John P Kirwan

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults
    S K Malin
    John P Kirwan, PhD, Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave NE40, Cleveland, OH 44195, Phone 216 444 3412, Fax 216 636 1496, Email
    J Nutr Health Aging 18:608-15. 2014
  2. ncbi request reprint Management of non-alcoholic fatty liver disease
    A Sourianarayanane
    Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 59:69-87. 2013
  3. pmc Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus
    John P Kirwan
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NE 40, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 297:E151-6. 2009
  4. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
  5. pmc Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults
    John P Kirwan
    Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ann Nutr Metab 55:326-33. 2009
  6. pmc Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 33:1561-6. 2010
  7. pmc Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Nutr Metab 61:135-41. 2012
  8. pmc Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio
    J Appl Physiol (1985) 115:988-94. 2013
  9. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
  10. pmc The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 296:E1269-74. 2009

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults
    S K Malin
    John P Kirwan, PhD, Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave NE40, Cleveland, OH 44195, Phone 216 444 3412, Fax 216 636 1496, Email
    J Nutr Health Aging 18:608-15. 2014
    ..To determine the effect of exercise on chemerin in relation to changes in fat loss, insulin action, and dyslipidemia in older adults...
  2. ncbi request reprint Management of non-alcoholic fatty liver disease
    A Sourianarayanane
    Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Minerva Gastroenterol Dietol 59:69-87. 2013
    ..This review focuses on the available current and potential future therapies for treating NASH...
  3. pmc Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus
    John P Kirwan
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NE 40, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 297:E151-6. 2009
    ..These improvements include increased peripheral insulin sensitivity and responsiveness as well as enhanced suppression of hepatic glucose production...
  4. pmc A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans
    Thomas Pj Solomon
    Department of Pathobiology, Lerner Research Institute and Nutrition, Case Western Reserve University, Cleveland, OH, USA
    Am J Clin Nutr 92:1359-68. 2010
    ..The optimal lifestyle intervention that reverses diabetes risk factors is not known...
  5. pmc Exercise training and dietary glycemic load may have synergistic effects on insulin resistance in older obese adults
    John P Kirwan
    Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ann Nutr Metab 55:326-33. 2009
    ..The aim of this study was to assess the combined effects of exercise and dietary glycemic load on insulin resistance in older obese adults...
  6. pmc Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 33:1561-6. 2010
    ..The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis...
  7. pmc Exercise training with weight loss and either a high- or low-glycemic index diet reduces metabolic syndrome severity in older adults
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, and Department of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Ann Nutr Metab 61:135-41. 2012
    ..Thus, we determined the effects of exercise training with a low (LoGIx)- or high (HiGIx)-glycemic index diet on the severity of the metabolic syndrome (Z-score)...
  8. pmc Fetuin-A is linked to improved glucose tolerance after short-term exercise training in nonalcoholic fatty liver disease
    Steven K Malin
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio
    J Appl Physiol (1985) 115:988-94. 2013
    ..Together, our findings highlight a role for fetuin-A in skeletal muscle insulin resistance and suggest that part of the exercise-induced improvement in glucose tolerance in patients with NAFLD may be due to lowering fetuin-A. ..
  9. pmc Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 98:E1181-8. 2013
    ..Hepatic steatosis, insulin resistance, inflammation, low levels of polyunsaturated lipids, and adiponectin are implicated in the development and progression of nonalcoholic fatty liver disease (NAFLD)...
  10. pmc The glucose-dependent insulinotropic polypeptide and glucose-stimulated insulin response to exercise training and diet in obesity
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 296:E1269-74. 2009
    ....
  11. pmc Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH44195, USA
    Am J Clin Nutr 90:1222-9. 2009
    ..The optimal combination of diet and exercise that produces the greatest reversal of obesity-related insulin resistance is unknown...
  12. ncbi request reprint Increased activation of nuclear factor kappaB triggers inflammation and insulin resistance in polycystic ovary syndrome
    Frank Gonzalez
    Department of Obstetrics and Gynecology, MetroHealth Medical Center, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    J Clin Endocrinol Metab 91:1508-12. 2006
    ..Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS)...
