Abhishek Deshpande

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 10:225-33. 2012
  2. doi request reprint Potential value of repeat stool testing for Clostridium difficile stool toxin using enzyme immunoassay?
    Abhishek Deshpande
    School of Biomedical Sciences, Kent State University, Kent, Ohio, USA
    Curr Med Res Opin 26:2635-41. 2010
  3. doi request reprint Repeat stool testing to diagnose Clostridium difficile infection using enzyme immunoassay does not increase diagnostic yield
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Ohio, USA
    Clin Gastroenterol Hepatol 9:665-669.e1. 2011
  4. doi request reprint Diagnostic accuracy of real-time polymerase chain reaction in detection of Clostridium difficile in the stool samples of patients with suspected Clostridium difficile Infection: a meta-analysis
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Neurological Institute, Desk S60, 9500 Euclid Ave, Cleveland Clinic, Cleveland, OH USA
    Clin Infect Dis 53:e81-90. 2011
  5. ncbi request reprint Repeat stool testing for Clostridium difficile using enzyme immunoassay in patients with inflammatory bowel disease increases diagnostic yield
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Cleveland, OH 44106 4984, USA
    Curr Med Res Opin 28:1553-60. 2012
  6. doi request reprint Community-associated Clostridium difficile infection and antibiotics: a meta-analysis
    Abhishek Deshpande
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Antimicrob Chemother 68:1951-61. 2013
  7. doi request reprint Dissociation between vascular endothelial growth factor receptor-2 and blood vessel density in the caudate nucleus after chronic hydrocephalus
    Abhishek Deshpande
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 29:1806-15. 2009
  8. doi request reprint Vascular endothelial growth factor in the CSF of elderly patients with ventriculomegaly: variability, periodicity and levels in drainage responders and non-responders
    Jun Yang
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, S 60, 9500 Euclid Avenue, Cleveland 44195, USA
    Clin Neurol Neurosurg 115:1729-34. 2013
  9. doi request reprint Accuracy of loop-mediated isothermal amplification for the diagnosis of Clostridium difficile infection: a systematic review
    Aaron Lloyd
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Diagn Microbiol Infect Dis 82:4-10. 2015
  10. doi request reprint Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis
    Abhishek Deshpande
    1Medicine Institute Center for Value Based Care Research, Cleveland Clinic, Cleveland, Ohio
    Infect Control Hosp Epidemiol 36:452-60. 2015

Collaborators

Detail Information

Publications33

  1. doi request reprint Association between proton pump inhibitor therapy and Clostridium difficile infection in a meta-analysis
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 10:225-33. 2012
    ..During this time, use of proton pump inhibitors (PPIs) has increased exponentially. We evaluated the association between PPI therapy and the risk of CDI by performing a meta-analysis...
  2. doi request reprint Potential value of repeat stool testing for Clostridium difficile stool toxin using enzyme immunoassay?
    Abhishek Deshpande
    School of Biomedical Sciences, Kent State University, Kent, Ohio, USA
    Curr Med Res Opin 26:2635-41. 2010
    ..difficile) toxin using an enzyme immunoassay (EIA) for toxin A&B and also propose a potential newer algorithm for diagnosing C. difficile...
  3. doi request reprint Repeat stool testing to diagnose Clostridium difficile infection using enzyme immunoassay does not increase diagnostic yield
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Cleveland Clinic, Ohio, USA
    Clin Gastroenterol Hepatol 9:665-669.e1. 2011
    ..We investigated whether repeat stool testing significantly improves the diagnostic yield for CDI...
  4. doi request reprint Diagnostic accuracy of real-time polymerase chain reaction in detection of Clostridium difficile in the stool samples of patients with suspected Clostridium difficile Infection: a meta-analysis
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Neurological Institute, Desk S60, 9500 Euclid Ave, Cleveland Clinic, Cleveland, OH USA
    Clin Infect Dis 53:e81-90. 2011
    ..Real-time polymerase chain reaction (PCR) may allow earlier and more accurate diagnosis of CDI than other currently available diagnostic tests. A meta-analysis was performed to determine the diagnostic accuracy of real-time PCR...
