Donna E Hansel

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi Challenges in the pathology of non-muscle-invasive bladder cancer: a dialogue between the urologic surgeon and the pathologist
    Donna E Hansel
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Urology 81:1123-30. 2013
  2. doi A contemporary update on pathology standards for bladder cancer: transurethral resection and radical cystectomy specimens
    Donna E Hansel
    Department of Pathology, Cleveland Clinic, Cleveland, OH, USA
    Eur Urol 63:321-32. 2013
  3. pmc Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability
    Yumay Chen
    Department of Medicine, Division of Endocrinology, University of California at Irvine, 1130 Gross Hall, Irvine, CA 92697, USA
    Mol Cancer 10:5. 2011
  4. pmc Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladder
    Zhongfa Zhang
    Van Andel Research Institute, Grand Rapids, MI 49503, USA
    BMC Med Genomics 3:58. 2010
  5. ncbi Renal carcinoid tumor: a clinicopathologic study of 21 cases
    Donna E Hansel
    Department of Pathology and Laboratory Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Surg Pathol 31:1539-44. 2007
  6. pmc Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
    Donna E Hansel
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Pathol 176:3062-72. 2010
  7. doi Limited smoothelin expression within the muscularis mucosae: validation in bladder diverticula
    Donna E Hansel
    Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Taussig Cancer Institute, and Genomic Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hum Pathol 42:1770-6. 2011
  8. doi Molecular genetics of hereditary renal cancer: new genes and diagnostic and therapeutic opportunities
    Donna E Hansel
    Department of Anatomic Pathology, Glickman Urological and Kidney Institute and Taussig Cancer Institute, The Cleveland Clinic, 9500 Euclid Avenue, Desk L25, Cleveland, OH 44195, USA
    Expert Rev Anticancer Ther 8:895-905. 2008
  9. ncbi Chronic kidney disease after nephroureterectomy for upper tract urothelial carcinoma and implications for the administration of perioperative chemotherapy
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
    Cancer 116:2967-73. 2010
  10. doi Inadequacy of biopsy for diagnosis of upper tract urothelial carcinoma: implications for conservative management
    Armine K Smith
    Glickman Urological and Kidney Institute, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Urology 78:82-6. 2011

Detail Information

Publications62

  1. doi Challenges in the pathology of non-muscle-invasive bladder cancer: a dialogue between the urologic surgeon and the pathologist
    Donna E Hansel
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Urology 81:1123-30. 2013
    ..Reasonable and objective recommendations are provided with the goal of improving urologist-pathologist communication, the efficiency of healthcare utilization, and outcomes for patients with NMIBC...
  2. doi A contemporary update on pathology standards for bladder cancer: transurethral resection and radical cystectomy specimens
    Donna E Hansel
    Department of Pathology, Cleveland Clinic, Cleveland, OH, USA
    Eur Urol 63:321-32. 2013
    ..Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes...
  3. pmc Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability
    Yumay Chen
    Department of Medicine, Division of Endocrinology, University of California at Irvine, 1130 Gross Hall, Irvine, CA 92697, USA
    Mol Cancer 10:5. 2011
    ..NEK1-deficient cells also fail to activate the checkpoint kinases CHK1 and CHK2, and fail to arrest properly at G1/S or G2/M-phase checkpoints after DNA damage...
  4. pmc Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladder
    Zhongfa Zhang
    Van Andel Research Institute, Grand Rapids, MI 49503, USA
    BMC Med Genomics 3:58. 2010
    ..Because differences may facilitate different screening and treatment modalities, we sought to examine the relationship between urothelial carcinoma of the renal pelvis (rUC) and urothelial carcinoma of the bladder (bUC)...
  5. ncbi Renal carcinoid tumor: a clinicopathologic study of 21 cases
    Donna E Hansel
    Department of Pathology and Laboratory Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Surg Pathol 31:1539-44. 2007
    ..Of the remaining patients, 7 patients were alive without disease and 6 patients were alive with disease. Additional metastases developed in 4 patients and included metastases to the liver and bone...
  6. pmc Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma
    Donna E Hansel
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Pathol 176:3062-72. 2010
    ..01) compared with vehicle-injected mice. These findings indicate that mTOR pathway activation frequently occurs in UCC and that mTOR inhibition may be a potential means to reduce UCC growth...
