Genomes and Genes
R M Gronostajski
Affiliation: Cleveland Clinic Foundation
- Roles of the NFI/CTF gene family in transcription and developmentR M Gronostajski
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Case Western Reserve University, OH 44195, USA
Gene 249:31-45. 2000..Here, we will review the properties of the NFI genes and proteins and their known functions in gene expression and development...
- Expression patterns of the four nuclear factor I genes during mouse embryogenesis indicate a potential role in developmentA Z Chaudhry
Department of Cancer Biology, Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
Dev Dyn 208:313-25. 1997....
- Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosumL das Neves
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
Proc Natl Acad Sci U S A 96:11946-51. 1999..This finding of an NFI gene required for a developmental process suggests that the four NFI genes may have distinct roles in vertebrate development...
- Nuclear factor I (NFI) isoforms differentially activate simple versus complex NFI-responsive promotersA Z Chaudhry
Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 273:18538-46. 1998..Here, we show that NFI heterodimers have intermediate activation potentials compared with homodimers, demonstrating one potential mechanism by which different NFI proteins can regulate gene expression...
- Nuclear factor I-mediated repression of the mouse mammary tumor virus promoter is abrogated by the coactivators p300/CBP and SRC-1A Z Chaudhry
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 274:7072-81. 1999..This abrogation of NFI-C-mediated repression by p300/CBP and SRC-1A suggests that repression by NFI-C may occur by interference with coactivator function at the MMTV promoter...
- Thioltransferase (glutaredoxin) reactivates the DNA-binding activity of oxidation-inactivated nuclear factor IS Bandyopadhyay
Lerner Research Institute, Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Biol Chem 273:392-7. 1998....
- Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2S Sinha
Department of Cancer Biology, NB40, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
Gene 258:15-29. 2000..These results suggest that the various T-box proteins, while highly conserved, likely use different mechanisms to modulate transcription and may have different targets in vivo...
- Altered expression of the developmentally regulated NFI gene family during phorbol ester-induced differentiation of human leukemic cellsS Kulkarni
Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195, USA
Cell Growth Differ 7:501-10. 1996..These studies indicate that although their DNA-binding specificities are similar, the proteins encoded by the four NFI genes may differ in their biological functions and play distinct roles in hematopoietic development...
- Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor IS Majumder
Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, 43210, USA
Gene Expr 9:203-15. 2001..Interaction of NFI with another protein(s), probably MTF-I, may be involved in this repression...
- Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteinsS Bandyopadhyay
Department of Cancer Biology, Cleveland Clinic Foundation Research Institute, Ohio 44195
J Biol Chem 269:29949-55. 1994..The presence of this nonessential Cys-3 residue in all known NFI proteins raises the possibility that it may function in a manner similar to redox-sensitive cysteine residues found in other site-specific DNA-binding proteins...
- NFI in the development of the olfactory neuroepithelium and the regulation of olfactory marker protein gene expressionM Behrens
Department of Anatomy and Neurobiology, University of Maryland at Baltimore, School of Medicine, Baltimore, MD 21201, USA
Eur J Neurosci 12:1372-84. 2000..These data on NFI activity, and on transcription factor expression, provide a basis to understand the role of NFI in regulating gene expression in olfactory receptor neurons...
- Identification of NFI-binding sites and cloning of NFI-cDNAs suggest a regulatory role for NFI transcription factors in olfactory neuron gene expressionH Baumeister
Deutsches Institut für Ernährungsforschung, Bergholz Rehbrücke, 14558, Germany
Brain Res Mol Brain Res 72:65-79. 1999..It now remains to characterize the tissue and cell specific patterns of expression of distinct NFI transcription factors during ontogeny and their roles in regulating gene expression...
- Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammalsC F Fletcher
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Mamm Genome 10:390-6. 1999..elegans-like ancestral gene, but that significant changes have occurred in the genomic organization of either the C. elegans or murine NFI genes during evolution...
- CREB binding protein coordinates the function of multiple transcription factors including nuclear factor I to regulate phosphoenolpyruvate carboxykinase (GTP) gene transcriptionP Leahy
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4935, USA
J Biol Chem 274:8813-22. 1999..NFI-A combines with dexamethasone or thyroid hormone in an additive manner to stimulate PEPCK gene transcription. We conclude that CBP coordinates the action of the multiple factors known to control transcription of the PEPCK gene...
- Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcriptionS S Mukhopadhyay
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 21:6859-69. 2001....