Graham Casey

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation
    Rajeev S Samant
    Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
    Mol Cancer 6:6. 2007
  2. ncbi Podocalyxin variants and risk of prostate cancer and tumor aggressiveness
    Graham Casey
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Mol Genet 15:735-41. 2006
  3. pmc Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer
    Graham Casey
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    JAMA 293:799-809. 2005
  4. ncbi RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
    Graham Casey
    Department of Cancer Biology, ND50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Genet 32:581-3. 2002
  5. ncbi Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Carcinogenesis 27:1842-8. 2006
  6. pmc Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients
    David G Hicks
    Department of Clinical and Anatomic Pathology, General Surgery Breast Center, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Cancer Res 12:6702-8. 2006
  7. ncbi Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity
    Muzaffer Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
    Cancer Res 65:3586-95. 2005
  8. ncbi Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 13:1331-6. 2004
  9. ncbi Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin
    Steven Sizemore
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Cancer Res 67:6183-91. 2007
  10. ncbi Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 14:2173-7. 2005

Research Grants

Collaborators

Detail Information

Publications67

  1. pmc Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation
    Rajeev S Samant
    Mitchell Cancer Institute, University of South Alabama, Mobile, Alabama, USA
    Mol Cancer 6:6. 2007
    ..BRMS1 is a member of mSin3-HDAC transcription co-repressor complex and has been shown to suppress the metastasis of breast cancer and melanoma cells in animal models. Hence we hypothesized that BRMS1 regulates OPN expression...
  2. ncbi Podocalyxin variants and risk of prostate cancer and tumor aggressiveness
    Graham Casey
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Hum Mol Genet 15:735-41. 2006
    ..48, 95%CI=1.02-2.14, P=0.04). These results implicate PODXL as a candidate prostate cancer tumor aggressiveness gene mapping to chromosome 7q32-q33...
  3. pmc Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer
    Graham Casey
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio 44195, USA
    JAMA 293:799-809. 2005
    ..Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when conventional DNA sequencing alone is used...
  4. ncbi RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
    Graham Casey
    Department of Cancer Biology, ND50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Genet 32:581-3. 2002
    ..Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk...
  5. ncbi Polymorphisms in estrogen bioactivation, detoxification and oxidative DNA base excision repair genes and prostate cancer risk
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Carcinogenesis 27:1842-8. 2006
    ....
  6. pmc Loss of breast cancer metastasis suppressor 1 protein expression predicts reduced disease-free survival in subsets of breast cancer patients
    David G Hicks
    Department of Clinical and Anatomic Pathology, General Surgery Breast Center, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Cancer Res 12:6702-8. 2006
    ....
  7. ncbi Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity
    Muzaffer Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio 44195, USA
    Cancer Res 65:3586-95. 2005
    ....
  8. ncbi Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 13:1331-6. 2004
    ..47, 95% CI 0.29-0.76; P = 0.002). Our findings suggest that 677T and 1298A, or another variant on their haplotype, may be associated with a reduced risk of progression to more advanced prostate cancer...
  9. ncbi Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin
    Steven Sizemore
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Cancer Res 67:6183-91. 2007
    ....
  10. ncbi Role of androgen metabolism genes CYP1B1, PSA/KLK3, and CYP11alpha in prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Lerner School of Medicine, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 14:2173-7. 2005
    ..71; 95% CI, 1.06-6.94; P = 0.04). Our findings suggest that CYP1B1 and PSA variants may affect the risk of prostate cancer and tumor aggressiveness...
  11. ncbi Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies
    Phillippa J Neville
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Genes Chromosomes Cancer 36:332-9. 2003
    ..06). These data provide strong evidence that we have mapped a prostate tumor aggressiveness locus to chromosome segments 19q12-q13.11 that may play a role in both familial and non-familial forms of prostate cancer...
  12. ncbi Polymorphisms in polycyclic aromatic hydrocarbon metabolism and conjugation genes, interactions with smoking and prostate cancer risk
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 15:756-61. 2006
    ..95; 95% CI, 0.53-1.71). Our results highlight the importance of considering genetic modifiers of carcinogens when evaluating smoking in prostate cancer...
  13. pmc FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans
    Nora L Nock
    Department of Epidemiology and Biostatistics, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106 7281, USA
    Carcinogenesis 32:748-56. 2011
    ..Our results are consistent with prior studies and show for the first time that FTO polymorphisms are associated with colorectal adenomas in African-Americans...
