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Genomes and Genes | Donna E HanselSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
A contemporary update on pathology standards for bladder cancer: transurethral resection and radical cystectomy specimensDonna E Hansel
Department of Pathology, Cleveland Clinic, Cleveland, OH, USA
Eur Urol 63:321-32. 2013..Pathology standards for the diagnosis of bladder cancer (BCa) have recently evolved to better reflect patient diagnosis and clinical outcomes...
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instabilityYumay Chen
Department of Medicine, Division of Endocrinology, University of California at Irvine, 1130 Gross Hall, Irvine, CA 92697, USA
Mol Cancer 10:5. 2011..NEK1-deficient cells also fail to activate the checkpoint kinases CHK1 and CHK2, and fail to arrest properly at G1/S or G2/M-phase checkpoints after DNA damage...- Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladderZhongfa Zhang
Van Andel Research Institute, Grand Rapids, MI 49503, USA
BMC Med Genomics 3:58. 2010..Because differences may facilitate different screening and treatment modalities, we sought to examine the relationship between urothelial carcinoma of the renal pelvis (rUC) and urothelial carcinoma of the bladder (bUC)... - Molecular genetics of hereditary renal cancer: new genes and diagnostic and therapeutic opportunitiesDonna E Hansel
Department of Anatomic Pathology, Glickman Urological and Kidney Institute and Taussig Cancer Institute, The Cleveland Clinic, 9500 Euclid Avenue, Desk L25, Cleveland, OH 44195, USA
Expert Rev Anticancer Ther 8:895-905. 2008.... 
Renal carcinoid tumor: a clinicopathologic study of 21 casesDonna E Hansel
Department of Pathology and Laboratory Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Surg Pathol 31:1539-44. 2007..Of the remaining patients, 7 patients were alive without disease and 6 patients were alive with disease. Additional metastases developed in 4 patients and included metastases to the liver and bone...- Limited smoothelin expression within the muscularis mucosae: validation in bladder diverticulaDonna E Hansel
Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Taussig Cancer Institute, and Genomic Medicine Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Hum Pathol 42:1770-6. 2011..A strong and robust staining of smooth, rounded muscle with smoothelin remains a useful diagnostic adjunct in the reliable recognition of muscularis propria... - Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinomaDonna E Hansel
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA
Am J Pathol 176:3062-72. 2010..01) compared with vehicle-injected mice. These findings indicate that mTOR pathway activation frequently occurs in UCC and that mTOR inhibition may be a potential means to reduce UCC growth... - Chronic kidney disease after nephroureterectomy for upper tract urothelial carcinoma and implications for the administration of perioperative chemotherapyBrian R Lane
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
Cancer 116:2967-73. 2010..Although multimodal treatment paradigms for UTUC are under-developed, this has important implications on patients' ability to receive cisplatin-based combination chemotherapy (CBCC)... - CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug targetDonna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Am J Surg Pathol 29:390-9. 2005..These findings suggest a role for CDC2/CDK1 in esophageal adenocarcinogenesis, both as a potential histopathologic marker of dysplasia and a putative treatment target... - Inadequacy of biopsy for diagnosis of upper tract urothelial carcinoma: implications for conservative managementArmine K Smith
Glickman Urological and Kidney Institute, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
Urology 78:82-6. 2011..However, concerns about potential understaging, inaccurate grading, incomplete resection, lack of effective tertiary chemoprevention, and need for ureteroscopic surveillance limits it appeal... - Neoadjuvant systemic therapy or early cystectomy? Single-center analysis of outcomes after therapy for patients with clinically localized micropapillary urothelial carcinoma of the bladderIslam A Ghoneim
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA
Urology 77:867-70. 2011..Radical cystectomy is considered the standard approach for treatment of patients with localized disease; however, the role of perioperative systemic therapy has been poorly defined... - MAGE1 is expressed by a subset of pancreatic endocrine neoplasms and associated lymph node and liver metastasesDonna E Hansel
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Int J Gastrointest Cancer 33:141-7. 2003..Expression of MAGE1 has subsequently been identified in a number of neoplastic cell types, including testicular germ cell and breast cancer cells, which has led to the development of antitumor MAGE1 vaccines... - Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostateDonna E Hansel
Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Cleveland, Ohio, USA
