M P Davis

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint The importance of cytochrome P450 monooxygenase CYP2D6 in palliative medicine
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Support Care Cancer 9:442-51. 2001
  2. ncbi request reprint Buprenorphine in cancer pain
    Mellar P Davis
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Support Care Cancer 13:878-87. 2005
  3. doi request reprint Fighting insomnia and battling lethargy: the yin and yang of palliative care
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine Case Western Reserve University, Cleveland, USA
    Curr Oncol Rep 16:377. 2014
  4. doi request reprint Oxycodone combined with opioid receptor antagonists: efficacy and safety
    Mellar Davis
    Taussig Cancer Institute, Cleveland Clinic, Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Expert Opin Drug Saf 12:389-402. 2013
  5. doi request reprint Reconstructing analgesic trials: reasons for following the lead of oncologists
    Mellar P Davis
    Clinical Fellowship Program, Division of Solid Tumor, Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, Palliative Medicine and Supportive Oncology Services, Cleveland Clinic, Cleveland, Ohio, USA
    Curr Opin Support Palliat Care 6:490-3. 2012
  6. doi request reprint Topics in research: structuring studies in palliative care
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Curr Opin Support Palliat Care 6:483-9. 2012
  7. doi request reprint Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine at Case Western University, OH 44195, USA
    J Support Oncol 10:209-19. 2012
  8. ncbi request reprint Opioid receptor targeting ligands for pain management: a review and update
    Mellar P Davis
    Department of Solid Tumor Oncology, The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA 1 216 444 7793 1 216 636 3179
    Expert Opin Drug Discov 5:1007-22. 2010
  9. doi request reprint The emerging role of palliative medicine in the treatment of lung cancer patients
    Mellar P Davis
    Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cleve Clin J Med 79:eS51-5. 2012
  10. doi request reprint Evidence from basic research for opioid combinations
    Mellar P Davis
    Taussig Cancer Institute, Case Western Reserve University, Lerner School of Medicine, Cleveland Clinic, Palliative Medicine and Supportive Oncology Services, Cleveland, OH 44195, USA
    Expert Opin Drug Discov 7:165-78. 2012

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint The importance of cytochrome P450 monooxygenase CYP2D6 in palliative medicine
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Support Care Cancer 9:442-51. 2001
    ..Clinically important drug interactions, which may be anticipated in the palliative medicine population, are reviewed...
  2. ncbi request reprint Buprenorphine in cancer pain
    Mellar P Davis
    Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Support Care Cancer 13:878-87. 2005
    ..Buprenorphine has been used extensively to control cancer pain. In certain clinical situations, buprenorphine may have particular advantages over other opioids...
  3. doi request reprint Fighting insomnia and battling lethargy: the yin and yang of palliative care
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine Case Western Reserve University, Cleveland, USA
    Curr Oncol Rep 16:377. 2014
    ..Treatment approaches for insomnia and fatigue are also discussed and reviewed, including the role of hypnotics, psychotropics, hormonal agents, and alternative therapies. ..
  4. doi request reprint Oxycodone combined with opioid receptor antagonists: efficacy and safety
    Mellar Davis
    Taussig Cancer Institute, Cleveland Clinic, Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Expert Opin Drug Saf 12:389-402. 2013
    ..A mu receptor antagonist combined with oxycodone (OXY) may improve pain control, reduce physical tolerance and withdrawal, minimizing opioid-related bowel dysfunction and act as an abuse deterrent...
  5. doi request reprint Reconstructing analgesic trials: reasons for following the lead of oncologists
    Mellar P Davis
    Clinical Fellowship Program, Division of Solid Tumor, Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, Palliative Medicine and Supportive Oncology Services, Cleveland Clinic, Cleveland, Ohio, USA
    Curr Opin Support Palliat Care 6:490-3. 2012
    ..Changes in drug trial designs in oncology, which involve targeted therapies and well genotyped cancers have important implications to the present trial designs used for analgesic development...
  6. doi request reprint Topics in research: structuring studies in palliative care
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Curr Opin Support Palliat Care 6:483-9. 2012
    ..This review describes the advances in trial methodology and presents new methodologies to meet some of the challenges of conducting trials in a palliative care setting. To describe why this review is timely and relevant...