  7. doi Limited smoothelin expression within the muscularis mucosae: validation in bladder diverticula
    Donna E Hansel
    Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Taussig Cancer Institute, and Genomic Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hum Pathol 42:1770-6. 2011
    ..A strong and robust staining of smooth, rounded muscle with smoothelin remains a useful diagnostic adjunct in the reliable recognition of muscularis propria...
  8. doi Molecular genetics of hereditary renal cancer: new genes and diagnostic and therapeutic opportunities
    Donna E Hansel
    Department of Anatomic Pathology, Glickman Urological and Kidney Institute and Taussig Cancer Institute, The Cleveland Clinic, 9500 Euclid Avenue, Desk L25, Cleveland, OH 44195, USA
    Expert Rev Anticancer Ther 8:895-905. 2008
    ....
  9. ncbi Chronic kidney disease after nephroureterectomy for upper tract urothelial carcinoma and implications for the administration of perioperative chemotherapy
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
    Cancer 116:2967-73. 2010
    ..Although multimodal treatment paradigms for UTUC are under-developed, this has important implications on patients' ability to receive cisplatin-based combination chemotherapy (CBCC)...
  10. doi Inadequacy of biopsy for diagnosis of upper tract urothelial carcinoma: implications for conservative management
    Armine K Smith
    Glickman Urological and Kidney Institute, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Urology 78:82-6. 2011
    ..However, concerns about potential understaging, inaccurate grading, incomplete resection, lack of effective tertiary chemoprevention, and need for ureteroscopic surveillance limits it appeal...
  11. ncbi Influence of histologic criteria and confounding factors in staging equivocal cases for microscopic perivesical tissue invasion (pT3a): an interobserver study among genitourinary pathologists
    Vijayalakshmi Ananthanarayanan
    Department of Pathology, University of Chicago, Chicago, IL Department of Biostatistics and Bioinformatics, Rollins School of Public Health Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN Department of Pathology, Johns Hopkins Hospital, Baltimore, MD Department of Pathology, University of California, San Diego, CA Division of Anatomic Pathology, Mayo Clinic, Rochester, MN Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH Department of Pathology, Massachusetts General Hospital, Boston, MA Department of Pathology, MD Anderson Cancer Center Department of Pathology, Methodist Hospital, Houston, TX Department of Pathology, Memorial Sloan Kettering Cancer Center, New York Department of Pathology, University of Rochester Medical Center, Rochester, NY Section of Pathological Anatomy, Polytechnic University of the Marche Region, Ancona, Italy Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada Department of Pathology, Nagoya Daini Red Cross Hospital, Nagoya
    Am J Surg Pathol 38:167-75. 2014
    ..This study highlights the need to adopt common criteria in defining the outer MP boundary. Future studies may identify the most clinically relevant histoanatomic criteria for MPVTI. ..
  12. ncbi CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Am J Surg Pathol 29:390-9. 2005
    ..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target...
  13. doi Neoadjuvant systemic therapy or early cystectomy? Single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladder
    Islam A Ghoneim
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Urology 77:867-70. 2011
    ..Radical cystectomy is considered the standard approach for treatment of patients with localized disease; however, the role of perioperative systemic therapy has been poorly defined...
  14. doi ICUD-EAU International Consultation on Bladder Cancer 2012: Pathology
    Mahul B Amin
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Eur Urol 63:16-35. 2013
    ..To present a summary of the 2nd International Consultation on Bladder Cancer recommendations on the pathology of bladder cancer using an evidence-based strategy...
  15. doi Presacral and retroperitoneal lymph node involvement in urothelial bladder cancer: results of a prospective mapping study
    Ranko Miocinovic
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195 0001, USA
    J Urol 186:1269-73. 2011
    ..We evaluated the incidence of positive lymph nodes in the presacral and retroperitoneal regions in patients who underwent radical cystectomy and extended pelvic lymph node dissection for urothelial bladder cancer...
  16. ncbi MAGE1 is expressed by a subset of pancreatic endocrine neoplasms and associated lymph node and liver metastases
    Donna E Hansel
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Gastrointest Cancer 33:141-7. 2003
    ..Expression of MAGE1 has subsequently been identified in a number of neoplastic cell types, including testicular germ cell and breast cancer cells, which has led to the development of antitumor MAGE1 vaccines...
