J R Goldblum

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Controversies in the diagnosis of Barrett esophagus and Barrett-related dysplasia: one pathologist's perspective
    John R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave L25, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 134:1479-84. 2010
  2. ncbi request reprint The histologic diagnosis of dysplasia, dysplasia-associated lesion or mass, and adenoma: a pathologist's perspective
    John R Goldblum
    Cleveland Clinic Foundation, 9500 Euclid Avenue, L25, Cleveland, OH 44195, U S A
    J Clin Gastroenterol 36:S63-9; discussion S94-6. 2003
  3. ncbi request reprint Barrett's esophagus and Barrett's-related dysplasia
    John R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mod Pathol 16:316-24. 2003
  4. ncbi request reprint Inflammation and intestinal metaplasia of the gastric cardia: Helicobacter pylori, gastroesophageal reflux disease, or both
    J R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis 18:14-9. 2000
  5. ncbi request reprint Sarcomas arising in dermatofibrosarcoma protuberans: a reappraisal of biologic behavior in eighteen cases treated by wide local excision with extended clinical follow up
    J R Goldblum
    Department of Anatomic Pathology of the Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Surg Pathol 24:1125-30. 2000
  6. ncbi request reprint Dysplasia arising in barrett's esophagus: diagnostic pitfalls and natural history
    John R Goldblum
    Cleveland Clinic Foundation, OH 44195, USA
    Semin Diagn Pathol 19:12-9. 2002
  7. ncbi request reprint N1 esophageal carcinoma: the importance of staging and downstaging
    T W Rice
    Department of Thoracic and Cardiovascular Surgery, The Center for Swallowing and Esophageal Disorders, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 121:454-64. 2001
  8. ncbi request reprint Esophageal carcinoma: depth of tumor invasion is predictive of regional lymph node status
    T W Rice
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 65:787-92. 1998
  9. ncbi request reprint The utility of cytokeratin subsets in distinguishing Barrett's-related oesophageal adenocarcinoma from gastric adenocarcinoma
    A H Ormsby
    Center for Swallowing and Esophageal Diseases and the Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Histopathology 38:307-11. 2001
  10. pmc Can extent of high grade dysplasia in Barrett's oesophagus predict the presence of adenocarcinoma at oesophagectomy?
    M S Dar
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gut 52:486-9. 2003

Detail Information

Publications94

  1. doi request reprint Controversies in the diagnosis of Barrett esophagus and Barrett-related dysplasia: one pathologist's perspective
    John R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave L25, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 134:1479-84. 2010
    ..athologists frequently assess esophageal biopsy specimens to “rule out Barrett esophagus,” as well as to assess for the presence or absence of dysplasia...
  2. ncbi request reprint The histologic diagnosis of dysplasia, dysplasia-associated lesion or mass, and adenoma: a pathologist's perspective
    John R Goldblum
    Cleveland Clinic Foundation, 9500 Euclid Avenue, L25, Cleveland, OH 44195, U S A
    J Clin Gastroenterol 36:S63-9; discussion S94-6. 2003
    ..This review article will summarize some of these issues from the gastrointestinal pathologist's perspective...
  3. ncbi request reprint Barrett's esophagus and Barrett's-related dysplasia
    John R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mod Pathol 16:316-24. 2003
    ..Identification of biomarkers that identify such patients before the histologic recognition of dysplasia will be an area of intensive research...
  4. ncbi request reprint Inflammation and intestinal metaplasia of the gastric cardia: Helicobacter pylori, gastroesophageal reflux disease, or both
    J R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis 18:14-9. 2000
    ..pylori infection as opposed to GERD, and preliminary data suggest a lower risk of progression to dysplasia and adenocarcinoma when compared to intestinal metaplasia of the distal esophagus...
  5. ncbi request reprint Sarcomas arising in dermatofibrosarcoma protuberans: a reappraisal of biologic behavior in eighteen cases treated by wide local excision with extended clinical follow up
    J R Goldblum
    Department of Anatomic Pathology of the Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Surg Pathol 24:1125-30. 2000
    ..Previous studies showing increased metastasis for sarcomas arising in DFSP should be re-evaluated to determine if, with treatment stratification, metastatic rate varies...