  14. doi A common 8q24 variant and the risk of colon cancer: a population-based case-control study
    Li Li
    Department of Family Medicine Research Division, Case Western Reserve University, 11001 Cedar Avenue, Suite 306, Cleveland, OH 44106 7136, USA
    Cancer Epidemiol Biomarkers Prev 17:339-42. 2008
    ..These data replicate the association identified from recent studies, providing additional evidence supporting the rs6983267 genetic polymorphism as a marker predisposing to colon cancer...
  15. ncbi Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Prostate 59:69-76. 2004
    ....
  16. ncbi Vitamin D receptor genotypes/haplotypes and prostate cancer risk
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 15:2549-52. 2006
    ..This would help explain the somewhat equivocal results for VDR genotype-level associations with prostate cancer...
  17. pmc SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers
    Hui Li
    Ireland Cancer Center, Department of Medicine, and Research Institute, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 100:8412-7. 2003
    ..Structural homology and functional testing demonstrated that SLC5A8 is a member of the family of sodium solute symporters, which are now added as a class of candidate colon cancer suppressor genes...
  18. ncbi CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer
    Sarah J Plummer
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 12:928-32. 2003
    ..07; 95% CI, 0.01-0.51; P=0.009). These findings suggest that the CYP3A4 and CYP3A5 variants, or other alleles on the haplotypes they help distinguish, are associated with prostate cancer risk and aggressiveness...
  19. pmc Association of common genetic variants in SMAD7 and risk of colon cancer
    Cheryl L Thompson
    Department of Family Medicine, Case Western Reserve University University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Carcinogenesis 30:982-6. 2009
    ..015 for rs4939827 and P = 0.061 for rs12953717). Similar effect modification was found in haplotype analyses. Our data add evidence supporting these genetic variants as markers predisposing to colon cancer, specifically in women...
  20. ncbi The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
    Anju Agarwal
    Department of Cancer Biology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Oncogene 24:1021-31. 2005
    ..These results indicate a role of this pathway in controlling gene expression important in tumor progression and metastasis...
  21. doi Interleukin-22 genetic polymorphisms and risk of colon cancer
    Cheryl L Thompson
    Department of Family Medicine Research Division, Case Western Reserve University University Hospitals of Cleveland, 11001 Cedar Ave, Suite 306, Cleveland, OH 44106 7136, USA
    Cancer Causes Control 21:1165-70. 2010
    ..52, 95% CI = 1.12-2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer...
  22. pmc Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studies
    Phillippa J Neville
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neoplasia 4:424-31. 2002
    ..05). These data imply that we have localized a prostate cancer tumor aggressiveness loci to chromosome 7q32-q33 that is involved in familial and nonfamilial forms of prostate cancer...
  23. ncbi No association between genetic polymorphisms in IGF-I and IGFBP-3 and prostate cancer
    Li Li
    Department of Family Medicine and Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Cancer Epidemiol Biomarkers Prev 13:497-8. 2004
  24. ncbi Characterization of the human polymeric immunoglobulin receptor (PIGR) 3'UTR and differential expression of PIGR mRNA during colon tumorigenesis
    June L Traicoff
    Department of Molecular Biology and Microbiology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    J Biomed Sci 10:792-804. 2003
    ..We hypothesize that differential regulation of PIGR mRNA stability may contribute to its downregulation in colon cancer...
  25. ncbi Fluorescence in situ hybridization of cytologic specimens from Barrett's esophagus: a pilot feasibility study
    Gary W Falk
    Center for Swallowing and Esophageal Disorders, Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastrointest Endosc 60:280-4. 2004
    ....
  26. ncbi Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates
    Ying Xiang
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Res 63:6795-801. 2003
    ..Our findings support the notion that RNASEL mutations and some variants allow tumor cells to escape a potent apoptotic pathway...
  27. doi Divergent oncogenic changes influence survival differences between colon and rectal adenocarcinomas
    Matthew F Kalady
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 52:1039-45. 2009
    ..This study evaluated the disparity in neoplastic changes between colon and rectal cancers...
