Leonard Calabrese

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Correlates and changes in empathy and attitudes toward interprofessional collaboration in osteopathic medical students
    Leonard H Calabrese
    The Cleveland Clinic, 9500 Euclid Ave, Desk A50, Cleveland, OH 44195 0001
    J Am Osteopath Assoc 113:898-907. 2013
  2. pmc Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations
    Dimitrios Vassilopoulos
    Athens University School of Medicine, 2nd Department of Medicine, Hippokration General Hospital, 114 Vass, Sophias Avenue, 115 27 Athens, Greece
    Arthritis Res Ther 10:215. 2008
  3. ncbi request reprint Using viral load, CD4+ levels, and clinical response to guide antiviral therapy for HIV
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, USA
    Cleve Clin J Med 67:321, 325-8. 2000
  4. ncbi request reprint Narrative review: reversible cerebral vasoconstriction syndromes
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 146:34-44. 2007
  5. ncbi request reprint Clinical management issues in vasculitis. Angiographically defined angiitis of the central nervous system: diagnostic and therapeutic dilemmas
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Clin Exp Rheumatol 21:S127-30. 2003
  6. pmc Hepatitis B virus (HBV) reactivation with immunosuppressive therapy in rheumatic diseases: assessment and preventive strategies
    L H Calabrese
    Department of Rheumatic and Immunological Disease, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ann Rheum Dis 65:983-9. 2006
  7. ncbi request reprint The yin and yang of tumor necrosis factor inhibitors
    Leonard Calabrese
    Section of Clinical Immunology, Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 73:251-6. 2006
  8. pmc Safety of antitumour necrosis factor (anti-TNF) therapy in patients with chronic viral infections: hepatitis C, hepatitis B, and HIV infection
    L H Calabrese
    Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland Ohio 44195, USA
    Ann Rheum Dis 63:ii18-ii24. 2004
  9. ncbi request reprint Infection with the human immunodeficiency virus type 1 and vascular inflammatory disease
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44118, USA
    Clin Exp Rheumatol 22:S87-93. 2004
  10. ncbi request reprint Rheumatic complications of human immunodeficiency virus infection in the era of highly active antiretroviral therapy: emergence of a new syndrome of immune reconstitution and changing patterns of disease
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Semin Arthritis Rheum 35:166-74. 2005

Detail Information

Publications53

  1. doi request reprint Correlates and changes in empathy and attitudes toward interprofessional collaboration in osteopathic medical students
    Leonard H Calabrese
    The Cleveland Clinic, 9500 Euclid Ave, Desk A50, Cleveland, OH 44195 0001
    J Am Osteopath Assoc 113:898-907. 2013
    ..Also, it is important to investigate the associations between measures of empathy and attitudes toward interprofessional collaboration, which are among major elements of professionalism in medicine...
  2. pmc Virally associated arthritis 2008: clinical, epidemiologic, and pathophysiologic considerations
    Dimitrios Vassilopoulos
    Athens University School of Medicine, 2nd Department of Medicine, Hippokration General Hospital, 114 Vass, Sophias Avenue, 115 27 Athens, Greece
    Arthritis Res Ther 10:215. 2008
    ..We believe that the knowledge of these key diagnostic and therapeutic features of virus-associated arthritides is important for the rheumatologist of the 21st century...
  3. ncbi request reprint Using viral load, CD4+ levels, and clinical response to guide antiviral therapy for HIV
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, USA
    Cleve Clin J Med 67:321, 325-8. 2000
    ..Although HIV RNA levels are the primary guide to therapy, the CD4+ count and clinical response are also important...
  4. ncbi request reprint Narrative review: reversible cerebral vasoconstriction syndromes
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Ann Intern Med 146:34-44. 2007
    ..In this review, we describe our current understanding of RCVS; summarize its key clinical, laboratory, and imaging features; and discuss strategies for diagnostic evaluation and treatment...
  5. ncbi request reprint Clinical management issues in vasculitis. Angiographically defined angiitis of the central nervous system: diagnostic and therapeutic dilemmas
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Clin Exp Rheumatol 21:S127-30. 2003
    ..A case of acute neurologic deficit accompanied by a cerebral angiogram consistent with CNS vasculitis is presented. The differential diagnosis and diagnostic decision process generated in this type of evaluation is illustrated...
  6. pmc Hepatitis B virus (HBV) reactivation with immunosuppressive therapy in rheumatic diseases: assessment and preventive strategies
    L H Calabrese
    Department of Rheumatic and Immunological Disease, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Ann Rheum Dis 65:983-9. 2006
    ....
  7. ncbi request reprint The yin and yang of tumor necrosis factor inhibitors
    Leonard Calabrese
    Section of Clinical Immunology, Department of Rheumatic and Immunologic Disease, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 73:251-6. 2006
    ..An increase in the risk of Mycobacterium tuberculosis and other opportunistic infections has been noted in patients treated with these agents. If we use these drugs, we need to weigh their beneficial and adverse effects...