  6. ncbi request reprint Dysplasia arising in barrett's esophagus: diagnostic pitfalls and natural history
    John R Goldblum
    Cleveland Clinic Foundation, OH 44195, USA
    Semin Diagn Pathol 19:12-9. 2002
    ..However, no biomarker has yet proven to be superior to the histologic recognition of dysplasia in identifying these high-risk patients...
  7. ncbi request reprint N1 esophageal carcinoma: the importance of staging and downstaging
    T W Rice
    Department of Thoracic and Cardiovascular Surgery, The Center for Swallowing and Esophageal Disorders, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 121:454-64. 2001
    ..To evaluate the effects of clinical staging and downstaging by induction chemoradiation therapy in patients with N1 esophageal carcinoma...
  8. ncbi request reprint Esophageal carcinoma: depth of tumor invasion is predictive of regional lymph node status
    T W Rice
    Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 65:787-92. 1998
    ..A retrospective review of 359 consecutive patients undergoing esophageal resection was conducted to define the relationship between T and N and to determine whether T is a significant predictor of regional lymph node metastasis (N1)...
  9. ncbi request reprint The utility of cytokeratin subsets in distinguishing Barrett's-related oesophageal adenocarcinoma from gastric adenocarcinoma
    A H Ormsby
    Center for Swallowing and Esophageal Diseases and the Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Histopathology 38:307-11. 2001
    ....
  10. pmc Can extent of high grade dysplasia in Barrett's oesophagus predict the presence of adenocarcinoma at oesophagectomy?
    M S Dar
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gut 52:486-9. 2003
    ..Aim: To determine if extent of high grade dysplasia in Barrett's oesophagus is a predictor of the presence of adenocarcinoma at the time of oesophagectomy...
  11. ncbi request reprint Superficial adenocarcinoma of the esophagus
    T W Rice
    Department of Thoracic and Cardiovascular Surgery, The Center for Swallowing and Esophageal Disorders, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 122:1077-90. 2001
    ..Experience with treatment and outcome of superficial adenocarcinoma of the esophagus is limited. The purpose of this study was to evaluate the results of surgical management and identify predictors of survival...
  12. doi request reprint Clinical implications of acellular mucin pools in resected rectal cancer with pathological complete response to neoadjuvant chemoradiation
    L F de Campos-Lobato
    Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Colorectal Dis 14:62-7. 2012
    ..The aim of this study was to evaluate the clinical implications of acellular mucin pools in patients with rectal adenocarcinoma achieving a pCR after neoadjuvant chemoradiation followed by proctectomy...
  13. ncbi request reprint Squamous mucosal alterations in esophagectomy specimens from patients with end-stage achalasia
    M B Lehman
    Center for Swallowing and Esophageal Disorders and the Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Surg Pathol 25:1413-8. 2001
    ..These changes may be related to the increased risk of squamous cell carcinoma in these patients...
  14. doi request reprint Do preoperative factors predict subsequent diagnosis of Crohn's disease after ileal pouch-anal anastomosis for ulcerative or indeterminate colitis?
    G B Melton
    Digestive Disease Institute, Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Colorectal Dis 12:1026-32. 2010
    ....
  15. ncbi request reprint The significance and etiology of intestinal metaplasia of the esophagogastric junction
    John R Goldblum
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 6:67-73. 2002
    ....
  16. doi request reprint Poor interobserver agreement in the distinction of high-grade dysplasia and adenocarcinoma in pretreatment Barrett's esophagus biopsies
    Erinn Downs-Kelly
    Cleveland Clinic Department of Anatomic Pathology, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 103:2333-40; quiz 2341. 2008
    ..To this end, our aim was to assess interobserver reproducibility among a group of gastrointestinal pathologists in the interpretation of preresection biopsies...
  17. pmc Observer variation in the diagnosis of superficial oesophageal adenocarcinoma
    A H Ormsby
    Department of Anatomic Pathology, Henry Ford Health System, Detroit, Michigan, USA
    Gut 51:671-6. 2002
    ..Interobserver agreement for a diagnosis of high grade dysplasia or intramucosal adenocarcinoma remains unknown and may have therapeutic implications...