  28. doi Association between phosphatidylinositol 3-kinase regulatory subunit p85alpha Met326Ile genetic polymorphism and colon cancer risk
    Li Li
    Department of Family Medicine Research Division, Case Western Reserve University, Cleveland, OH 44106 7136, USA
    Clin Cancer Res 14:633-7. 2008
    ..The phosphatidylinositol 3-kinase signaling pathway is frequently activated in cancer. Emerging evidence supports the p85alpha regulatory subunit gene, PIK3R1, as a novel oncogene...
  29. doi Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants
    Benjamin T Larson
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA
    J Urol 179:1344-8. 2008
    ..We assessed a series of men undergoing radical prostatectomy for clinical and pathological measures of tumor aggressiveness according to the RNASEL R462Q genotype...
  30. ncbi Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells
    Ryuichi Fukuyama
    Department of Cancer Biology, Cleveland Clinic, Cleveland, Ohio 44195, and School of Biomedical Sciences, Kent State University, USA
    Mol Carcinog 46:402-13. 2007
    ....
  31. pmc Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Cancer 6:241. 2006
    ..Here, we report on the prevalence and potential clinical significance of fascin expression in relation to the progression of colorectal adenocarcinoma and to tumor cell proliferation as measured by Ki67 index...
  32. pmc Reduced expression of autotaxin predicts survival in uveal melanoma
    Arun D Singh
    Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Br J Ophthalmol 91:1385-92. 2007
    ..In an effort to identify patients with uveal melanoma at high risk of metastasis, the authors undertook correlation of gene expression profiles with histopathology data and tumour-related mortality...
  33. ncbi Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells
    Muzaffer Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Clin Exp Metastasis 21:149-57. 2004
    ..Our results suggest that annexin I and alpha B-crystallin are important cellular proteins that are down regulated through BRMS1 mediated metastasis suppression...
  34. ncbi Novel enhanced lung-colonizing variant of murine MBT-2 bladder cancer cells
    Minoru Horinaga
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Urology 66:676-81. 2005
    ..To develop an enhanced lung-colonizing variant of murine bladder cancer that will allow the mechanism of metastasis to be studied more readily...
  35. ncbi Relation of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 to risk of prostate cancer (United States)
    Li Li
    Department of Family Medicine, Case Western Reserve University, Cleveland, OH 44106 4945, USA
    Cancer Causes Control 14:721-6. 2003
    ..Previous studies have inconsistently associated IGF-I and IGFBP-3 with prostate cancer. To try and further clarify these potential associations, we undertook a sibling-matched case-control study...
  36. ncbi ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer
    Bon Hun Koo
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Cancer 121:1710-6. 2007
    ....
  37. ncbi Genetic susceptibility and oxidative stress in prostate cancer: integrated model with implications for prevention
    Eric A Klein
    Section of Urologic Oncology, Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44122, USA
    Urology 68:1145-51. 2006
  38. ncbi Plasma lysophosphatidylcholine levels: potential biomarkers for colorectal cancer
    Zhenwen Zhao
    Department of Cancer Biology, Lerner Research Institute, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA
    J Clin Oncol 25:2696-701. 2007
    ..Plasma levels of lysophospholipids were evaluated as potential biomarkers for colorectal cancer (CRC), where a highly reliable and minimally invasive blood test is lacking...
  39. doi Identification of the methylator (serrated) colorectal cancer phenotype through precursor serrated polyps
    Craig A Messick
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA
    Dis Colon Rectum 52:1535-41. 2009
    ..This study analyzes characteristics of precursor polyps occurring within different molecular subtypes of sporadic colorectal cancer...
  40. ncbi Diffuse large B-cell lymphoma of the stomach: assessment of microsatellite instability, allelic imbalance, and trisomy of chromosomes 3, 12, and 18
    Marek Skacel
    Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Diagn Mol Pathol 11:75-82. 2002
    ..Because of the relatively low frequency of MSI in the high-grade B-cell lymphomas of the stomach, this feature cannot be used to reliably discriminate between the histologic types of extranodal diffuse large B-cell lymphoma...
  41. ncbi Chromosomal gains and genomic loss of p53 and p16 genes in Barrett's esophagus detected by fluorescence in situ hybridization of cytology specimens
    Mona Fahmy
    Department of Anatomic and Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mod Pathol 17:588-96. 2004
    ..Selected biomarkers from this study merit further investigation to determine their potential to detect genetic changes in patients with Barrett's esophagus prior to the development of high-grade dysplasia...
