Damir Janigro

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint What Non-neuronal Mechanisms Should Be Studied to Understand Epileptic Seizures?
    Damir Janigro
    Department of Molecular Medicine, Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    Adv Exp Med Biol 813:253-64. 2014
  2. pmc Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America
    PLoS ONE 6:e18200. 2011
  3. pmc A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches
    Damir Janigro
    Departments of Neurological Surgery, Cellular and Molecular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, U S A
    Epilepsia 54:30-2. 2013
  4. pmc Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier
    Damir Janigro
    Departments of Neurological Surgery, Molecular Medicine and Cell Biology, ClevelandClinic Foundation, Euclid Avenue, Cleveland, OH 44195, U S A
    Epilepsia 53:26-34. 2012
  5. pmc Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
    Lillian A Buhler
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
    BMC Neurosci 10:17. 2009
  6. pmc RLIP76, a non-ABC transporter, and drug resistance in epilepsy
    Sanjay Awasthi
    Department of Chemistry and Biochemistry, University of Texas at Arlington, USA
    BMC Neurosci 6:61. 2005
  7. pmc Alternating current electrical stimulation enhanced chemotherapy: a novel strategy to bypass multidrug resistance in tumor cells
    Damir Janigro
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106, USA
    BMC Cancer 6:72. 2006
  8. ncbi request reprint Blood-brain barrier, ion homeostatis and epilepsy: possible implications towards the understanding of ketogenic diet mechanisms
    D Janigro
    Cerebravascular Research, Cleveland Clinic Foundation, OH 44195, USA
    Epilepsy Res 37:223-32. 1999
  9. ncbi request reprint Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs
    Luca Cucullo
    Center for Cerebrovascular Research, Cleveland, Ohio, USA
    Epilepsia 48:505-16. 2007
  10. ncbi request reprint Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies
    Luca Cucullo
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 28:312-28. 2008

Research Grants

  1. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2010
  2. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2005
  3. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2006
  4. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2007
  5. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2007
  6. HETEROGENEITY OF HIPPOCAMPAL GLIA
    Damir Janigro; Fiscal Year: 2002
  7. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2001
  8. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2009
  9. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2000
  10. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2005

Collaborators

Detail Information

Publications86

  1. ncbi request reprint What Non-neuronal Mechanisms Should Be Studied to Understand Epileptic Seizures?
    Damir Janigro
    Department of Molecular Medicine, Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    Adv Exp Med Biol 813:253-64. 2014
    ..This review will briefly summarize these findings and propose mechanisms and targets for future research efforts on non-neuronal features of neurological disorders including epilepsy. ..
  2. pmc Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, United States of America
    PLoS ONE 6:e18200. 2011
    ..The mechanism encompasses improvement of BBB integrity. Our results also suggest that add on GCs could be of efficacy in controlling pediatric drug resistant seizures...
  3. pmc A role for inflammation in status epilepticus is revealed by a review of current therapeutic approaches
    Damir Janigro
    Departments of Neurological Surgery, Cellular and Molecular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, U S A
    Epilepsia 54:30-2. 2013
    ..For instance, corticosteroids have been shown to be beneficial and the same agents may be able to further reduce seizure burden in conjunction with currently prescribed antiepileptic drugs. ..
  4. pmc Are you in or out? Leukocyte, ion, and neurotransmitter permeability across the epileptic blood-brain barrier
    Damir Janigro
    Departments of Neurological Surgery, Molecular Medicine and Cell Biology, ClevelandClinic Foundation, Euclid Avenue, Cleveland, OH 44195, U S A
    Epilepsia 53:26-34. 2012
    ....
  5. pmc Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis
    Lillian A Buhler
    Division of Biomedical Sciences, University of California Riverside, 900 University Avenue, Riverside, CA 92521 0121, USA
    BMC Neurosci 10:17. 2009
    ....
  6. pmc RLIP76, a non-ABC transporter, and drug resistance in epilepsy
    Sanjay Awasthi
    Department of Chemistry and Biochemistry, University of Texas at Arlington, USA
    BMC Neurosci 6:61. 2005
    ..Because of a significant overlap in substrates between P-glycoprotein and RLIP76, present studies were carried out to determine the potential role of RLIP76 in AED transport in the brain...