  8. pmc Safety of antitumour necrosis factor (anti-TNF) therapy in patients with chronic viral infections: hepatitis C, hepatitis B, and HIV infection
    L H Calabrese
    Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland Ohio 44195, USA
    Ann Rheum Dis 63:ii18-ii24. 2004
    ....
  9. ncbi request reprint Infection with the human immunodeficiency virus type 1 and vascular inflammatory disease
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44118, USA
    Clin Exp Rheumatol 22:S87-93. 2004
    ..Further study of these disorders is necessary to identify specific epidemiologic features and pathogenesis...
  10. ncbi request reprint Rheumatic complications of human immunodeficiency virus infection in the era of highly active antiretroviral therapy: emergence of a new syndrome of immune reconstitution and changing patterns of disease
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Semin Arthritis Rheum 35:166-74. 2005
    ..To describe the impact of the introduction of highly active antiretroviral therapy (HAART) on the nature and frequency of rheumatic complications in human immunodeficiency virus (HIV)-infected patients...
  11. ncbi request reprint Viral arthritis
    Leonard H Calabrese
    Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic, Cleveland, OH 44195, USA
    Infect Dis Clin North Am 19:963-80, x. 2005
    ..This review addresses these and other common forms of viral arthritis, such as that caused by parvovirus B19...
  12. ncbi request reprint Progressive multifocal leukoencephalopathy in rheumatic diseases: evolving clinical and pathologic patterns of disease
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arthritis Rheum 56:2116-28. 2007
  13. ncbi request reprint Emerging viral infections and arthritis: the role of the rheumatologist
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, OH 44195, USA
    Nat Clin Pract Rheumatol 4:2-3. 2008
  14. ncbi request reprint Changing patterns of morbidity and mortality in HIV disease
    L H Calabrese
    Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 68:105, 109-10, 112. 2001
    ..Patterns of morbidity and mortality are changing: the leading cause of death is now kidney or liver failure instead of opportunistic infections...
  15. ncbi request reprint Placebo-controlled trial of cyclosporin-A in HIV-1 disease: implications for solid organ transplantation
    Leonard H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Acquir Immune Defic Syndr 29:356-62. 2002
    ..We report here the results of a randomized, double-blind, placebo-controlled trial to assess the safety and immunologic activity of CsA administration in early HIV disease...
  16. doi request reprint A rational approach to PML for the clinician
    Leonard Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA
    Cleve Clin J Med 78:S38-41. 2011
    ..In the case of natalizumab-associated PML, withdrawal of therapy and prompt institution of plasmapheresis to desaturate target receptors provides the best chance for long-term survival...
  17. ncbi request reprint Diagnostic strategies in vasculitis affecting the central nervous system
    Leonard H Calabrese
    Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 69:SII105-8. 2002
  18. ncbi request reprint Successful cardiac transplantation in an HIV-1-infected patient with advanced disease
    Leonard H Calabrese
    Department of Rheumatology and Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 348:2323-8. 2003
  19. doi request reprint Progressive multifocal leucoencephalopathy in the rheumatic diseases: assessing the risks of biological immunosuppressive therapies
    L H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Rheum Dis 67:iii64-5. 2008
    ..In particular, rheumatologists need to be vigilant and pursue the diagnosis of PML in all patients with unexplained neurological signs or symptoms with clinical and MRI findings compatible with the diagnosis...
  20. ncbi request reprint Rheumatic manifestations of hepatitis C infection
    Dimitrios Vassilopoulos
    Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Rheumatol Rep 5:200-4. 2003
    ..In this review, the recent advances in the epidemiology, pathogenesis, clinical findings, and treatment of HCV-associated rheumatic conditions are presented...
  21. ncbi request reprint Sir William Osler then and now: thoughts for the osteopathic profession
    Leonard H Calabrese
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Ohio University College of Osteopathic Medicine, USA
    J Am Osteopath Assoc 105:245-9. 2005
  22. pmc Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    Michael M Lederman
    Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 204:1217-26. 2011
    ..Failure to normalize CD4(+) T-cell numbers despite effective antiretroviral therapy is an important problem in human immunodeficiency virus (HIV) infection...
  23. ncbi request reprint HIV update 2005: origins, issues, prospects, and complications
    Wendy Armstrong
    Department of Infectious Disease, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 72:73-8. 2005
    ..However, therapy is out of reach for most people who need it in developing nations, where the infrastructure to deliver care and resources for medications is lacking. Worldwide, the epidemic is increasing at alarming rates...
