Matthew F Kalady

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Identifying Lynch syndrome: we are all responsible
    Julian A Sanchez
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 51:1750-6. 2008
  2. doi request reprint High-throughput arrays identify distinct genetic profiles associated with lymph node involvement in rectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 55:628-39. 2012
  3. doi request reprint Risk of colonic neoplasia after proctectomy for rectal cancer in hereditary nonpolyposis colorectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Surg 255:1121-5. 2012
  4. doi request reprint BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dis Colon Rectum 55:128-33. 2012
  5. ncbi request reprint Gene signature is associated with early stage rectal cancer recurrence
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    J Am Coll Surg 211:187-95. 2010
  6. doi request reprint Defining phenotypes and cancer risk in hyperplastic polyposis syndrome
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 54:164-70. 2011
  7. ncbi request reprint Risk of colorectal adenoma and carcinoma after colectomy for colorectal cancer in patients meeting Amsterdam criteria
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Surg 252:507-11; discussion 511-3. 2010
  8. ncbi request reprint Surgical management of hereditary nonpolyposis colorectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Sanford R Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH 44195, USA
    Adv Surg 45:265-74. 2011
  9. doi request reprint Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas
    Matthew F Kalady
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 52:1039-45. 2009
  10. doi request reprint Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Surg 250:582-9. 2009

Collaborators

Detail Information

Publications43

  1. doi request reprint Identifying Lynch syndrome: we are all responsible
    Julian A Sanchez
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 51:1750-6. 2008
    ..This study evaluated the impact of microsatellite instability pathology findings on Lynch syndrome evaluation by clinicians...
  2. doi request reprint High-throughput arrays identify distinct genetic profiles associated with lymph node involvement in rectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 55:628-39. 2012
    ..Preoperative clinical diagnosis of lymph node involvement guides treatment decisions for rectal cancer. Unfortunately, clinical staging still suffers from a lack of accuracy...
  3. doi request reprint Risk of colonic neoplasia after proctectomy for rectal cancer in hereditary nonpolyposis colorectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Surg 255:1121-5. 2012
    ..To define the neoplastic risk in the remaining colon after proctectomy for rectal cancer in patients with hereditary nonpolyposis colorectal cancer (HNPCC)...
  4. doi request reprint BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dis Colon Rectum 55:128-33. 2012
    ..Mutation in the BRAF oncogene is a key step in malignant transformation within the methylator pathway to colorectal cancer. However, there is a paucity of information about BRAF mutant colorectal tumors...
  5. ncbi request reprint Gene signature is associated with early stage rectal cancer recurrence
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    J Am Coll Surg 211:187-95. 2010
    ..Identifying biologic factors that predict the subset prone to recur could allow more directed therapy. This study identifies a tumor gene expression profile that accurately predicts disease recurrence...
  6. doi request reprint Defining phenotypes and cancer risk in hyperplastic polyposis syndrome
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 54:164-70. 2011
    ..We performed this review of a large series of patients who presented with multiple serrated polyps to look for clinical patterns that may confirm our hypothesis...
  7. ncbi request reprint Risk of colorectal adenoma and carcinoma after colectomy for colorectal cancer in patients meeting Amsterdam criteria
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Surg 252:507-11; discussion 511-3. 2010
    ..To report the risk of metachronous colorectal neoplasia after colectomy for cancer in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) syndrome...
  8. ncbi request reprint Surgical management of hereditary nonpolyposis colorectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Sanford R Weiss Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH 44195, USA
    Adv Surg 45:265-74. 2011
    ..For patients treated with anything less than total proctocolectomy, annual endoscopic surveillance of the remaining colorectum is mandatory...
  9. doi request reprint Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas
    Matthew F Kalady
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 52:1039-45. 2009
    ..This study evaluated the disparity in neoplastic changes between colon and rectal cancers...
  10. doi request reprint Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer
    Matthew F Kalady
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Surg 250:582-9. 2009
    ..This study evaluates factors associated with a pathologic complete response (pCR) after neoadjuvant chemoradiation for rectal cancer...
  11. ncbi request reprint Less than 12 nodes in the surgical specimen after total mesorectal excision following neoadjuvant chemoradiation: it means more than you think!
