Claudio Fiocchi

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Early versus late immune mediated inflammatory diseases
    Claudio Fiocchi
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Acta Gastroenterol Belg 74:548-52. 2011
  2. doi Towards a 'cure' for IBD
    Claudio Fiocchi
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis 30:428-33. 2012
  3. pmc Themes in fibrosis and gastrointestinal inflammation
    Claudio Fiocchi
    Dept of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195
    Am J Physiol Gastrointest Liver Physiol 300:G677-83. 2011
  4. doi Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand?
    Claudio Fiocchi
    Department of Pathobiology, Lerner Research Institute, and Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis 27:226-35. 2009
  5. pmc First international summit on fibrosis in intestinal inflammation: mechanisms and biological therapies
    Florian Rieder
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH, USA
    Fibrogenesis Tissue Repair 3:22. 2010
  6. pmc Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease
    Miquel Sans
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Gastroenterology 132:139-53. 2007
  7. pmc T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis
    Florian Rieder
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland, Ohio Department of Pathobiology, Lerner Research Institute, Cleveland, Ohio
    Gastroenterology 146:1266-77.e1-9. 2014
  8. ncbi Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification
    Silvio Danese
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 172:2011-5. 2004
  9. ncbi Redox equilibrium in mucosal T cells tunes the intestinal TCR signaling threshold
    Brenda M Rivera Reyes
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 175:2158-66. 2005
  10. doi Hyaluronan (HA) deposition precedes and promotes leukocyte recruitment in intestinal inflammation
    Sean Kessler
    Department of Pathobiology, Lerner Research Institute, NC2, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA
    Clin Transl Sci 1:57-61. 2008