  17. doi Lack of pathologic down-staging with neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma of the bladder: a contemporary series
    Christopher J Weight
    Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195 0001, USA
    Cancer 115:792-9. 2009
    ..The outcome of NC and open radical cystectomy (RC) was evaluated in a contemporary cohort of patients in a tertiary referral setting...
  18. ncbi Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasms
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Clin Cancer Res 10:6152-8. 2004
    ....
  19. pmc Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate
    Donna E Hansel
    Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Cleveland, Ohio, USA
    Prostate 69:603-9. 2009
    ..To address this, we performed transcriptome profiling and TP53 sequencing of concurrent small cell and prostatic adenocarcinoma to determine the relationship between these entities...
  20. ncbi A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening andtreatment
    Donna E Hansel
    Department of Pathology, Johns Hopkins Medical Institution, Baltimore, MD, USA
    Am J Clin Pathol 123:28-35. 2005
    ....
  21. doi Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder
    Anil A Thomas
    Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Hum Pathol 40:108-16. 2009
    ....
  22. doi Aggregate lymph node metastasis diameter and survival after radical cystectomy for invasive bladder cancer
    Andrew J Stephenson
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 75:382-6. 2010
    ..The aggregate LN metastasis diameter (ALNMD) may better reflect the burden of metastatic disease and improve the ability to predict recurrence-free (RFS) and overall survival (OS)...
  23. ncbi Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimens
    Gladell P Paner
    Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, IL, USA
    Am J Surg Pathol 34:792-9. 2010
    ....
  24. doi Folate hydrolase (prostate-specific membrane [corrected] antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature
    Mary K Samplaski
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 24:1521-9. 2011
    ..The finding of FH(PSA)1 in the bladder cancer neovasculature suggests that this molecule may promote tumor growth and may represent a potential new vascular target in this disease...
  25. doi HER2 gene amplification occurs frequently in the micropapillary variant of urothelial carcinoma: analysis by dual-color in situ hybridization
    Christina B Ching
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mod Pathol 24:1111-9. 2011
    ..These results suggest that HER2-targeted therapy may be successful on the genomic level in patients with this disease...
  26. ncbi Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladder
    Zhaoli Lane
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:1322-6. 2008
    ....
  27. ncbi HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tract
    Donna E Hansel
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Int J Gastrointest Cancer 35:15-23. 2005
    ..We propose that HLA-G expression is upregulated in a large percentage of gastrointestinal lesions and may serve to mediate immune-responsiveness in certain instances...
  28. doi Utility of a triple antibody cocktail intraurothelial neoplasm-3 (IUN-3-CK20/CD44s/p53) and α-methylacyl-CoA racemase (AMACR) in the distinction of urothelial carcinoma in situ (CIS) and reactive urothelial atypia
    Manju Aron
    Cedars Sinai Medical Center, Los Angeles, CA Cleveland Clinic, Cleveland, OH
    Am J Surg Pathol 37:1815-23. 2013
    ..The simultaneous evaluation of all 3 markers (p53, CD44s, and CK20) in a single slide in the form of a cocktail is advantageous, especially in small biopsy specimens. ..
  29. ncbi Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tract
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Surg Pathol 28:347-56. 2004
    ..This up-regulation appears to parallel invasive behavior and may therefore be used as a potential marker for cancer aggressiveness in this system...
  30. doi The sensitivity of initial transurethral resection or biopsy of bladder tumor(s) for detecting bladder cancer variants on radical cystectomy
    Ahmed Abd El-Latif
    Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA
    J Urol 189:1263-7. 2013
    ..We determined the ability of bladder biopsy and transurethral resection of the bladder to accurately predict bladder cancer variants on radical cystectomy since certain variants may affect prognosis and treatment...
  31. doi Histopathologic features and clinical outcomes in 71 cases of bladder diverticula
    Ecaterina F Tamas
    Department of Pathology, Quest Diagnostics, Teterboro, NJ, USA
    Arch Pathol Lab Med 133:791-6. 2009
    ..Bladder diverticula often come to clinical attention when complications or malignancy occur, although limited information is available regarding histopathologic features and clinical outcomes...
  32. doi Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists
    Ankur R Sangoi
    Department of Pathology, Stanford University, Stanford, CA, USA
    Am J Surg Pathol 34:1367-76. 2010
    ..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy...
  33. ncbi Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays
    Anirban Maitra
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Clin Cancer Res 9:5988-95. 2003
    ..Global expression microarrays can document abnormal pathways that impact on tumorigenesis and disease progression...
