Thomas W Frazier

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder
    Thomas W Frazier
    Department of Psychology, Case Western Reserve University, Cleveland, OH 44195, USA
    Neuropsychology 18:543-55. 2004
  2. ncbi request reprint Relationships among victoria symptom validity test indices and personality assessment inventory validity scales in a large clinical sample
    Kathryn A Haggerty
    Section of Neuropsychology, Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Neuropsychol 21:917-28. 2007
  3. doi request reprint Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groups
    Thomas W Frazier
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Child Adolesc Psychopharmacol 17:853-66. 2007
  4. ncbi request reprint A twin study of heritable and shared environmental contributions to autism
    Thomas W Frazier
    Center for Autism, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    J Autism Dev Disord 44:2013-25. 2014
  5. pmc Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection
    Thomas W Frazier
    Center for Pediatric Behavioral Health and Center for Autism, Cleveland Clinic Electronic address
    J Am Acad Child Adolesc Psychiatry 53:329-40.e1-3. 2014
  6. doi request reprint A two-year longitudinal MRI study of the corpus callosum in autism
    Thomas W Frazier
    Center for Autism CRS10 and Pediatric Behavioral Health, Cleveland Clinic, 2801 Martin Luther King Jr Drive, Cleveland, OH 44104, USA
    J Autism Dev Disord 42:2312-22. 2012
  7. pmc Prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver-reported attention-deficit/hyperactivity disorder
    Thomas W Frazier
    Center for Autism and Center for Pediatric Behavioral Health, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Child Adolesc Psychopharmacol 21:571-9. 2011
  8. doi request reprint Detection of simulated ADHD and reading disorder using symptom validity measures
    Thomas W Frazier
    The Cleveland Clinic, Center for Pediatric Behavioral Health CR11, 2801 Martin Luther King Jr Drive, Cleveland, OH 44104, USA
    Arch Clin Neuropsychol 23:501-9. 2008
  9. pmc A meta-analysis of the corpus callosum in autism
    Thomas W Frazier
    Center for Autism and Center for Pediatric Behavioral Health, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Biol Psychiatry 66:935-41. 2009
  10. doi request reprint Autism spectrum disorders as a qualitatively distinct category from typical behavior in a large, clinically ascertained sample
    Thomas W Frazier
    The Cleveland Clinic, OH 44195, USA
    Assessment 17:308-20. 2010

Detail Information

Publications40

  1. ncbi request reprint Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder
    Thomas W Frazier
    Department of Psychology, Case Western Reserve University, Cleveland, OH 44195, USA
    Neuropsychology 18:543-55. 2004
    ..These findings indicate that overall cognitive ability is significantly lower among persons with ADHD and that FSIQ may show as large a difference between ADHD and control participants as most other measures...
  2. ncbi request reprint Relationships among victoria symptom validity test indices and personality assessment inventory validity scales in a large clinical sample
    Kathryn A Haggerty
    Section of Neuropsychology, Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Neuropsychol 21:917-28. 2007
    ..These findings further suggest that measures of cognitive symptom validity only partially overlap with measures of psychopathological symptom exaggeration...
  3. doi request reprint Evaluation and comparison of psychometric instruments for pediatric bipolar spectrum disorders in four age groups
    Thomas W Frazier
    Department of Psychiatry, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Child Adolesc Psychopharmacol 17:853-66. 2007
    ..The CDRS-R may be better conceptualized as a two-factor measure in older adolescents. The semistructured K-SADS interview can be used to generate reliable diagnoses across a broad age range...
  4. ncbi request reprint A twin study of heritable and shared environmental contributions to autism
    Thomas W Frazier
    Center for Autism, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    J Autism Dev Disord 44:2013-25. 2014
    ..High heritability of extreme autism symptom levels confirms previous observations of strong genetic influences on autism. Future studies will require large, carefully ascertained family pedigrees and quantitative symptom measurements. ..
  5. pmc Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection
    Thomas W Frazier
    Center for Pediatric Behavioral Health and Center for Autism, Cleveland Clinic Electronic address
    J Am Acad Child Adolesc Psychiatry 53:329-40.e1-3. 2014
    ..To examine differences in behavioral symptoms and cognitive functioning between males and females with autism spectrum disorder (ASD)...
