B J Hoogwerf
Affiliation: Cleveland Clinic Foundation
- Blood glucose concentrations < or = 125 mg/dl and coronary heart disease riskByron J Hoogwerf
Preventive Cardiology and Rehabilitation Department, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 89:596-9. 2002
- Does intensive therapy of type 2 diabetes help or harm? Seeking accord on ACCORDByron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 75:729-37. 2008....
- Exenatide and pramlintide: new glucose-lowering agents for treating diabetes mellitusByron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 73:477-84. 2006..Glucagon-like peptide 1 (GLP-1), produced in the small intestine, and amylin, produced by beta cells in the pancreas, also have glucose-lowering effects. Synthetic analogues of these hormones are now available for clinical use...
- Postoperative management of the diabetic patientB J Hoogwerf
Department of Endocrinology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Med Clin North Am 85:1213-28. 2001....
- Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular riskByron J Hoogwerf
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, Cleveland, USA
Vasc Health Risk Manag 4:355-62. 2008..These data indicate that pramlintide has a role in glycemic control of both type 1 and type 2 DM. Pramlintide use is associated with favorable effects on weight, lipids and other biomarkers for atherosclerotic disease...
- The HOPE study. Ramipril lowered cardiovascular risk, but vitamin E did notB J Hoogwerf
Department of Endocrinology, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 67:287-93. 2000..On the other hand, vitamin E in the doses and duration studied (400 IU/day for 4.5 years) did not lower risk significantly...
- Perioperative management of diabetes mellitus: how should we act on the limited evidence?Byron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Cleve Clin J Med 73:S95-9. 2006..There is little role for oral antidiabetic medications in the early postoperative phase...
- Diabetes mellitus--overviewByron J Hoogwerf
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Foot Ankle Clin 11:703-15. 2006..Additional management strategies include laser therapy for retinopathy and appropriate footwear to reduce the risk of lower extremity amputations...
- Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft TrialB J Hoogwerf
Cleveland Clinic Foundation, OH 44195, USA
Diabetes 48:1289-94. 1999..The small number of diabetic patients provided limited power to detect significant differences between diabetic and nondiabetic patients or between diabetic patients in the aggressive versus moderate cholesterol treatment strategies...
- All-cause mortality risk predictors in a preventive cardiology clinic cohort-examining diabetes and individual metabolic syndrome criteria: a PRECIS database studyK B Doshi
Department of Endocrinology, Diabetes and Metabolism, The Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
Diabetes Obes Metab 11:102-8. 2009..We analysed which component(s) of NCEP MS criteria had greatest predictive value for mortality...
- Preoperative triglycerides predict post-coronary artery bypass graft survival in diabetic patients: a sex analysisD L Sprecher
Department of Preventive Cardiology and Rehabilitation, Cleveland Clinic Foundation, Ohio 44195, USA
Diabetes Care 23:1648-53. 2000..This study evaluates the predictive value of serum triglyceride levels on mortality in post-coronary artery bypass graft (CABG) diabetic patients with subsequent analysis by sex...
- Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trialFaramarz Ismail-Beigi
Department of Medicine, Division of Clinical and Molecular Endocrinology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4951, USA
Lancet 376:419-30. 2010..We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes...
- Relation of hemoglobin A1c to left ventricular relaxation in patients with type 1 diabetes mellitus and without overt heart diseaseMehdi H Shishehbor
Department of Internal Medicine, Cardiovascular Imaging Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Cardiol 91:1514-7, A9. 2003
- Clinical utility of waist circumference in predicting all-cause mortality in a preventive cardiology clinic population: a PreCIS Database StudyHarpreet S Bajaj
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, Ohio, USA
Obesity (Silver Spring) 17:1615-20. 2009....
- The relationship of glycaemic control and triglycerides in patients with diabetes mellitus: a PreCIS Database StudyM B Davidson
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH 44195, USA
Diabetes Obes Metab 11:118-22. 2009....
- Fluid retention after initiation of thiazolidinedione therapy in diabetic patients with established chronic heart failureW H Wilson Tang
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
J Am Coll Cardiol 41:1394-8. 2003..We sought to define the characteristics of fluid retention after thiazolidinedione (TZD) initiation in patients with established heart failure (HF)...
- Emerging cardiovascular risk factors that account for a significant portion of attributable mortality risk in chronic kidney diseaseMehdi H Shishehbor
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 101:1741-6. 2008..5 micromol/L (the top tertile) were associated with a sevenfold greater mortality risk. In conclusion, homocysteine and fibrinogen levels explain nearly 40% of the attributable mortality risk from CKD...