    Luiz Felipe de Campos-Lobato
    Desk A 30, Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Surg Oncol 20:3398-406. 2013
    ..However, a decreased number of LN is not unusual in patients receiving neoadjuvant chemoradiation...
  12. doi request reprint Pathologic complete response after neoadjuvant treatment for rectal cancer decreases distant recurrence and could eradicate local recurrence
    Luiz Felipe de Campos-Lobato
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Surg Oncol 18:1590-8. 2011
    ..The aim of this study was to evaluate the clinical implications of pathologic complete response (pCR) (i.e., T0N0M0) after neoadjuvant chemoradiation and radical surgery in patients with locally advanced rectal cancer...
  13. doi request reprint Downstaging without complete pathologic response after neoadjuvant treatment improves cancer outcomes for cIII but not cII rectal cancers
    Luiz Felipe de Campos-Lobato
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    Ann Surg Oncol 17:1758-66. 2010
    ..The aim of this study was to evaluate whether downstaging impacts prognosis in patients with cII versus cIII rectal cancer...
  14. doi request reprint Neoadjuvant therapy for rectal cancer: the impact of longer interval between chemoradiation and surgery
    Luiz Felipe de Campos-Lobato
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue A30, Cleveland, OH 44195, USA
    J Gastrointest Surg 15:444-50. 2011
    ..The aim of this study was to determine the effect of a longer interval between neoadjuvant chemoradiation and surgery on perioperative morbidity and oncologic outcomes...
  15. ncbi request reprint Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer
    Julian A Sanchez
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 17:1966-70. 2011
    ..This study compares the molecular characteristics of colitis-associated and common colorectal cancers...
  16. doi request reprint CEACAM-7: a predictive marker for rectal cancer recurrence
    Craig A Messick
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH 44106, USA
    Surgery 147:713-9. 2010
    ..This study evaluates carcinoembryonic antigen cellular adhesion molecule-7 (CEACAM-7) expression in rectal cancer as a predictive recurrence factor...
  17. doi request reprint Metachronous serrated neoplasia is uncommon after right colectomy in patients with methylator colon cancers with a high degree of microsatellite instability
    Craig A Messick
    1Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 2Sanford R Weiss, M D, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, Ohio 3Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    Dis Colon Rectum 57:39-46. 2014
    ..Serrated polyps also occur in Lynch syndrome, where right-sided microsatellite unstable cancers arise from germline mutations in mismatch repair genes...
  18. doi request reprint Anal transitional zone neoplasia in patients with familial adenomatous polyposis after restorative proctocolectomy and IPAA: incidence, management, and oncologic and functional outcomes
    Yavuz Ozdemir
    Department of Colorectal Surgery, Sanford R Weiss, MD Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 56:808-14. 2013
    ..Restorative proctocolectomy and IPAA in patients with familial adenomatous polyposis may leave residual anal transitional zone mucosa that is prone to neoplasia...
  19. doi request reprint Risk factors for delayed postpolypectomy bleeding: how to minimize your patients' risk
    Xian Rui Wu
    Department of Colorectal Surgery, Digestive Disease Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Int J Colorectal Dis 28:1127-34. 2013
    ..Most studies show polyp size, location, and shape to be important risk factors but other factors may allow refinement of risk. The aim of this study is to look for other factors associated with delayed postpolypectomy bleeding...
  20. doi request reprint The prevalence of hereditary hemorrhagic telangiectasia in juvenile polyposis syndrome
    Margaret O'Malley
    Sanford R Weiss MD Center for Hereditary Colorectal Neoplasia in the Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Dis Colon Rectum 55:886-92. 2012
    ..A juvenile polyposis-hereditary hemorrhagic telangiectasia overlap syndrome has previously been reported in 22% of patients with juvenile polyposis due to a SMAD4 mutation...
  21. doi request reprint Stage III colorectal cancer: molecular disparity between primary cancers and lymph node metastases
    Craig A Messick
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA
    Ann Surg Oncol 17:425-31. 2010
    ..This study evaluates molecular differences between primary colorectal cancers and matched lymph node (LN) metastases...
  22. ncbi request reprint Genetic and molecular diversity of colon cancer hepatic metastases
    Craig A Messick
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44106, USA
    Surgery 146:227-31. 2009
    ..This study seeks to describe molecular characteristics of colon cancer hepatic metastases in terms of oncogenic pathway...
