S M Flechner

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    Stuart M Flechner
    Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 83:883-92. 2007
  2. doi request reprint Intraoperative placing of drains decreases the incidence of lymphocele and deep vein thrombosis after renal transplantation
    Ithaar H Derweesh
    Section of Renal Transplantation, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    BJU Int 101:1415-9. 2008
  3. doi request reprint A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients
    Stuart M Flechner
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 95:1233-41. 2013
  4. doi request reprint The use of kidneys with small renal tumors for transplantation: who is taking the risk?
    S M Flechner
    The Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
    Am J Transplant 12:48-54. 2012
  5. doi request reprint Can the nephron be spared?
    Stuart M Flechner
    Cleveland Clinic Lerner College of Medicine, Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA
    Kidney Int 79:804-6. 2011
  6. ncbi request reprint The effect of 2-gram versus 1-gram concentration controlled mycophenolate mofetil on renal transplant outcomes using sirolimus-based calcineurin inhibitor drug-free immunosuppression
    Stuart M Flechner
    Section of Renal Transplantation, Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplantation 79:926-34. 2005
  7. doi request reprint The ORION study: comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients
    S M Flechner
    Cleveland Clinic Foundation, OH, USA
    Am J Transplant 11:1633-44. 2011
  8. doi request reprint Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity
    Stuart M Flechner
    Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Transplant 22:1-15. 2008
  9. doi request reprint Reviewing the evidence for de novo immunosuppression with sirolimus
    S M Flechner
    Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Transplant Proc 40:S25-8. 2008
  10. doi request reprint Use of the donor bladder trigone to facilitate pediatric en bloc kidney transplantation
    Stuart M Flechner
    Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Pediatr Transplant 15:53-7. 2011

Detail Information

Publications46

  1. ncbi request reprint Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    Stuart M Flechner
    Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 83:883-92. 2007
    ..We report the 5-year outcomes from a randomized prospective trial in primary adult renal allograft recipients, designed to evaluate calcineurin inhibitor (CNI)-free immunosuppression on kidney transplant function...
  2. doi request reprint Intraoperative placing of drains decreases the incidence of lymphocele and deep vein thrombosis after renal transplantation
    Ithaar H Derweesh
    Section of Renal Transplantation, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    BJU Int 101:1415-9. 2008
    ....
  3. doi request reprint A randomized, open-label study of sirolimus versus cyclosporine in primary de novo renal allograft recipients
    Stuart M Flechner
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 95:1233-41. 2013
    ..This study evaluated whether a CNI-free regimen, including sirolimus, mycophenolate mofetil, corticosteroids, and anti-interleukin-2 receptor antibody induction, results in improved long-term renal function...
  4. doi request reprint The use of kidneys with small renal tumors for transplantation: who is taking the risk?
    S M Flechner
    The Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA
    Am J Transplant 12:48-54. 2012
    ..In the case of an individual undergoing a live donor evaluation in which a small renal tumor is detected, a careful analysis of risk and benefit for the potential donor and the recipient is indicated...
  5. doi request reprint Can the nephron be spared?
    Stuart M Flechner
    Cleveland Clinic Lerner College of Medicine, Glickman Urological and Kidney Institute, Cleveland, Ohio 44195, USA
    Kidney Int 79:804-6. 2011
    ..At 1-2 years the glomerular filtration rate (GFR) was superior for the sirolimus group, with a loss of tolerability for about 20%...
  6. ncbi request reprint The effect of 2-gram versus 1-gram concentration controlled mycophenolate mofetil on renal transplant outcomes using sirolimus-based calcineurin inhibitor drug-free immunosuppression
    Stuart M Flechner
    Section of Renal Transplantation, Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplantation 79:926-34. 2005
    ..We performed a sequential study to determine the efficacy and side effects of low-dose (1 g) mycophenolate mofetil (MMF) in a CNI drug avoidance regimen including sirolimus/steroids...
  7. doi request reprint The ORION study: comparison of two sirolimus-based regimens versus tacrolimus and mycophenolate mofetil in renal allograft recipients
    S M Flechner
    Cleveland Clinic Foundation, OH, USA
    Am J Transplant 11:1633-44. 2011
    ..2, 17% vs. 6%; p = 0.004). Between-group malignancy rates were similar. The SRL-based regimens were not associated with improved outcomes for kidney transplantation patients...
  8. doi request reprint Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity
    Stuart M Flechner
    Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Clin Transplant 22:1-15. 2008
    ..Strategies to limit CNI exposure include CNI minimization, avoidance, and withdrawal. We sought to review the impact of CNI-sparing strategies in kidney, liver, and heart transplantation...
