Candece Gladson

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Progress on antiangiogenic therapy for patients with malignant glioma
    Manmeet S Ahluwalia
    Brain Tumor Neuro Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Oncol 2010:689018. 2010
  2. pmc Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity
    Dongyan Wang
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e19629. 2011
  3. pmc Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy
    Wei Michael Liu
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 8:e70804. 2013
  4. pmc The pathobiology of glioma tumors
    Candece L Gladson
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Annu Rev Pathol 5:33-50. 2010
  5. pmc Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies
    Manmeet S Ahluwalia
    Cleveland Clinic Main Campus, Cleveland, OH 44195, USA
    Cancer Lett 298:139-49. 2010
  6. pmc Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin
    Philip A Klenotic
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Pathol 176:2039-50. 2010

Research Grants

Collaborators

  • Richard A Prayson
  • Robert J Weil
  • Jun Lin Guan
  • Erwin Van Meir
  • M A Vogelbaum
  • Manmeet S Ahluwalia
  • Wei Michael Liu
  • Ping Huang
  • Dongyan Wang
  • Philip A Klenotic
  • Gaelle Muller-Greven
  • Niladri Kar
  • Clark W Distelhorst
  • Justin D Lathia
  • Jeremy N Rich
  • Monica Burgett
  • John C Kappes
  • Amy S Nowacki
  • Eric Toline
  • G Yancey Gillespie
  • Paul W Sanders
  • Russell O Pieper
  • Cheryl A Palmer
  • Mitchell A Olman
  • Jeongwu Lee
  • Russell Tipps
  • Jerry Stewart
  • Roy L Silverstein
  • Balveen Kaur
  • Maria Febbraio
  • Juan Palomo

Detail Information

Publications6

  1. pmc Progress on antiangiogenic therapy for patients with malignant glioma
    Manmeet S Ahluwalia
    Brain Tumor Neuro Oncology Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Oncol 2010:689018. 2010
    ....
  2. pmc Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity
    Dongyan Wang
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e19629. 2011
    ....
  3. pmc Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy
    Wei Michael Liu
    Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 8:e70804. 2013
    ..As the levels of Lyn protein or its activity are elevated in several cancers these findings may be of broad relevance to cancer biology. ..
  4. pmc The pathobiology of glioma tumors
    Candece L Gladson
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Annu Rev Pathol 5:33-50. 2010
    ....
  5. pmc Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies
    Manmeet S Ahluwalia
    Cleveland Clinic Main Campus, Cleveland, OH 44195, USA
    Cancer Lett 298:139-49. 2010
    ..The activity of these agents against solid tumors suggests that they may also be useful in treating brain metastases. This article reviews the potential for using SRC/SFK inhibitors to treat GBM and brain metastases...
  6. pmc Histidine-rich glycoprotein modulates the anti-angiogenic effects of vasculostatin
    Philip A Klenotic
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Pathol 176:2039-50. 2010
    ..These data help define a novel angiogenic axis that could be exploited for the treatment of human cancers and other diseases where excess angiogenesis occurs...

