Research Topics
Species | John P KirwanSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Management of non-alcoholic fatty liver diseaseA Chuthan Sourianarayanane
Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Minerva Gastroenterol Dietol 59:69-87. 2013..This review focuses on the available current and potential future therapies for treating NASH...
Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptideThomas P J Solomon
Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
Diabetes Care 33:1561-6. 2010..The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis...- Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitusJohn P Kirwan
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NE 40, Cleveland, OH 44195, USA
Am J Physiol Endocrinol Metab 297:E151-6. 2009..These improvements include increased peripheral insulin sensitivity and responsiveness as well as enhanced suppression of hepatic glucose production... - Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adultsJohn P Kirwan
Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Ann Nutr Metab 55:326-33. 2009..The aim of this study was to assess the combined effects of exercise and dietary glycemic load on insulin resistance in older obese adults... - A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humansThomas Pj Solomon
Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
Am J Clin Nutr 92:1359-68. 2010..The optimal lifestyle intervention that reverses diabetes risk factors is not known... 
Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adultsThomas P J Solomon
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NE 40, Cleveland, OH 44195, USA
J Appl Physiol 104:1313-9. 2008..We also demonstrate that leptin sensitivity is improved but that such a trend may rely on reducing caloric intake in addition to exercise training...- The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesityKaren R Kelly
Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA
Am J Physiol Endocrinol Metab 296:E1269-74. 2009.... - Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndromeFrank Gonzalez
Department of Obstetrics and Gynecology, MetroHealth Medical Center, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
J Clin Endocrinol Metab 91:1508-12. 2006..Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS)... - Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humansThomas P J Solomon
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH44195, USA
Am J Clin Nutr 90:1222-9. 2009..The optimal combination of diet and exercise that produces the greatest reversal of obesity-related insulin resistance is unknown... - A 7-d exercise program increases high-molecular weight adiponectin in obese adultsKaren R Kelly
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Med Sci Sports Exerc 44:69-74. 2012..Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown... - Intramyocellular lipid content and insulin sensitivity are increased following a short-term low-glycemic index diet and exercise interventionJacob M Haus
Dept of Pathobiology, Lerner Research Institute, Cleveland Clinic, OH 44195, USA
Am J Physiol Endocrinol Metab 301:E511-6. 2011..The lower systemic glucose levels that prevail while eating a low glycemic diet may promote redistribution of lipid stores in the muscle... - Free fatty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose toleranceJacob M Haus
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Clin Endocrinol Metab 95:323-7. 2010..The objective of the study was to examine the effects of an exercise/diet lifestyle intervention on free fatty acid (FFA)-induced hepatic insulin resistance in obese humans... - Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver diseaseCiarán E Fealy
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
J Appl Physiol 113:1-6. 2012.... - Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patientsHazel Huang
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Obesity (Silver Spring) 19:2235-40. 2011..62, P = 0.04). We conclude that there is a potential role for ceramide lipids as mediators of the proinflammatory state and improved insulin sensitivity after gastric bypass surgery... - A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adultsKaren R Kelly
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
J Nutr 141:1089-94. 2011..A low-glycemic index diet has antiinflammatory and antidiabetogenic effects when combined with exercise in older, obese prediabetics... - Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanismClaudia O Zein
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
Hepatology 56:1291-9. 2012..Additionally, this is the first report on the link between decreased oxidized lipid products and improved histological disease in the setting of a therapeutic trial in NASH... - Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgerySankar D Navaneethan
Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44195, USA
Obes Surg 20:308-15. 2010..In this pilot study, we determined the effect of weight loss induced by different types of bariatric surgery on albuminuria in severely obese type 2 diabetic (T2DM) subjects... - Altered tumor necrosis factor alpha release from mononuclear cells of obese reproductive-age women during hyperglycemiaFrank Gonzalez
Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
Metabolism 55:271-6. 2006.... - Decreased visfatin after exercise training correlates with improved glucose toleranceJacob M Haus
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Med Sci Sports Exerc 41:1255-60. 2009.... - Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fatChristine M Marchetti
Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44109-1998, USA
J Appl Physiol 100:1584-9. 2006..48, P < 0.05) but not adipocytokines. VF loss after aerobic exercise training improves glucose metabolism and is associated with the reversal of insulin resistance in older obese men and women... - Effects of aging on basal fat oxidation in obese humansThomas P J Solomon
