R M Gronostajski

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Roles of the NFI/CTF gene family in transcription and development
    R M Gronostajski
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Case Western Reserve University, OH 44195, USA
    Gene 249:31-45. 2000
  2. ncbi request reprint Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development
    A Z Chaudhry
    Department of Cancer Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Dev Dyn 208:313-25. 1997
  3. pmc Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
    L das Neves
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Proc Natl Acad Sci U S A 96:11946-51. 1999
  4. ncbi request reprint Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promoters
    A Z Chaudhry
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 273:18538-46. 1998
  5. ncbi request reprint Nuclear factor I-mediated repression of the mouse mammary tumor virus promoter is abrogated by the coactivators p300/CBP and SRC-1
    A Z Chaudhry
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 274:7072-81. 1999
  6. ncbi request reprint Thioltransferase (glutaredoxin) reactivates the DNA-binding activity of oxidation-inactivated nuclear factor I
    S Bandyopadhyay
    Lerner Research Institute, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 273:392-7. 1998
  7. ncbi request reprint Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2
    S Sinha
    Department of Cancer Biology, NB40, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Gene 258:15-29. 2000
  8. ncbi request reprint Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells
    S Kulkarni
    Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195, USA
    Cell Growth Differ 7:501-10. 1996
  9. ncbi request reprint Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I
    S Majumder
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, 43210, USA
    Gene Expr 9:203-15. 2001
  10. ncbi request reprint Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins
    S Bandyopadhyay
    Department of Cancer Biology, Cleveland Clinic Foundation Research Institute, Ohio 44195
    J Biol Chem 269:29949-55. 1994

Collaborators

  • S Sinha
  • S Kulkarni
  • A Z Chaudhry
  • S Bandyopadhyay
  • S Majumder
  • S S Mukhopadhyay
  • M Behrens
  • F L Margolis
  • P Leahy
  • H Baumeister
  • C F Fletcher
  • L das Neves
  • A D Vitullo
  • G E Lyons
  • K Ghoshal
  • J M Rosen
  • S L Wyszomierski
  • S T Jacob
  • G Venkatraman
  • R R Reed
  • C S Duchala
  • F Tolentino-Silva
  • C E Campbell
  • N G Copeland
  • R W Hanson
  • M A Haxhiu
  • D R Crawford
  • N A Jenkins
  • F Godinho
  • C Colmenares
  • G Grossman
  • W B Macklin
  • K G Butz
  • J J Mieyal
  • D W Starke

Detail Information

Publications15

  1. ncbi request reprint Roles of the NFI/CTF gene family in transcription and development
    R M Gronostajski
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Case Western Reserve University, OH 44195, USA
    Gene 249:31-45. 2000
    ..Here, we will review the properties of the NFI genes and proteins and their known functions in gene expression and development...
  2. ncbi request reprint Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in development
    A Z Chaudhry
    Department of Cancer Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    Dev Dyn 208:313-25. 1997
    ....
  3. pmc Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
    L das Neves
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Proc Natl Acad Sci U S A 96:11946-51. 1999
    ..This finding of an NFI gene required for a developmental process suggests that the four NFI genes may have distinct roles in vertebrate development...
  4. ncbi request reprint Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promoters
    A Z Chaudhry
    Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 273:18538-46. 1998
    ..Here, we show that NFI heterodimers have intermediate activation potentials compared with homodimers, demonstrating one potential mechanism by which different NFI proteins can regulate gene expression...
  5. ncbi request reprint Nuclear factor I-mediated repression of the mouse mammary tumor virus promoter is abrogated by the coactivators p300/CBP and SRC-1
    A Z Chaudhry
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 274:7072-81. 1999
    ..This abrogation of NFI-C-mediated repression by p300/CBP and SRC-1A suggests that repression by NFI-C may occur by interference with coactivator function at the MMTV promoter...
  6. ncbi request reprint Thioltransferase (glutaredoxin) reactivates the DNA-binding activity of oxidation-inactivated nuclear factor I
    S Bandyopadhyay
    Lerner Research Institute, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 273:392-7. 1998
    ....
  7. ncbi request reprint Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2
    S Sinha
    Department of Cancer Biology, NB40, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Gene 258:15-29. 2000
    ..These results suggest that the various T-box proteins, while highly conserved, likely use different mechanisms to modulate transcription and may have different targets in vivo...
  8. ncbi request reprint Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cells
    S Kulkarni
    Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195, USA
    Cell Growth Differ 7:501-10. 1996
    ..These studies indicate that although their DNA-binding specificities are similar, the proteins encoded by the four NFI genes may differ in their biological functions and play distinct roles in hematopoietic development...
  9. ncbi request reprint Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I
    S Majumder
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, 43210, USA
    Gene Expr 9:203-15. 2001
    ..Interaction of NFI with another protein(s), probably MTF-I, may be involved in this repression...
  10. ncbi request reprint Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins
    S Bandyopadhyay
    Department of Cancer Biology, Cleveland Clinic Foundation Research Institute, Ohio 44195
    J Biol Chem 269:29949-55. 1994
    ..The presence of this nonessential Cys-3 residue in all known NFI proteins raises the possibility that it may function in a manner similar to redox-sensitive cysteine residues found in other site-specific DNA-binding proteins...
  11. ncbi request reprint NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expression
    M Behrens
    Department of Anatomy and Neurobiology, University of Maryland at Baltimore, School of Medicine, Baltimore, MD 21201, USA
    Eur J Neurosci 12:1372-84. 2000
    ..These data on NFI activity, and on transcription factor expression, provide a basis to understand the role of NFI in regulating gene expression in olfactory receptor neurons...
  12. ncbi request reprint Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a regulatory role for NFI transcription factors in olfactory neuron gene expression
    H Baumeister
    Deutsches Institut für Ernährungsforschung, Bergholz Rehbrücke, 14558, Germany
    Brain Res Mol Brain Res 72:65-79. 1999
    ..It now remains to characterize the tissue and cell specific patterns of expression of distinct NFI transcription factors during ontogeny and their roles in regulating gene expression...
  13. ncbi request reprint Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals
    C F Fletcher
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    Mamm Genome 10:390-6. 1999
    ..elegans-like ancestral gene, but that significant changes have occurred in the genomic organization of either the C. elegans or murine NFI genes during evolution...
  14. ncbi request reprint CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcription
    P Leahy
    Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 274:8813-22. 1999
    ..NFI-A combines with dexamethasone or thyroid hormone in an additive manner to stimulate PEPCK gene transcription. We conclude that CBP coordinates the action of the multiple factors known to control transcription of the PEPCK gene...
  15. pmc Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription
    S S Mukhopadhyay
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 21:6859-69. 2001
    ....