  7. doi request reprint Twelve reasons for considering buprenorphine as a frontline analgesic in the management of pain
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine at Case Western University, OH 44195, USA
    J Support Oncol 10:209-19. 2012
    ..In light of evidence for efficacy, safety, versatility, and cost, buprenorphine should be considered as a first-line analgesic...
  8. ncbi request reprint Opioid receptor targeting ligands for pain management: a review and update
    Mellar P Davis
    Department of Solid Tumor Oncology, The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, 9500 Euclid Avenue R35, Cleveland, OH 44195, USA 1 216 444 7793 1 216 636 3179
    Expert Opin Drug Discov 5:1007-22. 2010
    ..These new opioid ligands are reviewed in detail. Take home message: Modified opioid peptides and MDL ligands are potentially better analgesics than morphine...
  9. doi request reprint The emerging role of palliative medicine in the treatment of lung cancer patients
    Mellar P Davis
    Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cleve Clin J Med 79:eS51-5. 2012
    ..Buprenorphine is a unique opioid with activity at mu and nociceptin receptors (also called opioid-receptor-like receptors); it improves pain states dominated by central sensitization...
  10. doi request reprint Evidence from basic research for opioid combinations
    Mellar P Davis
    Taussig Cancer Institute, Case Western Reserve University, Lerner School of Medicine, Cleveland Clinic, Palliative Medicine and Supportive Oncology Services, Cleveland, OH 44195, USA
    Expert Opin Drug Discov 7:165-78. 2012
    ..Basic science research has accumulated evidence that opioid combinations in animal models and in vitro have potential to improve the therapeutic index of opioids and/or prevent opioid tolerance...
  11. ncbi request reprint Management of fatigue in cancer patients
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic, 9500 Euclid Avenue, R35, Cleveland, OH 44195, USA
    Curr Pain Headache Rep 10:260-9. 2006
    ..Advances in the management of CRF will require an understanding of the underlying mechanism before target-specific therapies can be developed...
  12. doi request reprint A systematic review of the treatment of nausea and/or vomiting in cancer unrelated to chemotherapy or radiation
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Division of Solid Tumor, The Taussig Cancer Center, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Pain Symptom Manage 39:756-67. 2010
    ..Therefore, a systematic review based on the question "What is the evidence that supports antiemetic choices in advanced cancer?" guided this review...
  13. ncbi request reprint Controversies in pharmacotherapy of pain management
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, 9500 Euclid Avenue, R35, Cleveland, OH 44195, USA
    Lancet Oncol 6:696-704. 2005
    ....
  14. ncbi request reprint Look before leaping: combined opioids may not be the rave
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH, USA
    Support Care Cancer 13:769-74. 2005
    ..Opioid combinations should not be used until prospective randomized trials clarify the benefits and safety...
  15. ncbi request reprint Cancer pain: how to measure the fifth vital sign
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 71:625-32. 2004
    ..Outpatient pain diaries and hospital recordings of pain severity with the vital signs facilitate communication. Part of the goal should be to improve function and quality of life...
  16. ncbi request reprint Opioid dose titration for severe cancer pain: a systematic evidence-based review
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland, Ohio, USA
    J Palliat Med 7:462-8. 2004
    ..The studies all suffered significant methodological problems limiting broad conclusions. Until better data exist, opioid dose titration for severe/crescendo pain will be guided by expert opinion and experience...
  17. ncbi request reprint Appetite and cancer-associated anorexia: a review
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Department of Hematology Medical Oncology, FCCP, Cleveland Clinic Foundation, 9500 Euclid Avenue, R35, Cleveland, OH 44195, USA
    J Clin Oncol 22:1510-7. 2004
    ..There have been few clinical trials and very little translational research on anorexia despite its prevalence in cancer...
  18. ncbi request reprint What is new in neuropathic pain?
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Health System, 9500 Euclid Avenue, R35, Cleveland, OH 44195, USA
    Support Care Cancer 15:363-72. 2007
    ..Neuropathic pain occurs in 1% of the population and is difficult to manage. Responses to single drugs are limited in benefit. Thirty percent will fail to respond altogether. This is a review of newer drugs and treatment paradigms...