Prostate 69:603-9. 2009..To address this, we performed transcriptome profiling and TP53 sequencing of concurrent small cell and prostatic adenocarcinoma to determine the relationship between these entities... - A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening andtreatmentDonna E Hansel
Department of Pathology, Johns Hopkins Medical Institution, Baltimore, MD, USA
Am J Clin Pathol 123:28-35. 2005.... - Met proto-oncogene and insulin-like growth factor binding protein 3 overexpression correlates with metastatic ability in well-differentiated pancreatic endocrine neoplasmsDonna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Clin Cancer Res 10:6152-8. 2004.... - Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladderAnil A Thomas
Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
Hum Pathol 40:108-16. 2009.... - Presacral and retroperitoneal lymph node involvement in urothelial bladder cancer: results of a prospective mapping studyRanko Miocinovic
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195 0001, USA
J Urol 186:1269-73. 2011..We evaluated the incidence of positive lymph nodes in the presacral and retroperitoneal regions in patients who underwent radical cystectomy and extended pelvic lymph node dissection for urothelial bladder cancer... - Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimensGladell P Paner
Department of Pathology and Laboratory Medicine, Loyola University Medical Center, Maywood, IL, USA
Am J Surg Pathol 34:792-9. 2010.... - Aggregate lymph node metastasis diameter and survival after radical cystectomy for invasive bladder cancerAndrew J Stephenson
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Urology 75:382-6. 2010..The aggregate LN metastasis diameter (ALNMD) may better reflect the burden of metastatic disease and improve the ability to predict recurrence-free (RFS) and overall survival (OS)... - HLA-G upregulation in pre-malignant and malignant lesions of the gastrointestinal tractDonna E Hansel
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Int J Gastrointest Cancer 35:15-23. 2005..We propose that HLA-G expression is upregulated in a large percentage of gastrointestinal lesions and may serve to mediate immune-responsiveness in certain instances... - HER2 gene amplification occurs frequently in the micropapillary variant of urothelial carcinoma: analysis by dual-color in situ hybridizationChristina B Ching
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Mod Pathol 24:1111-9. 2011..These results suggest that HER2-targeted therapy may be successful on the genomic level in patients with this disease... - Immunohistochemical expression of prostatic antigens in adenocarcinoma and villous adenoma of the urinary bladderZhaoli Lane
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:1322-6. 2008.... - Folate hydrolase (prostate-specific membrane [corrected] antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculatureMary K Samplaski
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
Mod Pathol 24:1521-9. 2011..The finding of FH(PSA)1 in the bladder cancer neovasculature suggests that this molecule may promote tumor growth and may represent a potential new vascular target in this disease... - Lack of pathologic down-staging with neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma of the bladder: a contemporary seriesChristopher J Weight
Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195 0001, USA
Cancer 115:792-9. 2009..The outcome of NC and open radical cystectomy (RC) was evaluated in a contemporary cohort of patients in a tertiary referral setting... - Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarraysAnirban Maitra
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Clin Cancer Res 9:5988-95. 2003..Global expression microarrays can document abnormal pathways that impact on tumorigenesis and disease progression... - Histopathologic features and clinical outcomes in 71 cases of bladder diverticulaEcaterina F Tamas
Department of Pathology, Quest Diagnostics, Teterboro, NJ, USA
Arch Pathol Lab Med 133:791-6. 2009..Bladder diverticula often come to clinical attention when complications or malignancy occur, although limited information is available regarding histopathologic features and clinical outcomes... - Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologistsAnkur R Sangoi
Department of Pathology, Stanford University, Stanford, CA, USA
Am J Surg Pathol 34:1367-76. 2010..These findings suggest that more study of IMPC is needed to identify the individual pathologic features that might potentially correlate with an aggressive outcome and response to intravesical therapy... - Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationshipRuta Gupta
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 36:1265-78. 2012..The extremely poor prognosis and ongoing clinical trials with specific therapeutic protocols argue for their accurate distinction from other renal cell carcinoma subtypes... - HER2 overexpression and amplification in urothelial carcinoma of the bladder is associated with MYC coamplification in a subset of casesDonna E Hansel
Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Am J Clin Pathol 130:274-81. 2008..Further studies into the role of MYC coamplification in this population are needed to determine impacts on treatment with HER2-targeted therapy... - Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferationDonna E Hansel
Department of Pathology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Cancer Res 63:7032-7. 2003..We propose that APP may function to promote growth in pancreatic cancer cells via signaling through sAPP and may therefore represent a novel therapeutic target in pancreatic cancer... - Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinomaKatherine E Watts
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
Urology 80:361-6. 2012..To investigate the clinicopathologic and immunohistochemical features associated with invasive low-grade papillary urothelial carcinoma (LGPUC), an uncommon entity not previously described in published studies... - Expression of neuropilin-1 in high-grade dysplasia, invasive cancer, and metastases of the human gastrointestinal tractDonna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Am J Surg Pathol 28:347-56. 2004..This up-regulation appears to parallel invasive behavior and may therefore be used as a potential marker for cancer aggressiveness in this system... - Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lungAaron M Gruver
Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Ave, Desk L25, Cleveland, OH 44195, USA
Arch Pathol Lab Med 136:1339-46. 2012.... - Non-epithelial neoplasms of the prostateGladell P Paner
Department of Pathology, University of Chicago, Chicago, IL, USA
Histopathology 60:166-86. 2012..This review addresses and updates the clinicopathological features of the entire spectrum of non-epithelial tumours with an approach to the histological diagnosis... - Telomere length variation in biliary tract metaplasia, dysplasia, and carcinomaDonna E Hansel
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Mod Pathol 19:772-9. 2006..We conclude that telomere shortening is a consistent and early finding in the development of biliary tract carcinoma... - Spindle cell lesions of the adult prostateDonna E Hansel
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Mod Pathol 20:148-58. 2007..This review addresses the various entities that may present as spindle cell tumors within the adult prostate and discusses the functional aspects of the differential diagnosis of these lesions... - Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 casesAdeboye O Osunkoya
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 32:461-7. 2008..Pathologists need to be aware of this rare and unusual phenomenon, which is a potential pitfall in prostate cancer diagnosis... - ICUD-EAU International Consultation on Bladder Cancer 2012: pathologyMahul B Amin
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Eur Urol 63:16-35. 2013..To present a summary of the 2nd International Consultation on Bladder Cancer recommendations on the pathology of bladder cancer using an evidence-based strategy... - Transabdominal micro-ultrasound imaging of bladder cancer in a mouse model: a validation studyAmit R Patel
Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio 44113, USA
Urology 75:799-804. 2010..The current in vivo imaging systems for murine bladder cancer include magnetic resonance imaging, bioluminescent and fluorescent imaging, and intravesical ultrasound... - Vulnerability of continence structures to injury by simulated childbirthHardeep S Phull
Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic, OH 44195, USA
Am J Physiol Renal Physiol 301:F641-9. 2011..Increasing duration of VD caused progressively greater tissue edema, muscle damage, and morphological changes in the urethra and vagina. The EUS underwent the greatest insult, demonstrating its vulnerability to childbirth injury... - The Sensitivity of Initial Transurethral Resection or Biopsy of Bladder Tumor(s) for Detecting Bladder Cancer Variants on Radical CystectomyAhmed Abd El-Latif
Glickman Urological and Kidney Institute, Cleveland, Ohio
J Urol 189:1263-7. 2013..We determined the ability of bladder biopsy and transurethral resection of the bladder to accurately predict bladder cancer variants on radical cystectomy since certain variants may affect prognosis and treatment... - Primary lymphoepithelioma-like carcinoma of the ureterDaniela S Allende
Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA
Ann Diagn Pathol 14:209-14. 2010..Only 6 previous cases of LELC involving the ureter have been reported in the literature. We document an additional example of this uncommon entity and present a comprehensive review of LELC involving the ureter... - The role of HLA-G in gastrointestinal inflammatory disease and malignancyErinn Downs-Kelly
Department of Pathology and Laboratory Medicine, The Cleveland Clinic, L25, 9500 Euclid Ave, Cleveland, OH 44195, United States