  24. ncbi request reprint Lupus-related hepatitis: complication of lupus or autoimmune association? Case report and review of the literature
    Roop Kaw
    Section of General Internal Medicine, Department of General Internal Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Dig Dis Sci 51:813-8. 2006
  25. ncbi request reprint Anakinra treatment of patients with rheumatoid arthritis
    Leonard H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland, OH, USA
    Ann Pharmacother 36:1204-9. 2002
    ..To summarize the safety data arising from clinical trials of anakinra, a human recombinant form of interleukin-1 receptor antagonist (IL-1Ra) developed for the treatment of rheumatoid arthritis (RA)...
  26. ncbi request reprint Central nervous system vasculitis
    Rula A Hajj-Ali
    Center for Vasculitis Care and Research, Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Opin Rheumatol 21:10-8. 2009
    ..This review focuses on the major forms of primary CNS vasculitis, as well as secondary CNS vasculitis with emphasis on their clinical findings, diagnoses, and treatment...
  27. doi request reprint Progressive multifocal leukoencephalopathy in patients with rheumatic diseases: are patients with systemic lupus erythematosus at particular risk?
    Eamonn S Molloy
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Autoimmun Rev 8:144-6. 2008
    ..The mechanism of this putative predisposition of SLE patients to the development of PML remains unexplained...
  28. doi request reprint Progressive multifocal leukoencephalopathy: a national estimate of frequency in systemic lupus erythematosus and other rheumatic diseases
    Eamonn S Molloy
    Fasenmeyer Center for Clinical Immunology, Department of Rheumatic and Immunology Diseases, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Arthritis Rheum 60:3761-5. 2009
    ..The aim of this study was to generate a national estimate of the frequency of PML among patients with rheumatic diseases...
  29. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled trial of adjuvant methotrexate treatment for giant cell arteritis
    Gary S Hoffman
    Cleveland Clinic Foundation, Cleveland, Ohio 44915, USA
    Arthritis Rheum 46:1309-18. 2002
    ....
  30. doi request reprint Therapy: Targeted but not trouble-free: efalizumab and PML
    Eamonn S Molloy
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH 44195, USA
    Nat Rev Rheumatol 5:418-9. 2009
    ..This event highlights an urgent need for greater awareness and research into the screening, diagnosis and treatment of this potentially fatal disease in patients undergoing immunosuppressive therapy for chronic inflammatory disorders...
  31. ncbi request reprint Multifocal varicella-zoster virus vasculopathy without rash
    Andrew N Russman
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Arch Neurol 60:1607-9. 2003
    ..Treatment with intravenous acyclovir stabilized but did not significantly improve her neurological deficits...
  32. ncbi request reprint Biologic agents and liver toxicity: an added concern or therapeutic opportunity?
    Leonard H Calabrese
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44118, USA
    Nat Clin Pract Rheumatol 3:422-3. 2007
  33. ncbi request reprint Benign angiopathy of the central nervous system presenting with intracerebral hemorrhage
    Shaye I Moskowitz
    Department of Neurosurgery, Cleveland Clinic, Cleveland, OH 44195, USA
    Surg Neurol 67:522-7; discussion 527-8. 2007
    ..This syndrome of BACNS is successfully treated with low-dose steroids and calcium-channel blockers. Histologic confirmation, when performed, is normal...
  34. ncbi request reprint HIV update 2002: delaying treatment to curb rising resistance
    Wendy Armstrong
    Department of Infectious Disease, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 69:995-9. 2002
    ..Drug-resistant HIV is becoming a serious problem, even in treatment-naive patients. For HIV patients with organ failure, transplantation is increasingly an option...
  35. ncbi request reprint Induction of clinical autoimmune disease by therapeutic interferon-alpha
    Carmen Gota
    The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44118, USA
    Autoimmunity 36:511-8. 2003
  36. doi request reprint Do acute-phase reactants predict response to glucocorticoid therapy in retroperitoneal fibrosis?
    Marina N Magrey
    Department of Rheumatic and Immunologic Diseases, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Arthritis Rheum 61:674-9. 2009
    ....
  37. ncbi request reprint Central nervous system vasculitis in the intensive care unit
    Rula A Hajj-Ali
    Department of Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue G62, Cleveland, OH 44195, USA
    Crit Care Clin 18:897-914. 2002
    ..A brain biopsy may be required to confirm the diagnosis. High-dose steroid therapy with a prolonged course and gradual taper controls the disease in most cases. Additional immunosuppressive therapy is needed in some patients...
  38. ncbi request reprint Benign angiopathy of the central nervous system: cohort of 16 patients with clinical course and long-term followup
    Rula A Hajj-Ali
    Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Arthritis Rheum 47:662-9. 2002
    ..We retrospectively studied the clinical characteristics and prospectively assessed long-term outcome in a cohort of BACNS patients...
