DONNA DRISCOLL

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Mechanism and regulation of selenoprotein synthesis
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Annu Rev Nutr 23:17-40. 2003
  2. ncbi Finding needles in a haystack. In silico identification of eukaryotic selenoprotein genes
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC-10, Cleveland, Ohio 44195, USA
    EMBO Rep 5:140-1. 2004
  3. ncbi Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes
    Laurent Chavatte
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Struct Mol Biol 12:408-16. 2005
  4. ncbi Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation
    Michael E Budiman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell 35:479-89. 2009
  5. ncbi Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:34653-62. 2007
  6. ncbi Purification and analysis of selenocysteine insertion sequence-binding protein 2
    Paul R Copeland
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Methods Enzymol 347:40-9. 2002
  7. ncbi Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    RNA Biol 6:73-83. 2009
  8. ncbi Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing
    Anuradha Mehta
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    RNA 8:69-82. 2002
  9. ncbi Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation
    Prabha Sampath
    Department of Cell Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cell 119:195-208. 2004
  10. ncbi Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression
    Angela C Miniard
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Nucleic Acids Res 38:4807-20. 2010

Research Grants

  1. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    Donna M Driscoll; Fiscal Year: 2010
  2. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    DONNA DRISCOLL; Fiscal Year: 2009
  3. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    DONNA DRISCOLL; Fiscal Year: 2007
  4. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 2004
  5. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 1999
  6. Translational Recoding of UGA as Selenocysteine in Selenoprotein Synthesis
    Donna M Driscoll; Fiscal Year: 2010

Collaborators

  • Paul Copeland
  • Jodi L Bubenik
  • Michael E Budiman
  • Carri A Gerber
  • Angela C Miniard
  • Laurent Chavatte
  • Lisa M Middleton
  • Prabha Sampath
  • Anuradha Mehta
  • Ayla Cash
  • Andrea N Ladd
  • Bernard A Brown
  • Vasudevan Seshadri
  • Sunghoon Kim
  • J David Dignam
  • Barsanjit Mazumder
  • Shu M Ting
  • Paul L Fox
  • Michael Kinter

Detail Information

Publications10

  1. ncbi Mechanism and regulation of selenoprotein synthesis
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Annu Rev Nutr 23:17-40. 2003
    ..The efficiency and regulation of mammalian selenoprotein synthesis are considered in the context of current models for Sec insertion...
  2. ncbi Finding needles in a haystack. In silico identification of eukaryotic selenoprotein genes
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC-10, Cleveland, Ohio 44195, USA
    EMBO Rep 5:140-1. 2004
  3. ncbi Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes
    Laurent Chavatte
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Struct Mol Biol 12:408-16. 2005
    ..We propose a model in which SBP2 and L30 carry out different functions in the UGA recoding mechanism, with the SECIS acting as a molecular switch upon protein binding...
  4. ncbi Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation
    Michael E Budiman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell 35:479-89. 2009
    ..Our results support a model in which eIF4a3 links selenium status with differential selenoprotein expression...
  5. ncbi Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:34653-62. 2007
    ..We hypothesize that the selective loss of a subset of selenoproteins, including some involved in thyroid hormone homeostasis, is responsible for the abnormal thyroid hormone metabolism previously observed in the affected individuals...
  6. ncbi Purification and analysis of selenocysteine insertion sequence-binding protein 2
    Paul R Copeland
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Methods Enzymol 347:40-9. 2002
  7. ncbi Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    RNA Biol 6:73-83. 2009
    ..The identification of CUG-BP1 and HuR as factors that bind to the SBP2 3' UTR suggests that TTR-RBPs play a role in the regulation of SBP2, which then dictates the expression of the selenoproteome...
  8. ncbi Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing
    Anuradha Mehta
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    RNA 8:69-82. 2002
    ..The pairwise expression of RRM1 with RRM2 or RRM3 resulted in moderate affinity binding...
  9. ncbi Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation
    Prabha Sampath
    Department of Cell Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cell 119:195-208. 2004
    ....
  10. ncbi Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression
    Angela C Miniard
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Nucleic Acids Res 38:4807-20. 2010
    ..As selenoprotein transcript levels and localization did not change in siRNA-treated cells, our results suggest that nucleolin selectively enhances the expression of a subset of selenoproteins at the translational level...

Research Grants13

  1. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    Donna M Driscoll; Fiscal Year: 2010
    ..The successful pursuit of these aims may identify limiting factors and regulatory pathways that could be used therapeutically to modulate selenoprotein expression in vivo. ..
  2. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    DONNA DRISCOLL; Fiscal Year: 2009
    ..The successful pursuit of these aims may identify limiting factors and regulatory pathways that could be used therapeutically to modulate selenoprotein expression in vivo. ..
  3. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    DONNA DRISCOLL; Fiscal Year: 2007
    ..The successful pursuit of these aims may identify limiting factors and regulatory pathways that could be used therapeutically to modulate selenoprotein expression in vivo. ..
  4. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 2004
    ..The successful pursuit of these aims should provide insight into the mechanism of apo-B mRNA editing and the function of ACF. ..
  5. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 1999
    ..Other mRNA targets of the enzyme or its subunits will be identified using tissue-specific combinatorial RNA shape libraries. The results of our studies will provide insight into the mechanism of apo-B mRNA editing. ..
  6. Translational Recoding of UGA as Selenocysteine in Selenoprotein Synthesis
    Donna M Driscoll; Fiscal Year: 2010
    ....