  5. ncbi request reprint Repeat stool testing for Clostridium difficile using enzyme immunoassay in patients with inflammatory bowel disease increases diagnostic yield
    Abhishek Deshpande
    Department of Neurological Surgery, Neurological Institute, Cleveland, OH 44106 4984, USA
    Curr Med Res Opin 28:1553-60. 2012
    ..We investigated whether repeat stool testing improves diagnostic accuracy for CDI in hospitalized IBD patients compared to hospitalized patients with CDI and no IBD...
  6. doi request reprint Community-associated Clostridium difficile infection and antibiotics: a meta-analysis
    Abhishek Deshpande
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Antimicrob Chemother 68:1951-61. 2013
    ..e. symptom onset in the community with no healthcare facility admission within 12 weeks) and to determine the classes of antibiotics posing the greatest risk...
  7. doi request reprint Dissociation between vascular endothelial growth factor receptor-2 and blood vessel density in the caudate nucleus after chronic hydrocephalus
    Abhishek Deshpande
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Cereb Blood Flow Metab 29:1806-15. 2009
    ..These observed findings suggest that destructive forces may outweigh angiogenic forces and possibly show a disassociation between VEGFR-2 and BV expressions...
  8. doi request reprint Vascular endothelial growth factor in the CSF of elderly patients with ventriculomegaly: variability, periodicity and levels in drainage responders and non-responders
    Jun Yang
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, S 60, 9500 Euclid Avenue, Cleveland 44195, USA
    Clin Neurol Neurosurg 115:1729-34. 2013
    ..The aim of this study was to examine lumbar CSF-VEGF levels from elderly patients with ventriculomegaly to evaluate the possible circadian or periodic concentration profile and relevance to the prediction of drainage response...
  9. doi request reprint Accuracy of loop-mediated isothermal amplification for the diagnosis of Clostridium difficile infection: a systematic review
    Aaron Lloyd
    Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Diagn Microbiol Infect Dis 82:4-10. 2015
    ..99 (95% CI, 0.96-1.00; I(2)=97.0). LAMP is a useful diagnostic tool with high sensitivity and specificity for detecting CDI. The results should, however, be interpreted only in the presence of clinical suspicion and symptoms of CDI. ..
  10. doi request reprint Risk factors for recurrent Clostridium difficile infection: a systematic review and meta-analysis
    Abhishek Deshpande
    1Medicine Institute Center for Value Based Care Research, Cleveland Clinic, Cleveland, Ohio
    Infect Control Hosp Epidemiol 36:452-60. 2015
    ..While the actual mechanism of recurrence remains unknown, a variety of risk factors have been suggested and studied. The aim of this systematic review and meta-analysis was to evaluate current evidence on the risk factors for rCDI...
  11. doi request reprint Evaluation of a sporicidal peracetic acid/hydrogen peroxide-based daily disinfectant cleaner
    Abhishek Deshpande
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio
    Infect Control Hosp Epidemiol 35:1414-6. 2014
    ..OxyCide was minimally affected by organic load and was effective in reducing pathogen contamination in isolation rooms. ..
  12. pmc Outpatient healthcare settings and transmission of Clostridium difficile
    Lucy A Jury
    Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 8:e70175. 2013
    ..e., no healthcare facility admission within 90 days) may be increasing in frequency. We hypothesized that outpatient clinics could be an important source for acquisition of community-associated CDI...
  13. doi request reprint Acid-suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: a meta-analysis
    Abhishek Deshpande
    Department of Medicine, Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio 44106 4984, USA
    J Gastroenterol Hepatol 28:235-42. 2013
    ..The aim of this meta-analysis was to evaluate the association between acid-suppressive therapy and the risk of SBP in hospitalized patients with cirrhosis...
  14. doi request reprint Appropriateness of empiric therapy in patients with suspected Clostridium difficile infection
    Elie Saade
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Curr Med Res Opin 29:985-8. 2013
    ..The objective of this study was to test the hypothesis that many patients with suspected Clostridium difficile infection (CDI) receive inappropriate empiric therapy and/or receive continued therapy despite negative test results...
