Anton A Komar

Summary

Affiliation: Cleveland State University
Country: USA

Publications

  1. ncbi request reprint Silent SNPs: impact on gene function and phenotype
    Anton A Komar
    Cleveland State University, Department of Biological, Geological and Environmental Sciences, Cleveland, OH 44115, USA
    Pharmacogenomics 8:1075-80. 2007
  2. pmc Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins
    Thomas Lumsden
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA
    Nucleic Acids Res 38:1261-72. 2010
  3. pmc Birth, life and death of nascent polypeptide chains
    Sujata Jha
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Biotechnol J 6:623-40. 2011
  4. ncbi request reprint Genetics. SNPs, silent but not invisible
    Anton A Komar
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Science 315:466-7. 2007
  5. doi request reprint A pause for thought along the co-translational folding pathway
    Anton A Komar
    Department of Biological, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115, USA
    Trends Biochem Sci 34:16-24. 2009
  6. pmc Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states
    Anton A Komar
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, USA
    Cell Cycle 10:229-40. 2011
  7. ncbi request reprint Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation
    James Fernandez
    Departments of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mol Cell 17:405-16. 2005
  8. pmc A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae
    Lucas C Reineke
    Department of Biochemistry, Case Western Reserve University, Cleveland, School of Medicine, Ohio 44106, USA
    J Biol Chem 283:19011-25. 2008
  9. pmc The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation
    Mithu Majumder
    Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4954, USA
    Mol Cell Biol 29:2899-912. 2009
  10. pmc Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5
    Oleksandr Galkin
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio 44115, USA
    RNA 13:2116-28. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Silent SNPs: impact on gene function and phenotype
    Anton A Komar
    Cleveland State University, Department of Biological, Geological and Environmental Sciences, Cleveland, OH 44115, USA
    Pharmacogenomics 8:1075-80. 2007
    ..Thus, silent SNPs should no longer be neglected in determining the likelihood of development of various diseases, and should be taken into account in personalized drug treatment and development programs...
  2. pmc Yeast strains with N-terminally truncated ribosomal protein S5: implications for the evolution, structure and function of the Rps5/Rps7 proteins
    Thomas Lumsden
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, OH 44115, USA
    Nucleic Acids Res 38:1261-72. 2010
    ....
  3. pmc Birth, life and death of nascent polypeptide chains
    Sujata Jha
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Biotechnol J 6:623-40. 2011
    ..This review provides an overview of our current understanding of the complex co-translational events that accompany the synthesis, maturation, folding and degradation of nascent polypeptide chains...
  4. ncbi request reprint Genetics. SNPs, silent but not invisible
    Anton A Komar
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Science 315:466-7. 2007
  5. doi request reprint A pause for thought along the co-translational folding pathway
    Anton A Komar
    Department of Biological, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH 44115, USA
    Trends Biochem Sci 34:16-24. 2009
    ....
  6. pmc Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states
    Anton A Komar
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH, USA
    Cell Cycle 10:229-40. 2011
    ....
  7. ncbi request reprint Ribosome stalling regulates IRES-mediated translation in eukaryotes, a parallel to prokaryotic attenuation
    James Fernandez
    Departments of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Mol Cell 17:405-16. 2005
    ..This control is reminiscent of translation attenuation in prokaryotic operons, where inhibition of translation elongation can regulate both mRNA translation and gene transcription by altering mRNA structure...
  8. pmc A small stem loop element directs internal initiation of the URE2 internal ribosome entry site in Saccharomyces cerevisiae
    Lucas C Reineke
    Department of Biochemistry, Case Western Reserve University, Cleveland, School of Medicine, Ohio 44106, USA
    J Biol Chem 283:19011-25. 2008
    ..Our data provide the first insight into the RNA structural requirements of the yeast translational machinery for cap-independent initiation of protein synthesis...
  9. pmc The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation
    Mithu Majumder
    Department of Nutrition, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4954, USA
    Mol Cell Biol 29:2899-912. 2009
    ..It is proposed that PTB and hnRNP L are positive regulators of Cat-1 mRNA translation via the IRES under stress conditions that cause a global decrease of protein synthesis...
  10. pmc Roles of the negatively charged N-terminal extension of Saccharomyces cerevisiae ribosomal protein S5 revealed by characterization of a yeast strain containing human ribosomal protein S5
    Oleksandr Galkin
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio 44115, USA
    RNA 13:2116-28. 2007
    ....
  11. pmc Insights into the mechanism of ribosomal incorporation of mammalian L13a protein during ribosome biogenesis
    Priyanka Das
    Center for Gene Regulation in Health and Disease, Department of Biology, Geology and Environmental Sciences, Cleveland State University, Cleveland, Ohio, USA
    Mol Cell Biol 33:2829-42. 2013
    ..These results provide new insights into the mechanism of ribosomal incorporation of L13a and will be useful in guiding future studies aimed at fully deciphering mammalian ribosome biogenesis. ..
  12. pmc A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation
    Mithu Majumder
    Departments of Nutrition, Case Western University School of Medicine, Cleveland, Ohio, USA
    Mol Cell Biol 32:992-1003. 2012
    ..We propose a model in which eIF2α phosphorylation-mediated control of mRNA turnover is a molecular switch that regulates the stress response transcription program and the ER's capacity for protein folding during stress...
  13. pmc Characterization of hibernating ribosomes in mammalian cells
    Dawid Krokowski
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Cell Cycle 10:2691-702. 2011
    ..The identification of ribosomal dimers in rat cells will bring new insights in our thinking of the ribosome structure and its function during the cellular response to stress conditions...
  14. pmc An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation
    Vladimir V Zeenko
    Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    RNA 14:593-602. 2008
    ..In addition, cell-free systems from differentiated cells with the Ser51Ala mutation should provide a means for investigating cell type-specific features of protein synthesis...
  15. pmc L13a blocks 48S assembly: role of a general initiation factor in mRNA-specific translational control
    Purvi Kapasi
    Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Mol Cell 25:113-26. 2007
    ..However, our studies reveal a unique mechanism in which targeting of eIF4G by mRNA-bound L13a elicits transcript-specific translational repression...
  16. pmc Chimeric glutathione S-transferases containing inserts of kininogen peptides: potential novel protein therapeutics
    Amber A Bentley
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, Ohio 44115, USA
    J Biol Chem 287:22142-50. 2012
    ..These results suggest that the therapeutic efficacy of short peptides can be enhanced by insertion into larger proteins that are easily expressed and purified and that GST may potentially be used as such a carrier...
  17. pmc Genome-wide polysome profiling reveals an inflammation-responsive posttranscriptional operon in gamma interferon-activated monocytes
    Keyur Vyas
    Center for Gene Regulation in Health and Disease and Department of Biology, Cleveland State University, Cleveland, Ohio 44115, USA
    Mol Cell Biol 29:458-70. 2009
    ..This regulation of a cohort of mRNAs encoding inflammatory proteins may be important to resolve inflammation...
  18. ncbi request reprint Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A
    Anton A Komar
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 280:15601-11. 2005
    ..It was hypothesized that this instability allows for translational control through the level of eIF2A protein in yeast cells...
  19. pmc Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylation
    Sujan Chaudhuri
    Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, Ohio 44115, USA
    RNA 13:2224-37. 2007
    ..Thus, L13a may have evolved from an essential ribosomal protein in lower eukaryotes to having a role as a dispensable extra-ribosomal function in higher eukaryotes...
  20. pmc Requirement of rRNA methylation for 80S ribosome assembly on a cohort of cellular internal ribosome entry sites
    Abhijit Basu
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Mol Cell Biol 31:4482-99. 2011
    ..This work reveals a novel mechanism operating on a cohort of cellular IRESs that involves rRNA methylation for proper 80S complex assembly and efficient translation initiation...
  21. ncbi request reprint Characterization of mammalian eIF2A and identification of the yeast homolog
    Wendy L Zoll
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 277:37079-87. 2002
    ..The lack of any apparent phenotype in the DeltaeIF2A strain suggests that eIF2A functions in a minor pathway, perhaps internal initiation or in the translation of a small number of specific mRNAs...
  22. pmc A new framework for understanding IRES-mediated translation
    Anton A Komar
    Center for Gene Regulation in Health and Disease, Department of Biological, Geological and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA
    Gene 502:75-86. 2012
    ..It will become apparent that a mixture of descriptions is likely to become the norm in the near future (i.e. m(7)G-assisted internal initiation)...
  23. ncbi request reprint eIF4A: the godfather of the DEAD box helicases
    George W Rogers
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4935, USA
    Prog Nucleic Acid Res Mol Biol 72:307-31. 2002
    ....
  24. ncbi request reprint Co-repressor release but not ligand binding is a prerequisite for transcription activation by human retinoid acid receptor alpha ligand-binding domain
    Hung Ying Kao
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:7366-73. 2003
    ..Consequently, K262A functions as a dominant-negative mutant at low concentrations of all-trans-retinoic acid. As a result, transcriptional activation is mechanistically linked to co-repressor release...
  25. ncbi request reprint The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader
    Ibrahim Yaman
    Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cell 113:519-31. 2003
    ..This study suggests that the structure of the IRES is dynamic and regulation of this RNA structure is a mechanism of translational control...
  26. ncbi request reprint Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner
    Aristobolo M Silva
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 282:10164-71. 2007
    ..Thus, salicylates selectively trigger an endoplasmic reticulum stress-responsive signaling pathway initiated through activation of PERK to induce their cellular effects...
  27. pmc Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis
    Sergei Merkulov
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Blood 111:1274-81. 2008
    ..These results suggest that a single gene, mKng1, is responsible for production of plasma kininogen, and that plasma HK contributes to induced arterial thrombosis in mice...
  28. ncbi request reprint Internal ribosome entry sites in cellular mRNAs: mystery of their existence
    Anton A Komar
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 280:23425-8. 2005
    ..Recent findings on the structures of these IRESs and specifically regulation of their activity during nutritional stress, differentiation, and mitosis will be discussed...
  29. pmc The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation
    Hsin Sheng Yang
    Gene Regulation Section, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA
    Mol Cell Biol 23:26-37. 2003
    ..Pdcd4 binding to eIF4A is linked to its transformation-suppressing activity, as Pdcd4-eIF4A binding and consequent inhibition of translation are required for Pdcd4 transrepression of AP-1...
  30. pmc Internal initiation drives the synthesis of Ure2 protein lacking the prion domain and affects [URE3] propagation in yeast cells
    Anton A Komar
    Institut fur Biochemie und Molekularbiologie, Universitat Bern, Buehlstrasse 28, 3012 Bern, Switzerland
    EMBO J 22:1199-209. 2003
    ..We assume that the balance between the full-length and truncated (94-354) Ure2p forms plays an important role in yeast cell physiology and differentiation...
  31. doi request reprint Ribosome can resume the translation in both +1 or -1 frames after encountering an AGA cluster in Escherichia coli
    Sébastien Lainé
    Laboratoire de Genetique et Biologie Cellulaire, UMR 81 59 CNRS Université Versailles St Quentin EPHE, France
    Gene 412:95-101. 2008
    ..RNA 10, 221-230), thus confirming that AGA/AGG codons can serve as sites for -1 frameshifting events. Only +1 frameshifting was suggested previously to occur at the AGA/AGG clusters...