DONNA DRISCOLL

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Identification of nucleotides and amino acids that mediate the interaction between ribosomal protein L30 and the SECIS element
    Abby L Bifano
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Mol Biol 14:12. 2013
  2. ncbi request reprint Mechanism and regulation of selenoprotein synthesis
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Annu Rev Nutr 23:17-40. 2003
  3. pmc Finding needles in a haystack. In silico identification of eukaryotic selenoprotein genes
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC 10, Cleveland, Ohio 44195, USA
    EMBO Rep 5:140-1. 2004
  4. ncbi request reprint Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes
    Laurent Chavatte
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Struct Mol Biol 12:408-16. 2005
  5. ncbi request reprint Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:34653-62. 2007
  6. pmc Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation
    Michael E Budiman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell 35:479-89. 2009
  7. ncbi request reprint Purification and analysis of selenocysteine insertion sequence-binding protein 2
    Paul R Copeland
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Methods Enzymol 347:40-9. 2002
  8. pmc Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    RNA Biol 6:73-83. 2009
  9. ncbi request reprint Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation
    Prabha Sampath
    Department of Cell Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cell 119:195-208. 2004
  10. pmc Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression
    Angela C Miniard
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Nucleic Acids Res 38:4807-20. 2010

Collaborators

  • Paul Copeland
  • Jodi L Bubenik
  • Michael E Budiman
  • Carri A Gerber
  • Angela C Miniard
  • Abby L Bifano
  • Laurent Chavatte
  • Lisa M Middleton
  • Prabha Sampath
  • Anuradha Mehta
  • Tarik Atassi
  • Tracey Ferrara
  • Ayla Cash
  • Andrea N Ladd
  • Bernard A Brown
  • Shu M Ting
  • Paul L Fox
  • Michael Kinter
  • Vasudevan Seshadri
  • Sunghoon Kim
  • J David Dignam
  • Barsanjit Mazumder

Detail Information

Publications11

  1. pmc Identification of nucleotides and amino acids that mediate the interaction between ribosomal protein L30 and the SECIS element
    Abby L Bifano
    Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    BMC Mol Biol 14:12. 2013
    ..Previous studies showed that L30 and SBP2 compete for binding to the SECIS in vitro. The SBP2:SECIS interaction has been characterized but much less is known about how L30 recognizes the SECIS...
  2. ncbi request reprint Mechanism and regulation of selenoprotein synthesis
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Annu Rev Nutr 23:17-40. 2003
    ..The efficiency and regulation of mammalian selenoprotein synthesis are considered in the context of current models for Sec insertion...
  3. pmc Finding needles in a haystack. In silico identification of eukaryotic selenoprotein genes
    Donna M Driscoll
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, NC 10, Cleveland, Ohio 44195, USA
    EMBO Rep 5:140-1. 2004
  4. ncbi request reprint Ribosomal protein L30 is a component of the UGA-selenocysteine recoding machinery in eukaryotes
    Laurent Chavatte
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Struct Mol Biol 12:408-16. 2005
    ..We propose a model in which SBP2 and L30 carry out different functions in the UGA recoding mechanism, with the SECIS acting as a molecular switch upon protein binding...
  5. ncbi request reprint Altered RNA binding activity underlies abnormal thyroid hormone metabolism linked to a mutation in selenocysteine insertion sequence-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:34653-62. 2007
    ..We hypothesize that the selective loss of a subset of selenoproteins, including some involved in thyroid hormone homeostasis, is responsible for the abnormal thyroid hormone metabolism previously observed in the affected individuals...
  6. pmc Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation
    Michael E Budiman
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cell 35:479-89. 2009
    ..Our results support a model in which eIF4a3 links selenium status with differential selenoprotein expression...
  7. ncbi request reprint Purification and analysis of selenocysteine insertion sequence-binding protein 2
    Paul R Copeland
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Methods Enzymol 347:40-9. 2002
  8. pmc Known turnover and translation regulatory RNA-binding proteins interact with the 3' UTR of SECIS-binding protein 2
    Jodi L Bubenik
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    RNA Biol 6:73-83. 2009
    ..The identification of CUG-BP1 and HuR as factors that bind to the SBP2 3' UTR suggests that TTR-RBPs play a role in the regulation of SBP2, which then dictates the expression of the selenoproteome...
  9. ncbi request reprint Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation
    Prabha Sampath
    Department of Cell Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cell 119:195-208. 2004
    ....
  10. pmc Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression
    Angela C Miniard
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH 44195, USA
    Nucleic Acids Res 38:4807-20. 2010
    ..As selenoprotein transcript levels and localization did not change in siRNA-treated cells, our results suggest that nucleolin selectively enhances the expression of a subset of selenoproteins at the translational level...
  11. pmc Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing
    Anuradha Mehta
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    RNA 8:69-82. 2002
    ..The pairwise expression of RRM1 with RRM2 or RRM3 resulted in moderate affinity binding...

Research Grants13

  1. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    Donna M Driscoll; Fiscal Year: 2010
    ..The successful pursuit of these aims may identify limiting factors and regulatory pathways that could be used therapeutically to modulate selenoprotein expression in vivo. ..
  2. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    DONNA DRISCOLL; Fiscal Year: 2009
    ..The successful pursuit of these aims may identify limiting factors and regulatory pathways that could be used therapeutically to modulate selenoprotein expression in vivo. ..
  3. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    DONNA DRISCOLL; Fiscal Year: 2007
    ..The successful pursuit of these aims may identify limiting factors and regulatory pathways that could be used therapeutically to modulate selenoprotein expression in vivo. ..
  4. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 2004
    ..The successful pursuit of these aims should provide insight into the mechanism of apo-B mRNA editing and the function of ACF. ..
  5. EDITING OF APOLIPOPROTEIN-B MRNA
    DONNA DRISCOLL; Fiscal Year: 1999
    ..Other mRNA targets of the enzyme or its subunits will be identified using tissue-specific combinatorial RNA shape libraries. The results of our studies will provide insight into the mechanism of apo-B mRNA editing. ..
  6. Translational Recoding of UGA as Selenocysteine in Selenoprotein Synthesis
    Donna M Driscoll; Fiscal Year: 2010
    ....