  6. doi request reprint A two-year longitudinal MRI study of the corpus callosum in autism
    Thomas W Frazier
    Center for Autism CRS10 and Pediatric Behavioral Health, Cleveland Clinic, 2801 Martin Luther King Jr Drive, Cleveland, OH 44104, USA
    J Autism Dev Disord 42:2312-22. 2012
    ..Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions...
  7. pmc Prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver-reported attention-deficit/hyperactivity disorder
    Thomas W Frazier
    Center for Autism and Center for Pediatric Behavioral Health, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Child Adolesc Psychopharmacol 21:571-9. 2011
    ..Correlates of medication use were also examined...
  8. doi request reprint Detection of simulated ADHD and reading disorder using symptom validity measures
    Thomas W Frazier
    The Cleveland Clinic, Center for Pediatric Behavioral Health CR11, 2801 Martin Luther King Jr Drive, Cleveland, OH 44104, USA
    Arch Clin Neuropsychol 23:501-9. 2008
    ..Percentages of control participants and participants in simulation conditions scoring below a specified cut score are provided to give clinicians an estimate of the simulator (true) positive and control (false) positive rates...
  9. pmc A meta-analysis of the corpus callosum in autism
    Thomas W Frazier
    Center for Autism and Center for Pediatric Behavioral Health, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Biol Psychiatry 66:935-41. 2009
    ..However, studies have differed concerning the magnitude and/or region contributing to CC reductions. The present study determined the significance and magnitude of reductions in CC total and regional area measures in autism...
  10. doi request reprint Autism spectrum disorders as a qualitatively distinct category from typical behavior in a large, clinically ascertained sample
    Thomas W Frazier
    The Cleveland Clinic, OH 44195, USA
    Assessment 17:308-20. 2010
    ..The identified category was associated with external indicators of disability, supporting its validity. Results indicated that ASD is best characterized as a category, distinct from typical behavior within ASD-affected families...
  11. doi request reprint Effectiveness of medication combined with intensive behavioral intervention for reducing aggression in youth with autism spectrum disorder
    Thomas W Frazier
    Center for Autism, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Child Adolesc Psychopharmacol 20:167-77. 2010
    ..There are no studies examining the combined effectiveness of antipsychotic medications and intensive behavioral intervention (IBI) to treat aggression in ASD...
  12. doi request reprint Time course and predictors of health-related quality of life improvement and medication satisfaction in children diagnosed with attention-deficit/hyperactivity disorder treated with the methylphenidate transdermal system
    Thomas W Frazier
    Center for Pediatric Behavioral Health and Center for Autism Children s Hospital, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Child Adolesc Psychopharmacol 20:355-64. 2010
    ....
  13. pmc Relationship of persistent manic symptoms to the diagnosis of pediatric bipolar spectrum disorders
    Thomas W Frazier
    Center for Pediatric Behavioral Health and Center for Autism, Cleveland Clinic, 2801 Martin Luther King Jr Drive, Cleveland, OH 44104, USA
    J Clin Psychiatry 72:846-53. 2011
    ..The present study evaluated the possibility that the presence of persistent manic symptoms over a relatively short interval may increase the probability of a BPSD DSM diagnosis...
  14. pmc Validation of proposed DSM-5 criteria for autism spectrum disorder
    Thomas W Frazier
    Center for Pediatric Behavioral Health and Center for Autism, Cleveland Clinic, OH, USA
    J Am Acad Child Adolesc Psychiatry 51:28-40.e3. 2012
    ..The primary aim of the present study was to evaluate the validity of proposed DSM-5 criteria for autism spectrum disorder (ASD)...
  15. ncbi request reprint The latent structure of cognitive symptom exaggeration on the Victoria Symptom Validity Test
    Thomas W Frazier
    Section of Behavioral Medicine, The Cleveland Clinic, Cleveland, OH 44104, USA
    Arch Clin Neuropsychol 22:197-211. 2007
    ..13-.14 in the present sample. Likelihood ratios are presented to assist clinical detection of individuals exhibiting the category of cognitive symptom exaggeration...
  16. ncbi request reprint Exploratory and confirmatory factor analysis of the autism diagnostic interview-revised
    Thomas W Frazier
    Section of Behavioral Medicine, Children s Hospital for Rehabilitation, The Cleveland Clinic, Shaker Campus CR11, Cleveland, OH 44104, USA
    J Autism Dev Disord 38:474-80. 2008
    ..These findings indicate that the current ADI-R structure be revised to more accurately reflect the relationships between sub-scales...