  13. pmc Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave NE 40, Cleveland, OH 44195, USA
    J Appl Physiol (1985) 104:1313-9. 2008
    ..We also demonstrate that leptin sensitivity is improved but that such a trend may rely on reducing caloric intake in addition to exercise training...
  14. pmc Intramyocellular lipid content and insulin sensitivity are increased following a short-term low-glycemic index diet and exercise intervention
    Jacob M Haus
    Dept of Pathobiology, Lerner Research Institute, Cleveland Clinic, OH 44195, USA
    Am J Physiol Endocrinol Metab 301:E511-6. 2011
    ..The lower systemic glucose levels that prevail while eating a low glycemic diet may promote redistribution of lipid stores in the muscle...
  15. doi request reprint A 7-d exercise program increases high-molecular weight adiponectin in obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Sci Sports Exerc 44:69-74. 2012
    ..Previously, we found that 7 d of exercise improves insulin sensitivity in obese subjects; however, whether short-term exercise training affects HMW adiponectin in obese persons is unknown...
  16. pmc Free fatty acid-induced hepatic insulin resistance is attenuated following lifestyle intervention in obese individuals with impaired glucose tolerance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 95:323-7. 2010
    ..The objective of the study was to examine the effects of an exercise/diet lifestyle intervention on free fatty acid (FFA)-induced hepatic insulin resistance in obese humans...
  17. pmc Insulin sensitivity and metabolic flexibility following exercise training among different obese insulin-resistant phenotypes
    Steven K Malin
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    Am J Physiol Endocrinol Metab 305:E1292-8. 2013
    ..Additional work is required to assess the molecular mechanism(s) by which chronic hyperglycemia modifies insulin sensitivity following exercise training...
  18. pmc Reduced cardiovascular risk after bariatric surgery is linked to plasma ceramides, apolipoprotein-B100, and ApoB100/A1 ratio
    Helen M Heneghan
    Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Surg Obes Relat Dis 9:100-7. 2013
    ..We hypothesized that the beneficial effect of Roux-en-Y gastric bypass (RYGB) on CVD risk is related to ceramide-mediated improvement in lipoprotein profile...
  19. pmc Short-term exercise reduces markers of hepatocyte apoptosis in nonalcoholic fatty liver disease
    Ciarán E Fealy
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Appl Physiol (1985) 113:1-6. 2012
    ....
  20. pmc Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients
    Hazel Huang
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 19:2235-40. 2011
    ..62, P = 0.04). We conclude that there is a potential role for ceramide lipids as mediators of the proinflammatory state and improved insulin sensitivity after gastric bypass surgery...
  21. pmc Metabolic syndrome, ESRD, and death in CKD
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin J Am Soc Nephrol 8:945-52. 2013
    ..This study examined the associations between metabolic syndrome and its components with ESRD and death among those patients with stages 3 and 4 CKD (estimated GFR=15-59 ml/min per 1.73 m(2))...
  22. pmc A low-glycemic index diet and exercise intervention reduces TNF(alpha) in isolated mononuclear cells of older, obese adults
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Nutr 141:1089-94. 2011
    ..A low-glycemic index diet has antiinflammatory and antidiabetogenic effects when combined with exercise in older, obese prediabetics...
  23. pmc Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: analysis of a randomized control trial comparing surgery with intensive medical treatment
    Sangeeta R Kashyap
    Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes Care 36:2175-82. 2013
    ..To evaluate the effects of two bariatric procedures versus intensive medical therapy (IMT) on β-cell function and body composition...
  24. doi request reprint Gastrostomy tube placement in gastric remnant at gastric bypass: a rat model for selective gut stimulation
    Shai Eldar
    Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Surg Obes Relat Dis 9:442-6. 2013
    ..Our objective was to assess the feasibility of, and report on, our technique and initial experience with selective gut stimulation in a gastric bypass rat model at an academic medical center in the United States...
  25. pmc Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 56:1291-9. 2012
    ..Statistically significant correlations were demonstrated between the decrease in HODEs and oxoODEs and improved histological scores of fibrosis and between the decrease in HETEs and improved lobular inflammation...