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Metabolism 57:1141-7. 2008..This indicates that age, in addition to obesity, is an independent risk factor for weight gain and for the metabolic complications of elevated body fat... - Bariatric surgery versus intensive medical therapy in obese patients with diabetesPhilip R Schauer
Bariatric and Metabolic Institute, Cleveland Clinic M61, 9500 Euclid Ave, Cleveland, OH 44195, USA
N Engl J Med 366:1567-76. 2012..Observational studies have shown improvement in patients with type 2 diabetes mellitus after bariatric surgery... - A high glycemic meal suppresses the postprandial leptin response in normal healthy adultsHope Barkoukis
Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine and MetroHealth Medical Center, Cleveland, Ohio, USA
Ann Nutr Metab 51:512-8. 2007..To evaluate the metabolic effects of meals with varying glycemic index (GI)... - Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trialHussein N Yassine
Schwartz Center for Metabolism and Nutrition, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Gerontol A Biol Sci Med Sci 64:90-5. 2009..The prevalence of insulin resistance, metabolic syndrome, and cardiovascular disease is greatest in older obese patients, and effective evidence-based treatment strategies are lacking... - Progressive hyperglycemia across the glucose tolerance continuum in older obese adults is related to skeletal muscle capillarization and nitric oxide bioavailabilityThomas P J Solomon
Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Clin Endocrinol Metab 96:1377-84. 2011..Reduced tissue nutrient exposure may aid in the progression of glucose intolerance... - Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndromeFrank Gonzalez
Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
J Clin Endocrinol Metab 91:336-40. 2006..Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS)... - Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscleYanjun Li
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
Am J Physiol Endocrinol Metab 298:E1198-209. 2010..The reaction rate fluxes quantified by this detailed model of insulin/glucose metabolism provide information that can be used to evaluate the development of type 2 diabetes... - Role of ceramides in nonalcoholic fatty liver diseaseMangesh Pagadala
Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
Trends Endocrinol Metab 23:365-71. 2012..A better understanding of the role of ceramides in steatohepatitis has both diagnostic and therapeutic implications for the treatment of fatty liver disease... - Early effects of gastric bypass on endothelial function, inflammation, and cardiovascular risk in obese patientsStacy A Brethauer
Bariatric and Metabolic Institute, M61, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Surg Endosc 25:2650-9. 2011..We hypothesized that gastric bypass would produce rapid improvements in endothelial function, reduce inflammation, and lead to a decrease in cardiovascular risk... - Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose toleranceThomas P J Solomon
Department of Pathobiology, Lerner Research Institute, Cleveland, Ohio 441195, USA
Am J Physiol Endocrinol Metab 297:E552-9. 2009..7 +/- 7.8%, P < 0.05). We conclude that the exercise-induced improvement in FFA-induced insulin resistance is independent of the magnitude of weight loss and FFA turnover, yet it is linked to increased intracellular FFA utilization... - Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratioHelen M Heneghan
Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio
Surg Obes Relat Dis 9:100-7. 2013..We hypothesized that the beneficial effect of Roux-en-Y gastric bypass (RYGB) on CVD risk is related to ceramide-mediated improvement in lipoprotein profile... - Pancreatic islet isolation after gastric bypass in a rat model: technique and initial results for a promising research toolPatrick Gatmaitan
Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Surg Obes Relat Dis 6:532-7. 2010..We report the use of the isolated islet technique to assess pancreatic function and glucoregulatory mechanisms after RYGB surgery... - Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adultsAshley E Jorett
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
Am J Physiol Endocrinol Metab 293:E421-7. 2007..03, AdipoR2 P < 0.02). These data suggest that part of the improvement in insulin sensitivity following exercise and diet may be due to changes in the adiponectin oligomeric distribution and enhanced membrane receptor expression... - Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adultsSteven K Malin
Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
Ann Nutr Metab 61:135-41. 2012..Thus, we determined the effects of exercise training with a low (LoGIx)- or high (HiGIx)-glycemic index diet on the severity of the metabolic syndrome (Z-score)... - Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from "adiposopathy"Swathi Appachi
Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
Obes Surg 21:1928-36. 2011..We hypothesized that bariatric surgery reduces CVD risk by favorably altering the pro-inflammatory profile of adipose tissue as a result of weight loss... - Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humansKaren R Kelly
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Metabolism 59:200-5. 2010..We conclude that, during acute altitude exposure, there is a rapid metabolic response that is accompanied by a shift in the hormonal milieu that appears to favor increased glucose utilization... - Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patientsKaren R Kelly
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Obesity (Silver Spring) 18:663-6. 2010..55, P = 0.06). These data suggest that RBP4 may regulate adiposity, and p85 expression in obese-T2DM, thus providing a link to impaired insulin signaling and diabetes in severely obese patients... - Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistanceJacob M Haus
Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
Diabetes 58:337-43. 2009..Ceramides are a putative mediator of insulin resistance and lipotoxicity, and accumulation of ceramides within tissues in obese and diabetic subjects has been well described... - Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndromeFrank Gonzalez