  7. pmc Alternating current electrical stimulation enhanced chemotherapy: a novel strategy to bypass multidrug resistance in tumor cells
    Damir Janigro
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106, USA
    BMC Cancer 6:72. 2006
    ..The aim of the present study is to test the hypothesis that permeability of several MDR1 over-expressing tumor cell lines to the chemotherapic agent doxorubicin is enhanced by low frequency, low intensity AC stimulation...
  8. ncbi request reprint Blood-brain barrier, ion homeostatis and epilepsy: possible implications towards the understanding of ketogenic diet mechanisms
    D Janigro
    Cerebravascular Research, Cleveland Clinic Foundation, OH 44195, USA
    Epilepsy Res 37:223-32. 1999
    ..This hypothesis is supported by the fact that the ketogenic diet is the treatment of choice for the glucose transporter protein syndrome and pyruvate dehydrogenase deficiency, both associated with cerebral energy failure and seizures...
  9. ncbi request reprint Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs
    Luca Cucullo
    Center for Cerebrovascular Research, Cleveland, Ohio, USA
    Epilepsia 48:505-16. 2007
    ....
  10. ncbi request reprint Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies
    Luca Cucullo
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 28:312-28. 2008
    ..Pretreatment with ibuprofen (0.125 mmol/L) prevented BBB failure by decreasing the inflammatory response after flow cessation/reperfusion...
  11. ncbi request reprint Seizure-promoting effect of blood-brain barrier disruption
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:732-42. 2007
    ..However, evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures...
  12. pmc ProApolipoprotein A1: a serum marker of brain metastases in lung cancer patients
    Nicola Marchi
    Cerebrovascular Research, Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Cancer 112:1313-24. 2008
    ..However, a confounding factor was the presence of BBB changes due to cerebrovascular disease...
  13. pmc Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow
    Chaitali Ghosh
    Department of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Epilepsia 51:1408-17. 2010
    ..We have evaluated the cerebrovascular CYP expression and function, hypothesizing possible implication in drug-resistant epilepsy...
  14. pmc A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box
    Luca Cucullo
    Cerebrovascular Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Neurosci 14:18. 2013
    ....
  15. pmc Blood-brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Brain Res 1353:176-86. 2010
    ..Our data suggest that neither acute-induced nor chronic seizures correlate with WBC brain parenchymal migration while albumin and IgG brain leakage is a hallmark of acute and chronic seizures...
  16. pmc Cellular localization and functional significance of CYP3A4 in the human epileptic brain
    Chaitali Ghosh
    Cerebrovascular ResearchDepartments of Cell Biology Molecular Medicine Neurological Surgery Epilepsy Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 52:562-71. 2011
    ..We have evaluated the pattern of expression of the specific enzyme CYP3A4 and studied its co-localization with MDR1. We also determined whether an association exists between CYP3A4 expression and cell survival...
  17. pmc Blood-brain barrier damage and brain penetration of antiepileptic drugs: role of serum proteins and brain edema
    Nicola Marchi
    Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 50:664-77. 2009
    ..We tested the hypothesis that lipophilic and hydrophilic drug distribution is differentially affected by BBB damage...
  18. ncbi request reprint Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: a permeability study
    Stefano Santaguida
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106, USA
    Brain Res 1109:1-13. 2006
    ....
  19. pmc A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system
    Luca Cucullo
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 31:767-77. 2011
    ..We also observed abluminal extravasation of monocytes but only when the BBB was breached. In conclusion, the DIV-BBBr represents the most realistic in vitro system to study the immune cell trafficking across the BBB...
  20. ncbi request reprint Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model
    Ljiljana Krizanac-Bengez
    Department of Neurological Surgery, Cerebrovascular Research Center, Cleveland, Ohio 44195, USA
    J Cell Physiol 206:68-77. 2006
    ..In conclusion, loss of flow (flow cessation/reperfusion) independent of hypoxia-hypoglycemia plays a significant role in blood-brain barrier failure by stimulating leukocyte-mediated inflammatory mechanisms...
  21. pmc Antagonism of peripheral inflammation reduces the severity of status epilepticus
    Nicola Marchi
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44106, USA
    Neurobiol Dis 33:171-81. 2009
    ..Animals pre-treated with IL-1ra exhibited significant reduction of SE onset and of BBB damage. Our data support the concept of targeting systemic inflammation and BBB for the prevention of status epilepticus...