  18. doi request reprint Pyloric gland metaplasia and pouchitis in patients with ileal pouch-anal anastomoses
    R Kariv
    Department of Gastroenterology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Aliment Pharmacol Ther 31:862-73. 2010
    ..Pyloric gland metaplasia is a histological feature indicative of chronic mucosal inflammation. Its value in diagnosis and prognosis of pouch disorders has not been investigated...
  19. ncbi request reprint Clostridium difficile-associated pouchitis
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology Desk A30, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Dig Dis Sci 51:2361-4. 2006
    ..Clostridium difficile-associated pouchitis is rare. However, Clostridium difficile infection should be excluded in patients with chronic refractory pouchitis...
  20. ncbi request reprint Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis
    Mansour A Parsi
    Department of Gastroenterology, Center for Inflammatory Bowel Disease, Cleveland Clinic Foundation, Desk A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastroenterology 126:1280-6. 2004
    ..Distinction among these entities requires pouch endoscopy and biopsy. Noninvasive means of diagnosis are preferable...
  21. ncbi request reprint Barrett's esophagus: pathologic considerations and implications for treatment
    Thomas W Rice
    Cleveland Clinic Lerner College of Medicine, Section of General Thoracic Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Semin Thorac Cardiovasc Surg 17:292-300. 2005
    ..Treatment will not cause clinically significant regression of BE or prevent progression to cancer. Cancer development following successful antireflux surgery is uncommon...
  22. ncbi request reprint Refining esophageal cancer staging
    Thomas W Rice
    Center for Swallowing and Esophageal Disorders, Departments of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 125:1103-13. 2003
    ..The objectives of this study were to assess current esophageal cancer staging and to determine whether refinements of classification and stage grouping are necessary...
  23. ncbi request reprint Role of clinically determined depth of tumor invasion in the treatment of esophageal carcinoma
    Thomas W Rice
    Center for Swallowing and Esophageal Disorders, Departments of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Thorac Cardiovasc Surg 125:1091-102. 2003
    ..We sought to evaluate the effectiveness of clinical staging of depth of tumor invasion (cT), the relationship of cT to survival, the benefits of downstaging cT, and the role of cT in treatment decisions...
  24. ncbi request reprint Pathology of soft tissue sarcoma
    Brian P Rubin
    Department of Anatomic Pathology, Lerner Research Institute and Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Natl Compr Canc Netw 5:411-8. 2007
    ....
  25. doi request reprint Evaluation of tissue eosinophilia in the pouch and afferent limb in patients with restorative proctocolectomy
    Bo Shen
    Pouchitis Clinic, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 14:744-9. 2008
    ..The aim of this study was to assess whether tissue eosinophilia was associated with disease status of ileal pouches...
  26. doi request reprint The Seattle protocol does not more reliably predict the detection of cancer at the time of esophagectomy than a less intensive surveillance protocol
    Revital Kariv
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 7:653-8; quiz 606. 2009
    ....
  27. doi request reprint Esophageal leiomyoma: experience from a single institution
    W Jiang
    Department of Anatomic Pathology Thoracic, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Esophagus 26:167-74. 2013
    ..Patients with larger tumors were more likely to have symptoms. The majority of the tumors were in the lower and mid-esophagus, and arose from muscularis propria. These tumors behave in a clinically benign fashion...
  28. ncbi request reprint The ringed esophagus: histological features of GERD
    J B Morrow
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology, Cleveland Clinic Foundation, Ohio, USA
    Am J Gastroenterol 96:984-9. 2001
    ..In addition to a series of gradual esophageal dilations, we suggest using a proton pump inhibitor to provide acid suppression...
  29. ncbi request reprint Afferent limb ulcers predict Crohn's disease in patients with ileal pouch-anal anastomosis
    Jason M Wolf
    Department of Gastroenterology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastroenterology 126:1686-91. 2004
    ..Making the diagnosis of CD in patients with IPAA can be difficult, but it is important for prognostic and therapeutic purposes. The aim of this study was to identify diagnostic features of CD in patients with IPAA...
  30. ncbi request reprint Epithelioid sarcoma: an immunohistochemical analysis evaluating the utility of cytokeratin 5/6 in distinguishing superficial epithelioid sarcoma from spindled squamous cell carcinoma
    Lin Lin
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cutan Pathol 30:114-7. 2003
    ....
