Yanqing Gong

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 31:2035-43. 2011
  2. pmc The plasminogen system in regulating stem cell mobilization
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    J Biomed Biotechnol 2012:437920. 2012
  3. pmc A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response
    Jane Hoover-Plow
    Department of Molecular Cardiology, NB50, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Exp Biol Med (Maywood) 234:28-34. 2009
  4. pmc Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
    Yi Fan
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Cell Biol 14:1046-56. 2012
  5. pmc Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Clin Invest 118:3012-24. 2008
  6. ncbi request reprint Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Cardiovascular Medicine and Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio Division of Translational Medicine and Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 63:2862-72. 2014
  7. pmc Challenges for heart disease stem cell therapy
    Jane Hoover-Plow
    Departmentof Cardiovascular Medicine, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Vasc Health Risk Manag 8:99-113. 2012
  8. pmc Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration
    Yi Fan
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Dev Cell 16:661-74. 2009

Collaborators

Detail Information

Publications8

  1. pmc Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Arterioscler Thromb Vasc Biol 31:2035-43. 2011
    ..Plasminogen (Plg) has been shown to be critical for HPSC mobilization. Here, we investigated the role of Plg in G-CSF-induced HPSC mobilization and the underlying mechanism...
  2. pmc The plasminogen system in regulating stem cell mobilization
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    J Biomed Biotechnol 2012:437920. 2012
    ..Clear elucidation of the underlying mechanisms may lead to the development of new Plg-based therapeutic strategies to improve stem cell mobilization in treating hematological and cardiovascular diseases...
  3. pmc A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response
    Jane Hoover-Plow
    Department of Molecular Cardiology, NB50, Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Exp Biol Med (Maywood) 234:28-34. 2009
    ..Hence, apo(a) may function as a cell specific suppressor of the inflammatory response...
  4. pmc Stimulus-dependent phosphorylation of profilin-1 in angiogenesis
    Yi Fan
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Cell Biol 14:1046-56. 2012
    ....
  5. pmc Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Cardiovascular Medicine, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    J Clin Invest 118:3012-24. 2008
    ..Thus, targeting the Plg/MMP-9 pathway may be an attractive approach to regulate inflammatory responses and AAA development...
  6. ncbi request reprint Plasminogen regulates cardiac repair after myocardial infarction through its noncanonical function in stem cell homing to the infarcted heart
    Yanqing Gong
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Cardiovascular Medicine and Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio Division of Translational Medicine and Human Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Coll Cardiol 63:2862-72. 2014
    ..The purpose of this study was to investigate the role of plasminogen (Plg) in stem cell-mediated cardiac repair and regeneration after myocardial infarction (MI)...
  7. pmc Challenges for heart disease stem cell therapy
    Jane Hoover-Plow
    Departmentof Cardiovascular Medicine, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Vasc Health Risk Manag 8:99-113. 2012
    ..This review is an overview of stem cell therapy for CVD and discusses the challenges these three areas present for maximum optimization of the efficacy of stem cell therapy for heart disease, and new strategies in progress...
  8. pmc Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration
    Yi Fan
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Dev Cell 16:661-74. 2009
    ..Thus, the actin-Tbeta4 complex constitutes a latent coordinating center for cell migratory behavior, allowing profilin to initiate a cascade of events at the leading edge that couples actin polymerization to matrix degradation...