  23. doi request reprint Prone or lithotomy positioning during an abdominoperineal resection for rectal cancer results in comparable oncologic outcomes
    Luiz Felipe de Campos-Lobato
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 54:939-46. 2011
    ..There is debate whether performing the perineal part of the abdominoperineal resection in a prone position in comparison with a lithotomy position optimizes circumferential resection margins and, subsequently, cancer outcomes...
  24. doi request reprint Statin therapy is associated with improved pathologic response to neoadjuvant chemoradiation in rectal cancer
    Adam G Mace
    1 Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 2 Dahl Chase Pathology Associates, Bangor, Maine 3 Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
    Dis Colon Rectum 56:1217-27. 2013
    ..Statin therapy has been shown to enhance the impact of treatment in several malignancies, but little is known regarding the impact on rectal cancer response to neoadjuvant chemoradiation...
  25. ncbi request reprint Clinical criteria underestimate complete pathological response in rectal cancer treated with neoadjuvant chemoradiotherapy
    Fraser M Smith
    1Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 2Department of Pathology, Cleveland Clinic, Cleveland, Ohio 3Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio
    Dis Colon Rectum 57:311-5. 2014
    ..Published criteria define specific mucosal features of clinical complete response for rectal cancer after neoadjuvant chemoradiotherapy...
  26. doi request reprint Implementation of universal microsatellite instability and immunohistochemistry screening for diagnosing lynch syndrome in a large academic medical center
    Brandie Heald
    Cleveland Clinic, Cleveland, OH 44195, USA
    J Clin Oncol 31:1336-40. 2013
    ..No studies report how this process is implemented on a health system-wide basis...
  27. pmc Unique DNA methylome profiles in CpG island methylator phenotype colon cancers
    Yaomin Xu
    Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Genome Res 22:283-91. 2012
    ..These observations indicate that CIMP tumors have specific defects in controlling both DNA methylation seeding and spreading and serve as an important first step in delineating molecular mechanisms that control these processes...
  28. ncbi request reprint Sessile serrated polyps: an important route to colorectal cancer
    Matthew F Kalady
    From the Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio
    J Natl Compr Canc Netw 11:1585-94. 2013
    ..This article focuses on sessile serrated polyps as a unique and important route to colorectal cancer...
  29. ncbi request reprint Immunohistochemistry for annexin A10 can distinguish sporadic from Lynch syndrome-associated microsatellite-unstable colorectal carcinoma
    Reetesh K Pai
    Department of Anatomic Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Departments of Anatomic Pathology Colorectal Surgery Genomic Medicine Institute Digestive Disease Institute, Cleveland Clinic, Cleveland, OH
    Am J Surg Pathol 38:518-25. 2014
    ..On the basis of these results, immunohistochemistry for annexin A10 may be a useful marker to distinguish sporadic from LS-associated microsatellite-unstable colon cancer. ..
  30. ncbi request reprint Desmoid tumors do not prevent proctectomy following abdominal colectomy and ileorectal anastomosis in patients with familial adenomatous polyposis
    James M Church
    1Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 2Sanford R Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio 3Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio
    Dis Colon Rectum 57:343-7. 2014
    ..There are no data to support the reality of this concern...
  31. doi request reprint Snaring large serrated polyps
    Jennifer Liang
    Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Desk A 30, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Surg Endosc 27:1622-7. 2013
    ..Few studies describe the technique or outcomes of serrated polypectomy. We sought to present outcomes of a series of polypectomies of large serrated polyps in comparison to a series of endoscopic resections of large adenomas...
  32. doi request reprint Impact of obesity on operation performed, complications, and long-term outcomes in terms of restoration of intestinal continuity for patients with mid and low rectal cancer
    Erman Aytac
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 56:689-97. 2013
    ....
  33. doi request reprint Is adjuvant chemotherapy really needed after curative surgery for rectal cancer patients who are node-negative after neoadjuvant chemoradiotherapy?
    Ravi P Kiran
    Department of Colorectal Surgery, A30, Cleveland Clinic Foundation, Cleveland, OH, USA
    Ann Surg Oncol 19:1206-12. 2012
    ..We postulate that adjuvant chemotherapy adds minimal oncologic benefit for patients who undergo total mesorectal excision who are node-negative after neoadjuvant chemoradiation...