  9. doi request reprint Reviewing the evidence for de novo immunosuppression with sirolimus
    S M Flechner
    Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    Transplant Proc 40:S25-8. 2008
    ..In addition, the de novo introduction of sirolimus should be restricted in the obese, in the presence of dense oligoanuria, and among subjects at high immunologic risk for an acute rejection episode...
  10. doi request reprint Use of the donor bladder trigone to facilitate pediatric en bloc kidney transplantation
    Stuart M Flechner
    Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Pediatr Transplant 15:53-7. 2011
    ....
  11. ncbi request reprint Alemtuzumab induction and sirolimus plus mycophenolate mofetil maintenance for CNI and steroid-free kidney transplant immunosuppression
    S M Flechner
    Transplant Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Transplant 5:3009-14. 2005
    ..The reported higher than expected rate of acute rejection, leukopenia and possible pulmonary toxicity suggests excessive morbidity. Modifications such as an initial period of CNI use should be considered...
  12. ncbi request reprint De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years
    Stuart M Flechner
    Section of Renal Transplantation, Transplant Center, and Allogen Laboratories, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Transplant 4:1776-85. 2004
    ..All may provide for an alternative natural history with improved graft survival...
  13. doi request reprint Allotransplantation of cryopreserved parathyroid tissue for severe hypocalcemia in a renal transplant recipient
    S M Flechner
    Glickman Urological and Kidney Institute, Cleveland, OH, USA
    Am J Transplant 10:2061-5. 2010
    ..In our case, the need for second transplant suggests that the amount of tissue transferred for an allograft may need to be substantially greater than for an autograft...
  14. doi request reprint The role of proteasome inhibition with bortezomib in the treatment of antibody-mediated rejection after kidney-only or kidney-combined organ transplantation
    Stuart M Flechner
    Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 90:1486-92. 2010
    ..We report our initial experience in using the proteasome inhibitor, bortezomib, to treat established antibody-mediated rejection (AMR) in 20 patients...
  15. doi request reprint Sirolimus in kidney transplantation indications and practical guidelines: de novo sirolimus-based therapy without calcineurin inhibitors
    Stuart M Flechner
    Department of Surgery, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Transplantation 87:S1-6. 2009
    ..The late withdrawal of steroids may be possible, but awaits further evaluation in randomized controlled trials...
  16. ncbi request reprint Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine
    Stuart M Flechner
    Urological Institute and Transplant Center A110, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Transplantation 74:1070-6. 2002
    ..Progressive nephrotoxicity caused by calcineurin inhibitor drugs contributes to the long-term decline in renal function in kidney transplant patients...
  17. doi request reprint Renal autotransplantation and modified pyelovesicostomy for intractable metabolic stone disease
    Stuart M Flechner
    Glickman Urological and Kidney Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    J Urol 186:1910-5. 2011
    ..We offered these patients renal autotransplantation with a modified pyelovesicostomy as an alternative solution...
  18. ncbi request reprint The impact of sirolimus, mycophenolate mofetil, cyclosporine, azathioprine, and steroids on wound healing in 513 kidney-transplant recipients
    Stuart M Flechner
    Section of Renal Transplantation, Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Transplantation 76:1729-34. 2003
    ..The aim of this study was to determine whether there has been an increase in the incidence or severity of wound-healing complications that can be attributed to the introduction of newer immunosuppressive drugs...
  19. ncbi request reprint Ipsilateral dual-kidney transplantation using organs declined by other centers
    I H Derweesh
    Section of Renal Transplantation, Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplant Proc 35:856-7. 2003
  20. pmc Prominent impact of community risk factors on kidney transplant candidate processes and outcomes
    J D Schold
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH Center for Health Disparities, MetroHealth Medical Center and Case Western Reserve University, Cleveland, OH
    Am J Transplant 13:2374-83. 2013
    ..Community risks are powerful factors associated with processes of care and outcomes for transplant candidates and may be important considerations for developing effective interventions and measuring quality of care of transplant centers...
  21. ncbi request reprint Minimizing calcineurin inhibitor drugs in renal transplantation
    S M Flechner
    Section of Renal Transplantation, Transplant Center A110, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Transplant Proc 35:118S-121S. 2003
    ..Limiting nephrotoxic immunosuppression should be considered an important goal; but requires sufficient long-term follow-up to support the benefits suggested from initial analysis of the data...