  42. ncbi Breast cancers with brain metastases are more likely to be estrogen receptor negative, express the basal cytokeratin CK5/6, and overexpress HER2 or EGFR
    David G Hicks
    Clinical and Anatomic Pathology, Cleveland Clinic Foundation, OH 44195, USA
    Am J Surg Pathol 30:1097-104. 2006
    ....
  43. ncbi Chromosomal autonomy of hMLH1 methylation in colon cancer
    Hui Li
    Department of Microbiology and Molecular Biology, Case Western Reserve University, Cleveland, Ohio, OH 44106, USA
    Oncogene 21:1443-9. 2002
    ..We posit that hMLH1 methylation is dependent on and maintained by cis chromosomal marks, whose nature remains to be elucidated...
  44. ncbi Reconstitution of TGF-beta sensitivity in the VACO-411 human colon carcinoma line by somatic cell fusion with MCF-7
    June L Traicoff
    Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
    J Biomed Sci 10:253-9. 2003
    ..The data suggest that the VACO-411 defect in TGF-beta signaling will be able to be further complemented by microcell-mediated chromosome transfer...
  45. ncbi Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, NOR4411A, Los Angeles, CA 90089 9175, USA
    Cancer Res 67:11128-32. 2007
    ..These data suggest that common variants may play important roles in the risk of CRC...
  46. pmc 8q24 and prostate cancer: association with advanced disease and meta-analysis
    Iona Cheng
    Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, San Francisco, CA 94143 0794, USA
    Eur J Hum Genet 16:496-505. 2008
    ..Our findings provide the first confirmation that the three 8q24 regions independently influence the risk of prostate cancer and, in particular, advanced disease...
  47. ncbi Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue
    Jonine L Bernstein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Epidemiol Biomarkers Prev 11:809-14. 2002
    ..We concluded that DNA derived from PET that archived for less than 18 years can be used successfully for detecting BRCA1 gene mutations if quality control is strictly maintained...
  48. doi Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1
    Benjamin D Hedley
    London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
    Int J Cancer 123:526-34. 2008
    ..These studies clarify one mechanism by which BRMS1 can suppress metastasis...
  49. ncbi Toll-like receptor 4 genetic variation and advanced prostate cancer risk
    Iona Cheng
    Department of Epidemiology and Biostatistics and Center of Human Genetics, University of California at San Francisco, 94143 0794, USA
    Cancer Epidemiol Biomarkers Prev 16:352-5. 2007
    ..006). We estimated through permutation analysis that a similarly strong result would occur by chance 2.5% of the time. Our findings support previous studies and suggest that inherited differences in TLR4 influence prostate cancer risk...
  50. pmc Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant
    Anatoly Urisman
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 2:e25. 2006
    ..These findings also raise questions about the possible relationship between exogenous infection and cancer development in genetically susceptible individuals...
  51. ncbi DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer
    Benjamin A Rybicki
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 13:23-9. 2004
    ....
  52. pmc Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, Rochester, Minn, USA
    JAMA 293:1979-85. 2005
    ..Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but cancer incidence for individuals in AC-I families with no evidence of an MMR defect is unknown...
  53. ncbi No association between a tetranucleotide repeat polymorphism of CYP19 and prostate cancer
    Li Li
    Department of Epidemiology and Biostatistics, University of California at San Francisco, 500 Parnassus Avenue, MU 420 West, San Francisco, CA 94143 0560
    Cancer Epidemiol Biomarkers Prev 13:2280-1. 2004
  54. ncbi Nonsteroidal antiinflammatory drugs and decreased risk of advanced prostate cancer: modification by lymphotoxin alpha
    Xin Liu
    Department of Epidemiology and Biostatistics and Center for Human Genetics, University of California, San Francisco, San Francisco, CA 94143, USA
    Am J Epidemiol 164:984-9. 2006
    ..30). The authors observed similar associations when examining dose/duration of NSAID use. This suggests that any potential chemoprevention of prostate cancer by NSAIDs may be most appropriate for men with the LTA +80CC genotype...
  55. pmc Prediction of germline mutations and cancer risk in the Lynch syndrome
    Sining Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    JAMA 296:1479-87. 2006
    ..Current clinical guidelines are effective but limited by applicability and cost...