  22. pmc In vivo and in vitro effects of pilocarpine: relevance to ictogenesis
    Nicola Marchi
    Department of Cerebrovascular Research, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 48:1934-46. 2007
    ..The extent of such peripheral events and the contribution to SE are unknown and the possibility that pilocarpine also induces SE by peripheral actions is yet untested...
  23. pmc A pro-convulsive carbamazepine metabolite: quinolinic acid in drug resistant epileptic human brain
    Chaitali Ghosh
    Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurobiol Dis 46:692-700. 2012
    ..Our data suggest that a drug resistant BBB not only impedes drug access to the brain but may also allow the formation of neurotoxic metabolites...
  24. ncbi request reprint Glycerophosphoinositol and dexamethasone improve transendothelial electrical resistance in an in vitro study of the blood-brain barrier
    Luca Cucullo
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Brain Res 997:147-51. 2004
    ..Further experiments will confirm the efficacy of this treatment in vivo and elucidate the pathways that lead to BBB repair after exposure to GPI...
  25. ncbi request reprint Dissociation between in vitro and in vivo epileptogenicity in a rat model of cortical dysplasia
    Christoph Kellinghaus
    Department of Neurology, The Cleveland Clinic Foundation, Ohio, USA
    Epileptic Disord 9:11-9. 2007
    ..The freeze-lesion model in rats shows histopathological features similar to those found in human polymicrogyria. Previous studies reported in vitro hyperexcitability in this model, but in vivo epileptogenicity has not been confirmed...
  26. ncbi request reprint Blood-brain barrier damage induces release of alpha2-macroglobulin
    Luca Cucullo
    Department of Neurological Surgery, Cerebrovascular Research Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Cell Proteomics 2:234-41. 2003
    ..We conclude that, in addition to proinflammatory changes, BBB failure may also trigger protective release of alpha2M by perivascular astrocytes as well as peripheral source...
  27. pmc Peripheral markers of brain damage and blood-brain barrier dysfunction
    Nicola Marchi
    Cerebrovascular Research Center, Department of Neurological Surgery Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Restor Neurol Neurosci 21:109-21. 2003
    ....
  28. ncbi request reprint Vascular and parenchymal mechanisms in multiple drug resistance: a lesson from human epilepsy
    Matteo Marroni
    Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Drug Targets 4:297-304. 2003
    ..This second line of defense for xenobiotics may have profound implications for the pharmacokinetic properties of antiepileptic drugs and their capacity to reach neuronal targets...
  29. pmc Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    Nicola Marchi
    Cerebrovascular Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Med 2:37. 2004
    ..Since various antiepileptic drugs (AEDs) can act as substrates for MDR1, the enhanced expression/function of this protein may increase their active extrusion from the brain, resulting in decreased responsiveness to AEDs...
  30. pmc Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures
    Nicola Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 52:1627-34. 2011
    ..We tested the hypothesis that immunosupression by splenectomy or lack of perforin, a downstream factor of natural killer (NK) and cytotoxic T cells, could reduce seizure onset...
  31. ncbi request reprint Very low intensity alternating current decreases cell proliferation
    Luca Cucullo
    Division of Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Glia 51:65-72. 2005
    ..Brain stimulators currently used for the treatment of neurological disorders may thus also be used for the treatment of brain (or other) tumors...
  32. ncbi request reprint Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases
    Chaitali Ghosh
    Molecular Medicine Cerebrovascular Research Cleveland Clinic Foundation NB 20 9500 Euclid Ave Cleveland, OH 44195, USA
    Curr Drug Metab 12:742-9. 2011
    ..Finally, a link between P450 and MDT expression in the diseased brain and cell survival is discussed...
  33. pmc Serum S100B: a potential biomarker for suicidality in adolescents?
    Tatiana Falcone
    Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 5:e11089. 2010
    ..Others reported a possible link between inflammation, a microgliosis and the blood-brain barrier (BBB) in suicidal patients. Serum S100B is a marker of BBB function commonly used to study cerebrovascular wall function...
  34. pmc Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains
    Chaitali Ghosh
    Department of Cellular, Cleveland Clinic, Cleveland, Ohio, USA
    Epilepsia 54:1562-70. 2013
    ..The possibility that phase II metabolic enzymes could be expressed in the epileptic brain has been not evaluated. Phase II enzymes are involved in the metabolism of common antiepileptic drugs (AEDs)...
