency of synthetic small diameter vascular grafts...
  11. pmc A biomimetic peptide fluorosurfactant polymer for endothelialization of ePTFE with limited platelet adhesion
    Coby C Larsen
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Wickenden 309, Cleveland, OH 44106, USA
    Biomaterials 28:3537-48. 2007
    ..This EC-selectivity could potentially facilitate rapid in vivo endothelialization and healing without thrombosis for small-diameter ePTFE vascular grafts...
  12. pmc The influence of RGD-bearing hydrogels on the re-expression of contractile vascular smooth muscle cell phenotype
    Jeffrey A Beamish
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Biomaterials 30:4127-35. 2009
    ....
  13. pmc The effects of monoacrylated poly(ethylene glycol) on the properties of poly(ethylene glycol) diacrylate hydrogels used for tissue engineering
    Jeffrey A Beamish
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Wickenden 309, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 92:441-50. 2010
    ....
  14. pmc Affinity manipulation of surface-conjugated RGD peptide to modulate binding of liposomes to activated platelets
    Guofeng Huang
    Department of Biomedical Engineering, Case Western Reserve University, Wickenden Building, 10900 Euclid Avenue, Cleveland, OH 44106 7207, USA
    Biomaterials 29:1676-85. 2008
    ..Hence, the results establish the feasibility of modulating the platelet-targeting and binding ability of vascularly targeted liposomes by manipulating the affinity of surface-modifying ligands...
  15. pmc The effect of RGD fluorosurfactant polymer modification of ePTFE on endothelial cell adhesion, growth, and function
    Coby C Larsen
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Wickenden 309, Cleveland, OH 44106, USA
    Biomaterials 27:4846-55. 2006
    ..Our results indicate successful synthesis and surface modification with PFSP; this is a simple, quantitative, and effective approach to modifying ePTFE to encourage endothelial cell attachment, growth, and function...
  16. pmc Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectin
    Sharon Sagnella
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Tissue Eng 11:226-36. 2005
    ..These results indicate that the HBP surfaces promote initial HPAEC adhesion and spreading, but not long-term survival...
  17. ncbi request reprint Aspirin resistance and a single gene
    Brian K Jefferson
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 95:805-8. 2005
    ..Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1...
  18. pmc Molecular regulation of contractile smooth muscle cell phenotype: implications for vascular tissue engineering
    Jeffrey A Beamish
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Tissue Eng Part B Rev 16:467-91. 2010
    ..The application of an improved molecular understanding of SMC biology will facilitate the design of more potent cell-instructive scaffold systems to regulate SMC behavior...
  19. doi request reprint Pilot candidate gene analysis of patients ≥ 60 years old with aortic stenosis involving a tricuspid aortic valve
    Stephen G Ellis
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA
    Am J Cardiol 110:88-92. 2012
    ..Given the concerns regarding the problem of multiple statistical testing, validation studies are required to further assess these correlations...
  20. ncbi request reprint Simultaneous deep venous thrombosis and acquired factor VIII inhibitor
    Steven R Deitcher
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Appl Thromb Hemost 8:375-9. 2002
    ..The diagnostic and therapeutic challenges posed by these cases as well as a proposed mechanism by which pathologic thrombosis can develop in a patient with a life-threatening bleeding disorder are discussed...
  21. pmc The effects of heparin releasing hydrogels on vascular smooth muscle cell phenotype
    Jeffrey A Beamish
    Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Ave, Wickenden 205, Cleveland, OH 44106, USA
    Biomaterials 30:6286-94. 2009
    ..These results indicate that RGD-modified, heparin releasing PEGDA gels can act as cell-instructive scaffolds that promote contractile SMC phenotype...
  22. ncbi request reprint LightTyper platform for high-throughput clinical genotyping
    Gurunathan Murugesan
    The Cleveland Clinic Foundation, Department of Clinical Pathology, OH 44195, USA
    Expert Rev Mol Diagn 5:457-71. 2005
    ..The initial experience presented here suggests the potential use of the LightTyper for high-throughput clinical genotyping...
  23. ncbi request reprint Detection of a novel point mutation of the prothrombin gene at position 20209
    Ilka Warshawsky
    Department of Clinical Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Diagn Mol Pathol 11:152-6. 2002
    ....
  24. ncbi request reprint Lack of effect of enteric coating on aspirin-induced inhibition of platelet aggregation in healthy volunteers
    Juhana Karha
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am Heart J 151:976.e7-11. 2006
    ..Some individuals are less responsive to aspirin's antiplatelet effect, a phenomenon termed aspirin resistance. It is not known whether the antiplatelet effect is fully preserved with the enteric-coated (EC) formulation...
  25. ncbi request reprint Molecular genetic testing of polymorphisms associated with venous thrombosis: a review of molecular technologies
    Bo Xu
    Department of Clinical Pathology, The Cleveland Clinic Foundation Cleveland, OH 44195, USA
    Diagn Mol Pathol 14:193-202. 2005
    ..The choice of a technology for each individual laboratory would primarily depend on the specific requirements for the assay's accuracy, reliability, speed, throughput, and cost-effectiveness...
  26. ncbi request reprint The role of aspirin in the prevention of thrombotic complications of thalidomide and anthracycline-based chemotherapy for multiple myeloma
    Rachid Baz
    Cleveland Clinic Myeloma Research Program, Cleveland Clinic Foundation, OH 44195, USA
    Mayo Clin Proc 80:1568-74. 2005
    ....
  27. ncbi request reprint Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines
    Gurunathan Murugesan
    Department of Clinical Pathology L30, The Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Mol Cell Cardiol 35:1375-84. 2003
    ....