  19. ncbi request reprint The emerging role of cannabinoid neuromodulators in symptom management
    Mellar Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Support Care Cancer 15:63-71. 2007
    ..The cannabinoids nabilone (Cesamet) and dronabinol (Marinol) are indicated for the management of chemotherapy-induced nausea and vomiting (CINV) in cancer patients who have failed to respond adequately to conventional antiemetic therapy...
  20. ncbi request reprint Cholestasis and endogenous opioids: liver disease and exogenous opioid pharmacokinetics
    Mellar Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Pharmacokinet 46:825-50. 2007
    ..Exogenous opioid pharmacology is altered by liver disease. Dose reduction or prolongation of dose intervals is necessary depending on the severity of liver disease...
  21. doi request reprint Fentanyl for breakthrough pain: a systematic review
    Mellar P Davis
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, The Harry R Horvitz Center for Palliative Medicine, Cleveland, OH 44195, USA
    Expert Rev Neurother 11:1197-216. 2011
    ..OTFC and INFS have been used effectively to reduce acute pain in children who are opioid-naive. Abuse and addiction to OTFC, fentanyl buccal tablets and INFS was low, owing to patient selection...
  22. ncbi request reprint Mechanisms of fatigue
    Mellar P Davis
    Lerner Medical College, Cleveland Clinic, Case Western Reserve University, Cleveland, Ohio 44195, USA
    J Support Oncol 8:164-74. 2010
    ..This state-of-the-art review discusses these physiologic correlates of fatigue and the mechanisms described in a variety of chronic diseases...
  23. doi request reprint Recent development in therapeutics for breakthrough pain
    Mellar P Davis
    Cleveland Clinic Lerner School of Medicine, Case Western Reserve University, The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Expert Rev Neurother 10:757-73. 2010
    ..Nonpharmacological approaches to managing activity-related pain include radiation therapy, surgical correction of impending fractures, kyphoplasty and radioisotopes...
  24. doi request reprint Does palliative sedation always relieve symptoms?
    Mellar P Davis
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve, Cleveland, OH 44195, USA
    J Palliat Med 12:875-7. 2009
    ..Seventeen percent of individuals who undergo palliative sedation fail to have symptoms relieved by sedation. Routine use of sedation scales should be used during palliative sedation to minimize treatment failure...
  25. doi request reprint Bioelectrical impedance phase angle changes during hydration and prognosis in advanced cancer
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Center, Cleveland Clinic, Ohio 44195, USA
    Am J Hosp Palliat Care 26:180-7. 2009
    ..We wished to determine bioelectrical impedance (BIA) correlates before hydration or changes during hydration and determine if these changes were prognostically important...
  26. ncbi request reprint Oral nabilone capsules in the treatment of chemotherapy-induced nausea and vomiting and pain
    Mellar P Davis
    Director of Research The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, R35, Cleveland OH 44195, USA
    Expert Opin Investig Drugs 17:85-95. 2008
    ..Nabilone has been approved to treat chemotherapy-induced nausea and vomiting. Recent studies have explored cannabinoids in pain management...
  27. ncbi request reprint Practical guide to opioids and their complications in managing cancer pain. What oncologists need to know
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic, Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Oncology (Williston Park) 21:1229-38; discussion 1238-46, 1249. 2007
    ....
  28. ncbi request reprint When opioids cause pain
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Health Systems, Cleveland, OH, USA
    J Clin Oncol 25:4497-8. 2007
  29. ncbi request reprint Just whose autonomy is it?
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 21:67s-69s. 2003
  30. ncbi request reprint Management of symptoms associated with advanced cancer: olanzapine and mirtazapine. A World Health Organization project
    Mellar P Davis
    Harry R Horvtiz Center for Palliative Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Expert Rev Anticancer Ther 2:365-76. 2002
    ..The pharmacokinetics and pharmacodynamics of both agents are unique and explain many of the benefits. More research and clinical experience will be necessary to define their role in the palliation of advanced cancer...
  31. ncbi request reprint Modern management of cancer-related intestinal obstruction
    M P Davis
    Harry R Horvitz Center for Palliative Medicine A World Health Organization Demonstration Project
    Curr Pain Headache Rep 5:257-64. 2001
    ..Octreotide, either alone or added to the original regimen, will palliate symptoms that are resistant to the three-drug combination...