  35. pmc Management of the patient with medically refractory epilepsy
    Tiziana Granata
    Department of Neurology, Cleveland, OH, USA and Department of Child Neurology, Carlo Besta Neurological Institute, Milan, Italy
    Expert Rev Neurother 9:1791-802. 2009
    ..A promising approach is the use of corticosteroids that may have a dual beneficial effect. Resective brain surgery remains the ultimate and highly successful approach to multiple drug resistance in epileptic patients...
  36. pmc The role of shear stress in Blood-Brain Barrier endothelial physiology
    Luca Cucullo
    Cerebrovascular Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 USA
    BMC Neurosci 12:40. 2011
    ..With the use of a well established humanized dynamic in vitro BBB model and cDNA microarrays, we have profiled the effect of SS in the induction/suppression of ECs genes and related functions...
  37. ncbi request reprint Peripheral markers of blood-brain barrier damage
    Nicola Marchi
    Department of Neurological Surgery, Cerebrovascular Research Center, NB20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Chim Acta 342:1-12. 2004
    ..We will present clinical and laboratory evidence supporting the use of these markers as modern neurodiagnostic tools...
  38. pmc Multimodal investigations of trans-endothelial cell trafficking under condition of disrupted blood-brain barrier integrity
    Nicola Marchi
    Department of Cerebrovascular Research Cell Biology, Cleveland Clinic Lerner College of Medicine, 9500 Euclid Ave, Cleveland, 44106 Ohio, USA
    BMC Neurosci 11:34. 2010
    ..Transcranial Doppler was used to monitor cerebral blood flow. EEG recordings were used to detect seizures. Immunocytochemical detection (Cresyl Violet, anti-human CD8 for TALL-104, Evans Blue for BBB damage, GFAP and NEUN) was performed...
  39. ncbi request reprint In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance
    Emily Oby
    Cerebrovascular Research Center, The Cleveland Clinic, OH 44195, USA
    Brain Res 1086:201-13. 2006
    ..Taken together, our results support the hypothesis that multiple drug resistance to AEDs involves cerebrovascular changes that impede the achievement of appropriate drug levels in the central nervous system...
  40. ncbi request reprint Dynamic in vitro model of the blood-brain barrier. Gene profiling using cDNA microarray analysis
    Matteo Marroni
    Division of Cerebrovascular Research, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA
    Methods Mol Med 89:419-34. 2003
  41. ncbi request reprint Effects of transient loss of shear stress on blood-brain barrier endothelium: role of nitric oxide and IL-6
    Ljiljana Krizanac-Bengez
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation NB20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Brain Res 977:239-46. 2003
    ..Maintenance of BBB function during and following NNFC appears to depend on intact NO signaling and IL-6 release...
  42. ncbi request reprint Loss of flow induces leukocyte-mediated MMP/TIMP imbalance in dynamic in vitro blood-brain barrier model: role of pro-inflammatory cytokines
    Ljiljana Krizanac-Bengez
    Cerebrovascular Research Center, Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Cell Physiol 291:C740-9. 2006
    ..These data indicate that blood leukocytes and loss of flow are major factors in the activation of MMP-2, and that cytokine-mediated differential regulation of TIMP-1 and TIMP-2 may contribute significantly to BBB failure...
  43. ncbi request reprint S100beta as a predictor of brain metastases: brain versus cerebrovascular damage
    Michael A Vogelbaum
    Brain Tumor Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer 104:817-24. 2005
    ....
  44. pmc Intracellular and circulating neuronal antinuclear antibodies in human epilepsy
    Philip H Iffland
    Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA Department of Cellular and Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH, USA Kent State University School of Biomedical Sciences, Kent, OH, USA Electronic address
    Neurobiol Dis 59:206-19. 2013
    ..Seizures may be the trigger of neuronal uptake of antinuclear antibodies. ..
  45. pmc Small vessel ischemic disease of the brain and brain metastases in lung cancer patients
    Peter J Mazzone
    Respiratory Institute, The Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 4:e7242. 2009
    ..We aimed to determine if the presence of small vessel ischemic disease (SVID) of the brain is protective against the development of brain metastases in lung cancer patients...
  46. ncbi request reprint The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia
    Gabriel Moddel
    Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
    Brain Res 1046:10-23. 2005
    ..NR2B may constitute a target for new diagnostic and pharmacotherapeutic approaches...