  15. doi request reprint Clostridium difficile infection in the hospitalized pediatric population: increasing trend in disease incidence
    Abhishek Deshpande
    From the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK Research Service, Cleveland Veterans Affairs Medical Center and Department of Pediatrics, Case Western Reserve University School of Medicine, UH Rainbow Babies and Children s Hospital, Cleveland, OH
    Pediatr Infect Dis J 32:1138-40. 2013
    ..For the period of 2003 to 2009, we found an increasing trend in the incidence of C. difficile infection. These data suggest greater effort be given to prevent and treat this infection in children. ..
  16. doi request reprint An environmental disinfection odyssey: evaluation of sequential interventions to improve disinfection of Clostridium difficile isolation rooms
    Brett Sitzlar
    Case Western Reserve University School of Medicine, Cleveland, Ohio
    Infect Control Hosp Epidemiol 34:459-65. 2013
    ..Culturing of CDI rooms provides a valuable tool to drive improvements in environmental disinfection...
  17. doi request reprint Stability analysis of vascular endothelial growth factor in cerebrospinal fluid
    Jun Yang
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, S 60, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Neurochem Res 36:1947-54. 2011
    ..After centrifugation to remove cellular contents, VEGF in CSF was relatively stable during routine experimental procedures and storage...
  18. ncbi request reprint Do fluoroquinolones predispose patients to Clostridium difficile associated disease? A review of the evidence
    Abhishek Deshpande
    Cleveland Clinic, Cleveland, OH, USA
    Curr Med Res Opin 24:329-33. 2008
    ..The data suggesting that fluoroquinolones are an important risk factor for CDAD is becoming stronger. Also, different fluoroquinolones may pose different risks for CDAD development...
  19. pmc Acute endovascular reperfusion therapy in ischemic stroke: a systematic review and meta-analysis of randomized controlled trials
    Toshiya Osanai
    Cerebrovascular Center, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 10:e0122806. 2015
    ..Randomized controlled trials (RCTs) of endovascular therapy for acute ischemic stroke have had inconsistent results. We evaluated the efficacy and safety of endovascular therapy in published RCTs...
  20. pmc Sensitive and selective culture medium for detection of environmental Clostridium difficile isolates without requirement for anaerobic culture conditions
    Jennifer L Cadnum
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Microbiol 52:3259-63. 2014
    ..Our results suggest that CDBB-TC provides a sensitive and selective medium for the recovery of C. difficile organisms from environmental samples, without the need for anaerobic culture conditions. ..
  21. doi request reprint Trends in endoscopic retrograde cholangiopancreatography in children within the United States, 2000-2009
    Chaitanya Pant
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH Department of Medicine, Louisiana State University Health Sciences Center, New Orleans Department of Medicine, Baylor College of Medicine, Houston, TX Department of Medicine, University of Kansas Medical Center, Kansas City Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City
    J Pediatr Gastroenterol Nutr 59:57-60. 2014
    ..001 for each analysis). Our results define a recent increase in the use of therapeutic ERCPs in hospitalized children...
  22. pmc Association between insulin resistance and breast carcinoma: a systematic review and meta-analysis
    Adrian V Hernandez
    Instituto Médico de la Mujer Instituto Médico Metabólico, Lima, Peru Postgraduate and Medical Schools, Universidad Peruana de Ciencias Aplicadas UPC, Lima, Peru Health Outcomes and Clinical Epidemiology Section, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 9:e99317. 2014
    ..This study was undertaken to evaluate the association between components defining insulin resistance and breast cancer in women...
  23. pmc Efficacy of 5-nitroimidazoles for the treatment of giardiasis: a systematic review of randomized controlled trials
    Vinay Pasupuleti
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Negl Trop Dis 8:e2733. 2014
    ..We evaluated the efficacy of 5-nitroimidazoles (5-NI) in the treatment of giardiasis in a systematic review of randomized controlled trials (RCTs)...
  24. doi request reprint Potential for transmission of spores by patients awaiting laboratory testing to confirm suspected Clostridium difficile infection
    Venkata C K Sunkesula
    Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 34:306-8. 2013
    ..Preemptive isolation of patients with suspected CDI may reduce the risk of transmission...