  32. ncbi request reprint Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Support Care Cancer 9:73-83. 2001
    ..Several guidelines of administration have been established. Physicians who are involved in pain management should have a fundamental understanding of methadone's unique properties...
  33. ncbi request reprint Modern management of cancer-related intestinal obstruction
    M P Davis
    Harry R Horvitz Center for Palliative Medicine A World Health Organization Demonstration Project, Taussig Cancer Center of The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Oncol Rep 2:343-50. 2000
    ..Octreotide, either alone or added to the original regimen, will palliate symptoms that are resistant to the three-drug combination...
  34. ncbi request reprint Treatment of nausea and vomiting in advanced cancer
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Ohio 44195, USA
    Support Care Cancer 8:444-52. 2000
    ..Classes of agents are discussed, pharmacology and cost being among the aspects covered. A four-step approach to the medical management of nausea and vomiting is presented...
  35. ncbi request reprint Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, 9500 Euclid Avenue R35, Cleveland OH 44195, USA
    Support Care Cancer 10:117-38. 2002
    ..In this review the pharmacology of rectally administered palliative medications is reviewed and the use of individual drugs is outlined...
  36. ncbi request reprint Normal-release and controlled-release oxycodone: pharmacokinetics, pharmacodynamics, and controversy
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH 44195, USA
    Support Care Cancer 11:84-92. 2003
    ..Oxycodone's kappa receptor binding has little role in abuse or addiction. The cost of CR oxycodone is prohibitive for most American hospices...
  37. ncbi request reprint Demographics, assessment and management of pain in the elderly
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Drugs Aging 20:23-57. 2003
    ..Selection of the appropriate analgesics is also influenced by versatility, polypharmacy, severity and type of pain, drug availability, associated symptoms and cost...
  38. ncbi request reprint Methylphenidate for fatigue in advanced cancer: a prospective open-label pilot study
    N Sarhill
    Harry R. Horvitz Center for Palliative Medicine, World Health Organization Demonstration Project in Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:187-92. 2001
    ..A rapid onset of benefit was noted, even in the presence of mild anemia. Sedation and pain also improved in some. Only one patient had side effects severe enough to stop the medication...
  39. ncbi request reprint Olanzapine: another psychotropic?
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:129-32. 2001
    ..Reduced hospitalizations, at least in the psychiatric patient, may offset the drug cost...
  40. ncbi request reprint Methadone-induced myoclonus in advanced cancer
    N Sarhill
    Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:51-3. 2001
    ..A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. This has rarely been reported before in the literature. The pathophysiology and management of myoclonus are discussed...
  41. ncbi request reprint Dying at home: emergency medications for terminal symptoms
    S B LeGrand
    Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Ohio, USA
    Am J Hosp Palliat Care 18:421-3. 2001
    ..This innovation has been in place for more than two years at the Hospice of the Cleveland Clinic. There is no previously published information on this innovation in the literature...
  42. ncbi request reprint Thalidomide: dual benefits in palliative medicine and oncology
    M P Davis
    Harry R. Horvitz Center for Palliative Medicine (A World Health Organization Demonstration Project, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:347-51. 2001
    ..Since certain cytokines also promote tumor growth, we may have a class of agents with palliative and anti-tumor benefits in combination with anti-neoplastics and anti-cytokines, such as thalidomide...
  43. doi request reprint Nausea and vomiting in advanced cancer
    Sik Kim Ang
    Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 27:219-25. 2010
    ..Venting gastrostomy, octreotide, and corticosteroids will reduce nausea and vomiting associated with malignant bowel obstruction...
  44. ncbi request reprint A phase II study of methylphenidate for depression in advanced cancer
    J Homsi
    Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 18:403-7. 2001
    ..This study evaluated the use of methylphenidate for depression in advanced cancer..
  45. ncbi request reprint Assessment of delirium in advanced cancer: the use of the bedside confusion scale
    N Sarhill
    Harry R. Horvitz Center for Palliative Medicine (a World Health Organization Demonstration Project in Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:335-41. 2001
    ..The BSCS is simple, portable, valid, quick, and easy to use by any medical team member. Delirium is common in hospitalized patients with advanced cancer...