  47. ncbi request reprint The blood-brain barrier and epilepsy
    Emily Oby
    Cleveland Clinic Foundation, Department of Neurological Surgery, Cerebrovascular Research, Ohio 44195, USA
    Epilepsia 47:1761-74. 2006
    ..In this article we will review the relationships between BBB function and epilepsy. In particular, we will illustrate consensus and divergence between clinical reality and animal studies...
  48. ncbi request reprint Serum transthyretin monomer as a possible marker of blood-to-CSF barrier disruption
    Nicola Marchi
    Division of Cerebrovascular Research, Cleveland Clinic Foundation, Cleveland, Ohio 44196, USA
    J Neurosci 23:1949-55. 2003
    ..Because TTR is localized primarily in choroid plexus and, as a soluble monomer, in CSF, we concluded that although S-100beta is a marker of BBB integrity, TTR instead may be a peripheral tracer of blood-to-cerebrospinal barrier...
  49. pmc Pathophysiological impact of cigarette smoke exposure on the cerebrovascular system with a focus on the blood-brain barrier: expanding the awareness of smoking toxicity in an underappreciated area
    Peter Mazzone
    Department of Pulmonary Medicine, Cleveland Clinic Lerner College of Medicine, E 100 St, Cleveland, OH 44106, USA
    Int J Environ Res Public Health 7:4111-26. 2010
    ..We also discuss the potential toxicity of recently marketed "potential-reduced exposure products"...
  50. ncbi request reprint The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology
    Ljiljana Krizanac-Bengez
    Cerebrovascular Research Center, Neurosurgery NB 20, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Neurol Res 26:846-53. 2004
    ..This review summarizes the most recent data related to cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in blood-brain barrier homeostasis and pathophysiology...
  51. doi request reprint Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches
    Nicola Marchi
    Departments of Molecular Medicine Cell Biology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, U S A
    Epilepsia 53:1877-86. 2012
    ..We also present BBB neuroimaging as a tool to correlate BBB restoration to seizure mitigation. Add-on cerebrovascular drug could be of efficacy in reducing seizure burden when used in association with neuronal antiepileptic drugs...
  52. pmc The etiological role of blood-brain barrier dysfunction in seizure disorders
    Nicola Marchi
    Department of Molecular Medicine, Cleveland Clinic Foundation, NB 20 LRI 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cardiovasc Psychiatry Neurol 2011:482415. 2011
    ..The fact that the BBB plays an etiologic role in other neurological diseases will be discussed in the context of a more "holistic" approach to the patient with epilepsy, where comorbidity variables are also encompassed by drug therapy...
  53. pmc Is peripheral immunity regulated by blood-brain barrier permeability changes?
    Erin Bargerstock
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 9:e101477. 2014
    ..We propose a scenario where extravasated S100B may trigger a pathologic autoimmune reaction linking systemic and CNS immune responses. ..
  54. pmc Consequences of repeated blood-brain barrier disruption in football players
    Nicola Marchi
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    PLoS ONE 8:e56805. 2013
    ..The correlation of serum S100B, auto-antibodies and DTI changes support a link between repeated BBBD and future risk for cognitive changes...
  55. pmc Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol
    Stefania Bassanini
    Department of Cerebrovascular Research, Cleveland, OH, USA
    Neurobiol Dis 26:481-95. 2007
    ....
  56. ncbi request reprint Drug delivery and in vitro models of the blood-brain barrier
    Luca Cucullo
    Division of Cerebrovascular Research, Cleveland Clinic Foundation NB 20, Cleveland, OH 44195, USA
    Curr Opin Drug Discov Devel 8:89-99. 2005
    ..Herein we provide a detailed review and discussion of currently employed in vitro BBB models along with probable future developments...
  57. ncbi request reprint Reading and writing the blood-brain barrier: relevance to therapeutics
    Barry M Czeisler
    Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Recent Pat CNS Drug Discov 1:157-73. 2006
    ..These techniques for both "reading" and "writing" the BBB will help new and old medications to reach their pharmacological targets in the CNS...
  58. ncbi request reprint Mechanisms of epileptogenesis
    I Najm
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Neurol Clin 19:237-50. 2001
    ..The data on the roles of the glutamate, GABA, acetylcholine, and adenosine receptors is discussed. The recent information on the role of glial cells in the expression of epileptogenicity is reviewed...