  22. ncbi request reprint Fate of donor kidney: laparoscopic versus open technique
    Mahesh C Goel
    Section of Renal Transplant and Minimally Invasive Surgery, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Urol 172:2326-30. 2004
    ..We analyzed and compared the short and long-term outcomes of living transplant allografts from kidneys procured by laparoscopic or open donor (ODN) technique and managed with a single immunosuppression regimen in each group...
  23. ncbi request reprint Posttransplant diabetes mellitus in kidney transplant recipients receiving calcineurin or mTOR inhibitor drugs
    Motoo Araki
    Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 81:335-41. 2006
    ..The aim of this study was to evaluate the incidence and risk factors for posttransplant diabetes mellitus (PTDM; defined as new insulin use and/or new hyperglycemia) in 528 kidney recipients using different immunosuppressive agents...
  24. doi request reprint The impact of deceased donor kidney risk significantly varies by recipient characteristics
    E L G Heaphy
    Department of Quantitative Health Sciences, Cleveland, Clinic, Cleveland, OH, USA
    Am J Transplant 13:1001-11. 2013
    ..17; among African Americans the respective risks were 1.50 and 1.17 and among recipients 60 and over, it was between 1.64 and 1.22. These findings are critical considerations for informed decision-making for transplant candidates...
  25. ncbi request reprint A randomized prospective trial of low-dose OKT3 induction therapy to prevent rejection and minimize side effects in recipients of kidney transplants
    S M Flechner
    Department of Urology, Cleveland Clinic Foundation, Ohio 44195, USA
    Transplantation 69:2374-81. 2000
    ..We attempted to minimize the undesired side effects and maximize the benefit of OKT3 induction therapy in renal transplantation...
  26. ncbi request reprint Cyclosporine disposition and long-term renal function in a 500-pound kidney transplant recipient
    S M Flechner
    Departments of Urology and Pharmacology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Kidney Dis 32:E4. 1998
    ..These data confirm that stable cyclosporine delivery in very obese recipients can be sustained by dosing normalized to the ideal body weight and trough level monitoring...
  27. ncbi request reprint Differences in proteinuria and graft function in de novo sirolimus-based vs. calcineurin inhibitor-based immunosuppression in live donor kidney transplantation
    Brian R Stephany
    Department of Nephrology and Hypertension, Cleveland Clinic Foundation, OH 44195, USA
    Transplantation 82:368-74. 2006
    ..Calcineurin inhibitor(CNI)-free protocols using sirolimus (SRL) in kidney transplantation have proven effective, although reports have linked SRL to proteinuria. We sought to investigate this link and its impact on graft function...
  28. pmc Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes
    Stuart M Flechner
    Section of Renal Transplantation, Transplant Center A110, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Transplant 4:1475-89. 2004
    ....
  29. doi request reprint Hidden selection bias deriving from donor organ characteristics does not affect performance evaluations of kidney transplant centers
    Jesse D Schold
    Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Med Care 48:907-14. 2010
    ..An unresolved question is whether centers accepting higher-risk donations are placed in jeopardy for lower evaluations independent of actual quality of care...
  30. ncbi request reprint The effect of two different cyclosporine formulations on the long-term progression to chronic rejection in renal allograft recipients
    Mahesh Goel
    Section of Renal Transplantation, Urological Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Clin Transplant 16:442-9. 2002
    ..Our aim was to determine whether the microemulsion formulation of cyclosporine has reduced the long-term (5 yr or more) rates of chronic rejection (allograft nephropathy) in a renal transplant population...
  31. doi request reprint Management of the adrenal gland during partial nephrectomy
    Brian R Lane
    Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Urol 181:2430-6; discussion 2436-7. 2009
    ..We analyzed initial management and oncological outcomes of adrenal glands after open partial nephrectomy...
  32. doi request reprint A systematic approach to minimizing wound problems for de novo sirolimus-treated kidney transplant recipients
    Ho Yee Tiong
    The Transplant Center Glickman Kidney and Urological Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 87:296-302. 2009
    ....
  33. doi request reprint Glomerular filtration rate slopes have significantly improved among renal transplants in the United States
    Titte R Srinivas
    Department of Nephrology and Hypertension, Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 90:1499-505. 2010
    ..In recent years, the use of higher risk donor organs and steroid avoidance regimens with potential increased acute rejection risk have increased. We hypothesized that these patterns adversely affect changes in posttransplant renal function...