  46. ncbi request reprint The terminally ill Muslim: death and dying from the Muslim perspective
    N Sarhill
    Department of Internal Medicine, St. Vincent Charity Hospital, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:251-5. 2001
    ..Do not resuscitate (DNR) orders are acceptable. A deceased Muslim must always be buried after being ritually washed and wrapped. There are different Muslim schools of thought, but they are united regarding their views on death and dying...
  47. doi request reprint Errors in opioid prescribing: a prospective survey in cancer pain
    Philip E Shaheen
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Pain Symptom Manage 39:702-11. 2010
    ..Cancer pain is debilitating and has multidimensional consequences. It can be treated adequately in up to 90% of patients by following pain management guidelines. Nevertheless, inadequate pain control remains a global problem...
  48. pmc Methylphenidate side effects in advanced cancer: a retrospective analysis
    Wael Lasheen
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 27:16-23. 2010
    ..Methylphenidate (MP) is often recommended for symptom control in advanced cancer. Little is known about its side effects in frail adults. Objectives: To evaluate MP-associated symptoms or side effects (S/E)...
  49. doi request reprint Cancer symptom clusters: old concept but new data
    Jordanka Kirkova
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA
    Am J Hosp Palliat Care 27:282-8. 2010
    ..Symptom clusters require further research before becoming part of routine medical symptom assessment and management...
  50. ncbi request reprint Mirtazepine: heir apparent to amitriptyline?
    M P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:42-6. 2001
    ..Mirtazepine appears to be a "designer drug" for palliative medicine with a number of benefits, but cost may be a drawback...
  51. ncbi request reprint Systematic review of the treatment of cancer-associated anorexia and weight loss
    Tugba Yavuzsen
    Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 23:8500-11. 2005
    ..Literature databases were searched for randomized controlled trials of appetite stimulants in the treatment of cancer anorexia...
  52. doi request reprint Consistency of symptom clusters in advanced cancer
    Jordanka Kirkova
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 27:342-6. 2010
    ..The primary purpose was to assess consistency of SCs between 2 independent data sets. A secondary aim was to evaluate whether use of a sentinel symptom might abbreviate assessment but retain acceptable accuracy...
  53. ncbi request reprint Acute pain in advanced cancer: an opioid dosing strategy and illustration
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 21:47-50. 2004
    ..This article presents guidelines and case histories for safe and effective dosing...
  54. ncbi request reprint The business of palliative medicine: management metrics for an acute-care inpatient unit
    M P Davis
    Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 18:26-9. 2001
    ..In this article, we will review the administrative and financial factors we have identified that influence the business of acute palliative medicine...
  55. ncbi request reprint Does trazodone have a role in palliating symptoms?
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, M76, Cleveland, OH 44195, USA
    Support Care Cancer 15:221-4. 2007
    ..Trazodone is a unique antidepressant, which blocks the postsynaptic serotonin (5-HT) receptors, 5-HT(2A) and 5-HT(2C), and weakly inhibits presynaptic 5-HT transporters...
  56. doi request reprint Components of the anorexia-cachexia syndrome: gastrointestinal symptom correlates of cancer anorexia
    Tugba Yavuzsen
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, M 76, Cleveland, OH 44195, USA
    Support Care Cancer 17:1531-41. 2009
    ..We surveyed cancer patients with anorexia to learn more about the relationship between anorexia and these symptoms...
  57. doi request reprint Validation of a simplified anorexia questionnaire
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio, USA
    J Pain Symptom Manage 38:691-7. 2009
    ..Anorexia is a common symptom in cancer and is usually assessed by multiple questions and multidimensional questionnaires. A simplified questionnaire would be less burdensome to patients and abbreviate the process...
  58. ncbi request reprint Olanzapine as an antiemetic in refractory nausea and vomiting in advanced cancer
    Manish Srivastava
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Pain Symptom Manage 25:578-82. 2003
    ..The atypical antipsychotic, olanzapine, relieves nausea in some patients failing to respond to the usual antiemetics. Two case reports are presented and the rationale for olanzapine's benefit is discussed...
  59. doi request reprint Clocking delirium: the value of the Clock Drawing Test with case illustrations
    Ivan N Zama
    Experimental Therapeutics Solid Tumor Oncology Taussig Cancer Center Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Hosp Palliat Care 25:385-8. 2008
    ..However, very few studies have used the Clock Drawing Test to assess delirium in cancer and even fewer have used the Clock Drawing Test to determine response to interventions for delirium...