  26. pmc Urinary albumin excretion, HMW adiponectin, and insulin sensitivity in type 2 diabetic patients undergoing bariatric surgery
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Ave, Q7, Cleveland, OH 44195, USA
    Obes Surg 20:308-15. 2010
    ..In this pilot study, we determined the effect of weight loss induced by different types of bariatric surgery on albuminuria in severely obese type 2 diabetic (T2DM) subjects...
  27. doi request reprint Decreased visfatin after exercise training correlates with improved glucose tolerance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Sci Sports Exerc 41:1255-60. 2009
    ....
  28. ncbi request reprint Altered tumor necrosis factor alpha release from mononuclear cells of obese reproductive-age women during hyperglycemia
    Frank Gonzalez
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Metabolism 55:271-6. 2006
    ..002). In conclusion, these data suggest that there is an absence of the "normal" suppression of TNF-alpha in MNCs after hyperglycemia in obese women, and this response may contribute to impaired glucose disposal and insulin resistance...
  29. pmc Lower dipeptidyl peptidase-4 following exercise training plus weight loss is related to increased insulin sensitivity in adults with metabolic syndrome
    Steven K Malin
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Peptides 47:142-7. 2013
    ..Maintaining low plasma DPP-4 concentrations is a potential mechanism whereby exercise plus weight loss prevents/delays the onset of type 2 diabetes in adults with metabolic syndrome. ..
  30. pmc Effects of aging on basal fat oxidation in obese humans
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Metabolism 57:1141-7. 2008
    ..This indicates that age, in addition to obesity, is an independent risk factor for weight gain and for the metabolic complications of elevated body fat...
  31. ncbi request reprint Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat
    Valerie B O'Leary
    Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44109 1998, USA
    J Appl Physiol 100:1584-9. 2006
    ..48, P < 0.05) but not adipocytokines. VF loss after aerobic exercise training improves glucose metabolism and is associated with the reversal of insulin resistance in older obese men and women...
  32. pmc Bariatric surgery versus intensive medical therapy in obese patients with diabetes
    Philip R Schauer
    Bariatric and Metabolic Institute, Cleveland Clinic M61, 9500 Euclid Ave, Cleveland, OH 44195, USA
    N Engl J Med 366:1567-76. 2012
    ..Observational studies have shown improvement in patients with type 2 diabetes mellitus after bariatric surgery...
  33. pmc Progressive hyperglycemia across the glucose tolerance continuum in older obese adults is related to skeletal muscle capillarization and nitric oxide bioavailability
    Thomas P J Solomon
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Endocrinol Metab 96:1377-84. 2011
    ..Reduced tissue nutrient exposure may aid in the progression of glucose intolerance...
  34. pmc Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial
    Hussein N Yassine
    Schwartz Center for Metabolism and Nutrition, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Gerontol A Biol Sci Med Sci 64:90-5. 2009
    ..The prevalence of insulin resistance, metabolic syndrome, and cardiovascular disease is greatest in older obese patients, and effective evidence-based treatment strategies are lacking...
  35. ncbi request reprint Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome
    Frank Gonzalez
    Department of Reproductive Biology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, USA
    J Clin Endocrinol Metab 91:336-40. 2006
    ..Insulin resistance and chronic low level inflammation are often present in women with polycystic ovary syndrome (PCOS)...
  36. ncbi request reprint A high glycemic meal suppresses the postprandial leptin response in normal healthy adults
    Hope Barkoukis
    Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine and MetroHealth Medical Center, Cleveland, Ohio, USA
    Ann Nutr Metab 51:512-8. 2007
    ..To evaluate the metabolic effects of meals with varying glycemic index (GI)...
  37. pmc Computational model of cellular metabolic dynamics: effect of insulin on glucose disposal in human skeletal muscle
    Yanjun Li
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Physiol Endocrinol Metab 298:E1198-209. 2010
    ..The reaction rate fluxes quantified by this detailed model of insulin/glucose metabolism provide information that can be used to evaluate the development of type 2 diabetes...
  38. pmc Mice lacking C1q are protected from high fat diet-induced hepatic insulin resistance and impaired glucose homeostasis
    Antoinette D Hillian
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 288:22565-75. 2013
    ..Together, these studies reveal an important role for C1q in the classical pathway of complement activation in the development of high fat diet-induced insulin resistance. ..