  34. ncbi request reprint Evaluation of renal function in transplantation
    Emilio D Poggio
    Department of Nephrology and Hypertension and Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA
    Transplantation 84:131-6. 2007
    ..The performance of commonly used estimation equations and methods for measuring kidney function in renal and liver transplant patients are overviewed here along with their potential roles in clinical transplantation...
  35. pmc An emerging population: kidney transplant candidates who are placed on the waiting list after liver, heart, and lung transplantation
    Titte R Srinivas
    Department of Nephrology and Hypertension, Glickman Urologic and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue Q7, Cleveland, OH 44195, USA
    Clin J Am Soc Nephrol 5:1881-6. 2010
    ..ESRD has an adverse impact on patients who have had previous nonrenal solid-organ transplants (NRTxs; liver, heart, lung) and may be referred for a kidney transplant (KTx)...
  36. ncbi request reprint Laparoscopic live donor nephrectomy has equivalent early and late renal function outcomes compared with open donor nephrectomy
    Ithaar H Derweesh
    Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 65:862-6. 2005
    ....
  37. ncbi request reprint Salvage of compromised renal vessels in kidney transplantation using third-party cadaveric extenders: impact on posttransplant anti-HLA antibody formation
    Mahesh C Goel
    Transplant Center, Glickman Urological Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Transplantation 77:1899-902. 2004
    ..Two recipients developed HLA antibodies, one to DR7 and another DR13 (mismatched to the vessel donor) at 4 and 11 months posttransplant, respectively...
  38. doi request reprint The association of center performance evaluations and kidney transplant volume in the United States
    J D Schold
    Department of Quantitative Health Sciences, Cleveland Clinic, OH, USA
    Am J Transplant 13:67-75. 2013
    ..04). Findings indicate a significant association between reduced kidney transplant volume and low performance report card evaluations...
  39. ncbi request reprint Clinical characteristics of 13 solid organ transplant recipients with ganciclovir-resistant cytomegalovirus infection
    C M Isada
    Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Transpl Infect Dis 4:189-94. 2002
    ..Ganciclovir-resistant (GCV-R) cytomegalovirus (CMV) is now being reported with increasing frequency in solid organ transplant recipients...
  40. ncbi request reprint Simultaneous vs. sequential laparoscopic bilateral native nephrectomy and renal transplantation
    Hazem R Ismail
    Section of Renal Transplantation, Laparoscopic, and Minimally Invasive Surgery, Glickman Urological Institute Transplant Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Transplantation 80:1124-7. 2005
    ..Laparoscopic bilateral nephrectomy followed by kidney transplantation is a safe and feasible alternative...
  41. ncbi request reprint The influence of various maintenance immunosuppressive drugs on lymphocele formation and treatment after kidney transplantation
    Mahesh Goel
    Section of Renal Transplantation, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Urol 171:1788-92. 2004
    ..We compared the incidence of lymphocele formation and treatment in kidney transplant recipients given 3 immunosuppressive drug regimens...
  42. ncbi request reprint BK nephropathy in kidney transplant recipients treated with a calcineurin inhibitor-free immunosuppression regimen
    Gerald S Lipshutz
    Department of Surgery, University of California San Francisco, San Francisco, California, USA
    Am J Transplant 4:2132-4. 2004
    ..These cases demonstrate that, unlike reports linking tacrolimus and PVAN, polyomavirus infection may develop in patients maintained on CNI-free immunosuppressive regimens and have not had episodes of rejection...
  43. ncbi request reprint Current management of transplant renal artery stenosis: clinical utility of duplex Doppler ultrasonography
    Mahesh C Goel
    Glickman Urological Institute, Division of Renal Transplant, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 66:59-64. 2005
    ..To perform a retrospective study to determine the clinical utility of Doppler ultrasonography (DUS) and to determine its role in the management of transplant renal artery stenosis (TRAS)...
  44. ncbi request reprint Post-transplant diabetes mellitus: risk reduction strategies in the elderly
    Alain Duclos
    Transplant Center Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Drugs Aging 23:781-93. 2006
    ....
  45. ncbi request reprint Laparoscopic donor nephrectomy gene expression profiling reveals upregulation of stress and ischemia associated genes compared to control kidneys
    Sunil M Kurian
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Transplantation 80:1067-71. 2005
    ..These data demonstrate an altered renal transcriptome induced by several hours of CO2 pneumoperitoneum and laparoscopic surgery characterized by upregulation of ischemia and injury associated genes...
  46. ncbi request reprint Will you still list me when I'm 64? Apologies to Lennon and McCartney
    Stuart M Flechner
    J Am Geriatr Soc 50:195-7. 2002