MetroHealth Medical Center, Department of Obstetrics and Gynecology, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA
J Clin Endocrinol Metab 90:5336-42. 2005..Women with polycystic ovary syndrome (PCOS) are often insulin resistant and have chronic low-level inflammation... - Clinical utility and approaches for estimating insulin sensitivity in pregnancyPatrick M Catalano
Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109-1998, USA
Semin Perinatol 26:181-9. 2002..The information obtained from the IS(OGTT) will be useful in making clinical decisions on maternal care and facilitating optimal pregnancy outcome... - Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometryTakhar Kasumov
Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
Anal Biochem 401:154-61. 2010..This technique could be extended for quantification of other ceramides and sphingolipids with no significant modification... - Obesity, anthropometric measures and chronic kidney disease complicationsSankar D Navaneethan
Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Nephrol 36:219-27. 2012..We examined the associations of BMI and WC with various CKD complications... - Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labelingLing Li
Department of Research Core Services, Cleveland Clinic, Cleveland, Ohio 44195, USA
Mol Cell Proteomics 11:M111.014209. 2012..We conclude that this technique can effectively measure the synthesis of plasma proteins and can be used to study the regulation of protein homeostasis under physiological and pathological conditions... - Metabolic syndrome and kidney disease: a systematic review and meta-analysisGeorge Thomas
Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Clin J Am Soc Nephrol 6:2364-73. 2011..Risk estimates for eGFR <60 ml/min per 1.73 m(2) were extracted from individual studies and pooled using a random effects model. The results for proteinuria outcomes were not pooled because of the small number of studies... - TNF-alpha is a predictor of insulin resistance in human pregnancyJohn P Kirwan
Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building Rm G 232E, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
Diabetes 51:2207-13. 2002.... - Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetusPatrick M Catalano
Department of Reproductive Biology, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109, USA
J Nutr 133:1674S-1683S. 2003.... - Computational model of glucose homeostasis during exerciseJaeyeon Kim
Case Western Reserve University, Cleveland, OH 44106, USA
Conf Proc IEEE Eng Med Biol Soc 1:311-4. 2006..In conclusion, this model can be used as a valuable complement to experimental studies due to its ability to predict what is difficult to measure directly and to provide dynamic information about the system... - Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trialClaudia O Zein
Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
Hepatology 54:1610-9. 2011..Adverse effects were similar in both groups. CONCLUSION: PTX improved histological features of NASH compared to placebo. PTX was well tolerated in patients with NASH... - Modulation of insulin signaling in human skeletal muscle in response to exerciseJohn P Kirwan
Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
Exerc Sport Sci Rev 30:85-90. 2002..Recent discoveries in the molecular and cellular regulation of insulin-mediated glucose metabolism in skeletal muscle have provided a deeper understanding of how exercise modulates insulin action... - Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticlesVicky Cheng
Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio
Surg Obes Relat Dis 9:207-12. 2013..Our objectives were to determine the effect of bariatric surgery on the microparticle concentration and to correlate these changes with clinical parameters in a multispecialty group practice... - Sarcopenia and a physiologically low respiratory quotient in patients with cirrhosis: a prospective controlled studyCathy Glass
Department of Nutrition Therapy, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA
J Appl Physiol 114:559-65. 2013..Although low RQ does not predict short-term mortality in these patients, it may reflect a decompensated metabolic state that requires careful nutritional management with appropriate consideration for preservation of skeletal muscle mass... - Higher bone mineral density is associated with a decreased risk of colorectal adenomasNora L Nock
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106 7136, USA
Int J Cancer 129:956-64. 2011..Although additional larger, prospective studies are needed, our results suggest that BMD may be a biomarker for colorectal cancer precursor lesions...
Research Grants
- AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLEJohn Kirwan; Fiscal Year: 2000..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietary intervention are related to changes in body composition and a reduction in abdominal fat. ..
- AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLEJohn Kirwan; Fiscal Year: 2002..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
- Age, Exercise, Diet: Effects on Insulin ResistanceJohn Kirwan; Fiscal Year: 2007..abstract_text> ..
- DIETARY SUPPLEMENT AND EXERCISE ON WEIGHT LOSS, ENERGY EXPENDITURE & BODY COMPJohn Kirwan; Fiscal Year: 1999..data on the effects of the interventions on insulin, leptin and tumor necrosis factor alpha in a young, moderately obese population who are at risk for the development of non-insulin dependent diabetes mellitus ..
- AGE, EXERCISE AND DIET EFFECTS ON GLUCOSE AND FATTY ACIDJohn Kirwan; Fiscal Year: 1999..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
- EFFECTS OF EXERCISE INDUCED MUSCLE TISSUE DAMAGE & INSULIN SIGNALINGJohn Kirwan; Fiscal Year: 1999..abstract_text> ..
- Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes: The B2D TrialPhilip R Schauer; Fiscal Year: 2010..The proposed research will compare Bariatric Surgery with Intensive Medical Therapy using a randomized control trial in moderately obese patients with type 2 diabetes. ..