F Dong

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Youth is wasted on the young
    Marc S Penn
    Skirball Laboratory for Cardiovascular Cellular Therapeutics, Cleveland Clinic, NE3, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Stem Cell Res Ther 2:24. 2011
  2. ncbi The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation
    F Dong
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 167:6447-52. 2001
  3. ncbi Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival
    F Dong
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:10811-6. 2001
  4. ncbi Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route
    R M Barge
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:2148-53. 1996
  5. pmc Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia
    F Dong
    Dr Daniel den Hoed Cancer Center, Department of Hematology, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 91:4480-4. 1994
  6. ncbi Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes
    J P de Koning
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:132-40. 1996
  7. ncbi Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    F Dong
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    N Engl J Med 333:487-93. 1995
  8. ncbi Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation
    P M Grimley
    Department of Pathology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20854, USA
    Cytokine Growth Factor Rev 10:131-57. 1999
  9. ncbi Cloning and characterization of the murine pkd2 promoter
    J H Park
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Genomics 66:305-12. 2000
  10. pmc Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor
    Y H Wang
    Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
    Br J Pharmacol 154:429-39. 2008

Collaborators

  • L Zhang
  • Wen Guo
  • J S Gutkind
  • Johannes L Bos
  • Toshio Hayashi
  • J J Davis
  • F Teraishi
  • Marc S Penn
  • Y H Wang
  • B Fang
  • Martiza E Mayorga
  • J H Park
  • P M Grimley
  • J P de Koning
  • J W Sheng
  • C X Shi
  • Y F Xu
  • L Wang
  • K Xu
  • L Ji
  • J Sasaki
  • S Wu
  • I P Touw
  • B Lowenberg
  • R M Barge
  • C Rubin
  • L Li
  • Y Cai
  • Y Maeda
  • G Wu
  • S Somlo
  • H Rui
  • K Pouwels
  • A M Schelen
  • C van Buitenen
  • B M Burgering

Detail Information

Publications12

  1. pmc Youth is wasted on the young
    Marc S Penn
    Skirball Laboratory for Cardiovascular Cellular Therapeutics, Cleveland Clinic, NE3, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Stem Cell Res Ther 2:24. 2011
    ..The present commentary reviews these results and attempts to offer perspective as to how these important findings relate to current and future strategies to prevent and treat cardiac dysfunction in clinical populations...
  2. ncbi The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation
    F Dong
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 167:6447-52. 2001
    ....
  3. ncbi Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival
    F Dong
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 276:10811-6. 2001
    ..Together, these data implicate Erk5 as an important signaling component in the biological actions of G-CSF...
  4. ncbi Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route
    R M Barge
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:2148-53. 1996
    ....
  5. pmc Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia
    F Dong
    Dr Daniel den Hoed Cancer Center, Department of Hematology, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 91:4480-4. 1994
    ..The mutant receptor chain may act in a dominant negative manner to block granulocytic maturation...
  6. ncbi Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes
    J P de Koning
    Institute of Hematology, Erasmus University, Rotterdam, The Netherlands
    Blood 87:132-40. 1996
    ..In addition, tyrosine 764 also specifically mediated binding of GRB2 to p90 without the involvement of Shc. These findings indicate that tyrosine 764 of G-CSF-R has a prominent role in G-CSF signal transduction...
  7. ncbi Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia preceded by severe congenital neutropenia
    F Dong
    Department of Hematology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    N Engl J Med 333:487-93. 1995
    ..Abnormalities in the signal-transduction pathways for granulocyte colony-stimulating factor (G-CSF) may play a part in the progression to acute myeloid leukemia...
  8. ncbi Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation
    P M Grimley
    Department of Pathology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20854, USA
    Cytokine Growth Factor Rev 10:131-57. 1999
    ....
  9. ncbi Cloning and characterization of the murine pkd2 promoter
    J H Park
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, 10461, USA
    Genomics 66:305-12. 2000
    ..A 922-bp fragment from -744 to +178 showed the highest level of CAT activity in the cell lines tested. These data define a functional promoter candidate region for Pkd2...
  10. pmc Inhibition of the rapid component of the delayed rectifier potassium current in ventricular myocytes by angiotensin II via the AT1 receptor
    Y H Wang
    Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
    Br J Pharmacol 154:429-39. 2008
    ..The rapid component of the delayed rectifier K(+) current (I(Kr)) plays a critical role in cardiac repolarization. Hence, the aim of this study was to assess the effect of Ang II on I(Kr) in guinea-pig ventricular myocytes...
  11. pmc JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells
    F Teraishi
    Department of Thoracic and Cardiovascular Surgery, Unit 445, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cell Mol Life Sci 62:2382-9. 2005
    ..Our results demonstrate that thiazolidin compounds can effectively induce G2/M arrest in cancer cells and that this G2/M arrest requires JNK activation...
  12. pmc Oncolysis and suppression of tumor growth by a GFP-expressing oncolytic adenovirus controlled by an hTERT and CMV hybrid promoter
    J J Davis
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 13:720-3. 2006
    ..Together, these results demonstrate that an hTERT-specific oncolytic adenovirus expressing an hTERT-specific transgene is applicable for cancer therapy...