Jennifer L Hunt

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Identifying cross contaminants and specimen mix-ups in surgical pathology
    Jennifer L Hunt
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Adv Anat Pathol 15:211-7. 2008
  2. doi request reprint Molecular pathology in anatomic pathology practice: a review of basic principles
    Jennifer L Hunt
    Cleveland Clinic, Department of Pathology, 9500 Euclid Ave L25, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 132:248-60. 2008
  3. doi request reprint Molecular alterations in hereditary and sporadic thyroid and parathyroid diseases
    Jennifer L Hunt
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Adv Anat Pathol 16:23-32. 2009
  4. pmc Molecular diagnosis in head and neck: what a surgical pathologist must know
    Jennifer L Hunt
    Department of Anatomic Pathology L25, Head and Neck Pathology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, 9500, Euclid Street, Cleveland, OH 44195, USA
    Head Neck Pathol 2:99-102. 2008
  5. ncbi request reprint Fractional allelic loss of tumor suppressor genes identifies malignancy and predicts clinical outcome in follicular thyroid tumors
    Jennifer L Hunt
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Thyroid 16:643-9. 2006
  6. doi request reprint Molecular testing in solid tumors: an overview
    Jennifer L Hunt
    Department of Anatomic Pathology, L25, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 132:164-7. 2008
  7. ncbi request reprint Molecular evidence of anaplastic transformation in coexisting well-differentiated and anaplastic carcinomas of the thyroid
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 27:1559-64. 2003
  8. ncbi request reprint Thyroidectomies from patients with history of therapeutic radiation during childhood and adolescence have a unique mutational profile
    Adel Assaad
    Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA
    Mod Pathol 21:1176-82. 2008
  9. doi request reprint BRAF mutational analysis in papillary carcinomas with mixed follicular and papillary growth patterns
    Maureen Jakubowski
    Department of Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Surg Pathol 33:1590-3. 2009
  10. ncbi request reprint Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study
    John A Ozolek
    Department of Pathology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 131:530-7. 2007

Collaborators

Detail Information

Publications65

  1. doi request reprint Identifying cross contaminants and specimen mix-ups in surgical pathology
    Jennifer L Hunt
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Adv Anat Pathol 15:211-7. 2008
    ..The methods and techniques behind DNA fingerprinting for tissue and sample identity are also discussed in detail...
  2. doi request reprint Molecular pathology in anatomic pathology practice: a review of basic principles
    Jennifer L Hunt
    Cleveland Clinic, Department of Pathology, 9500 Euclid Ave L25, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 132:248-60. 2008
    ..This review focuses on basic molecular pathology concepts, with particular emphasis on the challenge of tissue-based testing in anatomic pathology...
  3. doi request reprint Molecular alterations in hereditary and sporadic thyroid and parathyroid diseases
    Jennifer L Hunt
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Adv Anat Pathol 16:23-32. 2009
    ..The molecular alterations in parathyroid and thyroid tumors and tumor-like processes are reviewed, with a focus on the potentially clinically useful diagnostic markers...
  4. pmc Molecular diagnosis in head and neck: what a surgical pathologist must know
    Jennifer L Hunt
    Department of Anatomic Pathology L25, Head and Neck Pathology, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, 9500, Euclid Street, Cleveland, OH 44195, USA
    Head Neck Pathol 2:99-102. 2008
    ..Basic histology is reviewed and the genetic alterations are discussed, along with a brief discussion of potential diagnostic implications...
  5. ncbi request reprint Fractional allelic loss of tumor suppressor genes identifies malignancy and predicts clinical outcome in follicular thyroid tumors
    Jennifer L Hunt
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Thyroid 16:643-9. 2006
    ..002). Based on these results, a tumor suppressor gene panel for allelic imbalance in follicular-derived tumors (FTT) may correlate with both malignancy and outcome in patients with follicular-derived carcinomas of the thyroid...
  6. doi request reprint Molecular testing in solid tumors: an overview
    Jennifer L Hunt
    Department of Anatomic Pathology, L25, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 132:164-7. 2008
    ....