  28. ncbi request reprint Ximelagatran, a new oral anticoagulant--how will it affect laboratory practice? A laboratory perspective
    Kandice Kottke-Marchant
    Cleveland Clinic Foundation, USA
    Lab Hematol 10:173-5. 2004
  29. ncbi request reprint RGD-modified liposomes targeted to activated platelets as a potential vascular drug delivery system
    Anirban Sen Gupta
    Department of Biomedical Engineering, Wickenden Building, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 7207, USA
    Thromb Haemost 93:106-14. 2005
    ..Furthermore, the approach can be extended to the development of liposomes for other vascular targets, for application in drug delivery or gene therapy...
  30. ncbi request reprint A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease
    Patricia A Gum
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Am Coll Cardiol 41:961-5. 2003
    ..This study was designed to determine if aspirin resistance is associated with clinical events...
  31. ncbi request reprint Elevated fibrinogen and homocysteine levels enhance the risk of mortality in patients from a high-risk preventive cardiology clinic
    Monica Acevedo
    Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 22:1042-5. 2002
    ..Although no significant interaction between Fib and tHcy was demonstrated, both provided independent information after adjustment for traditional risk factors...
  32. ncbi request reprint Coagulation analyzers
    Kandice Kottke-Marchant
    Department of Clinical Pathology, Cleveland Clinic Foundation, USA
    CAP Today 17:18-22, 26-8, 30-3. 2003
  33. ncbi request reprint Differences in warfarin dosing decisions based on international normalized ratio measurements with two point-of-care testing devices and a reference laboratory measurement
    Kenneth M Shermock
    Department of Pharmacy, The Cleveland Clinic Foundation, Ohio 44195, USA
    Pharmacotherapy 22:1397-404. 2002
    ....
  34. ncbi request reprint Pseudo-protein S deficiency due to activated protein C resistance
    Steven R Deitcher
    Department of Hematology and Medical Oncology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Thromb Res 112:349-53. 2003
  35. ncbi request reprint Biometric surfactant polymers designed for shear-stable endothelialization on biomaterials
    Sharon Sagnella
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biomed Mater Res A 67:689-701. 2003
    ..Furthermore, improved shear stability increases with increasing peptide density and is related to the EC's ability to reorganize its cytoskeleton...
  36. ncbi request reprint Endothelial cell formation of focal adhesions on hydrophilic plasma polymers
    Sharon L Sanborn
    Department of Clinical Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Biomaterials 23:1-8. 2002
    ..These results suggest that EC can form cytoskeletal structures necessary for cell survival on plasma polymers, especially on more hydrophilic NVP, which could be exploited as interface material for seeding endothelial cells...
  37. ncbi request reprint Integrin-dependent interaction of human vascular endothelial cells on biomimetic peptide surfactant polymers
    Gurunathan Murugesan
    Department of Clinical Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cell Commun Adhes 9:59-73. 2002
    ....
  38. ncbi request reprint Human microvascular endothelial cell growth and migration on biomimetic surfactant polymers
    Sharon M Sagnella
    Department of Biomedical Engineering, Case Western Reserve Univeristy, Cleveland, OH 44106, USA
    Biomaterials 25:1249-59. 2004
    ..2%+/-0.07/h on the 100% RGD surface. Our results show that surface peptide density affects cellular functions such as growth and migration, with the highest peptide density supporting the most proliferation but the slowest migration...
  39. ncbi request reprint Extracellular matrix-like surfactant polymers containing arginine-glycine-aspartic acid (RGD) peptides
    Eric H Anderson
    Department of Macromolecular Science, Wickenden 201, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7207, USA
    Macromol Biosci 4:766-75. 2004
    ..Molecular model of a peptide surfactant polymer, consisting of poly(vinyl amine) backbone with peptide, dextran oligosaccharide and hexyl branches coupled to the polymer chain...
  40. ncbi request reprint Correlation of point-of-care ecarin clotting time versus activated clotting time with bivalirudin concentrations
    Leslie Cho
    Department of Cardiology, Loyola University Medical Center, Maywood, Illinois, USA
    Am J Cardiol 91:1110-3. 2003
  41. ncbi request reprint Effect of fondaparinux on coagulation assays: results of College of American Pathologists proficiency testing
    Agata Smogorzewska
    Department of Pathology and Laboratory Medicine, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Arch Pathol Lab Med 130:1605-11. 2006
    ..It may also be efficacious, safe, and cost-effective for other patients; thus, more widespread use of fondaparinux is likely. The effect of fondaparinux on coagulation testing needs to be thoroughly examined...
  42. ncbi request reprint A review of the technical, diagnostic, and epidemiologic considerations for protein S assays
    Andrew J Goodwin
    Department of Pathology, University of Vermont, Burlington 05405, USA
    Arch Pathol Lab Med 126:1349-66. 2002
    ..As described elsewhere, results of discussions at the College of American Pathologists Conference XXXVI on Diagnostic Issues in Thrombophilia were used to revise the manuscript into its final form...
  43. ncbi request reprint Recommendations for evaluation of coagulation analyzers
    Chris Gardiner
    University College London Hospitals, London, UK
    Lab Hematol 12:32-8. 2006
  44. ncbi request reprint Hypersensitivity of platelets to adenosine diphosphate in patients with stable cardiovascular disease predicts major adverse events despite antiplatelet therapy
    Douglas J Christie
    Dade Behring Inc, Newark, DE 19702, USA
    Platelets 19:104-10. 2008
    ....
  45. ncbi request reprint The Ultegra rapid platelet-function assay: comparison to standard platelet function assays in patients undergoing percutaneous coronary intervention with abciximab therapy
    Guy L Wheeler
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Am Heart J 143:602-11. 2002
    ..Furthermore, a diminished degree of platelet inhibition is an independent predictor of adverse cardiac events, highlighting the need for accurate and precise monitoring of platelet function...