  31. ncbi request reprint The pathogenesis of pseudoachalasia: a clinicopathologic study of 13 cases of a rare entity
    Wendy Liu
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Surg Pathol 26:784-8. 2002
    ..The most common mechanism is direct involvement of the esophageal myenteric plexus by neoplastic cells. Rarely, a distant neoplasm may cause this syndrome as a paraneoplastic process...
  32. ncbi request reprint p53 expression in low grade dysplasia in Barrett's esophagus: correlation with interobserver agreement and disease progression
    Marek Skacel
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:2508-13. 2002
    ..In the current study, we analyzed the immunohistochemical staining for p53 in patients diagnosed with LGD with known clinical outcome and interobserver agreement data...
  33. ncbi request reprint Long-term outcome of patients with perianal Paget's disease
    P Marchesa
    Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Surg Oncol 4:475-80. 1997
    ..Perianal Paget's disease (PPD) is a rare intraepithelial adenocarcinoma with a significant rate of recurrence after treatment and high risk of progression to an invasive cancer...
  34. ncbi request reprint Immunohistochemical analysis of anaplastic lymphoma kinase expression in deep soft tissue calcifying fibrous pseudotumor: evidence of a late sclerosing stage of inflammatory myofibroblastic tumor?
    J E Sigel
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Diagn Pathol 5:10-4. 2001
    ..Ann Diagn Pathol 5:10-14, 2001...
  35. ncbi request reprint Cytokeratin subset immunostaining in rectal adenocarcinoma and normal anal glands
    P Ramalingam
    Division of Pathology and Laboratory Medicine, Department of Anatomic Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Arch Pathol Lab Med 125:1074-7. 2001
    ..These data suggest that rectal adenocarcinoma unassociated with perianal Paget disease has a different cytokeratin profile than rectal adenocarcinoma associated with perianal Paget disease...
  36. ncbi request reprint Fluorescence in situ hybridization of cytologic specimens from Barrett's esophagus: a pilot feasibility study
    Gary W Falk
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastrointest Endosc 60:280-4. 2004
    ....
  37. doi request reprint Detection of MDM2 gene amplification or protein expression distinguishes sclerosing mesenteritis and retroperitoneal fibrosis from inflammatory well-differentiated liposarcoma
    Joshua Weaver
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 22:66-70. 2009
    ..However, lack of MDM2 immunoexpression would rule out the possibility of inflammatory well-differentiated liposarcoma...
  38. doi request reprint Asymmetric endoscopic inflammation of the ileal pouch: a sign of ischemic pouchitis?
    Bo Shen
    Pouchitis Clinic, Departmentsof Gastroenterology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 16:836-46. 2010
    ..The aim was to describe a disease phenotype of the ileal pouch with an endoscopic appearance suggestive of ischemia...
  39. ncbi request reprint Endoscopic ultrasound errors in esophageal cancer
    Gregory Zuccaro
    Department of Gastroenterology, Cleveland Clinic, Ohio, USA
    Am J Gastroenterol 100:601-6. 2005
    ..Fewer data exist on EUS errors in a cohort balanced between early and advanced disease...
  40. ncbi request reprint Angiosarcoma involving the gastrointestinal tract: a series of primary and metastatic cases
    Kimberly H Allison
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Surg Pathol 28:298-307. 2004
    ..Immunohistochemistry with vascular markers, CK20, and S-100 protein may be helpful in differentiating angiosarcoma from carcinoma and melanoma...
  41. ncbi request reprint Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens
    Mona Fahmy
    Department of Anatomic and Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 17:588-96. 2004
    ..Selected biomarkers from this study merit further investigation to determine their potential to detect genetic changes in patients with Barrett's esophagus prior to the development of high-grade dysplasia...
  42. ncbi request reprint Adenocarcinoma of the small bowel: a study of 37 cases with emphasis on histologic prognostic factors
    Neil A Abrahams
    Department of Anatomic Pathology, Cleveland Clinic Foundation, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA
    Dis Colon Rectum 45:1496-502. 2002
    ..The purpose of this study was to perform a comprehensive analysis of the Cleveland Clinic experience with small-bowel adenocarcinoma, with emphasis on histopathologic parameters as prognostic indicators...