- High school body mass index and body mass index at entry to a cardiac disease risk prevention clinic and the association to all-cause mortality and coronary heart disease: a PreCIS database studyKatherine K Gambino
Preventive Cardiology and Rehabilitation and Nurse Manager, Women s Cardiovascular Center, Cleveland Clinic, Ohio, USA
J Cardiovasc Nurs 25:99-105. 2010....
- Cholesterol guidelines update: more aggressive therapy for higher-risk patientsJulie C Huang
Preventive Cardiology Section, Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 72:253-62. 2005..These more aggressive guidelines are based on results of five clinical studies published since 2001...
- Serum uric acid, mortality and glucose control in patients with Type 2 diabetes mellitus: a PreCIS database studyA G Ioachimescu
Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH 44195, USA
Diabet Med 24:1369-74. 2007..To determine the association of serum uric acid with all-cause mortality and hyperglycaemia in patients with Type 2 diabetes...
- Serum uric acid is an independent predictor of all-cause mortality in patients at high risk of cardiovascular disease: a preventive cardiology information system (PreCIS) database cohort studyAdriana G Ioachimescu
Cleveland Clinic, Cleveland, Ohio 44195, USA
Arthritis Rheum 58:623-30. 2008..The purpose of this study was to evaluate the prognostic value of serum uric acid levels in a large cohort of men and women at high risk of cardiovascular disease...
- A truly deadly quartet: obesity, hypertension, hypertriglyceridemia, and hyperinsulinemiaVijay Nambi
Department of Internal Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 69:985-9. 2002..Thiazolidinedione drugs increase insulin sensitivity, but their use in the metabolic syndrome is only speculative at present. We recommend they be used only as indicated to treat diabetes mellitus...
- Relation of diurnal blood pressure variation and triglyceride-to-high-density lipoprotein cholesterol ratio in patients without diabetes mellitusMichael B Davidson
Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 95:123-6. 2005..3, 95% confidence interval 2.6 to 16.4, p <0.0001) before the development of abnormal levels of fasting blood glucose...
- Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndromeAdrian W Messerli
Department of Preventive Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 92:610-2. 2003..These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction...
- Advances in the treatment of diabetes mellitus in the elderly. Development of insulin analoguesB J Hoogwerf
Department of Endocrinology, Cleveland Clinic Foundation, Ohio, USA
Drugs Aging 9:438-48. 1996....
- Autoantibodies to IA-2 and GAD65 in patients with type 2 diabetes mellitus of varied duration: prevalence and correlation with clinical featuresY Z Grasso
Department of Clinical Pathology, L30, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Endocr Pract 7:339-45. 2001..166; P = 0.48). CONCLUSION: Irrespective of duration of disease, measurement of IA-2Ab and GADAb can help to identify those patients with type 2 diabetes most likely to require insulin therapy...
- Association of dyslipidemia and effects of statins on nonmacrovascular diseasesSarkis B Baghdasarian
Cardiovascular Medicine Department, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Clin Ther 26:337-51. 2004..Statins have mechanisms of action that expand their effects beyond cholesterol lowering and atherosclerotic medical conditions...
- Reversible decerebrate posturing after profound and prolonged hypoglycemiaM M Kirk
Department of Pulmonary Disease, Cleveland Clinic Foundation, Ohio
Cleve Clin J Med 58:361-3. 1991..We present the case of a patient who recovered fully from prolonged decerebrate rigidity associated with hypoglycemic coma. This case emphasizes the possibility of recovery from severe, prolonged hypoglycemia...
- A summary of the findings from the Post-CABG trialB J Hoogwerf
Cleveland Clinic Foundation, University of Minnesota, Cleveland, USA
Minerva Cardioangiol 50:291-9. 2002..At the time of the extended follow-up the aggressive lipid strategy was associated with reduced clinical events; low dose warfarin was also associated with reduced clinical events...
- Pancreas transplantation in type 1 diabetes: hope vs realityJ T Mayes
Department of General Surgery, Cleveland Clinic, OH 44195, USA
Cleve Clin J Med 67:281-6. 2000..Increasing evidence suggests that it may slow the progression of long-term diabetic complications. On the other hand, patients risk the adverse effects of lifelong immunosuppression...