  60. ncbi request reprint Common symptoms in advanced cancer
    Ruth L Lagman
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, M76 Cleveland, OH 44195, USA
    Surg Clin North Am 85:237-55. 2005
    ..Constipation should be treated with laxatives and stool softeners. Both should start with the first opioid dose...
  61. ncbi request reprint Opioid rotation in cancer patients: pros and cons
    Bassam Estfan
    The Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Oncology (Williston Park) 19:511-6; discussion 516-8, 521-3, 527-8. 2005
    ..Weighing the advantages and disadvantages is essential prior to making a decision about opioid rotation selection...
  62. ncbi request reprint Anti-infective therapy at the end of life: ethical decision-making in hospice-eligible patients
    Paul J Ford
    The Department of Bioethics JJ60, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Bioethics 19:379-92. 2005
    ....
  63. ncbi request reprint New drugs for the anorexia-cachexia syndrome
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Center, The Cleveland Clinic Foundation, R35, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Oncol Rep 4:264-74. 2002
    ..Several of the anticachectic agents have demonstrated in vivo or in vitro antitumor activity. The biologic and clinical activity of each drug is reviewed herein, and potentially useful combinations are listed...
  64. ncbi request reprint Palliative medicine: old dogs and new tricks
    M P Davis
    Department of Hematology Medical Oncology, Cleveland Clinic, USA
    Cleve Clin J Med 67:557-9. 2000
    ..In palliative medicine, many older drugs can be used for off-label indications, either to augment the action of approved drugs or to substitute for approved drugs that fail to provide relief...
  65. doi request reprint Opioid equianalgesic tables: are they all equally dangerous?
    Philip E Shaheen
    The Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Center Institute, Cleveland, OH 44195, USA
    J Pain Symptom Manage 38:409-17. 2009
    ..Current information in equianalgesic tables is confusing for physicians, and dangerous to the public...
  66. ncbi request reprint Epidemiology of cancer pain and factors influencing poor pain control
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 21:137-42. 2004
    ..Other factors include lack of physician education and failure to follow existing guidelines. Patients fear addiction, drug tolerance, and side effects. Despite adequate resources, pain is still undertreated...
  67. doi request reprint Buprenorphine for neuropathic pain--targeting hyperalgesia
    Raghava R Induru
    Division of Solid Tumor, Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic, Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 26:470-3. 2009
    ..We found buprenorphine to be effective in reducing hypersensitivity in neuropathic pain when pure mu agonists fail to produce a response or in individuals who are intolerant to pure mu agonists...
  68. ncbi request reprint Respiratory function during parenteral opioid titration for cancer pain
    Bassam Estfan
    The Harry R Horvitz Center for Palliative Medicine, The Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Palliat Med 21:81-6. 2007
    ..The primary outcome measure was to measure changes in end-tidal CO(2) (ET-CO(2)) during opioid titration to pain control...
  69. doi request reprint Fatigue in advanced cancer: a prospective study
    Katherine Hauser
    Harry R Horvitz Center for Palliative Medicine, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 25:372-8. 2008
    ..Brain metastases and poor quality of life independently predicted severity. Hemoglobin level did not predict fatigue. Further studies are necessary to define the clinical features and relationships of fatigue...
  70. ncbi request reprint Early satiety in cancer patients: a common and important but underrecognized symptom
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH, USA
    Support Care Cancer 14:693-8. 2006
    ..The severity of anorexia correlates with the presence of early satiety. The sense of fullness limits nutritional intake. The symptom is poorly understood because most assessment questionnaires do not include early satiety...
  71. doi request reprint Cytokines and cancer anorexia cachexia syndrome
    Nabila Bennani-Baiti
    Harry R Horvitz Center for Palliative Medicine a World Health Organization demonstration project in palliative medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio 44195, USA
    Am J Hosp Palliat Care 25:407-11. 2008
    ..The purpose of this review is to summarize the latest developments in the field of cytokines and their role in cancer anorexia cachexia syndrome. The emphasis is on the role of cytokines in anorexia and tissue wasting...