  39. doi request reprint The frequency of low muscle mass and its overlap with low bone mineral density and lipodystrophy in individuals with HIV--a pilot study using DXA total body composition analysis
    Bjoern Buehring
    University of Wisconsin Madison, Osteoporosis Clinical Research Program, Madison, WI 53705, USA
    J Clin Densitom 15:224-32. 2012
    ..Future research needs to examine what impact decreased muscle mass and function has on morbidity, physical function, and quality of life in individuals with HIV...
  40. ncbi request reprint Pilot study of coronary atherosclerotic risk and plaque burden in HIV patients: 'a call for cardiovascular prevention'
    Monica Acevedo
    Section of Preventive Cardiology and Rehabilitation, Department of Cardiology, The Cleveland Clinic Foundation, OH 44195, USA
    Atherosclerosis 163:349-54. 2002
    ..At this time, further corroboration of the emerging evidence for increased coronary risk, as well as complimentary estimates of coronary artery atherosclerotic burden, would be valuable to practicing physicians...
  41. ncbi request reprint Recent advances in vascular inflammation: C-reactive protein and other inflammatory biomarkers
    Kathleen Maksimowicz-McKinnon
    Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Curr Opin Rheumatol 16:18-24. 2004
    ..New insights into the pathophysiology of vascular inflammation have identified other potential markers that may improve detection and monitoring of these conditions...
  42. ncbi request reprint The clinical picture. An expanding skin lesion in a patient on immunosuppressive therapy
    Ravindran A Padmanabhan
    Department of Infectious Diseases, The Cleveland Clinic Foundation, OH 44195, USA
    Cleve Clin J Med 73:170-1. 2006
  43. ncbi request reprint Cryoglobulinemic vasculitis and lymphocytic interstitial pneumonitis in a person with HIV infection
    Jose R Castillo
    Department of Infectious Diseases, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    AIDS Read 15:252-5. 2005
    ..This case illustrates the complexity of the differential diagnosis of inflammatory and autoimmune disease states in HIV-1-infected patients...
  44. ncbi request reprint Hepatitis C virus infection and vasculitis: implications of antiviral and immunosuppressive therapies
    Dimitrios Vassilopoulos
    Hippokration General Hospital, Athens University, Athens, Greece
    Arthritis Rheum 46:585-97. 2002
  45. ncbi request reprint Persistent cryoglobulinemic vasculitis following successful treatment of hepatitis C virus
    James W Levine
    Rheumatology and Clinical Immunology Division, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Rheumatol 32:1164-7. 2005
    ..Successful treatment of HCV infection has resulted in resolution of cryoglobulinemia and vasculitis. We describe 4 patients who had persistent MC and vasculitis despite successful eradication of HCV with antiviral therapy...
  46. ncbi request reprint Risks of immunosuppressive therapies including biologic agents in patients with rheumatic diseases and co-existing chronic viral infections
    Dimitrios Vassilopoulos
    Assistant Professor of Medicine Rheumatology, 2nd Department of Medicine, Hippokration General Hospital, Athens University School of Medicine, Athens, Greece
    Curr Opin Rheumatol 19:619-25. 2007
    ....
  47. doi request reprint The effects of rituximab on immunocompetency in patients with autoimmune disease
    R John Looney
    University of Rochester, Rochester, New York 14642, USA
    Arthritis Rheum 58:5-14. 2008
  48. ncbi request reprint Extrahepatic immunological complications of hepatitis C virus infection
    Dimitrios Vassilopoulos
    Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, Athens, Greece
    AIDS 19:S123-7. 2005
    ..g. sialadenitis, lichen planus). In this review, the latest data on the pathogenesis and clinical manifestations of the most common autoimmune extrahepatic manifestations of chronic HCV infection are presented...
  49. ncbi request reprint Primary central nervous system vasculitis: progress and questions
    Leonard H Calabrese
    Ann Neurol 62:430-2. 2007
  50. ncbi request reprint The pathophysiology of HCV induced B-cell clonal disorders
    Dan Avi Landau
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, F 75013 France
    Autoimmun Rev 6:581-7. 2007
    ..Finally, genetic events such as bcl-2 rearrangement may also be involved in clonal expansion. In this review, evidence linking HCV with MC and NHL, as well as known events in the pathophysiological process are described...
  51. ncbi request reprint Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus
    Michelle A Petri
    Johns Hopkins University Medical Center, Baltimore, Maryland 21205, USA
    Arthritis Rheum 50:2858-68. 2004
    ..To determine whether prasterone administration results in improvement or stabilization of systemic lupus erythematosus (SLE) disease activity and its symptoms...
  52. pmc Assessment of the item selection and weighting in the Birmingham vasculitis activity score for Wegener's granulomatosis
    Alfred D Mahr
    Boston University, Boston, Massachusetts 02118, USA
    Arthritis Rheum 59:884-91. 2008
    ..To assess the Birmingham Vasculitis Activity Score for Wegener's Granulomatosis (BVAS/WG) with respect to its selection and weighting of items...