  59. pmc Significance of ubiquitin carboxy-terminal hydrolase l1 elevations in athletes after sub-concussive head hits
    Vikram Puvenna
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 9:e96296. 2014
    ..UCH-L1 did not display any interpretable change in football players or in individuals with mild TBI. The significance of UCH-L1 changes in sub-concussions or mTBI needs to be further elucidated. ..
  60. pmc Suicidal behavior in adolescents with first-episode psychosis
    Tatiana Falcone
    Department of Psychiatry, Cleveland Clinic Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue P57, Cleveland, OH 44195, USA
    Clin Schizophr Relat Psychoses 4:34-40. 2010
    ..Studies have reported an increased risk for suicide in adults with schizophrenia, but limited data on younger populations are available...
  61. ncbi request reprint Why do many NMDA antagonists fail, while others are safe and effective at blocking excitotoxicity associated with dementia and acute injury?
    Benedict C Albensi
    Center for Cerebrovascular Research, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University Cleveland, Ohio, USA
    Am J Alzheimers Dis Other Demen 19:269-74. 2004
    ....
  62. pmc Inflammatory pathways of seizure disorders
    Nicola Marchi
    Department of Molecular Medicine, Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA Department of Neurobiology, Institute of Functional Genomics, Centre National de la Recherche Scientifique, Montpellier, France
    Trends Neurosci 37:55-65. 2014
    ..Here, we summarize recent advances in the understanding and treatment of epileptic seizures that derive from a non-neurocentric viewpoint and suggest key avenues for future research. ..
  63. ncbi request reprint Thrombospondin-4 and its variants: expression and differential effects on endothelial cells
    Olga I Stenina
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Circulation 108:1514-9. 2003
    ..TSP-4 had not previously been implicated in vascular pathology, and very little information is available on its expression and functions...
  64. ncbi request reprint A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier
    Luca Cucullo
    Department of Neurological Surgery, Cerebrovascular Research Center, Cleveland Clinic Foundation, NB20, 9500 Euclid Avenue NB20, Cleveland, OH 44195, USA
    Brain Res 951:243-54. 2002
    ....
  65. ncbi request reprint Mechanisms of endothelial survival under shear stress
    Shailesh Y Desai
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue NB20, Cleveland, OH 44195, USA
    Endothelium 9:89-102. 2002
    ..These changes may explain longevity and antioxidant efficiency of ECs and may provide insight in mechanisms leading to pathological conditions such as arteriosclerosis...
  66. doi request reprint APOE epsilon4 is associated with postictal confusion in patients with medically refractory temporal lobe epilepsy
    Jessica S Chapin
    Epilepsy Center, Department of Psychiatry and Psychology, Neurological Institute, Cleveland Clinic P57, 9500 Euclid Avenue, Cleveland, OH 44195, United States
    Epilepsy Res 81:220-4. 2008
    ..These preliminary results demonstrate that APOE epsilon4 is associated with an increased risk of postictal confusion in patients with medically intractable TLE, suggesting possible dysfunction in neuronal recovery mechanisms...
  67. ncbi request reprint Traumatic brain injury and its effects on synaptic plasticity
    Benedict C Albensi
    Department of Neurological Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Brain Inj 17:653-63. 2003
    ..Collectively, this mini review surveys investigations of head trauma involving altered mechanisms of synaptic plasticity and how trauma may be related to increased risk for dementia...
  68. ncbi request reprint Mechanisms of glucose transport at the blood-brain barrier: an in vitro study
    M S McAllister
    Department of Neurological Surgery, Cerebrovascular Research Center, Cleveland Clinic Foundation/NB20, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Brain Res 904:20-30. 2001
    ..We conclude that glucose transport at the CNS/blood interface appears to be dependent on and regulated by a serial chain of membrane-bound and intracellular transporters and enzymes...
  69. ncbi request reprint Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
    S M Dombrowski
    Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 42:1501-6. 2001
    ..CONCLUSIONS: Complex MDR expression changes may play a role in AEDs pharmacoresistance by altering the permeability of AEDs across the BBB...
  70. ncbi request reprint Regional variation in brain capillary density and vascular response to ischemia
    M Cavaglia
    Cerebrovascular Research Center, Department of Neurological Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Brain Res 910:81-93. 2001
    ..We conclude that in addition to neuronal and glial heterogeneity, cortical structures are also endowed with region-specific vascular patterns characterized by distinct pathophysiological responses...