  7. ncbi request reprint Molecular evidence of anaplastic transformation in coexisting well-differentiated and anaplastic carcinomas of the thyroid
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 27:1559-64. 2003
    ..The patterns of allelic loss in our results showed that the majority of cases have a core of conserved mutations in the two morphologically distinct areas and substantial increases in mutation rates in the anaplastic components...
  8. ncbi request reprint Thyroidectomies from patients with history of therapeutic radiation during childhood and adolescence have a unique mutational profile
    Adel Assaad
    Department of Pathology, Virginia Mason Medical Center, Seattle, WA, USA
    Mod Pathol 21:1176-82. 2008
    ..These data from human thyroids support prior cell culture experiments and show that radiation induces genetic mutational damage even in benign proliferative processes in these thyroids...
  9. doi request reprint BRAF mutational analysis in papillary carcinomas with mixed follicular and papillary growth patterns
    Maureen Jakubowski
    Department of Clinical Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Surg Pathol 33:1590-3. 2009
    ..Tumors with mixed patterns of growth, including distinctive area of follicular and papillary growth, have not been well studied for the presence of the BRAF gene mutation...
  10. ncbi request reprint Basal/myoepithelial cells in chronic sinusitis, respiratory epithelial adenomatoid hamartoma, inverted papilloma, and intestinal-type and nonintestinal-type sinonasal adenocarcinoma: an immunohistochemical study
    John A Ozolek
    Department of Pathology, Children s Hospital of Pittsburgh, 3705 Fifth Ave, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 131:530-7. 2007
    ..One feature of malignant glandular lesions is loss of the basal/myoepithelial layer. The immunophenotype of the basal/myoepithelial layer has not been fully examined in benign glandular lesions of the sinonasal tract...
  11. ncbi request reprint Loss of heterozygosity of the VHL gene identifies malignancy and predicts death in follicular thyroid tumors
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh School of Medicine, University Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Surgery 134:1043-7; discussion 1047-8. 2003
    ..Follicular thyroid tumors (FTT) usually require resection to distinguish adenoma from carcinoma. Better markers that predict histologic subtype and prognosis are needed for FTT...
  12. ncbi request reprint Molecular genotyping of medullary thyroid carcinoma can predict tumor recurrence
    Hina A Sheikh
    Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 28:101-6. 2004
    ..004). Frequency of allelic loss in tumor suppressor genes may provide a useful adjunctive prognostic test in medullary thyroid carcinoma...
  13. ncbi request reprint Tumor suppressor gene allelic loss profiles of the variants of papillary thyroid carcinoma
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, Pittsburgh, PA 15213, USA
    Diagn Mol Pathol 13:41-6. 2004
    ....
  14. ncbi request reprint Molecular alterations in atypical adenomatous hyperplasia occurring in benign and cancer-bearing lungs
    Joel F Gradowski
    Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Diagn Mol Pathol 16:87-90. 2007
    ..Therefore, AAH may represent a smoking induced low-grade neoplastic lesion that may be a precursor lesion of only a subset of invasive lung adenocarcinoma...
  15. ncbi request reprint Allelic loss in parathyroid neoplasia can help characterize malignancy
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 29:1049-55. 2005
    ..This difference in the mutational profile suggests that this type of assay may be useful as an adjunctive diagnostic test in cases of parathyroid neoplasia...
  16. doi request reprint Encapsulated papillary oncocytic neoplasms of the thyroid: morphologic, immunohistochemical, and molecular analysis of 18 cases
    Randall Lyndon Woodford
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Surg Pathol 34:1582-90. 2010
    ..Our results confirm that EPONs are histologically, immunohistochemically, and molecularly distinct from papillary thyroid carcinoma and seem to be most related to follicular neoplasms...
  17. ncbi request reprint Allelic loss of 3 different tumor suppressor gene loci in benign and malignant endothelial tumors of the head and neck
    Akosua B Domfeh
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Pathol Lab Med 130:1184-7. 2006
    ..Although overexpression of p53 and WT-1 has been found in angiosarcoma, little is known about the molecular changes involved...
  18. ncbi request reprint Immunohistochemical evaluation of androgen receptor, HER-2/neu, and p53 in benign pleomorphic adenomas
    Tom C DeRoche
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 132:1907-11. 2008
    ..These markers may be useful in differentiating pleomorphic adenoma with cytologic atypia from intracapsular carcinoma ex pleomorphic adenoma (CXPA), as these tumors are often difficult to distinguish on the basis of morphology alone...