  17. ncbi request reprint The latent structure of attention-deficit/hyperactivity disorder in a clinic-referred sample
    Thomas W Frazier
    Department of Psychiatry and Psychology, Section of Neuropsychology, The Cleveland Clinic, Cleveland, OH 44195, USA
    Neuropsychology 21:45-64. 2007
    ..Alternatively, the null findings may have resulted from inadequate indicator selection. A dimensional model may better facilitate accurate identification of individuals at risk for functional impairment...
  18. ncbi request reprint ADHD and achievement: meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students
    Thomas W Frazier
    Section of Behavioral Medicine, The Cleveland Clinic, Shaker Medical Campus, OH 44104, USA
    J Learn Disabil 40:49-65. 2007
    ..However, unlike earlier studies with children and adolescents, student ratings were as predictive as parent ratings. Findings are discussed in terms of the impact of moderator variables on ADHD and achievement...
  19. pmc What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?
    Mary A Fristad
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
    Bipolar Disord 14:497-506. 2012
    ....
  20. pmc Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 71:1664-72. 2010
    ..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally...
  21. pmc Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms
    Danella Hafeman
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 15:240-52. 2013
    ....
  22. pmc Clinical characteristics of children receiving antipsychotic medication
    Robert L Findling
    University Hospitals Case Medical Center Case Western Reserve University, Cleveland, OH 44106, USA
    J Child Adolesc Psychopharmacol 21:311-9. 2011
    ..However, the only diagnoses associated with a greater likelihood of being treated with an antipsychotic were psychotic disorders or unmodified DSM-IV bipolar 1 disorder...
  23. pmc Pediatric bipolar spectrum disorder and ADHD: comparison and comorbidity in the LAMS clinical sample
    L Eugene Arnold
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, 1670 Upham Drive, Columbus, OH 43210, USA
    Bipolar Disord 13:509-21. 2011
    ..To compare attention-deficit hyperactivity disorder (ADHD), bipolar spectrum disorders (BPSDs), and comorbidity in the Longitudinal Assessment of Manic Symptoms (LAMS) study...
  24. doi request reprint Double-blind, randomized, placebo-controlled long-term maintenance study of aripiprazole in children with bipolar disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals, Case Medical Center, Cleveland, OH 44106, USA
    J Clin Psychiatry 73:57-63. 2012
    ..This study evaluates the long-term efficacy of aripiprazole compared to placebo in children with bipolar disorders...
  25. pmc An open-label study of aripiprazole in children with a bipolar disorder
    Robert L Findling
    Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Child Adolesc Psychopharmacol 21:345-51. 2011
    ..The purpose of this open-label study was to describe the effectiveness of aripiprazole (APZ) in the treatment of children with bipolar disorders suffering from manic symptomatology...
  26. ncbi request reprint Multivariate neuropsychological prediction of seizure lateralization in temporal epilepsy surgical cases
    Therese A Keary
    Department of Psychiatry and Psychology, Section of Neuropsychology, Cleveland Clinic, Cleveland, Ohio, U S A
    Epilepsia 48:1438-46. 2007
    ....
  27. doi request reprint Age differences in the phenomenology of pediatric bipolar disorder
    Christine A Demeter
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, OH, United States
    J Affect Disord 147:295-303. 2013
    ..The primary purpose of this study was to explore whether age differences in the phenomenology of bipolar disorders from 4 to 17 years of age exist...
  28. ncbi request reprint Double-blind, placebo-controlled trial of divalproex monotherapy in the treatment of symptomatic youth at high risk for developing bipolar disorder
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University, and the University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
    J Clin Psychiatry 68:781-8. 2007
    ..To determine if divalproex sodium was superior to placebo in the treatment of symptomatic youths who suffer from a bipolar spectrum disorder and who also have a parent with a diagnosis of a bipolar illness...
  29. doi request reprint HRQL and medication satisfaction in children with ADHD treated with the methylphenidate transdermal system
    Michael Manos
    Cleveland Clinic, Cleveland, OH, USA
    Curr Med Res Opin 25:3001-10. 2009
    ....
  30. ncbi request reprint Utility of the Boston naming test in predicting ultimate side of surgery in patients with medically intractable temporal lobe epilepsy
    Robyn M Busch
    Department of Psychiatry and Psychology, Section of Neuropsychology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Epilepsia 46:1773-9. 2005
    ..Despite wide and frequent use, few studies have examined the utility of confrontation naming tasks in individuals with temporal lobe epilepsy (TLE)...