  71. ncbi request reprint Relationship between expression of multiple drug resistance proteins and p53 tumor suppressor gene proteins in human brain astrocytes
    M Marroni
    Division of Cerebrovascular Research, Department of Neurological Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neuroscience 121:605-17. 2003
    ..Other apoptotic markers were also absent in epileptic glia. Our results suggest a possible link between loss of p53 function and expression of multiple drug resistance in non-tumor CNS cells...
  72. pmc Tobacco smoke: a critical etiological factor for vascular impairment at the blood-brain barrier
    M Hossain
    Cerebrovascular Research, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Brain Res 1287:192-205. 2009
    ..In conclusion, TS is a strong vascular inflammatory primer that can facilitate the loss of BBB function and viability in pathological settings involving a local transient loss of cerebral blood flow such as during ischemic insults...
  73. doi request reprint Transporters in drug-refractory epilepsy: clinical significance
    N Marchi
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Clin Pharmacol Ther 87:13-5. 2010
    ..As discussed here, the field is replete with controversies and false starts, in particular as it concerns the existence of genetic predisposition to inadequate pharmacological seizure control...
  74. ncbi request reprint Serum S-100beta as a possible marker of blood-brain barrier disruption
    M Kapural
    Department of Neurological Surgery, Cleveland Clinic Foundation NB 20, 9500 Euclid Avenue, NB2 137, Cleveland, OH 44195, USA
    Brain Res 940:102-4. 2002
    ..Serum S-100beta increased significantly after mannitol infusion (P<0.05) while NSE did not. This suggests that S-100beta is an early marker of BBB opening that is not necessarily related to neuronal damage...
  75. pmc Combined effects of prenatal inhibition of vasculogenesis and neurogenesis on rat brain development
    Q Y Fan
    Cerebrovascular Research Center, Department of Molecular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neurobiol Dis 32:499-509. 2008
    ..These morphological abnormalities gradually disappeared at adult stages. Although the adult MAM-THAL rats showed normal cortical morphology, abnormal hippocampal connectivity and mossy fiber sprouting persisted well into adulthood...
  76. ncbi request reprint A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine
    Nicola Marchi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsia 46:1613-9. 2005
    ....
  77. ncbi request reprint Drug resistance in epilepsy: the role of the blood-brain barrier
    N Joan Abbott
    Blood Brain Barrier Research Group, Centre for Neuroscience Research, King s College London, UK
    Novartis Found Symp 243:38-47; discussion 47-53, 180-5. 2002
    ..This complicates interpretation of drug resistance in epilepsy, and therapeutic strategies...
  78. ncbi request reprint Adenosine-induced modulation of excitatory amino acid transport across isolated brain arterioles
    Gerald A Grant
    Department of Neurological Surgery, University of Washington, Seattle, Washington 98104, USA
    J Neurosurg 98:554-60. 2003
    ..In the present study, the authors explored the effect of adenosine on EAA transport across the BBB...
  79. ncbi request reprint Persistent SIV infection of a blood-brain barrier model
    Lisa Strelow
    Oregon Health and Science University, Department of Microbiology and Immunology, Portland, Oregon 97006, USA
    J Neurovirol 8:270-80. 2002
    ..These studies indicate that SIV can persist in MVEC without overtly compromising BBB function, and suggest that the DIV-BBB will be a highly valuable and suitable model for studies of HIV neuropathogenesis...
  80. ncbi request reprint Activation of long-term synaptic plasticity causes suppression of epileptiform activity in rat hippocampal slices
    Benedict C Albensi
    Cerebrovascular Research Center, Cleveland Clinic Foundtion, Ohio 44195, USA
    Brain Res 998:56-64. 2004
    ....
  81. ncbi request reprint Peripheral detection of S100beta during cardiothoracic surgery: what are we really measuring?
    Vincent Fazio
    Cerebrovascular Research Center, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 78:46-52; discussion 52-3. 2004
    ..Objectives of this study were (1) to quantify S100 beta levels in serum and pericardial cavity during coronary artery bypass grafting (CABG), and (2) to identify proteins recognized by standard immunodetection as S100beta...
  82. ncbi request reprint Insulin permeability across an in vitro dynamic model of endothelium
    Francesca Salvetti
    Departimento di Psichiatria, Neurobiologia, Farmacologia e Biotechnologie, Facolta di Farmacia, Universita degli Studi di Pisa, Italy
    Pharm Res 19:445-50. 2002
    ..Endothelium insulin permeability was investigated using in vitro, dynamic culture of endothelial cells...
