Research Topics
| A FurlanSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Detail Information
Publications
Patent foramen ovale and stroke: to close or not to close?Anthony J Furlan
Department of Neurology, Cleveland Clinic, Cleveland, OH 44195, USA
Cleve Clin J Med 74:S118-20. 2007
Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral ThromboembolismA Furlan
Cerebrovascular Center, Department of Neurology, Cleveland Clinic Foundation, Ohio 44195, USA
JAMA 282:2003-11. 1999..Intravenous tissue-type plasminogen activator can be beneficial to some patients when given within 3 hours of stroke onset, but many patients present later after stroke onset and alternative treatments are needed...
Intra-arterial thrombolysis for acute strokeAnthony Furlan
Section of Stroke and Neurologic Intensive Care, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Cleve Clin J Med 71:S31-8. 2004
Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onsetAnthony J Furlan
Department of Neurology, The Cleveland Clinic, Cleveland, OH 44195, USA
Stroke 37:1227-31. 2006..This study evaluated safety and efficacy of intravenous (IV) desmoteplase in patients with perfusion/diffusion mismatch on MRI 3 to 9 hours after onset of acute ischemic stroke...
The role of recombinant pro-urokinase (r-pro-UK) and intra-arterial thrombolysis in acute ischaemic stroke: the PROACT trials. Prolyse in Acute Cerebral ThromboembolismAnthony J Furlan
Curr Med Res Opin 18:s44-7. 2002..However the American Heart Association has deemed IA thrombolysis an 'acceptable alternative therapy' and many stroke centres are offering it to patients with a major acute stroke presenting within 6 h...
Patent foramen ovale and recurrent stroke: closure is the best option: yesAnthony J Furlan
Department of Neurology, Cleveland Clinic, Cerebrovascular Center, Cleveland, Ohio, 44195-5001, USA
Stroke 35:803-4. 2004
Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtableMarc Fisher
UMass Memorial Healthcare Center, 119 Belmont St, Worcester, MA 01605, USA
Stroke 36:1808-13. 2005..A fourth (STAIR-IV) was held to discuss relevant issues related to acute stroke drug development and regulatory approval...
Quality improvement for stroke management at the Cleveland Clinic Health SystemEric D Hixson
Measurement Services, The Quality Institute, Cleveland Clinic Health System, Cleveland, USA
Jt Comm J Qual Patient Saf 31:447-54. 2005..Improvement activities included professional education, public awareness, process improvement, focused data collection with routine feedback, protocol refinement, and coordination of clinical personnel within and between hospitals...
Multimodal therapy for the treatment of severe ischemic stroke combining GPIIb/IIIa antagonists and angioplasty after failure of thrombolysisAlex Abou-Chebl
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Stroke 36:2286-8. 2005..9+/-8.7) and 6 (50%) had an NIHSS < or =4 at discharge. CONCLUSIONS: Multimodal rescue therapy was effective at recanalizing occluded cerebral vessels that failed thrombolysis without an excess risk of ICH...
IV tissue plasminogen activator for stroke in the community: what we know and don't know 10 years after FDA approvalAnthony J Furlan
Stroke 37:281. 2006
Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 studyMichael D Hill
Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Stroke 37:2322-5. 2006..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set...
Recanalization of an acute middle cerebral artery occlusion using a self-expanding, reconstrainable, intracranial microstent as a temporary endovascular bypassMichael E Kelly
Division of Cerebrovascular and Endovascular Neurosurgery, Department of Neurosurgery, Cleveland Clinic, S80, Cleveland, OH 44195, USA
Stroke 39:1770-3. 2008..We describe a technique in which a reconstrainable stent was used to provide a temporary endovascular bypass to achieve MCA recanalization without permanent stent implantation...
Utilization of intravenous tissue plasminogen activator for acute ischemic strokeIrene L Katzan
Department of Neurology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Arch Neurol 61:346-50. 2004..Intravenous tissue plasminogen activator (tPA) is the only approved therapy for acute ischemic stroke, although only 2% of patients with stroke receive intravenous tPA nationally...
Computed tomographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to middle cerebral artery occlusion: results from the PROACT II trialHeidi C Roberts
Department of Radiology, University of California, San Francisco, USA
Stroke 33:1557-65. 2002..The purpose of this study was to evaluate the role of noncontrast CT in the selection of patients to receive thrombolytic therapy for acute ischemic stroke and to predict radiological and clinical outcomes...
Acute stroke therapy: beyond i.v. tPAAnthony J Furlan
Cerebrovascular Center, Department of Neurology, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 69:730-4. 2002..Several medical centers are turning to angiography to guide intra-arterial infusion of thrombolytic agents and mechanical endovascular interventions...
Cuyahoga County Operation Stroke speed of emergency department evaluation and compliance with National Institutes of Neurological Disorders and Stroke time targetsIrene L Katzan
MetroHealth Medical Center, Cleveland Clinic Foundation, Ohio 44109 1998, USA
Stroke 34:994-8. 2003..To track compliance with NINDS guidelines, Cuyahoga County Operation Stroke implemented a countywide data collection process that provides comparative reporting of hospital performance...
Quality improvement and tissue-type plasminogen activator for acute ischemic stroke: a Cleveland updateIrene L Katzan
Department of Neurology, Cleveland Clinic Foundation, 9500 Euclid Ave, S91, Cleveland, Ohio 44195, USA
Stroke 34:799-800. 2003..We now report updated results of intravenous tPA use in the Cleveland Clinic Health System (CCHS)...
Factors influencing outcome and treatment effect in PROACT IILawrence R Wechsler
University of Pittsburgh, Pittsburgh, PA, USA
Stroke 34:1224-9. 2003..The purpose of the current study was to examine baseline factors to determine predictors of good outcome and response to treatment...
Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic strokeRandall T Higashida
University of California, San Francisco Medical Center, Department of Radiology, 505 Parnassus Ave, Rm L 352, San Francisco, CA 94143 0628, USA
Stroke 34:e109-37. 2003....
Training, competency, and credentialing standards for diagnostic cervicocerebral angiography, carotid stenting, and cerebrovascular intervention: a joint statement from the American Academy of Neurology, the American Association of Neurological Surgeons, John J Connors
Baptist Cardiac and Vascular Institute, Baptist Hospital Miami, 8900 N. Kendall Avenue, Miami, FL 33133, USA
Neurology 64:190-8. 2005
Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic strokeAnthony J Furlan
Department of Neurology, University of Massachusetts Medical School, Worcester, Mass 01605-2982, USA
Stroke 36:398-9. 2005
Training, competency, and credentialing standards for diagnostic cervicocerebral angiography, carotid stenting, and cerebrovascular intervention: a joint statement from the American Academy of Neurology, the American Association of Neurological Surgeons, John J Connors
Interventional Neuroradiology, Miami Cardiac and Vascular Institute, FL 33176, USA
J Vasc Interv Radiol 15:1347-56. 2004
Time is brainAnthony J Furlan
Stroke 37:2863-4. 2006
Acute stroke trials: strengthening the underpoweredAnthony J Furlan
Stroke 33:1450-1. 2002
Training, competency, and credentialing standards for diagnostic cervicocerebral angiography, carotid stenting, and cerebrovascular intervention: a joint statement from the American Academy of Neurology, American Association of Neurological Surgeons, AmerJohn J Connors
Radiology 234:26-34. 2005