  39. pmc Role of ceramides in nonalcoholic fatty liver disease
    Mangesh Pagadala
    Department of Gastroenterology Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Trends Endocrinol Metab 23:365-71. 2012
    ..A better understanding of the role of ceramides in steatohepatitis has both diagnostic and therapeutic implications for the treatment of fatty liver disease...
  40. pmc Effects of exercise training and diet on lipid kinetics during free fatty acid-induced insulin resistance in older obese humans with impaired glucose tolerance
    Thomas P J Solomon
    Department of Pathobiology, Lerner Research Institute, Cleveland, Ohio 441195, USA
    Am J Physiol Endocrinol Metab 297:E552-9. 2009
    ..7 +/- 7.8%, P < 0.05). We conclude that the exercise-induced improvement in FFA-induced insulin resistance is independent of the magnitude of weight loss and FFA turnover, yet it is linked to increased intracellular FFA utilization...
  41. doi request reprint Early effects of gastric bypass on endothelial function, inflammation, and cardiovascular risk in obese patients
    Stacy A Brethauer
    Bariatric and Metabolic Institute, M61, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Surg Endosc 25:2650-9. 2011
    ..We hypothesized that gastric bypass would produce rapid improvements in endothelial function, reduce inflammation, and lead to a decrease in cardiovascular risk...
  42. pmc Pancreatic β-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes
    Steven K Malin
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    Am J Physiol Endocrinol Metab 305:E1248-54. 2013
    ..Our data suggest that higher exercise doses (i.e., >2,000 kcal/wk) are necessary to enhance β-cell function in adults with poor insulin secretion capacity...
  43. pmc Randomized controlled pilot study of a SystemCHANGE™ weight management intervention in stroke survivors: rationale and protocol
    Matthew Plow
    Department of Biomedical Engineering, Physical Medicine and Rehabilitation, Cleveland Clinic Lerner Research Institute, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
    Trials 14:130. 2013
    ..SystemCHANGE™ focuses on redesigning the social environment to achieve a specific goal...
  44. pmc Retinol-binding protein 4 (RBP4) protein expression is increased in omental adipose tissue of severely obese patients
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Obesity (Silver Spring) 18:663-6. 2010
    ..55, P = 0.06). These data suggest that RBP4 may regulate adiposity, and p85 expression in obese-T2DM, thus providing a link to impaired insulin signaling and diabetes in severely obese patients...
  45. ncbi request reprint Enhanced adiponectin multimer ratio and skeletal muscle adiponectin receptor expression following exercise training and diet in older insulin-resistant adults
    Ashley E Jorett
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Endocrinol Metab 293:E421-7. 2007
    ..03, AdipoR2 P < 0.02). These data suggest that part of the improvement in insulin sensitivity following exercise and diet may be due to changes in the adiponectin oligomeric distribution and enhanced membrane receptor expression...
  46. doi request reprint Pancreatic islet isolation after gastric bypass in a rat model: technique and initial results for a promising research tool
    Patrick Gatmaitan
    Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Surg Obes Relat Dis 6:532-7. 2010
    ..We report the use of the isolated islet technique to assess pancreatic function and glucoregulatory mechanisms after RYGB surgery...
  47. pmc Glucose-stimulated oxidative stress in mononuclear cells is related to pancreatic β-cell dysfunction in polycystic ovary syndrome
    Steven K Malin
    Department of Pathobiology S K M, J P K, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195 Department of Nutrition S K M, J P K, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 and Department of Obstetrics and Gynecology C L S, F G, Indiana University School of Medicine, Indianapolis, Indiana 46202
    J Clin Endocrinol Metab 99:322-9. 2014
    ..Oxidative stress induced by reactive oxygen species (ROS) is involved in the development of pancreatic β-cell dysfunction...
  48. pmc Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans
    Karen R Kelly
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Metabolism 59:200-5. 2010
    ..We conclude that, during acute altitude exposure, there is a rapid metabolic response that is accompanied by a shift in the hormonal milieu that appears to favor increased glucose utilization...
  49. pmc Reduced cardiovascular risk following bariatric surgeries is related to a partial recovery from "adiposopathy"
    Swathi Appachi
    Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Obes Surg 21:1928-36. 2011
    ..We hypothesized that bariatric surgery reduces CVD risk by favorably altering the pro-inflammatory profile of adipose tissue as a result of weight loss...
