Tatiana V Byzova

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint A mechanism for modulation of cellular responses to VEGF: activation of the integrins
    T V Byzova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Cell 6:851-60. 2000
  2. ncbi request reprint Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo
    Tatiana V Byzova
    Department of Molecular Cardiology and Cardiology, The Cleveland Clinic Foundation, OH 44195, USA
    Blood 99:4434-42. 2002
  3. ncbi request reprint Integrins in bone recognition and metastasis
    Tatiana Byzova
    JJ Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland OH 44195, USA
    J Musculoskelet Neuronal Interact 4:374. 2004
  4. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
  5. pmc The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells
    Weiyi Feng
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Biol 183:1145-57. 2008
  6. pmc Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
    Xiaoxia Z West
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nature 467:972-6. 2010
  7. pmc Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain
    Yongzhong Zhao
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 287:40012-20. 2012
  8. pmc Integrin affinity modulation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Cycle 7:335-47. 2008
  9. pmc A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing
    Weiyi Feng
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
    Blood 117:3893-902. 2011
  10. pmc Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis
    Soumya Panigrahi
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, NB 5, Cleveland, OH 44195, USA
    Circ Res 112:103-12. 2013

Research Grants

Collaborators

Detail Information

Publications46

  1. ncbi request reprint A mechanism for modulation of cellular responses to VEGF: activation of the integrins
    T V Byzova
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Foundation, Ohio 44195, USA
    Mol Cell 6:851-60. 2000
    ..Thus, integrin activation provides a mechanism for VEGF to induce a broad spectrum of cellular responses...
  2. ncbi request reprint Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo
    Tatiana V Byzova
    Department of Molecular Cardiology and Cardiology, The Cleveland Clinic Foundation, OH 44195, USA
    Blood 99:4434-42. 2002
    ....
  3. ncbi request reprint Integrins in bone recognition and metastasis
    Tatiana Byzova
    JJ Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland OH 44195, USA
    J Musculoskelet Neuronal Interact 4:374. 2004
  4. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
    ....
  5. pmc The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells
    Weiyi Feng
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Biol 183:1145-57. 2008
    ..Thus, beta(3) integrin has the potential to control processes such as tumor growth and wound healing by regulating BMDC recruitment to sites undergoing pathological and adaptive angiogenesis...
  6. pmc Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
    Xiaoxia Z West
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nature 467:972-6. 2010
    ..Taken together, these findings establish a new function of TLR2 as a sensor of oxidation-associated molecular patterns, providing a key link connecting inflammation, oxidative stress, innate immunity and angiogenesis...
  7. pmc Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain
    Yongzhong Zhao
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 287:40012-20. 2012
    ..This represents a novel mechanism regulating reversibility of integrin adhesion complexes in leukocytes, which, in turn, is critical for their successful transmigration through the extracellular matrix...
  8. pmc Integrin affinity modulation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Cycle 7:335-47. 2008
    ..Although inhibition of expression of each subunit substantially affected capillary growth stimulated by VEGF, the loss of beta(3) integrin was the most inhibitory...
  9. pmc A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing
    Weiyi Feng
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
    Blood 117:3893-902. 2011
    ..Our data demonstrate that platelets stimulate BMDC homing in a VAMP-8-dependent manner, revealing a previously unknown role for platelets as key mediators between hypoxic tissues and the bone marrow during angiogenesis...
  10. pmc Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis
    Soumya Panigrahi
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, NB 5, Cleveland, OH 44195, USA
    Circ Res 112:103-12. 2013
    ..Platelets express a number of TLRs, including TLR9; however, the role of TLR in platelet function and thrombosis is poorly understood...
  11. pmc 14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio, USA
    J Cell Physiol 218:394-404. 2009