  19. ncbi request reprint Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa
    John A Ozolek
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Surg Pathol 30:1576-80. 2006
    ..Appreciable allelic loss within REAH suggests the possibility that REAH may be a benign neoplasm rather than a hamartoma...
  20. doi request reprint The T1799A BRAF mutation is absent in cribriform-morular variant of papillary carcinoma
    David Schuetze
    Department of Anatomic Pathology, Cleveland Clinic, Ohio 44195, USA
    Arch Pathol Lab Med 133:803-5. 2009
    ..However, one of the most common mutations in papillary carcinoma, the BRAF mutation, has not been reported in this variant of papillary carcinoma...
  21. ncbi request reprint Microsatellite instability in nasopharyngeal and lymphoepithelial carcinomas of the head and neck
    Joshua Sckolnick
    Department of Otolaryngology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Surg Pathol 30:1250-3. 2006
    ..These data suggest that alterations in DNA MMR system are not a common mechanism of tumorigenesis in LEC of the head and neck in a nonendemic country...
  22. ncbi request reprint Microscopic papillary thyroid carcinoma compared with clinical carcinomas by loss of heterozygosity mutational profile
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Surg Pathol 27:159-66. 2003
    ..These data are further evidence that microscopic and clinically sized PTCa are pathogenetically related...
  23. ncbi request reprint p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, PA 15213, USA
    Mod Pathol 17:526-9. 2004
    ..In this study, we provide additional evidence for this relationship, by demonstrating that SMECE stain strongly positive for p63, which is a new marker for UBB/solid cell nests...
  24. ncbi request reprint Molecular assessment of allelic loss in Warthin tumors
    Muammar Arida
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 18:964-8. 2005
    ....
  25. ncbi request reprint Microsatellite instability is uncommon in lymphoepithelioma-like carcinoma of the lung
    Sanja Dacic
    Department of Pathology, Division of Anatomic Pathology, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 127:282-6. 2007
    ..55). MSI is very uncommon in LELC, indicating that MSI is not an important event in carcinogenesis for this tumor subtype. The presence of LOH suggests a probable role of tumor suppressor genes in LELC carcinogenesis...
  26. ncbi request reprint Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract
    Raja R Seethala
    Head and Neck Endocrine Division, Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:44-57. 2007
    ..Immunohistochemistry can aid diagnosis by highlighting the biphasic nature of the tumor...
  27. ncbi request reprint NM-23 gene loss of heterozygosity and protein expression in high-stage laryngeal squamous cell carcinomas
    Hina Sheikh
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Diagn Mol Pathol 15:1-6. 2006
    ..These data imply that nm-23 may be tumor suppressor gene involved in HNSCC but that it may not function as a tumor metastasis suppressor in high-stage laryngeal carcinoma...
  28. doi request reprint An update on molecular diagnostics of squamous and salivary gland tumors of the head and neck
    Jennifer L Hunt
    Department of Pathology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Arch Pathol Lab Med 135:602-9. 2011
    ..Within the category of salivary gland tumors, 3 tumors have recently been recognized that contain oncogenic translocations...
  29. doi request reprint KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis
    Xiuli Liu
    Dept of Anatomic Pathology, Cleveland Clinic Foundation, OH, USA
    Am J Clin Pathol 135:245-52. 2011
    ..022) and apoptosis (77% vs 28%; P = .00012), and a greater mean of mitotic figures (P = .0002) and apoptotic cells (P = .0008). KRAS mutation was associated with higher tumor cell turnover...
  30. ncbi request reprint Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic
    Narasimhan P Agaram
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 128:313-7. 2004
    ..Whether they are developmental or neoplastic continues to be debated...
  31. ncbi request reprint KRAS mutation testing in colorectal cancer
    Thomas P Plesec
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Adv Anat Pathol 16:196-203. 2009
    ..Herein, the authors present an up-to-date review of the biologic, clinical, and laboratory aspects of KRAS mutation testing in colorectal cancer...