  50. pmc Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    Jacob M Haus
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Diabetes 58:337-43. 2009
    ..Ceramides are a putative mediator of insulin resistance and lipotoxicity, and accumulation of ceramides within tissues in obese and diabetic subjects has been well described...
  51. pmc Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults
    Karen R Kelly
    1Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 2Department of Nutrition, Case Western Reserve University, School of Medicine, Cleveland, OH 3Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH 4Department of Physiology, Case Western Reserve University, School of Medicine, Cleveland, OH and 5Metabolic Translational Research Center, Cleveland Clinic, Cleveland, OH
    Med Sci Sports Exerc 46:920-6. 2014
    ..5 yr, body mass index = 34.5 ± 0.7 kg·m)...
  52. pmc Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
    Takhar Kasumov
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Anal Biochem 401:154-61. 2010
    ..This technique could be extended for quantification of other ceramides and sphingolipids with no significant modification...
  53. pmc Restoration of glycemic control in patients with type 2 diabetes mellitus after bariatric surgery is associated with reduction in microparticles
    Vicky Cheng
    Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Surg Obes Relat Dis 9:207-12. 2013
    ..Our objectives were to determine the effect of bariatric surgery on the microparticle concentration and to correlate these changes with clinical parameters in a multispecialty group practice...
  54. ncbi request reprint Hyperglycemia alters tumor necrosis factor-alpha release from mononuclear cells in women with polycystic ovary syndrome
    Frank Gonzalez
    MetroHealth Medical Center, Department of Obstetrics and Gynecology, Hamann S4 44, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA
    J Clin Endocrinol Metab 90:5336-42. 2005
    ..Women with polycystic ovary syndrome (PCOS) are often insulin resistant and have chronic low-level inflammation...
  55. ncbi request reprint Clinical utility and approaches for estimating insulin sensitivity in pregnancy
    Patrick M Catalano
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109 1998, USA
    Semin Perinatol 26:181-9. 2002
    ..The information obtained from the IS(OGTT) will be useful in making clinical decisions on maternal care and facilitating optimal pregnancy outcome...
  56. pmc Sarcopenia and a physiologically low respiratory quotient in patients with cirrhosis: a prospective controlled study
    Cathy Glass
    Department of Nutrition Therapy, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Appl Physiol (1985) 114:559-65. 2013
    ..Although low RQ does not predict short-term mortality in these patients, it may reflect a decompensated metabolic state that requires careful nutritional management with appropriate consideration for preservation of skeletal muscle mass...
  57. ncbi request reprint Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus
    Stacy A Brethauer
    Bariatric and Metabolic Institute and Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH and Department of Surgery, Loyola University, Chicago, IL
    Ann Surg 258:628-36; discussion 636-7. 2013
    ..Evaluate the long-term effects of bariatric surgery on type 2 diabetes (T2DM) remission and metabolic risk factors...
  58. pmc Obesity, anthropometric measures and chronic kidney disease complications
    Sankar D Navaneethan
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Nephrol 36:219-27. 2012
    ..We examined the associations of BMI and WC with various CKD complications...
  59. pmc β-Cell dysfunction is associated with metabolic syndrome severity in adults
    Steven K Malin
    1 Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    Metab Syndr Relat Disord 12:79-85. 2014
    ..We hypothesized that poor β-cell function would independently predict a higher metabolic syndrome Z-score (i.e., severity)...
  60. ncbi request reprint The effect of selective gut stimulation on glucose metabolism after gastric bypass in the Zucker diabetic fatty rat model
    Hideharu Shimizu
    Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, Ohio
    Surg Obes Relat Dis 10:29-35. 2014
    ..The aim of this study was to evaluate the effects of selective gut stimulation on glucose metabolism in an obese diabetic rat model...
  61. pmc Plasma proteome dynamics: analysis of lipoproteins and acute phase response proteins with 2H2O metabolic labeling
    Ling Li
    Department of Research Core Services, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 11:M111.014209. 2012
    ..We conclude that this technique can effectively measure the synthesis of plasma proteins and can be used to study the regulation of protein homeostasis under physiological and pathological conditions...