    ....
  12. pmc Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
    Juhua Chen
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Med 11:1188-96. 2005
    ..Re-expression of TSP-1 and TSP-2 in mice transplanted with wild-type bone marrow corrected the angiogenic abnormalities in Akt1(-/-) mice. These findings establish a crucial role of an Akt-thrombospondin axis in angiogenesis...
  13. ncbi request reprint Metastatic properties of prostate cancer cells are controlled by VEGF
    Juhua Chen
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Departments of Molecular Cardiology, Cardiology and Taussig Cancer Center, Cleveland Clinic Foundation, NB50, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cell Commun Adhes 11:1-11. 2004
    ..Tumor suppressor PTEN was involved in control of VEGF/VEGFR-2 stimulated prostate cancer cell adhesion as well as proliferation...
  14. ncbi request reprint Methods for isolation of endothelial and smooth muscle cells and in vitro proliferation assays
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic Foundation, OH, USA
    Methods Mol Med 129:197-208. 2006
    ..Therefore, this apparent heterogeneity has highlighted the requirement for the endothelial cell isolation and culture from a variety of tissues of different species in order to establish more realistic in vitro angiogenic models...
  15. pmc Augmented osteolysis in SPARC-deficient mice with bone-residing prostate cancer
    N Patrick McCabe
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neoplasia 13:31-9. 2011
    ..Our findings indicate that bone stromal SPARC suppresses tumor-induced bone lesion expansion by limiting osteoclast maturation and function...
  16. pmc Integrin β3 crosstalk with VEGFR accommodating tyrosine phosphorylation as a regulatory switch
    Xiaoxia Z West
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
    PLoS ONE 7:e31071. 2012
    ..Importantly, these peptides have no effect on fibroblast growth factor receptor signaling. Collectively these data provide novel mechanistic insights into phosphorylation dependent cross-talk between integrin and VEGFR2...
  17. pmc Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI
    Manojkumar Valiyaveettil
    Departments of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Blood 111:1962-71. 2008
    ..These novel findings suggest that contrary to the prothrombotic activity of oxidized low-density lipoprotein (OxLDL), HDL upon oxidation acquires antithrombotic activity that depends on platelet SR-BI...
  18. pmc Molecular pathway for cancer metastasis to bone
    Sarmishtha De
    Departments of Molecular Cardiology and Cardiology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 278:39044-50. 2003
    ..Supporting this model, activated integrins were found to colocalize with VEGFR-2 in tissue samples of metastatic prostate tumors from patients...
  19. pmc Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing
    Payaningal R Somanath
    Departments of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Angiogenesis 11:277-88. 2008
    ..These findings may have clinical applications for the improvement of treatment procedures with reported history of wound healing complications...
  20. pmc Cooperation between integrin alphavbeta3 and VEGFR2 in angiogenesis
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Angiogenesis 12:177-85. 2009
    ..The pathological consequences and regulatory events involved in this receptor cross-talk are also presented...
  21. pmc Thrombospondin-1 up-regulates expression of cell adhesion molecules and promotes monocyte binding to endothelium
    Natalya V Narizhneva
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 19:1158-60. 2005
    ..Taken together, this study identifies a novel mechanism regulating CAM expression and subsequent monocyte binding to endothelium, which might influence the development of anti-atherosclerosis therapeutic strategies...
  22. pmc Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice
    Liang Ding
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell Metab 15:861-72. 2012
    ..These studies demonstrate the nonredundant atheroprotective role for Akt3 exerted via the previously unknown link between the Akt signaling pathway and cholesterol metabolism...
  23. pmc Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly
    Payaningal R Somanath
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 282:22964-76. 2007
    ..Finally, expression of myrAkt1 corrected the phenotype of Akt1(-/-) fibroblasts thus showing that Akt1 regulates fibronectin assembly through activation of integrin alpha(5)beta(1)...
  24. pmc VEGF-integrin interplay controls tumor growth and vascularization
    Sarmishtha De
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 102:7589-94. 2005