  34. doi request reprint Does reevaluation of colorectal cancers with inadequate nodal yield lead to stage migration or the identification of metastatic lymph nodes?
    Lilian Chen
    1Department of Colon and Rectal Surgery, Lahey Clinic, Burlington, Massachusetts 2Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio
    Dis Colon Rectum 57:432-7. 2014
    ..The National Comprehensive Cancer Network recommends routine reevaluation of all stage II colon cancer specimens with fewer than 12 lymph nodes. However, there are few data demonstrating the effect of reevaluation on stage...
  35. ncbi request reprint Prevalence of occult gynecologic malignancy at the time of risk reducing and nonprophylactic surgery in patients with Lynch syndrome
    Mark P Lachiewicz
    Women s Health Institute Cleveland Clinic, Cleveland, OH, USA Electronic address
    Gynecol Oncol 132:434-7. 2014
    ..A secondary aim was to determine the prevalence of occult gynecologic malignancy at the time of surgery for non-prophylactic indications in patients with Lynch Syndrome...
  36. pmc Epigenomic enhancer profiling defines a signature of colon cancer
    Batool Akhtar-Zaidi
    Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Science 336:736-9. 2012
    ..We propose that reproducible changes in the epigenome at enhancer elements drive a specific transcriptional program to promote colon carcinogenesis...
  37. ncbi request reprint Is the phenotype mixed or mistaken? Hereditary nonpolyposis colorectal cancer and hyperplastic polyposis syndrome
    Awad M Jarrar
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 52:1949-55. 2009
    ..We hypothesized that this may represent a unique group of patients, and this study investigates a possible association between the two syndromes...
  38. doi request reprint Hand-assisted laparoscopic right colectomy: how does it compare to conventional laparoscopy?
    Jon D Vogel
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    J Am Coll Surg 212:367-72. 2011
    ..With this deficiency in mind, we performed a study to compare the short-term outcomes of right colectomy performed by either the hand-assisted or conventional laparoscopic technique...
  39. pmc Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
    Fiorenza Lotti
    Department of Stem Cell Biology and Regenerative Medicine, 2 Department of Cellular and Molecular Medicine, and 3 Department of Cancer Biology, Lerner Research Institute 4 Department of Colorectal Surgery, Digestive Disease Institute 5 Department of Anatomical Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195
    J Exp Med 210:2851-72. 2013
    ..Incorporating simultaneous disruption of CIC mechanisms and interplay with the tumor microenvironment could optimize therapeutic targeting of cancer. ..
  40. doi request reprint Identification of the methylator (serrated) colorectal cancer phenotype through precursor serrated polyps
    Craig A Messick
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 52:1535-41. 2009
    ..This study analyzes characteristics of precursor polyps occurring within different molecular subtypes of sporadic colorectal cancer...
  41. pmc Multiplex flow cytometry barcoding and antibody arrays identify surface antigen profiles of primary and metastatic colon cancer cell lines
    Kumar Sukhdeo
    Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA
    PLoS ONE 8:e53015. 2013
    ..Multiplexed antibody arrays can easily be applied to other tumor types or pathologies for discovery-based approaches to target identification...
  42. doi request reprint Anal neoplasms
    Kelly Garrett
    Department of Colorectal Surgery, Digestive Disease Institute, 9500 Euclid Avenue, A30 Cleveland Clinic, Cleveland, OH 44195, USA
    Surg Clin North Am 90:147-61, Table of Contents. 2010
    ..Treatment strategies are based on anatomic location and histopathology. In this article different tumors and management of each, including a brief review of local excision for rectal cancer, are discussed in turn...
  43. pmc Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy
    Kenneth Yan
    Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA Case Western Reserve University School of Medicine, Cleveland, Ohio 44195, USA Department of Cell Biology, Case Western Reserve University, Cleveland, Ohio 44195, USA
    Genes Dev 28:1085-100. 2014
    ..This study establishes CSC-derived Gremlin1 as a driving force in maintaining glioblastoma tumor proliferation and glioblastoma hierarchies through the modulation of endogenous prodifferentiation signals. ..