  32. ncbi request reprint Assessment of microsatellite instability in very small microdissected samples and in tumor samples that are contaminated with normal DNA
    Cynthia L Trusky
    Department of Pathology, University of Pittsburgh, USA
    Diagn Mol Pathol 15:63-9. 2006
    ..Contaminating normal cell DNA can mask the presence of MSI. MSI testing on tissue fragments that are <5.5 mm can lead to a false-negative MSI test...
  33. ncbi request reprint BRAF mutation is unusual in chronic lymphocytic thyroiditis-associated papillary thyroid carcinomas and absent in non-neoplastic nuclear atypia of thyroiditis
    Rachel Sargent
    Department of Pathology, University of Pittsburgh Medical Center, USA
    Endocr Pathol 17:235-41. 2006
    ..These data suggest that BRAF is a less frequent mechanism of tumorigenesis in a background of CLT and that BRAF mutation is not present in the atypical follicular epithelium of CLT...
  34. ncbi request reprint Microdissection techniques for molecular testing in surgical pathology
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 128:1372-8. 2004
    ..To describe the techniques for microdissection of paraffin-embedded and frozen tissue sections for the use in molecular applications...
  35. ncbi request reprint Unusual adrenal cortical tumor of unknown biologic potential: a nodule in a nodule in a nodule
    Sarangarajan Ranganathan
    Department of Pathology, Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatr Dev Pathol 8:483-8. 2005
    ..Molecular analysis to assess the clonality and mutation rates of the 3 distinct areas showed only 2 genetic loci with allelic imbalances...
  36. ncbi request reprint Unusual thyroid tumors: a review of pathologic and molecular diagnosis
    Jennifer L Hunt
    University of Pittsburgh Medical Center, Department of Pathology, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Expert Rev Mol Diagn 5:725-34. 2005
    ..The diagnostic features of these rare tumors, including the histology, immunohistochemical expression profiles and the known molecular mutational profiles of each, are reviewed...
  37. ncbi request reprint Molecular mutations in thyroid carcinogenesis
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Clin Pathol 118:S116-27. 2002
    ..Thyroid tumors and their characteristic molecular mutations are discussed in this review. The current practice in diagnostic testing for thyroid tumors also is examined...
  38. ncbi request reprint Prostatic adenocarcinoma metastatic to the head and neck and the workup of an unknown epithelioid neoplasm
    Jennifer L Hunt
    PUH A616 3, Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    Head Neck 26:171-8. 2004
    ..One unusual, but important, primary tumor that can metastasize to the head and neck is carcinoma of the prostate (CAP)...
  39. ncbi request reprint A microdissection and molecular genotyping assay to confirm the identity of tissue floaters in paraffin-embedded tissue blocks
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 127:213-7. 2003
    ..While many cases can be resolved histologically, a significant number remain unclear and may have serious clinical and medicolegal implications...
  40. ncbi request reprint Comparison of allelic losses in chondroblastoma and primary chondrosarcoma of bone and correlation with fluorescence in situ hybridization analysis
    Dionysios J Papachristou
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian Shadyside, Pittsburgh, PA 15213, USA
    Hum Pathol 37:890-8. 2006
    ..The role of p53 in CBL is uncertain; however, given the benign behavior of this tumor, it is probably unrelated to tumor progression...
  41. ncbi request reprint Simultaneous diffuse sclerosis variant of papillary thyroid carcinoma and diffuse toxic hyperplasia (Graves' disease)
    Gladell P Paner
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Endocr Pathol 15:77-82. 2004
    ..This report illustrates the histologic features as well as the diagnostic challenge encountered in a rare simultaneous occurrence of DSVPTC and GD.<P>..