    ..These observations identify a link between beta3 integrins and VEGF in tumor growth and angiogenesis and, therefore, may influence anti-integrin as well as anti-VEGF therapeutic strategies...
  25. pmc Akt1 in endothelial cell and angiogenesis
    Payaningal R Somanath
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cell Cycle 5:512-8. 2006
    ....
  26. doi request reprint Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress
    Bethany A Kerr
    1Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Sci Signal 6:ra67. 2013
    ..Thus, interference with Akt1 signaling in vivo could be protective and improve survival under dyslipidemic conditions by reducing oxidative stress and responses to oxidized lipids. ..
  27. pmc Oxidation as "the stress of life"
    Nikolay L Malinin
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Aging (Albany NY) 3:906-10. 2011
    ..Importantly, besides their role in a number of pathologies, oxidative products of phospholipids contribute to tissue repair processes thereby antagonizing the destructive effects of oxidation...
  28. pmc Kindlins in FERM adhesion
    Nikolay L Malinin
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, OH 44195, USA
    Blood 115:4011-7. 2010
    ..This review discusses recent progress in the studies of Kindlin protein family, emphasizing newly identified functions and potential mechanisms underlying differential activities of the family members...
  29. pmc Intraosseous injection of RM1 murine prostate cancer cells promotes rapid osteolysis and periosteal bone deposition
    N Patrick McCabe
    Department of Molecular Cardiology, NB50, The Cleveland Clinic Lerner Research Institute, Cleveland, OH 44195, USA
    Clin Exp Metastasis 25:581-90. 2008
    ....
  30. pmc Integrin and growth factor receptor alliance in angiogenesis
    Payaningal R Somanath
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, NB50, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Cell Biochem Biophys 53:53-64. 2009
    ..In this review, our focus will be on updating the recent developments in the field of integrin-growth factor receptor associations and their implications in the vascular processes...
  31. pmc Angiogenesis in melanoma
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, J J Jacobs Center for Thrombosis and Vascular Biology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Semin Oncol 34:555-65. 2007
    ..Many recently developed compounds targeting key pathways in angiogenesis are in their final stages of clinical trials...
  32. pmc Integrin signaling is critical for pathological angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Exp Med 203:2495-507. 2006
    ..These findings provide novel mechanistic insights into the role of integrin-VEGF axis in pathological angiogenesis...
  33. pmc A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
    Nikolay L Malinin
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Med 15:313-8. 2009
    ..Furthermore, allogeneic bone marrow transplantation was shown to alleviate the symptoms of the disease...
  34. pmc Inflammation and oxidative stress in angiogenesis and vascular disease
    Young Woong Kim
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, OH 44195, USA
    J Mol Med (Berl) 91:323-8. 2013
    ..This review discusses the recent findings in the area bridging neovascularization and oxidation and highlights novel mechanisms of inflammation- and oxidative stress-driven angiogenesis...
  35. pmc ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish
    Bin Ren
    Department of Cell Biology, Cleveland Clinic Foundation, Ohio, USA
    J Clin Invest 120:1217-28. 2010
    ..We therefore conclude that PI3K-ERK1/2 crosstalk plays a key role in the regulation of arterial growth and that the augmentation of ERK signaling via suppression of the PI3K signaling pathway can effectively stimulate arteriogenesis...
  36. pmc Comparison of tumor and microenvironment secretomes in plasma and in platelets during prostate cancer growth in a xenograft model
    Bethany A Kerr
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland, OH, USA
    Neoplasia 12:388-96. 2010
    ..As predicted by our model, monocyte chemotactic protein 1 and tumor necrosis factor alpha may be biomarkers for human cancers. Thus, our study identified several potential biomarkers that might be predictive of prostate cancer...
  37. ncbi request reprint Phase II trial of GM-CSF + thalidomide in patients with androgen-independent metastatic prostate cancer
    Robert Dreicer
    Department of Hematology Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Urol Oncol 23:82-6. 2005
    ..We performed a Phase II trial of this combination to assess its toxicity and potential utility as an immunomodulatory approach to management of advanced prostate cancer...
  38. pmc Kindling the flame of integrin activation and function with kindlins
    Edward F Plow