  43. ncbi request reprint Helicobacter pylori infection, not gastroesophageal reflux, is the major cause of inflammation and intestinal metaplasia of gastric cardiac mucosa
    John R Goldblum
    Center for Swallowing and Esophageal Disorders and Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:302-11. 2002
    ..pylori infection, and intestinal metaplasia in patients with GERD and Barrett's esophagus compared with age-matched controls...
  44. ncbi request reprint Epithelioid smooth-muscle tumors of the uterus: a clinicopathologic study of 18 patients
    R A Prayson
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Surg Pathol 21:383-91. 1997
    ..e., epithelioid leiomyosarcomas) typically have the combination of significant nuclear atypia (either grade 2 or grade 3 nuclei) and some mitotic activity (usually at least 3 to 4 MF/10 HPF); most also have tumor cell necrosis...
  45. ncbi request reprint The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma
    J E Sigel
    The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cutan Pathol 28:520-4. 2001
    ..However, some cases of cutaneous SSCC can only be confirmed ultrastructurally, as up to one-third may not show evidence of epithelial differentiation using an expanded immunohistochemical panel...
  46. doi request reprint Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, OH, USA
    Adv Anat Pathol 16:383-91. 2009
    ..Finally, we discuss the advantages and disadvantages of FISH as a technique when appraising soft tissue neoplasms...
  47. ncbi request reprint Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis
    Jacqueline K Trupiano
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Ann Thorac Surg 73:628-30. 2002
    ..Detection of this translocation is of paramount importance to confirm this diagnosis, particularly when this neoplasm arises in atypical locations outside the extremities...
  48. ncbi request reprint The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms
    Erinn Downs-Kelly
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Surg Pathol 32:8-13. 2008
    ..FISH is capable of providing specific ancillary information useful in this often difficult differential diagnosis...
  49. ncbi request reprint Abnormal p53 immunohistochemistry is associated with an increased colorectal cancer-related mortality in patients with ulcerative colitis
    Bret A Lashner
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Gastroenterol 98:1423-7. 2003
    ..The aim of this study was to determine whether abnormal p53 staining of the tumor correlated with cancer-related mortality in ulcerative colitis patients...
  50. ncbi request reprint Pagetoid squamous cell carcinoma in situ (pagetoid Bowen's disease) of the external genitalia
    Rajeeva R Raju
    Department of Anatomic Pathology, Division of Pathology and Laboratory Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Int J Gynecol Pathol 22:127-35. 2003
    ..Combined with mucin stains, a limited immunohistochemical panel may be of diagnostic value in particularly difficult cases...
  51. ncbi request reprint Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases
    K A Downes
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mod Pathol 14:179-84. 2001
    ..Although this tumor has a wide range of histologic appearances, no clinical or pathologic feature is predictive of a more aggressive clinical course...
  52. ncbi request reprint A 20-year retrospective review of surgically treated liposarcoma at the Cleveland Clinic
    Steven A Lietman
    The Cleveland Clinic, Cleveland, OH 44195, USA
    Orthopedics 30:227-34. 2007
    ..The 5-year disease-specific survival for extremity tumors was 92% (95% confidence interval [CI]; range: 84%-100%), while general 5-year survival for extremity tumors was 66% (95% Cl; range: 48%-85%)...
  53. doi request reprint Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms
    Joshua Weaver
    Pathology and Laboratory Medicine Institute, Cleveland Clinic and the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA
    Mod Pathol 21:943-9. 2008
    ....
  54. doi request reprint Low-fat and fat-free pleomorphic lipomas: a diagnostic challenge
    Mandi P Sachdeva
    Department of Dermatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Dermatopathol 31:423-6. 2009
    ..When fat is absent or present in reduced amounts, clinical context and identification of classic nonlipogenic components are essential for the diagnosis of pleomorphic lipomas...
  55. doi request reprint The role of allergy evaluation in adults with eosinophilic esophagitis
    Joshua D Penfield
    Department of Gastroenterology and Hepatology, Center for Swallowing and Esophageal Disorders, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Clin Gastroenterol 44:22-7. 2010
    ..Allergy evaluation and skin prick testing for foods are recommended in all patients with eosinophilic esophagitis. However, the yield of allergy evaluation in adult eosinophilic esophagitis is not known...