  42. ncbi request reprint The pathology milestones and the next accreditation system
    Wesley Y Naritoku
    From the Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles Dr Naritoku the Department of Pathology, University of Alabama Birmingham Dr Alexander the American Board of Pathology, Tampa, Florida Dr Bennett and Johnson the Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston Dr Black Schaffer the Hematopathology Division, Joint Pathology Center, Silver Springs, Maryland, and Washington, DC Dr Brissette the Department of Pathology, Virginia Commonwealth University Medical Center, Richmond Dr Grimes the Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee Dr Hoffman the Department of Pathology, University of Arkansas for Medical Sciences, Little Rock Dr Hunt the Department of Pathology, University of Virginia Health System, Charlottesville Dr Iezzoni the Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha Dr Kozel the Department of Pathology, East Carolina University, Greenville, North Carolina Dr Mendoza the Department of Pathology, University of Colorado School of Medicine, Aurora Dr Post the Department of Pathology and Genomic Medicine, The Methodist Hospital, Houston, Texas Dr Powell the Department of Molecular Pathology, Cleveland Clinic Foundation, The Pathology and Laboratory Medicine Institute, Cleveland, Ohio Dr Procop the Department of Pathology, Albert Einstein College of Medicine, Bronx, New York Dr Steinberg and the Accreditation Council for Graduate Medical Education, Chicago
    Arch Pathol Lab Med 138:307-15. 2014
    ..By the mid-2000s the stakeholders in resident education and the general public felt that the Outcomes Project had fallen short of expectations...
  43. doi request reprint Mixed Medullary-follicular-derived carcinomas of the thyroid gland
    Peter M Sadow
    Department of Pathology, Massachusetts General Hospital, Boston, 02114, USA
    Adv Anat Pathol 17:282-5. 2010
    ..The clinical, histologic, and molecular features of these mixed tumors and the classification guidelines are reviewed...
  44. doi request reprint Detection and classification of diagnostic discrepancies (errors) in surgical pathology
    Jennifer E Roy
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Adv Anat Pathol 17:359-65. 2010
    ..Most importantly, these data should be incorporated into quality assurance and quality improvement activities, such that departments strive to reduce errors, and to help improve overall quality in SP...
  45. ncbi request reprint Nasal chondromesenchymal hamartoma in older children and adults: series and immunohistochemical analysis
    John A Ozolek
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Pathol Lab Med 129:1444-50. 2005
    ..Their pathogenesis is unknown, but they may be derived from embryologic rests. To our knowledge, only 1 case in an older child has been reported, and no cases have been reported in adults...
  46. ncbi request reprint Repeat thyroid nodule fine-needle aspiration in patients with initial benign cytologic results
    Melina B Flanagan
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Clin Pathol 125:698-702. 2006
    ..1% to 11.4%. With more than 1 repeat FNA, there was no improvement in performance characteristics. These data make a strong argument for 1 repeat FNA following an initial benign FNA diagnosis...
  47. ncbi request reprint Recurrent sarcoidosis in lung transplant allografts: granulomas are of recipient origin
    Diana N Ionescu
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Diagn Mol Pathol 14:140-5. 2005
    ..The origin of the histiocytes composing the noncaseating granulomas in the allograft lung in patients with recurrent sarcoidosis (RS) was analyzed using DNA identity testing in 4 cases...
  48. ncbi request reprint Potential diagnostic use of p16INK4A, a new marker that correlates with dysplasia in oral squamoproliferative lesions
    Olguta Gologan
    Department of Pathology, University of Pittsburgh Medical Center, Presbyterian Hospital, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 29:792-6. 2005
    ....
  49. ncbi request reprint Immunophenotypic comparison of salivary gland oncocytoma and metastatic renal cell carcinoma
    John A Ozolek
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Laryngoscope 115:1097-100. 2005
    ..This study compared immunohistochemical staining characteristics of oncocytomas arising from salivary gland to metastatic renal cell carcinoma using a panel of markers...
  50. doi request reprint Assessing physician competency: an update on the joint commission requirement for ongoing and focused professional practice evaluation
    Jennifer L Hunt
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Adv Anat Pathol 19:388-400. 2012
    ..It also provides scenarios to illustrate the concepts and charts that can be used to create OPPE and FPPE documents for a practice...
  51. ncbi request reprint Non-tumor-associated psammoma bodies in the thyroid
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Clin Pathol 119:90-4. 2003
    ..If no carcinoma is identified in a lobectomy, discussion with the surgeon should indicate the need for close clinical follow-up...
  52. ncbi request reprint Spindle cell carcinoma of the larynx with actinomyces chondritis of the larynx and trachea
    Sara B Silvestri
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Otolaryngol Head Neck Surg 134:345-7. 2006
  53. ncbi request reprint Sentinel lymph node evaluation for tumor metastasis
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Semin Diagn Pathol 19:263-77. 2002
    ..The history, technical details, and histopathologic work-up for sentinel lymph node biopsy are reviewed. Particular attention is paid to the intraoperative consultation and a protocol for optimal histopathologic management is presented...