Research Grants

Collaborators

Detail Information

Publications52

  1. ncbi Early versus late immune mediated inflammatory diseases
    Claudio Fiocchi
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Acta Gastroenterol Belg 74:548-52. 2011
    ..Therefore, it is crucial to better understand why and how the IMID associated immune abnormalities evolve over time, so that time-dependent therapies may be rationally implemented for an improved clinical outcome...
  2. doi Towards a 'cure' for IBD
    Claudio Fiocchi
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis 30:428-33. 2012
    ..We are still not studying the 'omes' of IBD, we should be using 'omics' technologies that can generate a more global vision of IBD pathogenesis on which to base novel, multiple pathway-integrated therapies...
  3. pmc Themes in fibrosis and gastrointestinal inflammation
    Claudio Fiocchi
    Dept of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195
    Am J Physiol Gastrointest Liver Physiol 300:G677-83. 2011
    ..This themes series aims to illustrate the importance of research in this area in gastrointestinal health and disease...
  4. doi Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand?
    Claudio Fiocchi
    Department of Pathobiology, Lerner Research Institute, and Department of Gastroenterology and Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis 27:226-35. 2009
    ....
  5. pmc First international summit on fibrosis in intestinal inflammation: mechanisms and biological therapies
    Florian Rieder
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic, Cleveland, OH, USA
    Fibrogenesis Tissue Repair 3:22. 2010
    ....
  6. pmc Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease
    Miquel Sans
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Gastroenterology 132:139-53. 2007
    ..We investigated FKN production by the mucosal microvasculature in inflammatory bowel disease (IBD), its capacity for leukocyte recruitment into the gut, and the number of CX3CR1+ cells in the circulation and mucosa of IBD patients...
  7. pmc T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis
    Florian Rieder
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland, Ohio Department of Pathobiology, Lerner Research Institute, Cleveland, Ohio
    Gastroenterology 146:1266-77.e1-9. 2014
    ..We investigated mechanisms of dysphagia, assessing the response of human esophageal fibroblasts (HEFs), human esophageal muscle cells (HEMCs), and esophageal muscle strips to eosinophil-derived products...
  8. ncbi Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification
    Silvio Danese
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 172:2011-5. 2004
    ..These results show the existence of a novel platelet-dependent pathway of immune response amplification which brings these nonimmune cells close to the level of pathogenic relevance traditionally attributed to classical immune cells...
  9. ncbi Redox equilibrium in mucosal T cells tunes the intestinal TCR signaling threshold
    Brenda M Rivera Reyes
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Immunol 175:2158-66. 2005
    ..We conclude that the high TCR signaling threshold of mucosal T cells is tuned by intracellular redox equilibrium, whose dysregulation may mediate intestinal inflammation...
  10. doi Hyaluronan (HA) deposition precedes and promotes leukocyte recruitment in intestinal inflammation
    Sean Kessler
    Department of Pathobiology, Lerner Research Institute, NC2, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio, USA
    Clin Transl Sci 1:57-61. 2008
    ..Therefore, HA deposition is an early event in inflamed gut tissue, preceding and likely promoting leukocyte infiltration...
  11. pmc Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis
    Florian Rieder
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Pathol 179:2660-73. 2011
    ....
  12. pmc Gene-gene and gene-environment interactions in ulcerative colitis
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A31, Cleveland, OH, 44195, USA
    Hum Genet 133:547-58. 2014
    ..UC risk can be predicted by a 133 loci and improved by adding gene-gene and gene-environment interactions. ..
  13. pmc Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease
    Florian Rieder
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Gastrointest Liver Physiol 303:G786-801. 2012
    ....
  14. pmc Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis
    Luca Pastorelli
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 107:8017-22. 2010
    ..Taken together, the IL-33/ST2 system plays an important role in IBD and experimental colitis, is modulated by anti-TNF therapy, and may represent a specific biomarker for active UC...
  15. doi Mechanisms of tissue remodeling in inflammatory bowel disease
    Florian Rieder
    Department of Pathobiology, Lerner Research Institute, and Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Dig Dis 31:186-93. 2013
    ....
  16. pmc Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines
    Carol de la Motte
    Lerner Research Institute, NC2, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Pathol 174:2254-64. 2009
    ..The platelet may thus provide an interface between acute and chronic inflammation, wound healing, and their subsequent fibrotic responses...
  17. doi Intestinal fibrosis in IBD--a dynamic, multifactorial process
    Florian Rieder
    The Cleveland Clinic Foundation, Lerner Research Institute, Department of Pathobiology, Cleveland, OH 44195, USA
    Nat Rev Gastroenterol Hepatol 6:228-35. 2009
    ....
  18. pmc Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis
    Anja Schirbel
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastroenterology 144:613-623.e9. 2013
    ..We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis...
  19. ncbi Inflammatory bowel disease pathogenesis: therapeutic implications
    Claudio Fiocchi
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Chin J Dig Dis 6:6-9. 2005
    ..It is anticipated that combination therapies targeting multiple pathogenic components will prove more effective than those blocking single components of IBD pathogenesis...