  62. pmc Metabolic syndrome and kidney disease: a systematic review and meta-analysis
    George Thomas
    Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin J Am Soc Nephrol 6:2364-73. 2011
    ..Risk estimates for eGFR <60 ml/min per 1.73 m(2) were extracted from individual studies and pooled using a random effects model. The results for proteinuria outcomes were not pooled because of the small number of studies...
  63. ncbi request reprint Computational model of glucose homeostasis during exercise
    Jaeyeon Kim
    Case Western Reserve University, Cleveland, OH 44106, USA
    Conf Proc IEEE Eng Med Biol Soc 1:311-4. 2006
    ..In conclusion, this model can be used as a valuable complement to experimental studies due to its ability to predict what is difficult to measure directly and to provide dynamic information about the system...
  64. ncbi request reprint Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus
    Patrick M Catalano
    Department of Reproductive Biology, Schwartz Center for Metabolism and Nutrition, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH 44109, USA
    J Nutr 133:1674S-1683S. 2003
    ....
  65. ncbi request reprint TNF-alpha is a predictor of insulin resistance in human pregnancy
    John P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Bell Greve Building Rm G 232E, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    Diabetes 51:2207-13. 2002
    ....
  66. pmc Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial
    Claudia O Zein
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44915, USA
    Hepatology 54:1610-9. 2011
    ..038). Although not statistically significant (P = 0.17), improvement in fibrosis was observed in a greater proportion (35%) of patients in the PTX group compared to placebo (15%). Adverse effects were similar in both groups...
  67. ncbi request reprint Modulation of insulin signaling in human skeletal muscle in response to exercise
    John P Kirwan
    Department of Reproductive Biology, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, Ohio 44109 1998, USA
    Exerc Sport Sci Rev 30:85-90. 2002
    ..Recent discoveries in the molecular and cellular regulation of insulin-mediated glucose metabolism in skeletal muscle have provided a deeper understanding of how exercise modulates insulin action...
  68. pmc Higher bone mineral density is associated with a decreased risk of colorectal adenomas
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106 7136, USA
    Int J Cancer 129:956-64. 2011
    ..Although additional larger, prospective studies are needed, our results suggest that BMD may be a biomarker for colorectal cancer precursor lesions...

Research Grants22

  1. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 1999
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietary intervention are related to changes in body composition and a reduction in abdominal fat. ..
  2. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 2000
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietary intervention are related to changes in body composition and a reduction in abdominal fat. ..
  3. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 2001
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
  4. AGE, EXERCISE, DIET--EFFECTS ON GLUCOSE FATTY ACID CYCLE
    John Kirwan; Fiscal Year: 2002
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
  5. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2004
    ..abstract_text> ..
  6. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2005
    ..abstract_text> ..
  7. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2006
    ..abstract_text> ..
  8. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2005
    ..abstract_text> ..
  9. Age, Exercise, Diet: Effects on Insulin Resistance
    John Kirwan; Fiscal Year: 2007
    ..abstract_text> ..
  10. DIETARY SUPPLEMENT AND EXERCISE ON WEIGHT LOSS, ENERGY EXPENDITURE & BODY COMP
    John Kirwan; Fiscal Year: 1999
    ..data on the effects of the interventions on insulin, leptin and tumor necrosis factor alpha in a young, moderately obese population who are at risk for the development of non-insulin dependent diabetes mellitus ..
  11. AGE, EXERCISE AND DIET EFFECTS ON GLUCOSE AND FATTY ACID
    John Kirwan; Fiscal Year: 1999
    ..7) Improvements in glucose and fat metabolism at rest and during a HEC after exercise training and dietart intervention are related to changes in body composition and a reduction in abdominal fat. ..
  12. EFFECTS OF EXERCISE INDUCED MUSCLE TISSUE DAMAGE & INSULIN SIGNALING
    John Kirwan; Fiscal Year: 1999
    ..abstract_text> ..
  13. Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes: The B2D Trial
    Philip R Schauer; Fiscal Year: 2010
    ..The proposed research will compare Bariatric Surgery with Intensive Medical Therapy using a randomized control trial in moderately obese patients with type 2 diabetes. ..