Research Grants23

  1. The Role of TSP-1 and 2 in the Biology of Astrocytomas
    Candece Gladson; Fiscal Year: 2004
    ..Mouse malignant glioma cell clones will be injected intracerebrally into the TSP-2 knockout mouse and the wild-type mouse, and studies to analyze tumor angiogenesis and proliferation performed. ..
  2. The Role of Lyn in Glioma Progression and Migration
    Candece Gladson; Fiscal Year: 2005
    ..The results will be of general interest, i.e., tumors other than brain tumors, as increased cellular Src family member activity also likely promotes the progression and metastasis of non-glioma tumors. ..
  3. The Role of TSP-1 and 2 in the Biology of Astrocytomas
    Candece Gladson; Fiscal Year: 2005
    ..Mouse malignant glioma cell clones will be injected intracerebrally into the TSP-2 knockout mouse and the wild-type mouse, and studies to analyze tumor angiogenesis and proliferation performed. ..
  4. The Role of TSP-1 and 2 in the Biology of Astrocytomas
    Candece Gladson; Fiscal Year: 2006
    ..Mouse malignant glioma cell clones will be injected intracerebrally into the TSP-2 knockout mouse and the wild-type mouse, and studies to analyze tumor angiogenesis and proliferation performed. ..
  5. The Role of Lyn in Glioma Progression and Migration
    Candece Gladson; Fiscal Year: 2007
    ..The results will be of general interest, i.e., tumors other than brain tumors, as increased cellular Src family member activity also likely promotes the progression and metastasis of non-glioma tumors. ..
  6. The Role of Lyn in Glioma Progression and Migration
    Candece Gladson; Fiscal Year: 2009
    ..The results will be of general interest, i.e., tumors other than brain tumors, as increased cellular Src family member activity also likely promotes the progression and metastasis of non-glioma tumors. ..
  7. Inhibition of Glioma Growth by a Novel Molecule
    Candece Gladson; Fiscal Year: 2009
    ..Relevance: This work should lead directly to a novel therapeutic strategy for the treatment of malignant astrocytic tumors, which would represent a major advance in the treatment of this devastating disease. ..
  8. Inhibition of Glioma Growth by a Novel Molecule
    Candece L Gladson; Fiscal Year: 2010
    ..Relevance: This work should lead directly to a novel therapeutic strategy for the treatment of malignant astrocytic tumors, which would represent a major advance in the treatment of this devastating disease. ..
  9. The Role of TSP-1 and 2 in the Biology of Astrocytomas
    Candece Gladson; Fiscal Year: 2003
    ..Mouse malignant glioma cell clones will be injected intracerebrally into the TSP-2 knockout mouse and the wild-type mouse, and studies to analyze tumor angiogenesis and proliferation performed. ..
  10. Brain Endothelial TNF-R1 Can Function to Inhibit Angiogenesis
    Candece L Gladson; Fiscal Year: 2010
    ..This approach would be a significant advance over the therapies currently being tested that retard the growth of the blood vessels, but do not eliminate them. ..
  11. FAK AND CAS AND ASTROCYTOMA MIGRATION/INVASION
    Candece Gladson; Fiscal Year: 1999
    ..Completion of this work will establish a model of p125 FAK and p130CAS signaling after ligation of integrins on astrocytoma cells, which will lead to the development of therapy directed toward specific steps in the invasion process. ..
  12. FAK AND CAS AND ASTROCYTOMA MIGRATION/INVASION
    Candece Gladson; Fiscal Year: 2000
    ..Completion of this work will establish a model of p125 FAK and p130CAS signaling after ligation of integrins on astrocytoma cells, which will lead to the development of therapy directed toward specific steps in the invasion process. ..
  13. FAK AND CAS AND ASTROCYTOMA MIGRATION/INVASION
    Candece Gladson; Fiscal Year: 2001
    ..Completion of this work will establish a model of p125 FAK and p130CAS signaling after ligation of integrins on astrocytoma cells, which will lead to the development of therapy directed toward specific steps in the invasion process. ..
  14. FAK AND CAS AND ASTROCYTOMA MIGRATION/INVASION
    Candece Gladson; Fiscal Year: 2002
    ..Completion of this work will establish a model of p125 FAK and p130CAS signaling after ligation of integrins on astrocytoma cells, which will lead to the development of therapy directed toward specific steps in the invasion process. ..
  15. The Role of TSP-1 and 2 in the Biology of Astrocytomas
    Candece Gladson; Fiscal Year: 2002
    ..Mouse malignant glioma cell clones will be injected intracerebrally into the TSP-2 knockout mouse and the wild-type mouse, and studies to analyze tumor angiogenesis and proliferation performed. ..
  16. The Role of Lyn in Glioma Progression and Migration
    Candece Gladson; Fiscal Year: 2006
    ..The results will be of general interest, i.e., tumors other than brain tumors, as increased cellular Src family member activity also likely promotes the progression and metastasis of non-glioma tumors. ..
  17. FAK AND CAS AND ASTROCYTOMA MIGRATION/INVASION
    Candece Gladson; Fiscal Year: 2003
    ..Completion of this work will establish a model of p125 FAK and p130CAS signaling after ligation of integrins on astrocytoma cells, which will lead to the development of therapy directed toward specific steps in the invasion process. ..