  56. ncbi request reprint Course and follow-up of solitary Peutz-Jeghers polyps: a case series
    Mustafa Oncel
    Department of Colorectal Surgery, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Colorectal Dis 18:33-5. 2003
    ..Rarely, solitary Peutz-Jeghers polyps (PJP) arise in patients without other features of PJS...
  57. doi request reprint Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Mod Pathol 23:93-7. 2010
    ..Finally, we discuss some of the potential pitfalls of this technique, including confusion with other mesenchymal neoplasms containing rearrangement of EWSR1, in particular Ewing's sarcoma/PNET...
  58. ncbi request reprint Extragastrointestinal stromal tumors presenting as vulvovaginal/rectovaginal septal masses: a diagnostic pitfall
    Maggie M Lam
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Int J Gynecol Pathol 25:288-92. 2006
    ..Thus, it is imperative to consider EGISTs in the differential diagnosis of mesenchymal neoplasms in the vulvovaginal/rectovaginal septum...
  59. ncbi request reprint Immunohistochemical detection of human herpes virus-8 latent nuclear antigen-1 is useful in the diagnosis of Kaposi sarcoma
    Rajiv M Patel
    Division of Pathology and Laboratory Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 17:456-60. 2004
    ..As such, it is an extremely useful tool for differentiating between Kaposi sarcoma and other vascular and nonvascular spindle cell lesions, which do not express human herpes virus 8 latent nuclear antigen-1...
  60. ncbi request reprint Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma
    Lin Lin
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 18:705-9. 2005
    ..The high level of cyclin D1 protein expression in epithelioid sarcoma appears to be regulated by translational and/or post-translational mechanisms...
  61. ncbi request reprint Gastrointestinal stromal tumors. A review of characteristics morphologic, immunohistochemical, and molecular genetic features
    John R Goldblum
    Department of Anatomic Pathology, Cleveland Clinic Foundation, 9500 Euclid Ave, L25, Cleveland, OH 44195, USA
    Am J Clin Pathol 117:S49-61. 2002
    ..These tumors uniformly express CD117, and mutations of the c-kit gene are central to their pathogenesis and likely the key to effective therapeutic intervention...
  62. ncbi request reprint Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis
    Kimberly H Allison
    Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA 98195, USA
    Am J Clin Pathol 124:685-92. 2005
    ..However, identification of a benign precursor or origin from a nerve may be the most definitive way to properly classify these rare lesions...
  63. ncbi request reprint TFE3 immunoreactivity in alveolar soft part sarcoma of the uterine cervix: case report
    Andres A Roma
    Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Int J Gynecol Pathol 24:131-5. 2005
    ..To the best of our knowledge, this is the first report of ASPS of the female genital tract with immunoreactivity for TFE3. Other interesting findings in our case were the small size of the tumor and the absence of clinical symptoms...
  64. ncbi request reprint Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene
    Fredrik Mertens
    Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
    Lab Invest 85:408-15. 2005
    ..Taken together, the results indicate that virtually all LGFMS are characterized by a chimeric FUS/CREB3L2 gene, and that rare cases may display a variant FUS/CREB3L1 fusion...
  65. pmc Determination of stromal signatures in breast carcinoma
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, California, USA
    PLoS Biol 3:e187. 2005
    ..Our findings suggest that the host stromal response varies significantly among carcinomas and that gene expression patterns characteristic of soft tissue tumors can be used to discover new markers for normal connective tissue cells...
  66. ncbi request reprint Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation
    Nicole Carlson
    Department of Pathology and Medicine, Baylor College of Medicine, Methodist Hospital, Houston, Texas 77030, USA
    Am J Gastroenterol 97:1340-5. 2002
    ..The aim of this study was to test the hypothesis that AST may not alter malignant progression in BM if key genes involved in DNA repair and cell cycle control, particularly p53, are defective...
  67. ncbi request reprint Extent of low-grade dysplasia in Barrett's esophagus: is it useful for risk stratification?
    Gary W Falk
    Am J Gastroenterol 102:494-6. 2007
    ..However, these findings, if confirmed by studies utilizing a simpler measure of the extent of low-grade dysplasia, may help us determine the prognostic significance of this lesion in the future...