  72. ncbi request reprint The financial benefits of acute inpatient palliative medicine: an inter-institutional comparative analysis by all patient refined-diagnosis related group and case mix index
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, OH, USA
    J Support Oncol 3:313-6. 2005
    ..We conclude that an acute inpatient palliative medicine unit operating within a comprehensive integrated palliative medicine program is cost-effective in providing specialized care for people with advanced disease...
  73. ncbi request reprint Opioids in cancer pain: common dosing errors
    Romeen Kochhar
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Oncology (Williston Park) 17:571-5; discussion 575-6, 579. 2003
    ..This article describes these errors and offers strategies with which to improve outcomes for patients suffering with cancer pain...
  74. doi request reprint Cancer-related fatigue: central or peripheral?
    Tugba Yavuzsen
    The Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Pain Symptom Manage 38:587-96. 2009
    ..These data demonstrate that CRF patients exhibited greater central fatigue, indicated by shorter ET and less voluntary muscle recruitment during an SC relative to controls...
  75. doi request reprint Symptom severity and distress in advanced cancer
    Jordanka Kirkova
    Section of Palliative Medicine and Supportive Oncology, Department of Solid Tumor Oncology, Cleveland Clinic Taussig Cancer Institute, Cleveland, OH, USA
    Palliat Med 24:330-9. 2010
    ..Mild symptoms were often distressful. After adjustment for severity, age, gender, and performance status all influenced symptom distress...
  76. doi request reprint A day in the life: a case series of acute care palliative medicine--the Cleveland model
    Ruth Lagman
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio
    Am J Hosp Palliat Care 25:24-32. 2008
    ..The cases illustrate the sophisticated medical care involved for each individual and the important skill sets of the palliative medicine specialist required to provide high-quality acute medical care for the very ill...
  77. ncbi request reprint Integrating palliative medicine into an oncology practice
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Foundation, Ohio, USA
    Am J Hosp Palliat Care 22:447-56. 2005
  78. ncbi request reprint Mirtazapine for pruritus
    Mellar P Davis
    The Harry R Horvitz Center for Palliative Medicine, Cleveland, OH, USA
    J Pain Symptom Manage 25:288-91. 2003
    ..Medical management recently has included the use of ondansetron and paroxetine. We report four patients whose pruritus responded to mirtazapine...
  79. ncbi request reprint A syllabus for fellowship education in palliative medicine
    Susan B Legrand
    Palliative Medicine Fellowship Program, The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 20:279-89. 2003
    ..This article outlines the syllabus developed for this fellowship, given what we believe to be the essential knowledge base for the field of palliative medicine...
  80. ncbi request reprint Hematology in palliative medicine
    Mellar P Davis
    The Harrny R Horvitz Center for Palliative Medicine, Cleveland Taussig Cancer Center, Cleveland, Ohio, USA
    Am J Hosp Palliat Care 21:445-54. 2004
    ..Patients undergoing chemotherapy and bone marrow transplant have unique problems that include neutropenias and chemotherapy-induced drug toxicities, which will not be covered in this article...
  81. ncbi request reprint A phase II study of hydrocodone for cough in advanced cancer
    Jade Homsi
    Harry R Horvitz Center for Palliative Medicine a World Health Organization demonstration project in palliative medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:49-56. 2002
    ..Cough is a common symptom in advanced cancer. The use of hydrocodone as an antitussive has not been studied previously in this setting. This study evaluates hydrocodone for cough in advanced cancer..
  82. ncbi request reprint All patient refined-diagnostic related group and case mix index in acute care palliative medicine
    Ruth L Lagman
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Support Oncol 5:145-9. 2007
    ....
  83. ncbi request reprint Acute inpatient palliative medicine in a cancer center: clinical problems and medical interventions--a prospective study
    Ruth Lagman
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Taussig Cancer Center, Cleveland, OH 44195, USA
    Am J Hosp Palliat Care 24:20-8. 2007
    ..An acute inpatient palliative medicine unit within a tertiary level medical center has a definable and important role in comprehensive cancer care...
  84. ncbi request reprint The clinical effects of music therapy in palliative medicine
    Lisa M Gallagher
    The Harry R Horvitz Center for Palliative Medicine A World Health Organization Demonstration Project, Cleveland Clinic Taussig Cancer Center, Cleveland Clinic Foundation, 9500 Euclid Avenue, M76, Cleveland, OH 44195, USA
    Support Care Cancer 14:859-66. 2006
    ..This study was to objectively assess the effect of music therapy on patients with advanced disease...