- Renin-angiotensin system blockade and cardiovascular and renal protectionByron J Hoogwerf
Department of Endocrinology, Diabetes, and Metabolism, Cleveland Clinic, Cleveland, Ohio, USA
Am J Cardiol 105:30A-5A. 2010..However, telmisartan showed better tolerability than ramipril in ONTARGET, with less cough and angioedema. This difference was obtained despite patients having been selected for tolerability to both drugs at study entry...
- Association of triglyceride-to-HDL cholesterol ratio with heart rate recoveryMehdi H Shishehbor
Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Diabetes Care 27:936-41. 2004..49, 95% CI 1.08-2.04; P = 0.015). CONCLUSIONS: HRR is associated with triglyceride-to-HDL cholesterol ratio and identifies patients with insulin resistance who are at increased risk of death...
- Elevated international normalized ratio in the ED: clinical course and physician adherence to the published recommendationsAshish Atreja
Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am J Emerg Med 23:40-4. 2005..There is a need for formal endorsement of recommendations by emergency medicine organizations and development of disposition criteria based on bleeding status and site of bleeding...
- Development of renal disease in people at high cardiovascular risk: results of the HOPE randomized studyJohannes F E Mann
Department of Cardiology and Population Health Research Institute, McMaster University, Hamilton, Canada
J Am Soc Nephrol 14:641-7. 2003..Microalbuminuria itself predicts clinical proteinuria in nondiabetic and in diabetic people. Ramipril prevents or delays the progression of albuminuria...
- Heart rate and blood pressure responses to mental stress and clinical cardiovascular events in men and women after coronary artery bypass grafting: the Post Coronary Artery Bypass Graft (Post-CABG) biobehavioral studyJ Alan Herd
Department of Medicine, Baylor College of Medicine, Houston, Tex, USA
Am Heart J 146:273-9. 2003..01; SBP, P =.07; DBP, P =.01). CONCLUSIONS: Vigorous HR and BP responses to MST may be markers for a lower risk of incidence of clinical cardiovascular events among patients who have undergone recent CABG surgery...
- Progression of renal insufficiency in type 2 diabetes with and without microalbuminuria: results of the Heart Outcomes and Prevention Evaluation (HOPE) randomized studyJohannes F E Mann
Department of Cardiology, McMaster University, Hamilton, Canada
Am J Kidney Dis 42:936-42. 2003..We studied changes in serum creatinine levels during 3.5 to 5.5 years in a large cohort of people with diabetes at high cardiovascular risk with microalbuminuria or normalbuminuria...
- The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trialBernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
Ann Intern Med 146:477-85. 2007..Exenatide therapy is effective in combination with metformin or sulfonylureas for treating type 2 diabetes. Thiazolidinediones (TZDs) also are commonly used, but the efficacy of exenatide with a TZD has not been reported...
- HgbA1c and glucose control: we cannot play it straight with patientsByron J Hoogwerf
J Lab Clin Med 147:5-6. 2006
- Effects of vitamin E on cardiovascular outcomes in people with mild-to-moderate renal insufficiency: results of the HOPE studyJohannes F E Mann
Department of Nephrology and Hypertension, Schwabing General Hospital, Munich, Germany
Kidney Int 65:1375-80. 2004..There are no data for renal insufficiency before the stage of terminal renal failure. We evaluated effects of vitamin E supplementation on cardiovascular and renal outcomes in 993 people with a serum creatinine > or =1.4 to 2.3 mg/dL...
- Nutrition recommendations and interventions for diabetes--2006: a position statement of the American Diabetes AssociationJohn P Bantle
Diabetes Care 29:2140-57. 2006
- Coronary artery bypass graft surgery and cognitive performanceGilles Dupuis
Department of Psychosomatic Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
Am J Crit Care 15:471-8; quiz 479. 2006..Some studies have indicated a decline in patients' cognitive performance after coronary artery bypass graft surgery...
- Quality of life after coronary artery bypass graft: results from the POST CABG TrialNorma Lynn Fox
Maryland Medical Research Institute, Baltimore, MD, USA
Chest 126:487-95. 2004..Low-dose anticoagulation therapy did not reduce the progression of atherosclerosis. We conducted this analysis to determine the effects of both lipid-lowering and low-dose anticoagulation therapy on health-related quality of life (HRQL)...
- A DASH-like diet can decrease cardiovascular risk, but barriers to implementation existByron J Hoogwerf
Cleve Clin J Med 71:755-6. 2004
- Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes AssociationJohn P Bantle
Diabetes Care 31:S61-78. 2008