  68. ncbi request reprint Low-grade dysplasia in ulcerative colitis: natural history data still unknown
    Mary P Bronner
    Gastroenterology 127:362-3; author reply 363-4. 2004
  69. ncbi request reprint Low-grade dysplasia in Barrett's esophagus
    Robert D Odze
    Clin Gastroenterol Hepatol 4:1419-20; author reply 1420. 2006
  70. ncbi request reprint Interinstitutional variability and effect of tissue fixative on the interpretation of a Barrett cytokeratin 7/20 immunoreactivity pattern in Barrett esophagus
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Pathol 36:58-65. 2005
    ..Nevertheless, specific criteria for interpretation of CK7/20 staining can be successfully applied between institutions and need to be developed before use of this technique in clinical practice...
  71. ncbi request reprint Rab11a immunohistochemical analysis does not distinguish indefinite, low-, and high-grade dysplasia in Barrett esophagus
    Marie E Robert
    Department of Pathology, Yale University, New Haven, CT 06520, USA
    Am J Clin Pathol 124:519-27. 2005
    ..Rab11a immunoreactivity did not enhance the diagnostic assessment of dysplasia in Barrett esophagus. The previously reported positive correlation of p53 immunoreactivity with the presence of dysplasia in Barrett esophagus was confirmed...
  72. ncbi request reprint Are ulcers a marker for invasive carcinoma in Barrett's esophagus? Data from a diagnostic variability study with clinical follow-up
    Elizabeth Montgomery
    Department of Pathology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Gastroenterol 97:27-31. 2002
    ..We correlated follow-up information from 138 patients with Barrett's esophagus and varying degrees of dysplasia with the presence of ulcers...
  73. ncbi request reprint Patterns of colonic involvement at initial presentation in ulcerative colitis: a retrospective study of 46 newly diagnosed cases
    Marie E Robert
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Am J Clin Pathol 122:94-9. 2004
    ..Because rectal sparing at UC onset has been reported, a prospective study using uniform biopsy protocols is needed to establish the true incidence of rectal sparing at presentation...
  74. doi request reprint Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival
    Paul J Zhang
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Hum Pathol 39:1385-95. 2008
    ..Tumor grade appeared to be prognostically important in cardiac sarcoma. Long survival was achieved in patients who survived the initial surgery well...
  75. ncbi request reprint Apo D in soft tissue tumors: a novel marker for dermatofibrosarcoma protuberans
    Robert B West
    Department of Pathology, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Surg Pathol 28:1063-9. 2004
    ..stanford.edu/tma_portal/apod/). We conclude that Apo D is strongly expressed in DFSPs and neural lesions and may be useful in differentiating DFSP from fibrous histiocytoma...
  76. ncbi request reprint Primary intravascular synovial sarcoma: a disease of young adult women? Report of a case diagnosed by aspiration biopsy and review of the literature
    Guo Xia Tong
    Department of Pathology, Columbia University Medical Center, New York, NY, USA
    Diagn Cytopathol 34:834-8. 2006
    ..Although clinically similar to previously reported IVSS, this is the first case arising in large veins of the upper portion of the trunk and diagnosed by FNAB...
  77. ncbi request reprint Analysis of protein expression and gene mutation of c-kit in colorectal neuroendocrine carcinomas
    Olaronke Akintola-Ogunremi
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Surg Pathol 27:1551-8. 2003
    ..More importantly, our observations may have potential therapeutic implications since specific tyrosine kinase inhibitors have shown promise in the management of patients with kit-expressing malignancies...
  78. ncbi request reprint Benign fibroblastic polyps of the colon: a histologic, immunohistochemical, and ultrastructural study
    Fatima Eslami-Varzaneh
    Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Surg Pathol 28:374-8. 2004
    ..In summary, these lesions represent a distinctive type of colonic mucosal polyp that should be distinguished from other stromal polyps of the gastrointestinal tract...
  79. ncbi request reprint CD117-expressing cells in the human gastrointestinal tract with particular emphasis on its localization in myenteric ganglion cells (MGC)
    Kyung Whan Min
    Hum Pathol 34:825-6; author reply 827. 2003
  80. doi request reprint Pro: Villous elements and high-grade dysplasia help guide post-polypectomy colonoscopic surveillance
    Douglas K Rex
    Indiana University Hospital, Indianapolis, Indiana, USA
    Am J Gastroenterol 103:1327-9. 2008
  81. doi request reprint Angiosarcoma of the uterus: report of 2 new cases with deviant clinicopathologic features and review of the literature
    Loredana Cardinale
    Department of Pathology, General Hospital, Lodi, Italy
    Ann Diagn Pathol 12:217-21. 2008
    ..Occurrence in childbearing age or a deviant histologic pattern, as documented in this report, may be added to the clinicopathologic spectrum of uterine angiosarcoma...