  20. doi Pathogenesis of postoperative recurrence in Crohn's disease
    Tasneem Ahmed
    Department of Gastroenterology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Gut 60:553-62. 2011
    ..This paper reviews the postoperative disease outcome and evolution based on defining the combination of the patient's microbial flora, environmental exposure history, immune response and genetic make-up...
  21. pmc Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis?
    Zhonghui Wen
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4952, USA
    Clin Dev Immunol 11:195-204. 2004
    ....
  22. ncbi Inflammatory bowel disease: the role of environmental factors
    Silvio Danese
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, BRB 425, 10900 Euclid Avenue, Cleveland, OH 44106 4952, USA
    Autoimmun Rev 3:394-400. 2004
    ..Finally, an increased intestinal permeability may increase the risk for developing CD, whereas an appendectomy lowers the risk of developing UC...
  23. ncbi Inflammatory bowel disease: progress and current concepts of etiopathogenesis
    Franco Scaldaferri
    Department of Gastroenterology and Hepatology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Dig Dis 8:171-8. 2007
    ....
  24. doi Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease
    Silvia D'Alessio
    aDivision of Gastroenterology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy bDepartment of Gastroenterology and Hepatology, Digestive Disease Institute cDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA Authors Silvia D Alessio and Carlotta Tacconi share co first authorship
    Curr Opin Gastroenterol 29:608-13. 2013
    ....
  25. pmc A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 19:1799-808. 2013
    ..The value of genetic variants in clinical practice is not defined because of limited explained heritability...
  26. ncbi A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B
    Ian C Lawrance
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Gastroenterology 125:1750-61. 2003
    ..To elucidate extracellular matrix (ECM) changes underlying intestinal fibrosis, a frequent complication of inflammatory bowel disease, we developed a murine model of chronic colitis associated with intestinal fibrosis...
  27. pmc Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease
    Heitor S P de Souza
    Department of Internal Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Gastroenterology 143:1017-26.e9. 2012
    ..Survivin, a member of the inhibitors of apoptosis family, prevents cell death and regulates cell division. Survivin has been studied extensively in cancer, but little is known about its role in Crohn's disease...
  28. doi Genes and 'in-vironment': how will our concepts on the pathophysiology of inflammatory bowel disease develop in the future?
    Claudio Fiocchi
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA fiocchc ccf org
    Dig Dis 30:2-11. 2012
    ..Current knowledge of GXG and GXE and their impact on IBD pathogenesis is the focus of this review...
  29. ncbi Introduction: First International Symposium on: pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, U.S.A
    Claudio Fiocchi
    Case Western Reserve University, Cleveland, Ohio, USA
    J Pediatr Gastroenterol Nutr 40:S1. 2005
  30. ncbi An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial
    Douglas L Seidner
    Department of Gastroenterology A30, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Clin Gastroenterol Hepatol 3:358-69. 2005
    ....
  31. doi Impact of abdominal visceral adipose tissue on disease outcome in pediatric Crohn's disease
    Victor Uko
    Departments of Pediatric Gastroenterology, and Pathobiology, Cleveland Clinic, Cleveland, Ohio Department of Gastroenterology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio Department of Radiology, Children s Hospital and Research Center of Oakland, Oakland, California and Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, Ohio
    Inflamm Bowel Dis 20:2286-91. 2014
    ..The objective of this study was to investigate the differences in VAT between pediatric patients with IBD and age-matched controls and identify associations between VAT and Crohn's disease (CD) outcomes...
  32. doi Fibrosis in ulcerative colitis: mechanisms, features, and consequences of a neglected problem
    Ilyssa O Gordon
    Department of Anatomic Pathology, Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio Department of Hospital Medicine, Medicine Institute, Cleveland Clinic Foundation, Cleveland, Ohio Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio and Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio
    Inflamm Bowel Dis 20:2198-206. 2014
    ..This systematic review summarizes the current knowledge of ulcerative colitis-related fibrosis, including epidemiology, basic mechanisms, histopathology, and clinical implications...
  33. ncbi CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration
    Jon D Vogel
    Division of Gastroenterology, University Hospitals of Cleveland, Case Western University School of Medicine, Cleveland, OH 44106, USA
    Gastroenterology 126:63-80. 2004
    ....
  34. ncbi One commensal bacterial molecule--all we need for health?
    Claudio Fiocchi
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, USA
    N Engl J Med 353:2078-80. 2005
  35. ncbi Intestinal fibrosis in inflammatory bowel disease - Current knowledge and future perspectives
    Florian Rieder
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, USA Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, USA
    J Crohns Colitis 2:279-90. 2008
    ..This review discusses existing and developing knowledge of intestinal fibrosis and its implications for therapy...
  36. ncbi Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospital of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    Gastroenterology 122:1334-45. 2002
    ..Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored...
  37. ncbi Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients
    Kouhei Fukushima
    Div of Gastroenterology, Univ Hospitals of Cleveland, Case Western Reserve Univ School of Medicine BRB 425 10900 Euclid Ave, Cleveland, OH 44106 4952, USA
    Am J Physiol Gastrointest Liver Physiol 286:G804-13. 2004
    ..Because comparable abnormalities are absent in active CD, the mtDNA deletion pattern of active UC suggests that colonocytes respond uniquely to inflammation-associated stress in this condition...
  38. pmc p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling
    Andreas Sturm
    Division of Gastroenterology, Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4952, USA
    J Clin Invest 109:1481-92. 2002
    ..By slowing LPT cycling, p53 may act as a negative regulator of mucosal immunity, promoting immunological tolerance by preventing excessive T cell replication...
  39. ncbi Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications
    Silvio Danese
    Catholic University of Rome, Rome, Italy
    Am J Gastroenterol 99:938-45. 2004
    ....
  40. ncbi Progress in basic inflammatory bowel disease research
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Semin Pediatr Surg 16:146-53. 2007
    ....
  41. ncbi TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease
    Silvio Danese
    Department of Internal Medicine, Catholic University, Rome, Italy
    J Immunol 176:2617-24. 2006
    ..Thus, in addition to neutralizing TNF-alpha and inducing T cell death, the therapeutic effects of infliximab in CD appear to be also mediated by inhibition of vascular inflammation in the gut...
  42. ncbi Inflammatory bowel disease-associated gene expression in intestinal epithelial cells by differential cDNA screening and mRNA display
    Kouhei Fukushima
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Inflamm Bowel Dis 9:290-301. 2003
    ....
  43. ncbi Angiogenesis as a novel component of inflammatory bowel disease pathogenesis
    Silvio Danese
    Division of Gastroenterology, Istituto Clinico Humanitas, IRCCS in Gastroenterology, Rozzano, Milan, Italy
    Gastroenterology 130:2060-73. 2006
    ..We assessed mucosal vascularization, expression of endothelial alphaVbeta3 integrin, angiogenic factors, and their bioactivity in Crohn's disease (CD) and ulcerative colitis (UC) mucosa...
  44. ncbi Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 593 Eddy St, SWP 510, Providence, RI 02903, USA
    Am J Physiol Gastrointest Liver Physiol 286:G833-43. 2004
    ..We conclude that H(2)O(2) may contribute to reduction of NKA-induced Ca(2+) release from intracellular Ca(2+) stores in UC and contribute to the observed colonic motor dysfunction...
  45. pmc Angiogenesis blockade as a new therapeutic approach to experimental colitis
    Silvio Danese
    Division of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Milan 20089, Italy
    Gut 56:855-62. 2007
    ..Neoangiogenesis is a critical component of chronic inflammatory disorders. Inhibition of angiogenesis is an effective treatment in animal models of inflammation, but has not been tested in experimental colitis...
  46. ncbi Intestinal fibroblast-derived IL-10 increases survival of mucosal T cells by inhibiting growth factor deprivation- and Fas-mediated apoptosis
    Kenji Ina
    Division of Medical Oncology, Nagoya Memorial Hospital, Nagoya University School of Medicine, Nagoya, Japan
    J Immunol 175:2000-9. 2005
    ....
  47. ncbi Dual function of the extracellular matrix: stimulatory for cell cycle progression of naive T cells and antiapoptotic for tissue-derived memory T cells
    Andreas Sturm
    Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, OH 44106, USA
    J Immunol 173:3889-900. 2004
    ..When naive PBT encounter Ag in the context of ECM, their progression through the cell cycle is enhanced, favoring clonal expansion; while tissue T cell longevity may be mediated by interactions with the ECM...
  48. ncbi Mucosal T cell proliferation and apoptosis in inflammatory bowel disease
    Andreas Sturm
    Department of Hepatology and Gastroenterology, Charite Universitatsmedizin Berlin, Campus Virchow Clinic, Augustenburger Platz 1, 13353 Berlin, Germany
    Curr Drug Targets 9:381-7. 2008
    ....
  49. ncbi Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation
    Alessandro Musso
    Division of Gastroenterology, Ospedale San Giovanni Battista, University of Torino, Torino, Italy
    Inflamm Bowel Dis 11:91-8. 2005
    ....
  50. pmc Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis
    Hu Zhang
    Department of Gastroenterology, Sichuan University West China Hospital, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 11:1775-8. 2005
    ..This study was aimed to investigate the relationship between the expression of GRalpha and GRbeta in colonic mucosal cells of patients with UC, the efficacy of GC therapy and the intensity of inflammation...
  51. ncbi Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis
    Weibiao Cao
    Department of Surgery, Brown Medical School and Rhode Island Hospital, 2 Dudley St, Suite 470, Providence, RI 02905, USA
    J Pharmacol Exp Ther 311:60-70. 2004
    ..IL-1beta reproduces these changes, possibly by production of H(2)O(2) via sequential activation of MAPKs (ERK1/ERK2) and cPLA(2)...
  52. ncbi Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis
    Weibiao Cao
    Dept of Medicine, Brown Medical School and Rhode Island Hospital, 55 Claverick St, Rm 337, Providence, RI 02903, USA
    Am J Physiol Cell Physiol 289:C1408-16. 2005
    ..Sodium nitroprusside inhibited NKA but not the caffeine-induced Ca2+ signal. We conclude that in UC the mucosa releases IL-1beta, H2O2, and NO, which may contribute to the impaired Ca2+ release and altered sigmoid muscle contractility...

Research Grants2

  1. Intl Pediatric Inflammatory Bowel Disease (IBD) Meeting
    Claudio Fiocchi; Fiscal Year: 2003
    ..abstract_text> ..
  2. MUCOSAL LYMPHOKINES IN INFLAMMATORY BOWEL DISEASE
    Claudio Fiocchi; Fiscal Year: 2008
    ..We believe this proposal provides a novel conceptual framework that will allow a more detailed and mechanistic understanding of IBD pathogenesis. ..