  34. ncbi Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship
    Ruta Gupta
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 36:1265-78. 2012
    ..The extremely poor prognosis and ongoing clinical trials with specific therapeutic protocols argue for their accurate distinction from other renal cell carcinoma subtypes...
  35. pmc The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo
    Ning Zhou
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Cancer Res 19:1717-28. 2013
    ..We evaluated Aurora kinase A, identified as an upregulated candidate molecule in bladder cancer, as a potential therapeutic target...
  36. doi Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinoma
    Katherine E Watts
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 80:361-6. 2012
    ..To investigate the clinicopathologic and immunohistochemical features associated with invasive low-grade papillary urothelial carcinoma (LGPUC), an uncommon entity not previously described in published studies...
  37. doi HER2 overexpression and amplification in urothelial carcinoma of the bladder is associated with MYC coamplification in a subset of cases
    Donna E Hansel
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Clin Pathol 130:274-81. 2008
    ..Further studies into the role of MYC coamplification in this population are needed to determine impacts on treatment with HER2-targeted therapy...
  38. ncbi Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation
    Donna E Hansel
    Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Cancer Res 63:7032-7. 2003
    ..We propose that APP may function to promote growth in pancreatic cancer cells via signaling through sAPP and may therefore represent a novel therapeutic target in pancreatic cancer...
  39. ncbi Gene profiling suggests a common evolution of bladder cancer subtypes
    Donna E Hansel
    Department of Pathology, University of California at San Diego, 9500 Gilman Drive, MC 0612, La Jolla, CA 92093, USA
    BMC Med Genomics 6:42. 2013
    ..The relationship between these subtypes has not been explored in detail...
  40. ncbi The role of HLA-G in gastrointestinal inflammatory disease and malignancy
    Erinn Downs-Kelly
    Department of Pathology and Laboratory Medicine, The Cleveland Clinic, L25, 9500 Euclid Ave, Cleveland, OH 44195, United States
    Semin Cancer Biol 17:451-8. 2007
    ..Although there are only a limited number of studies that have examined HLA-G in the gastrointestinal tract, the role of HLA-G has been controversial in this organ system with conflicting results reported even within the same tumor type...
  41. doi Non-epithelial neoplasms of the prostate
    Gladell P Paner
    Department of Pathology, University of Chicago, Chicago, IL, USA
    Histopathology 60:166-86. 2012
    ..This review addresses and updates the clinicopathological features of the entire spectrum of non-epithelial tumours with an approach to the histological diagnosis...
  42. doi Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 cases
    Adeboye O Osunkoya
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 32:461-7. 2008
    ..Pathologists need to be aware of this rare and unusual phenomenon, which is a potential pitfall in prostate cancer diagnosis...
  43. ncbi Spindle cell lesions of the adult prostate
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Mod Pathol 20:148-58. 2007
    ..This review addresses the various entities that may present as spindle cell tumors within the adult prostate and discusses the functional aspects of the differential diagnosis of these lesions...
  44. doi Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung
    Aaron M Gruver
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Desk L25, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 136:1339-46. 2012
    ....
  45. ncbi Telomere length variation in biliary tract metaplasia, dysplasia, and carcinoma
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Mod Pathol 19:772-9. 2006
    ..We conclude that telomere shortening is a consistent and early finding in the development of biliary tract carcinoma...
  46. doi Transabdominal micro-ultrasound imaging of bladder cancer in a mouse model: a validation study
    Amit R Patel
    Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio 44113, USA
    Urology 75:799-804. 2010
    ..The current in vivo imaging systems for murine bladder cancer include magnetic resonance imaging, bioluminescent and fluorescent imaging, and intravesical ultrasound...
  47. pmc Vulnerability of continence structures to injury by simulated childbirth
    Hardeep S Phull
    Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic, OH 44195, USA
    Am J Physiol Renal Physiol 301:F641-9. 2011
    ..Increasing duration of VD caused progressively greater tissue edema, muscle damage, and morphological changes in the urethra and vagina. The EUS underwent the greatest insult, demonstrating its vulnerability to childbirth injury...
  48. doi Diagnostically challenging cases: what are atypia and dysplasia?
    Joseph Sanfrancesco
    Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Urol Clin North Am 40:281-93. 2013
    ..In addition, the effects of inflammation, specific therapies, and instrumentation on the bladder mucosa as well as the associated difficulty in achieving the appropriate diagnosis are also discussed...