  82. ncbi request reprint Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma
    Rajiv M Patel
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30355, USA
    Mod Pathol 18:1585-90. 2005
    ..As the studied probe can be utilized in routinely processed tissue, FISH provides an excellent alternative to reverse-transcriptase polymerase chain reaction in cases where fresh tissue is unavailable...
  83. pmc A landscape effect in tenosynovial giant-cell tumor from activation of CSF1 expression by a translocation in a minority of tumor cells
    Robert B West
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:690-5. 2006
    ....
  84. ncbi request reprint Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product
    Paul J Zhang
    Anatomic Pathology, 6 Founders Pavilion, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19147, USA
    Mod Pathol 16:229-35. 2003
    ..Detection of EWS-WT1 fusion becomes critical for the diagnosis when the characteristic divergent phenotype cannot be detected immunohistochemically...
  85. ncbi request reprint Molecular diagnosis of Campylobacter jejuni infection in cases of focal active colitis
    Elizabeth N Schneider
    Department of Pathology, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, and Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA
    Am J Surg Pathol 30:782-5. 2006
    ..Furthermore, PCR analysis performed on fixed, routinely processed colon biopsies is an excellent diagnostic method for detection of this organism...
  86. ncbi request reprint Protocol for the examination of specimens from patients with invasive carcinomas of the appendix
    Joseph Misdraji
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Arch Pathol Lab Med 130:1433-9. 2006
  87. ncbi request reprint Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation
    Jeffrey D Goldsmith
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19147, USA
    Am J Surg Pathol 26:1627-33. 2002
    ..In addition to its role as a germ cell marker, PLAP may also be used as a myogenic marker in the diagnosis of soft tissue tumors...
  88. ncbi request reprint The gene expression profile of extraskeletal myxoid chondrosarcoma
    Subbaya Subramanian
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94035, USA
    J Pathol 206:433-44. 2005
    ..Small molecule inhibitors for PPARG exist and PPARG could be a potential therapeutic target for EMC...
  89. ncbi request reprint TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma emerging from gene expression profiling studies
    Jefferson Terry
    Genetic Pathology Evaluation Centre, British Columbia Cancer Agency, 600 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 4E6
    Am J Surg Pathol 31:240-6. 2007
    ..Our findings establish TLE as a robust immunohistochemical marker for synovial sarcoma, and may have implications for understanding the biology of synovial sarcoma and for developing experimental therapies for this cancer...
  90. ncbi request reprint Immunostaining for SYT protein discriminates synovial sarcoma from other soft tissue tumors: analysis of 146 cases
    Rui He
    Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA
    Mod Pathol 20:522-8. 2007
    ....
  91. ncbi request reprint Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation
    Audrey N Schuetz
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Mod Pathol 18:1403-10. 2005
    ..Desmosomal and adherens junction protein expression was rare to absent. Our findings provide additional evidence that ES/PNET frequently show partial epithelial differentiation...
  92. ncbi request reprint Soft-tissue perineurioma in a 20-year-old patient with neurofibromatosis type 1 (NF1): report of a case and review of the literature
    Gregory G Ausmus
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    J Cutan Pathol 34:726-30. 2007
    ..Although mutations in the neurofibromatosis 2 (NF2) gene have been documented in this tumor, there is no known association between perineuriomas and type 1 or 2 NF...
  93. doi request reprint Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement
    Ilan Weinreb
    Department of Pathology and Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada
    J Cutan Pathol 35:855-60. 2008
    ..Pleomorphic AFH should be included in the differential diagnosis of atypical mesenchymal tumors of skin and superficial subcutis and molecular testing may prove helpful in this regard...
  94. ncbi request reprint Molecular characterization of soft tissue tumors
    Ernest C Borden
    Curr Oncol Rep 4:497-8. 2002