  54. ncbi request reprint Analysis of allelic loss as an adjuvant tool in evaluation of malignancy in uterine smooth muscle tumors
    Nicole Nicosia Esposito
    Division of Anatomic Pathology, Magee Womens Hospital, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 30:97-103. 2006
    ..Molecular profiling may thus provide a valuable tool in assessment of malignancy in uterine smooth muscle tumors. Additionally, NM-23 is a promising candidate gene for determination of metastatic potential in these tumors...
  55. ncbi request reprint Loss of heterozygosity mutations of tumor suppressor genes in cytologically atypical areas in chronic lymphocytic thyroiditis
    Jennifer L Hunt
    University of Pittsburgh, Medical Center, Pittsburgh, PA 15213, USA
    Endocr Pathol 13:321-30. 2002
    ..These genetic mutations are evidence of clonal preneoplastic or neoplastic changes in the follicular cells of CLT. The clinical malignant potential of these minute foci is likely to be very small but remains to be determined...
  56. ncbi request reprint Analysis of loss of heterozygosity in single-system and multisystem Langerhans' cell histiocytosis
    Kudakwashe R Chikwava
    University of Pittsburgh School of Medicine and Department of Pathology, Presbyterian University Hospital, PA 15213, USA
    Pediatr Dev Pathol 10:18-24. 2007
    ..Further investigation of the potential use of LOH at 5q23 will be necessary to establish utility for this assay to predict disease progression and poor outcome...
  57. ncbi request reprint A novel microdissection and genotyping of follicular-derived thyroid tumors to predict aggressiveness
    Jennifer L Hunt
    University of Pittsburgh Medical Center, Pittsburgh, PA and University of Pennsylvania Medical Center, Philadelphia, PA 15213, USA
    Hum Pathol 34:375-80. 2003
    ....
  58. ncbi request reprint Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor
    Chiaki Takahashi
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 38:118-23. 2006
    ..These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression...
  59. ncbi request reprint Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes
    Melissa H Fowler
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Mod Pathol 19:350-5. 2006
    ..Furthermore, these data support prior studies that suggest a common clonal origin for the benign and malignant components of carcinomas ex pleomorphic adenoma...
  60. ncbi request reprint Encapsulated follicular variant of papillary thyroid carcinoma
    Jennifer L Hunt
    Am J Clin Pathol 118:602-3; author reply 605-6. 2002
  61. ncbi request reprint Warthin tumors do not have microsatellite instability and express normal DNA mismatch repair proteins
    Jennifer L Hunt
    Head and Neck and Endocrine Pathology, Molecular Anatomic Pathology, Presbyterian Hospital A610 2, Pittsburgh, PA 15213, USA
    Arch Pathol Lab Med 130:52-6. 2006
    ..A recent study described the absence of staining for hMLH1 and hMSH2 proteins in the epithelial component of Warthin tumors, suggesting that they arise secondary to defects in the DNA mismatch repair system...
  62. ncbi request reprint Myoepithelial neoplasia of the submandibular gland: case report and therapeutic considerations
    Jayakar V Nayak
    Department of Otolaryngology, University of Pittsburgh School of Medicine, PA, USA
    Arch Otolaryngol Head Neck Surg 129:359-62. 2003
    ..Increasing use of immunohistochemistry panels to assess parotid neoplasms also suggests that myoepithelioma may be underrecognized...
  63. ncbi request reprint Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:1683-94. 2007
    ..ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns. The high propensity for lymph node metastases suggests a role for neck dissection in patients with this rare tumor...
  64. ncbi request reprint Pathology quiz case 2. Parathyroid lipoadenoma
    Raja R Seethala
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 132:1391-3. 2006
  65. ncbi request reprint Pathology quiz case 2. Anaplastic thyroid carcinoma (ATC) arising in a preexisting tall cell variant of papillary thyroid cancer
    Genevieve Williamson
    University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Arch Otolaryngol Head Neck Surg 129:486, 488. 2003