Semin Cancer Biol 17:451-8. 2007..Although there are only a limited number of studies that have examined HLA-G in the gastrointestinal tract, the role of HLA-G has been controversial in this organ system with conflicting results reported even within the same tumor type... - Utility of diagnostic and prognostic markers in urothelial carcinoma of the bladderJoshua F Coleman
Department of Anatomic Pathology, Glickman Urological and Kidney Institute, Taussig Cancer Institute and Genomic Medicine Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Adv Anat Pathol 16:67-78. 2009..This review focuses on some of the more commonly encountered biomarkers in UCC and their role in addressing key diagnostic and prognostic issues in this disease process... - Sarcomatoid carcinoma of the prostate: a study of 42 casesDonna E Hansel
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA
Am J Surg Pathol 30:1316-21. 2006..Sarcomatoid carcinoma is an aggressive form of prostate cancer, the prognosis of which is dismal regardless of other histologic or clinical findings... - Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinomaArmine Karapetian Smith
Glickman Urological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
Urology 71:915-8. 2008..The relationship between these entities and the subsequent development of bladder carcinoma remains unclear... - Von Hippel Lindau syndromeJenny J Kim
Cleveland Clinic, Taussig Cancer Institute, Celveland, Ohio 44195, USA
Adv Exp Med Biol 685:228-49. 2010..Further details regardingvariegated molecular pathways and mechanisms ofVHLS are emerging with the subsequent advent of novel treatment protocols that are currently in clinical trials... - Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterationsAnil A Thomas
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Urol 180:2463-7. 2008..Urethral diverticula are uncommon and occur predominantly in women. We examined a large series of female urethral diverticula to determine associated neoplastic alterations and subsequent clinical outcomes... - Diagnostically Challenging Cases: What are Atypia and Dysplasia?Joseph Sanfrancesco
Pathology and Laboratory Medicine Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Urol Clin North Am 40:281-93. 2013..In addition, the effects of inflammation, specific therapies, and instrumentation on the bladder mucosa as well as the associated difficulty in achieving the appropriate diagnosis are also discussed... - Epidermoid cyst of the testicleArmine Karapetian Smith
Cleveland Clinic, Glickman Urological and Kidney Institute, Cleveland, OH 44195, USA
Urology 74:544. 2009..We report on a case of testicular mass with classic radiographic appearance for epidermoid cyst... - Loss of p27 nuclear expression in a prognostically favorable subset of well-differentiated pancreatic endocrine neoplasmsAyman Rahman
Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 632, Baltimore, MD 21205, USA
Am J Clin Pathol 120:685-90. 2003..Expression of p27 protein therefore appears to be lost in a subset of well-differentiated PENs with indolent features but paradoxically retained in PENs associated with metastatic disease... - Emerging concepts in micropapillary urothelial carcinomaKatherine E Watts
Department of Anatomic Pathology, Cleveland Clinic, OH 44195, USA
Adv Anat Pathol 17:182-6. 2010..This review discusses the histologic features required for diagnosis and the clinical significance of rendering a diagnosis of micropapillary urothelial carcinoma... - Liver metastases arising from well-differentiated pancreatic endocrine neoplasms demonstrate increased VEGF-C expressionDonna E Hansel
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mod Pathol 16:652-9. 2003..We postulate that the upregulation of VEGF-C may be involved in PEN progression and metastases, although not via a direct proangiogenic mechanism... - Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancerMichael G House
Department of Surgery, the Indiana University School of Medicine, Indianapolis, USA
J Gastrointest Surg 10:138-45. 2006..Patterns of liver metastases from islet cell tumors, specifically multiple bilobar metastases that are not amenable to resection and/or ablation, predict a poor outcome despite resection of the primary pancreatic tumor... - Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of VaterDonna E Hansel
MBBS, Department of Surgery, The Johns Hopkins University School of Medicine, 720 Rutland Ave, Ross 771, Baltimore, MD 21205, USA
J Clin Oncol 23:1811-8. 2005..We assessed the expression of these putative intestinal epithelial-specific transcription factors and their influence on patient outcome... - Molecular pathogenesis of pancreatic cancerDonna E Hansel
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Annu Rev Genomics Hum Genet 4:237-56. 2003..Ultimately, understanding the genetic events underlying the development of pancreatic cancer may serve as a useful adjunct in the screening and treatment of patients suffering from, or at risk for, pancreatic cancer...