  31. doi request reprint Clinical utility of the Boston Naming Test in predicting ultimate side of surgery in patients with medically intractable temporal lobe epilepsy: A double cross-validation study
    Robyn M Busch
    Cleveland Clinic Epilepsy Center, Neurological Institute, 9500 Euclid Avenue, P57, Cleveland, OH 44195, USA
    Epilepsia 50:1270-3. 2009
    ..8% of the combined sample. These results further support the clinical utility of the BNT in predicting side of surgery...
  32. doi request reprint Working memory and intelligence are associated with victoria symptom validity test hard item performance in patients with intractable epilepsy
    Therese A Keary
    Department of Psychiatry and Psychology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Int Neuropsychol Soc 19:314-23. 2013
    ..Results suggest VSVT hard item scores may be impacted by working memory difficulties and/or low intellectual functioning...
  33. ncbi request reprint Evidence-based assessment of attention-deficit/hyperactivity disorder: using multiple sources of information
    Thomas W Frazier
    Department of Psychiatry and Psychology, Section of Neuropsychology, Cleveland Clinic Foundation, John Carroll University, OH 44118, USA
    J Am Acad Child Adolesc Psychiatry 45:614-20. 2006
  34. ncbi request reprint Increasing the reliability of ipsative interpretations in neuropsychology: a comparison of reliable components analysis and other factor analytic methods
    Thomas W Frazier
    Department of Psychology, Case Western Reserve University, Cleveland, Ohio, USA
    J Int Neuropsychol Soc 10:578-89. 2004
    ..These findings suggest that difference scores derived from orthogonal factor solutions, particularly RCA solutions, may improve reliability for clinical assessment purposes...
  35. pmc Cognitive characteristics of PTEN hamartoma tumor syndromes
    Robyn M Busch
    Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Genet Med 15:548-53. 2013
    ..We sought to characterize cognition in individuals with germline PTEN mutations (n = 23) as well as in PTEN mutation-negative individuals with classic Cowden syndrome or Bannayan-Riley-Ruvalcaba syndrome (n = 2)...
  36. pmc Biochemical screening and PTEN mutation analysis in individuals with autism spectrum disorders and macrocephaly
    Judith A Hobert
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Eur J Hum Genet 22:273-6. 2014
    ..PTEN sequencing should be carried out for all individuals with ASDs and macrocephaly with OFC ≥2SDs above the mean. A proportion of individuals with ASDs may have an underlying disorder in sulfur amino acid metabolism. ..
  37. pmc Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model
    Jessica L Mester
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Eur J Hum Genet 19:763-8. 2011
    ..Clinicians should consider germline PTEN testing at an early point in the diagnostic work-up for patients with extreme macrocephaly...
  38. ncbi request reprint Preliminary quantitative investigation of predictors of treatment non-adherence in pediatric transplantation: a brief report
    Shoshana Y Kahana
    Center for the Promotion of Adherence and Self Management, Division of Behavioral Medicine and Clinical Psychology, Cincinnati Childrens Hospital Medical Center, OH, USA
    Pediatr Transplant 12:656-60. 2008
    ..17, 95% CI = -0.15-0.49, n = 3) and donor source (mean d = 0.33, 95% CI = -0.10-0.76, n = 4) exhibited small, non-significant relationships with non-adherence. Limitations of the study are discussed as are future directions for research...
  39. ncbi request reprint Psychometric adequacy and comparability of the short and full forms of the Personality Assessment Inventory
    Thomas W Frazier
    Department of Psychology, John Carroll University, University Heights, OH 44118, USA
    Psychol Assess 18:324-33. 2006
    ..However, low levels of reliability across less impaired ranges of the latent trait, diminished content coverage, and altered validity detection may limit the utility of some of the short form scales...
  40. pmc Developing a 10-item mania scale from the Parent General Behavior Inventory for children and adolescents
    Eric A Youngstrom
    Department of Psychology, University of North Carolina at Chapel Hill, NC 27599 3270, USA
    J Clin Psychiatry 69:831-9. 2008
    ..The goal of the present study was to develop and validate a brief (10 item) instrument to assess mania in a large sample of outpatients presenting with a variety of different DSM-IV diagnoses, including frequent comorbid conditions...