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, OH 44195, USA
    Curr Opin Hematol 16:323-8. 2009
    ..However, in-vivo data on the functions of the kindlins and their mechanisms of action have been lacking...
  39. pmc Integrin signaling in vascular function
    Nikolay L Malinin
    Department of Molecular Cardiology, Taussig Cancer Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Curr Opin Hematol 19:206-11. 2012
    ..In the current review, we outline the recent findings on the role of kindlins in the vascular system, as well as new studies that have begun shaping the mechanistic model of kindlins' function...
  40. ncbi request reprint Coronary artery disease and the thrombospondin single nucleotide polymorphisms
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology NB50, Cleveland Clinic Foundation Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:1013-30. 2004
    ....
  41. pmc Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
    Juhua Chen
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic Foundation, NB50, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Blood 104:1703-10. 2004
    ..As a consequence of impaired alpha(IIb)beta(3) activation and platelet aggregation, Akt-1 null mice showed significantly longer bleeding times than wild-type mice...
  42. pmc Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
    Eugene A Podrez
    Department of Molecular Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Med 13:1086-95. 2007
    ..Thus, interactions of platelet CD36 with specific endogenous oxidized lipids play a crucial role in the well-known clinical associations between dyslipidemia, oxidant stress and a prothrombotic phenotype...
  43. pmc The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell
    Katarzyna Bialkowska
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 285:18640-9. 2010
    ..Thus, the prevailing view that individual kindlins exert their functions in a cell type-specific manner must now be modified to consider distinct functions of the different family members within the same cell type...
  44. pmc Molecular and functional differences induced in thrombospondin-1 by the single nucleotide polymorphism associated with the risk of premature, familial myocardial infarction
    Natalya V Narizhneva
    Department of Molecular Cardiology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    J Biol Chem 279:21651-7. 2004
    ..These data suggest a potential molecular and cellular basis for a genetic risk factor associated with early onset myocardial infarction...
  45. pmc Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation
    Kamila Bledzka
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 285:30370-4. 2010
    ..These observations indicate that transitions between the phosphorylated and non-phosphorylated states of the integrin β(3) CT determine reactivity with kindlin-2 and govern the role of kindlin-2 in regulating integrin activation...
  46. ncbi request reprint Integrin alphaIIbbeta3 and its antagonism
    Martin J Quinn
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology NB50, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
    Arterioscler Thromb Vasc Biol 23:945-52. 2003
    ..An in-depth understanding of how antagonists engage and influence the function of alphaIIbbeta3 and platelets in the context of the new structural insights may explain its salutary and potential deleterious effects...

Research Grants15

  1. Regulation of Integrins in Neovasculature Development
    Tatiana V Byzova; Fiscal Year: 2010
    ..The goal of this proposal is to assess the molecular and cellular mechanisms of angiogenesis with an emphasis on pathophysiologically relevant models. ..
  2. Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2003
    ....
  3. Role of Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2009
    ..Our studies will define new directions for the development of therapies that target tumor growth in bone. ..
  4. Regulation of Integrins in Neovasculature Development
    Tatiana Byzova; Fiscal Year: 2009
    ..The goal of this proposal is to assess the molecular and cellular mechanisms of angiogenesis with an emphasis on pathophysiologically relevant models. ..
  5. Role of Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2007
    ..Our studies will define new directions for the development of therapies that target tumor growth in bone. ..
  6. Activation of alpha5beta3 integrin on blood and endothelial cells
    Tatiana Byzova; Fiscal Year: 2007
    ..abstract_text> ..
  7. Integrins and bone matrix in prostate cancer
    Tatiana Byzova; Fiscal Year: 2006
    ..abstract_text> ..
  8. Role of Integrins and bone matrix in prostate cancer
    Tatiana V Byzova; Fiscal Year: 2010
    ..Our studies will define new directions for the development of therapies that target tumor growth in bone. ..