Clemencia Colmenares

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice
    Clemencia Colmenares
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Genet 30:106-9. 2002
  2. ncbi Ocular abnormalities in mice lacking the Ski proto-oncogene
    Peter McGannon
    Center for Genetic Eye Diseases, Cole Eye Institute, Cleveland, OH 44195, USA
    Invest Ophthalmol Vis Sci 47:4231-7. 2006
  3. ncbi Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice
    Sheila Ernest
    Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 15:3387-93. 2006
  4. ncbi Genetic and molecular control of folate-homocysteine metabolism in mutant mice
    Sheila Ernest
    Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mamm Genome 13:259-67. 2002
  5. pmc Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors
    Pallavi Bhattaram
    Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Commun 1:9. 2010
  6. pmc Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
    Ping Dai
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Ibaraki, Japan
    Genes Dev 16:2843-8. 2002
  7. ncbi SKI activates Wnt/beta-catenin signaling in human melanoma
    Dahu Chen
    Huffington Center on Aging and Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:6626-34. 2003
  8. ncbi The protooncogene Ski controls Schwann cell proliferation and myelination
    Suzana Atanasoski
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Neuron 43:499-511. 2004

Research Grants

  1. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2006
  2. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2003
  3. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2004
  4. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2005
  5. ANALYTIC SERVICES
    Clemencia Colmenares; Fiscal Year: 2007

Collaborators

Detail Information

Publications8

  1. ncbi Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice
    Clemencia Colmenares
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Genet 30:106-9. 2002
    ..3 and is deleted in all of the individuals tested so far who have this syndrome. Thus, SKI may contribute to some of the phenotypes common in 1p36 deletion syndrome, and particularly to facial clefting...
  2. ncbi Ocular abnormalities in mice lacking the Ski proto-oncogene
    Peter McGannon
    Center for Genetic Eye Diseases, Cole Eye Institute, Cleveland, OH 44195, USA
    Invest Ophthalmol Vis Sci 47:4231-7. 2006
    ..This study involved a novel mouse model of PHPV, generated by a null mutation of the Ski proto-oncogene, that displays other anterior segment and retinal malformations often found in human cases of PHPV...
  3. ncbi Parallel changes in metabolite and expression profiles in crooked-tail mutant and folate-reduced wild-type mice
    Sheila Ernest
    Department of Genetics, Center for Computational Genomics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Hum Mol Genet 15:3387-93. 2006
    ..These results raise the possibility of using metabolite and expression profiles to distinguish folate-responsive and resistance adult females who are at risk for bearing fetuses with an NTD...
  4. ncbi Genetic and molecular control of folate-homocysteine metabolism in mutant mice
    Sheila Ernest
    Department of Genetics, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Mamm Genome 13:259-67. 2002
    ..These results begin to unravel the complex relations between elevation of a single amino acid in the blood and the diverse birth defects and adult diseases associated with hyperhomocysteinemia...
  5. pmc Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors
    Pallavi Bhattaram
    Department of Cell Biology, and Orthopaedic and Rheumatologic Research Center, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio 44195, USA
    Nat Commun 1:9. 2010
    ..SoxC genes therefore ensure neural and mesenchymal progenitor cell survival, and function in part by activating this transcriptional mediator of the Hippo signalling pathway...
  6. pmc Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3
    Ping Dai
    Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Ibaraki, Japan
    Genes Dev 16:2843-8. 2002
    ..Furthermore, a Ski mutation enhanced the digit abnormalities caused by the Gli3 gene mutation. Thus, Ski plays an important role in pattern formation...
  7. ncbi SKI activates Wnt/beta-catenin signaling in human melanoma
    Dahu Chen
    Huffington Center on Aging and Departments of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 63:6626-34. 2003
    ..Taken together, these results suggest that by targeting members of the tumor growth factor beta and beta-catenin pathways, SKI regulates crucial events required for melanoma growth, survival, and invasion...
  8. ncbi The protooncogene Ski controls Schwann cell proliferation and myelination
    Suzana Atanasoski
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Neuron 43:499-511. 2004
    ..The myelination-regulating transcription factor Oct6 is involved in a complex modulatory relationship with Ski. We conclude that Ski is a crucial signal in Schwann cell development and myelination...

Research Grants5

  1. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2006
    ..These studies will contribute to our understanding of the gene regulatory networks that control craniofacial development, and of how disruption of these networks result in craniofacial defects. ..
  2. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2003
    ..These studies will contribute to our understanding of the gene regulatory networks that control craniofacial development, and of how disruption of these networks result in craniofacial defects. ..
  3. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2004
    ..These studies will contribute to our understanding of the gene regulatory networks that control craniofacial development, and of how disruption of these networks result in craniofacial defects. ..
  4. SKI-Regulated Networks in Facial and Skull Defects
    Clemencia Colmenares; Fiscal Year: 2005
    ..These studies will contribute to our understanding of the gene regulatory networks that control craniofacial development, and of how disruption of these networks result in craniofacial defects. ..
  5. ANALYTIC SERVICES
    Clemencia Colmenares; Fiscal Year: 2007
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