  25. pmc Deficient reporting and interpretation of non-inferiority randomized clinical trials in HIV patients: a systematic review
    Adrian V Hernandez
    Health Outcomes and Clinical Epidemiology Section, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 8:e63272. 2013
    ..We evaluated the reporting of NI RCTs in HIV patients according to the CONSORT statement and assessed the degree of misinterpretation of RCTs when NI was inconclusive or not established...
  26. doi request reprint Emergency department visits related to cirrhosis: a retrospective study of the nationwide emergency department sample 2006 to 2011
    Chaitanya Pant
    From the Division of Gastroenterology, Hepatology and Motility, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS CP, MO, RG, PKP, JCO, MOV, TR and Medicine Institute Center for Value Based Care Research, Cleveland Clinic, Cleveland, OH AD
    Medicine (Baltimore) 94:e308. 2015
    ..Further studies are required to investigate the increased incidence of spontaneous bacterial peritonitis and hepatorenal renal syndrome in the cirrhotic population. ..
  27. pmc Metabolomics analysis identifies intestinal microbiota-derived biomarkers of colonization resistance in clindamycin-treated mice
    Robin L P Jump
    Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 9:e101267. 2014
    ..We used a mouse model to test the hypothesis that alterations in levels of bacterial metabolites in fecal specimens could provide useful biomarkers indicating disrupted or intact colonization resistance after antibiotic treatment...
  28. pmc Pseudo-outbreak of Klebsiella oxytoca spontaneous bacterial peritonitis attributed to contamination of multidose vials of culture medium supplement
    Federico Perez
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio
    Infect Control Hosp Epidemiol 35:139-43. 2014
    ..To determine the source of a cluster of Klebsiella oxytoca isolates cultured from peritoneal fluid of 3 patients with cirrhosis on a single day...
  29. pmc Effect of rural-to-urban within-country migration on cardiovascular risk factors in low- and middle-income countries: a systematic review
    Adrian V Hernandez
    Health Outcomes and Clinical Epidemiology Section, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, OH 44195, USA
    Heart 98:185-94. 2012
    ..Limited information is available of effects of rural-to-urban within-country migration on cardiovascular (CV) risk factors in low- and middle- income countries (LMIC)...
  30. doi request reprint Statin Therapy and Mortality from Sepsis: A Meta-analysis of Randomized Trials
    Abhishek Deshpande
    Medicine Institute Center for Value Based Care, Cleveland Clinic, Cleveland, Ohio Department of Infectious Diseases, Medicine Institute, Cleveland Clinic, Cleveland, Ohio Department of Medicine, Case Western Reserve University, Cleveland, Ohio Electronic address
    Am J Med 128:410-417.e1. 2015
    ..However, randomized controlled trials have not demonstrated this benefit. We conducted a systematic review and meta-analysis of randomized trials to evaluate the effect of statin therapy on mortality in patients with sepsis...
  31. doi request reprint Clostridium difficile infection is associated with poor outcomes in end-stage renal disease
    Chaitanya Pant
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Investig Med 60:529-32. 2012
    ..To investigate the association of Clostridium difficile infection (CDI) with the outcomes of hospitalized patients with end-stage renal disease (ESRD)...
  32. doi request reprint Pulmonary hypertension: an important predictor of outcomes in patients undergoing non-cardiac surgery
    Roop Kaw
    Department of Hospital Medicine, Medicine Institute, Cleveland Clinic Lerner College of Medicine, Desk A13, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Respir Med 105:619-24. 2011
    ..We report perioperative outcomes in a large cohort of patients undergoing NCS, comparing those with and without PH...
  33. pmc VEGF/VEGFR-2 changes in frontal cortex, choroid plexus, and CSF after chronic obstructive hydrocephalus
    Jun Yang
    Department of Neurological Surgery, Section of Pediatric and Congenital Neurological Surgery, CSF Physiology Laboratory, Neurological Institute, Cleveland Clinic, S 60, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Neurol Sci 296:39-46. 2010
    ....