  56. ncbi Genome-wide scan of brothers: replication and fine mapping of prostate cancer susceptibility and aggressiveness loci
    John S Witte
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
    Prostate 57:298-308. 2003
    ..Here we investigate prostate cancer susceptibility and aggressiveness with genome-wide linkage analyses of affected brothers...
  57. ncbi Plasminogen activator inhibitor type-1 (PAI-1) polymorphism 4G/5G is associated with prostate cancer among men with a positive family history
    Eric Jorgenson
    Department of Epidemiology and Biostatistics, Center for Human Genetics, University of California, San Francisco, San Francisco, California 94143 0794, USA
    Prostate 67:172-7. 2007
    ..To evaluate the effect of PAI-1 expression on cancer development, we examined the association of the 4G/5G polymorphism in a sibling-based case-control study of prostate cancer...
  58. ncbi Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2
    Anu Loukola
    Amersham Biosciences, Sunnyvale, CA 94085, USA
    Eur J Hum Genet 12:321-32. 2004
    ..02). Undertaking a two-phase study comprising SNP discovery, haplotype tagging, and association analyses allowed us to more fully decipher the relation between CYP17A1, CYP3A4, and SRD5A2 and prostate cancer...
  59. ncbi Trans-fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant
    Xin Liu
    Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California, San Francisco, CA 94143 0794, USA
    Carcinogenesis 28:1232-6. 2007
    ..This suggests that among Caucasians, positive association between higher trans-fatty acid consumption and prostate cancer may be modified by the functional RNASEL variant R462Q...
  60. ncbi Association of testis derived transcript gene variants and prostate cancer risk
    Xin Liu
    Department of Epidemiology and Biostatistics, and Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143 0794, USA
    J Urol 177:894-8. 2007
    ..To investigate this concept we evaluated the effects of 7 tagging single nucleotide polymorphisms that comprehensively captured the common genetic variants in TES on aggressive prostate cancer in a case-control study...
  61. ncbi Relationship between body size and prostate cancer in a sibling based case-control study
    Xin Liu
    Department of Epidemiology and Biostatistics, University of California San Francisco, 500 Parnassus Avenue, San Francisco, CA 94143 0560, USA
    J Urol 174:2169-73. 2005
    ..To further understand this we examined the effects of weight, height, body mass index and lean body mass (LBM) on PCa risk and aggressiveness in a sibling based case-control study...
  62. ncbi No association between genetic polymorphisms in insulin and insulin receptor substrate-1 and prostate cancer
    Li Li
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 500 Parnassus Avenue, MU 420 West, San Francisco, CA 94143 0560, USA
    Cancer Epidemiol Biomarkers Prev 14:2462-3. 2005
  63. pmc Association of vitamin D receptor gene variants, adiposity and colon cancer
    Heather M Ochs-Balcom
    Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    Carcinogenesis 29:1788-93. 2008
    ..Our results suggest that genetic variation at the VDR locus, in particular Cdx-2 and FokI SNPs, may influence colon cancer risk and these associations may be modified by adiposity...
  64. pmc Development of a clinically feasible molecular assay to predict recurrence of stage II colon cancer
    Yuqiu Jiang
    Veridex LLC, a Johnson and Johnson Company, 33 Technology Drive, Warren, NJ 07059, USA
    J Mol Diagn 10:346-54. 2008
    ..The ability to identify colon cancer patients with an unfavorable outcome may help patients at high risk for recurrence to seek more aggressive therapy...
  65. ncbi Ascending the learning curve--MSI testing experience of a six-laboratory consortium
    Noralane M Lindor
    Department of Medical Genetics, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Biomark 2:5-9. 2006
    ..The aim of this paper is to share lessons learned and to describe the final concordance rates in scoring MSI markers within this consortium...
  66. pmc Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435
    Lalita A Shevde
    University of South Alabama Mitchell Cancer Institute, Mobile, AL 36688 0002, USA
    Clin Exp Metastasis 23:123-33. 2006
    ..Thus, in addition to the widely reported roles of OPN in late stages of tumor progression, these results provide functional evidence that OPN contributes to breast tumor growth as well...
  67. ncbi MIC1 and IL1RN genetic variation and advanced prostate cancer risk
    Iona Cheng
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0794, USA
    Cancer Epidemiol Biomarkers Prev 16:1309-11. 2007

Research Grants1

  1. Genomic Wide Association Study of Colorectal Cancer
    Graham Casey; Fiscal Year: 2007
    ....