KATHLEEN ANNE DERWIN
Affiliation: Cleveland Clinic Foundation
- Regional variability, processing methods, and biophysical properties of human fascia lata extracellular matrixKathleen A Derwin
Department of Biomedical Engineering, Lerner Research Institute and Orthopaedic Research Center, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Biomed Mater Res A 84:500-7. 2008..001). The mechanical, chemical and ultrastructural similarities between fascia lata and tendon may make fresh or processed fascia an attractive ECM scaffold for soft tissue, particularly tendon, repair...
- Low-dose CT imaging of radio-opaque markers for assessing human rotator cuff repair: accuracy, repeatability and the effect of arm positionK A Derwin
Department of Biomedical Engineering and Orthopedic and Rheumatologic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
J Biomech 45:614-8. 2012..8 to -1.6 mm (RMS 1.3 mm). We conclude that a range of ± 3 mm is a conservative estimate of the uncertainty in anchor-to-bead distance for patients repeatedly scanned in clinically-relevant arm positions...
- Preclinical models for translating regenerative medicine therapies for rotator cuff repairKathleen A Derwin
Department of Biomedical Engineering, Orthopaedic Research Center, Cleveland Clinic, Cleveland, Ohio 44122, USA
Tissue Eng Part B Rev 16:21-30. 2010....
- Rotator cuff repair augmentation in a canine model with use of a woven poly-L-lactide deviceKathleen A Derwin
Department of Biomedical Engineering, ND2 20, Cleveland Clinic, Cleveland, OH 44122, USA
J Bone Joint Surg Am 91:1159-71. 2009..The purpose of this study was to evaluate the extent to which augmentation of acute repair of rotator cuff tendons with a newly designed poly-L-lactide repair device would improve functional and biomechanical outcomes in a canine model...
- Assessment of the canine model of rotator cuff injury and repairKathleen A Derwin
Department of Biomedical Engineering, Lerner Research Institute and Orthopaedic Research Center, The Cleveland Clinic, Cleveland, OH 44195, USA
J Shoulder Elbow Surg 16:S140-8. 2007..Thus a partial-width injury in the canine may model the mechanical environment of many single tendon tears in the human injury condition and warrants further investigation...
- Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular propertiesKathleen A Derwin
Department of Biomedical Engineering, ND 20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Bone Joint Surg Am 88:2665-72. 2006..In this study, the properties of GraftJacket, TissueMend, Restore, and CuffPatch were quantified and compared with each other. The elastic moduli were also compared with that of normal canine infraspinatus tendon...
- Extracellular matrix scaffold devices for rotator cuff repairKathleen A Derwin
Department of Biomedical Engineering, Orthopaedic Research Center, Cleveland Clinic, Cleveland, OH 44195, USA
J Shoulder Elbow Surg 19:467-76. 2010..We will then discuss the implications of these data on the future directions for use of these scaffolds in tendon repair procedures...
- Mechanical conditioning of cell-seeded small intestine submucosa: a potential tissue-engineering strategy for tendon repairCaroline Androjna
The Cleveland Clinic, Department of Biomedical Engineering, Cleveland, Ohio 44195, USA
Tissue Eng 13:233-43. 2007..These data provide the basis for future studies investigating in vitro conditioning (mechanical, chemical) of cell-seeded ECM scaffolds and the use of such constructs for enhancing tendon repair in vivo...
- Oxygen diffusion through natural extracellular matrices: implications for estimating "critical thickness" values in tendon tissue engineeringCaroline Androjna
Department of Biomedical Engineering, The Cleveland Clinic, Cleveland, Ohio 44195, USA
Tissue Eng Part A 14:559-69. 2008..We used the experimental oxygen diffusivity data for these natural ECMs in a mathematical model of oxygen diffusion through a cell-seeded scaffold to estimate the critical size of cell-seeded scaffold that can be cultured in vitro...
- Improved time-zero biomechanical properties using poly-L-lactic acid graft augmentation in a cadaveric rotator cuff repair modelJesse A McCarron
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
J Shoulder Elbow Surg 19:688-96. 2010..This study was designed to determine whether application of a woven poly-L-lactic acid device (X-Repair; Synthasome, San Diego, CA) would improve the mechanical properties of rotator cuff repair in vitro...
- Changes in rotator cuff muscle volume, fat content, and passive mechanics after chronic detachment in a canine modelOri Safran
Department of Orthopaedic Surgery and the Orthopaedic Research Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
J Bone Joint Surg Am 87:2662-70. 2005..We hypothesized that infraspinatus muscle stiffness would increase, volume would decrease, and fat content would increase at twelve weeks following tendon detachment...
- Effect of altered mechanical load conditions on the structure and function of cultured tendon fasciclesEduardo L Abreu
Department of Orthopaedic Surgery, Children s Hospital of Boston, 300 Longwood Avenue, Enders 1022, Boston, Massachusetts 02115, USA
J Orthop Res 26:364-73. 2008..Together these results suggest a role for GAG but not collagen or water in the elastic and viscoelastic changes measured in tendon fascicles cultured for 1 week under altered load conditions...
- Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorinPaul S Robinson
McKay Orthopaedic Research Laboratory, University of Pennsylvania, 3450 Hamilton Walk, 424 Stemmler Hall, Philadelphia, PA 19104 6081, USA
J Biomech Eng 126:252-7. 2004..This study provides quantitative evidence for structure-function relationships in tendon, including the role of proteoglycan in viscoelasticity...
- Rotator cuff repair using hyaluronan enriched fascia extracellular matrixKATHLEEN ANNE DERWIN; Fiscal Year: 2010....
- A role for intrinsic tendon cells in overuse injuryKathleen Derwin; Fiscal Year: 2005..A role for intrinsic tendon cells in the pathogenesis of tendon overuse injury would be implied by a lower damage threshold in vital tendon. ..
- Clinically relevant large animal model of rotator cuff injury and repairKathleen Derwin; Fiscal Year: 2007..Successful development of this model would lead to important studies of critical factors thought to affect the outcome of this common clinical problem such as surgical technique, tear morphology and timing. ..
- Rotator cuff repair using hyaluronan enriched fascia extracellular matrixKathleen Derwin; Fiscal Year: 2009....