  83. ncbi request reprint RLIP76 in AED drug resistance
    Damir Janigro
    Epilepsia 48:1218-9; author reply 1219-20. 2007
  84. ncbi request reprint Use of a three-dimensional in vitro model of the rat blood-brain barrier to assay nucleoside efflux from brain
    Fiona E Parkinson
    Department of Pharmacology, University of Manitoba, A403, 753 McDermot Avenue, Winnipeg, MB R3E 0T6, Canada
    Brain Res 980:233-41. 2003
    ..In conclusion, these data indicate that in addition to inhibiting nucleoside efflux across the barrier, dipyridamole can also improve blood-brain barrier function in this model...
  85. ncbi request reprint Serum S100beta: a noninvasive marker of blood-brain barrier function and brain lesions
    Andrew A Kanner
    Brain Tumor Institute, The Cleveland Clinic, Ohio 44195, USA
    Cancer 97:2806-13. 2003
    ....

Research Grants20

  1. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2010
    ..Finally, we will validate the usefulness of these markers in the early detection of recurrent brain tumors or metastases, to specifically address one of the mandates of this PA. ..
  2. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2005
    ..g. Alzheimer's, demyelinating diseases, brain tumors). ..
  3. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2006
    ..g. Alzheimer's, demyelinating diseases, brain tumors). ..
  4. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2007
    ..Finally, we will validate the usefulness of these markers in the early detection of recurrent brain tumors or metastases, to specifically address one of the mandates of this PA. ..
  5. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2007
    ..g. Alzheimer's, demyelinating diseases, brain tumors). ..
  6. HETEROGENEITY OF HIPPOCAMPAL GLIA
    Damir Janigro; Fiscal Year: 2002
    ..The outcome of the proposed experiments may be useful for further extrapolations applicable to other physiological aspects of glia(c)neuronal interactions. ..
  7. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2001
    ..2) To elucidate the mechanisms of potassium-mediated dilations in vivo. These studies will allow better understanding on neuronal-vascular interactions and will open new perspectives for the treatment of neurological diseases. ..
  8. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2009
    ..Finally, we will validate the usefulness of these markers in the early detection of recurrent brain tumors or metastases, to specifically address one of the mandates of this PA. ..
  9. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2000
    ..2) To elucidate the mechanisms of potassium-mediated dilations in vivo. These studies will allow better understanding on neuronal-vascular interactions and will open new perspectives for the treatment of neurological diseases. ..
  10. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2005
    ..In particular, we are investigating how changes in blood-brain barrier function may drive glia and neurons into an "epileptic" phenotype. ..
  11. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2006
    ..Finally, we will validate the usefulness of these markers in the early detection of recurrent brain tumors or metastases, to specifically address one of the mandates of this PA. ..
  12. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2004
    ..g. Alzheimer's, demyelinating diseases, brain tumors). ..
  13. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2004
    ..In particular, we are investigating how changes in blood-brain barrier function may drive glia and neurons into an "epileptic" phenotype. ..
  14. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2003
    ..2) To elucidate the mechanisms of potassium-mediated dilations in vivo. These studies will allow better understanding on neuronal-vascular interactions and will open new perspectives for the treatment of neurological diseases. ..
  15. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2003
    ..In particular, we are investigating how changes in blood-brain barrier function may drive glia and neurons into an "epileptic" phenotype. ..
  16. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2002
    ..2) To elucidate the mechanisms of potassium-mediated dilations in vivo. These studies will allow better understanding on neuronal-vascular interactions and will open new perspectives for the treatment of neurological diseases. ..
  17. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2002
    ..In particular, we are investigating how changes in blood-brain barrier function may drive glia and neurons into an "epileptic" phenotype. ..
  18. HETEROGENEITY OF HIPPOCAMPAL GLIA
    Damir Janigro; Fiscal Year: 2001
    ..The outcome of the proposed experiments may be useful for further extrapolations applicable to other physiological aspects of glia(c)neuronal interactions. ..
  19. HETEROGENEITY OF HIPPOCAMPAL GLIA
    Damir Janigro; Fiscal Year: 2000
    ..The outcome of the proposed experiments may be useful for further extrapolations applicable to other physiological aspects of glia(c)neuronal interactions. ..