  85. doi request reprint Malignant bowel obstruction: individualized treatment near the end of life
    Aileen Soriano
    Harry R Horvitz Center for Palliative Medicine, Section of Palliative Medicine and Supportive Oncology, Cleveland Clinic, OH, USA
    Cleve Clin J Med 78:197-206. 2011
    ..Surgery should not be routinely done. Less-invasive approaches such as gastric and colonic stenting are useful...
  86. ncbi request reprint Cancer symptom assessment instruments: a systematic review
    Jordanka Kirkova
    Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Clin Oncol 24:1459-73. 2006
    ..A variety of assessment instruments have been created to identify cancer symptoms. We reviewed systematically cancer symptom assessment instruments published in English...
  87. ncbi request reprint The opioid bowel syndrome: a review of pathophysiology and treatment
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Taussig Cancer Center, The Cleveland Clinic Foundation, Ohio, USA
    J Opioid Manag 1:153-61. 2005
    ..The development of quaternary opioid receptor antagonists is a step toward target-specific therapy for opioid-induced bowel dysfunction. This review will discuss the pathophysiology and management of OBS...
  88. ncbi request reprint The business of palliative medicine--Part 2: The economics of acute inpatient palliative medicine
    Mellar P Davis
    Harry R Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Ohio, USA
    Am J Hosp Palliat Care 19:89-95. 2002
    ..In the future, an international CMI or APR-DRG will allow palliative inpatient units to compare disease severity, resource utilization, and outcome measures...
  89. ncbi request reprint Morphine in cancer pain management: a practical guide
    Sinead Donnelly
    Harry R Horvitz Center for Palliative Medicine
    Support Care Cancer 10:13-35. 2002
    ..Guidelines for morphine administration are reviewed, and in particular those of the Harry R. Horvitz Center for Palliative Medicine are outlined...
  90. ncbi request reprint Revisiting truth and consequences: what to do when the patient doesn't want to know
    Mellar P Davis
    J Clin Oncol 20:4403-4. 2002
  91. ncbi request reprint Re: increased plasma morphine metabolites and delirium
    Mellar P Davis
    J Pain Symptom Manage 24:273; author reply 273-4. 2002
  92. ncbi request reprint Guidelines for breakthrough pain dosing
    Mellar P Davis
    Am J Hosp Palliat Care 20:334. 2003
  93. ncbi request reprint Cancer constipation: are opioids really the culprit?
    Mellar P Davis
    Support Care Cancer 16:427-9. 2008
  94. ncbi request reprint Randomized clinical trial of an implantable drug delivery system
    Mellar P Davis
    J Clin Oncol 21:2800-1; author reply 2802-3. 2003
  95. ncbi request reprint The efficacy and tolerability of long-term use of dronabinol in cancer-related anorexia: a case series
    Declan Walsh
    J Pain Symptom Manage 30:493-5. 2005
  96. ncbi request reprint Can we really say that nebulized morphine works?
    Wael Lasheen
    J Pain Symptom Manage 32:101-2; author reply 102-3. 2006
  97. ncbi request reprint Ketorolac in neuropathic pain
    Fariha Kausar
    J Pain Symptom Manage 32:202-4. 2006
  98. ncbi request reprint NSAIDs: gastroprotection or selective COX-2 inhibitors?
    Mellar P Davis
    Palliat Med 19:165; author reply 166-7. 2005
  99. ncbi request reprint Re: Anemia at the end of life
    Mellar P Davis
    J Pain Symptom Manage 27:392-3; author reply 393. 2004
  100. doi request reprint Combining objective and subjective outcomes in cancer-related fatigue: illustrations from a single case report
    Dilara Seyidova Khoshknabi
    The Harry R Horvitz Center for Palliative Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Palliat Med 11:829-33. 2008
    ..She remained at 10 mg twice daily for 8 months. Improvement in severe CRF (Brief Fatigue Inventory score) was associated with normalization of neurophysiologic tests...
  101. ncbi request reprint Eicosapentaenoic acid: the answers are not all in
    Mellar P Davis
    J Clin Oncol 23:3854; author reply 3854-5. 2005