  49. doi Primary lymphoepithelioma-like carcinoma of the ureter
    Daniela S Allende
    Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Ann Diagn Pathol 14:209-14. 2010
    ..Only 6 previous cases of LELC involving the ureter have been reported in the literature. We document an additional example of this uncommon entity and present a comprehensive review of LELC involving the ureter...
  50. ncbi Utility of diagnostic and prognostic markers in urothelial carcinoma of the bladder
    Joshua F Coleman
    Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Taussig Cancer Institute and Genomic Medicine Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Adv Anat Pathol 16:67-78. 2009
    ..This review focuses on some of the more commonly encountered biomarkers in UCC and their role in addressing key diagnostic and prognostic issues in this disease process...
  51. ncbi Uroplakin II outperforms uroplakin III in diagnostically challenging settings
    Steven C Smith
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Histopathology 65:132-8. 2014
    ..We performed a head-to-head comparison of an antibody against uroplakin III (UP3) and a new uroplakin II (UP2) antibody that remains untested in diagnostically challenging settings...
  52. doi Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma
    Armine Karapetian Smith
    Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Urology 71:915-8. 2008
    ..The relationship between these entities and the subsequent development of bladder carcinoma remains unclear...
  53. ncbi Sarcomatoid carcinoma of the prostate: a study of 42 cases
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
    Am J Surg Pathol 30:1316-21. 2006
    ..Sarcomatoid carcinoma is an aggressive form of prostate cancer, the prognosis of which is dismal regardless of other histologic or clinical findings...
  54. ncbi Von Hippel Lindau syndrome
    Jenny J Kim
    Cleveland Clinic, Taussig Cancer Institute, Celveland, Ohio 44195, USA
    Adv Exp Med Biol 685:228-49. 2010
    ..Further details regardingvariegated molecular pathways and mechanisms ofVHLS are emerging with the subsequent advent of novel treatment protocols that are currently in clinical trials...
  55. doi Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterations
    Anil A Thomas
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 180:2463-7. 2008
    ..Urethral diverticula are uncommon and occur predominantly in women. We examined a large series of female urethral diverticula to determine associated neoplastic alterations and subsequent clinical outcomes...
  56. doi Epidermoid cyst of the testicle
    Armine Karapetian Smith
    Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH 44195, USA
    Urology 74:544. 2009
    ..We report on a case of testicular mass with classic radiographic appearance for epidermoid cyst...
  57. ncbi Loss of p27 nuclear expression in a prognostically favorable subset of well-differentiated pancreatic endocrine neoplasms
    Ayman Rahman
    Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 632, Baltimore, MD 21205, USA
    Am J Clin Pathol 120:685-90. 2003
    ..Expression of p27 protein therefore appears to be lost in a subset of well-differentiated PENs with indolent features but paradoxically retained in PENs associated with metastatic disease...
  58. doi Emerging concepts in micropapillary urothelial carcinoma
    Katherine E Watts
    Department of Anatomic Pathology, Cleveland Clinic, OH 44195, USA
    Adv Anat Pathol 17:182-6. 2010
    ..This review discusses the histologic features required for diagnosis and the clinical significance of rendering a diagnosis of micropapillary urothelial carcinoma...
  59. ncbi Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expression
    Donna E Hansel
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mod Pathol 16:652-9. 2003
    ..We postulate that the upregulation of VEGF-C may be involved in PEN progression and metastases, although not via a direct proangiogenic mechanism...
  60. ncbi Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater
    Donna E Hansel
    MBBS, Department of Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 771, Baltimore, MD 21205, USA
    J Clin Oncol 23:1811-8. 2005
    ..We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome...
  61. ncbi Molecular pathogenesis of pancreatic cancer
    Donna E Hansel
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
    Annu Rev Genomics Hum Genet 4:237-56. 2003
    ..Ultimately, understanding the genetic events underlying the development of pancreatic cancer may serve as a useful adjunct in the screening and treatment of patients suffering from, or at risk for, pancreatic cancer...
  62. ncbi Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancer
    Michael G House
    Department of Surgery, the Indiana University School of Medicine, Indianapolis, USA
    J Gastrointest Surg 10:138-45. 2006
    ..Patterns of liver metastases from islet cell tumors, specifically multiple bilobar metastases that are not amenable to resection and/or ablation, predict a poor outcome despite resection of the primary pancreatic tumor...