Research Topics
| Sorin J BrenerSummaryAffiliation: Cleveland Clinic Foundation Country: USA Publications
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Publications
Comparison of percutaneous versus surgical revascularization of severe unprotected left main coronary stenosis in matched patientsSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
Am J Cardiol 101:169-72. 2008..Diabetes mellitus and advanced co-morbidity were the principal determinants of survival. These findings support the need for randomized trials with adequate follow-up to compare the 2 approaches...
Adjunctive therapy for percutaneous revascularization in acute myocardial infarctionSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Curr Pharm Des 10:399-405. 2004....- Propensity analysis of long-term survival after surgical or percutaneous revascularization in patients with multivessel coronary artery disease and high-risk featuresSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave, Desk F 25, Cleveland, Ohio 44195, USA
Circulation 109:2290-5. 2004.... - Relationship between activated clotting time and ischemic or hemorrhagic complications: analysis of 4 recent randomized clinical trials of percutaneous coronary interventionSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Circulation 110:994-8. 2004..Despite significant pharmacological and mechanical advancements in PCI, uncertainty remains about the optimal activated clotting time (ACT) for prevention of ischemic or hemorrhagic complications... - The relationship between baseline risk and mortality in ST-elevation acute myocardial infarction treated with pharmacological reperfusion: insights from the Global Utilization of Strategies To open Occluded arteries (GUSTO) V trialSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am Heart J 150:89-93. 2005.... - Predictors of revascularization method and long-term outcome of percutaneous coronary intervention or repeat coronary bypass surgery in patients with multivessel coronary disease and previous coronary bypass surgerySorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk F 25, Cleveland, OH 44195 USA
Eur Heart J 27:413-8. 2006..The optimal revascularization strategy in patients with symptomatic multivessel coronary artery disease (CAD) and previous coronary artery bypass grafting (CABG) remains unknown... - Insights into the pathophysiology of ST-elevation myocardial infarctionSorin J Brener
Angiography Core Laboratory, Interventional Cardiology Cleveland Clinic Foundation, Cleveland, OH, USA
Am Heart J 151:S4-10. 2006.... - Antihypertensive therapy and regression of coronary artery disease: insights from the Comparison of Amlodipine versus Enalapril to Limit Occurrences of Thrombosis (CAMELOT) and Norvasc for Regression of Manifest Atherosclerotic Lesions by Intravascular SoSorin J Brener
Department of Cardiovascular Medicine and Biostatistics, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Am Heart J 152:1059-63. 2006..We set out to explore the relationship between quantitative coronary angiography parameters, baseline characteristics, and clinical events in a large trial of CAD regression with antihypertensive agents... - Prolonged dual antiplatelet therapy after percutaneous coronary intervention reduces ischemic events without affecting the need for repeat revascularization: insights from the CREDO trialSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44122, USA
J Invasive Cardiol 19:287-90. 2007..The relationship between target vessel revascularization (TVR) and ischemic events in patients treated with aspirin and clopidogrel or aspirin alone from 1 month to 1 year after PCI has not been studied... - Culprit-only or multivessel revascularization in patients with acute coronary syndromes: an American College of Cardiology National Cardiovascular Database Registry reportSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Am Heart J 155:140-6. 2008..Although an early invasive strategy improves outcome in these patients, there are limited data on culprit-only, single-vessel (SV) percutaneous coronary intervention (PCI) or MV PCI in the NSTE ACS setting... - Revisiting optimal anticoagulation with unfractionated heparin during coronary stent implantationSorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 92:1468-71. 2003..3%, 7.5%, 8.1%, and 7.1%, respectively (p=0.71). The incidence of bleeding complications was 6.6%, 5.9%, 6.9%, and 7.3%, respectively (p=0.81). ACT did not independently predict either ischemic or hemorrhagic complications... - Eptifibatide and low-dose tissue plasminogen activator in acute myocardial infarction: the integrilin and low-dose thrombolysis in acute myocardial infarction (INTRO AMI) trialSorin J Brener
Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Am Coll Cardiol 39:377-86. 2002..This study was designed to test the hypothesis that eptifibatide and reduced-dose tissue plasminogen activator (t-PA) will enhance infarct artery patency at 60 min in patients with acute myocardial infarction (AMI)... - Efficacy and safety of multivessel percutaneous revascularization and tirofiban therapy in patients with acute coronary syndromesSorin J Brener
Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 90:631-3. 2002 - Abciximab-facilitated percutaneous coronary intervention and long-term survival--a prospective single-center registrySorin J Brener
Department of Cardiology, Cleveland Clinic Foundation, OH 44195, USA
Eur Heart J 24:630-8. 2003..To identify predictors of use of abciximab and evaluate the long-term survival after percutaneous coronary intervention with or without abciximab in a broad spectrum of patients... - Association between CK-MB elevation after percutaneous or surgical revascularization and three-year mortalitySorin J Brener
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 40:1961-7. 2002..The goal of this study was to assess the long-term impact of creatine kinase-MB isoform (CK-MB) elevation after percutaneous or surgical revascularization... - A randomized multicenter trial comparing a new, low-pressure versus a conventional coronary stent: primary results from the CONSERVE trialSorin J Brener
The Cleveland Clinic Foundation, OH 44195, USA
J Invasive Cardiol 15:128-32. 2003..02). Thus, the new LP stent achieves rates of revascularization that are not inferior to the Guidant stent, but this effect cannot be linked to lower-pressure deployment... - Comparison of drug-eluting stents versus bare-metal stents for treating ST-segment elevation myocardial infarctionMehdi H Shishehbor
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
JACC Cardiovasc Interv 1:227-32. 2008..We sought to examine the clinical outcomes of patients treated with drug-eluting stents (DES) compared with bare-metal stents (BMS) during primary angioplasty for ST-segment elevation myocardial infarction (STEMI)... - Prognostic significance of creatine kinase-MB elevation after percutaneous coronary intervention in patients with chronic renal dysfunctionAllen Jeremias
Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am Heart J 143:1040-5. 2002..05-1.73, P =.02). CONCLUSIONS: This analysis of patients with chronic renal insufficiency undergoing PCI suggests that postprocedural CK-MB elevation is an independent predictor of late mortality even in the presence of renal dysfunction... - In unstable angina or non-ST-segment acute coronary syndrome, should patients with multivessel coronary artery disease undergo multivessel or culprit-only stenting?Mehdi H Shishehbor
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
J Am Coll Cardiol 49:849-54. 2007.... - Real-world bare metal stenting: identification of patients at low or very low risk of 9-month coronary revascularizationStephen G Ellis
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Catheter Cardiovasc Interv 63:135-40. 2004..Conversely, if the benefits of DESs are attenuated in routine practice, many groups of patients treated with BMSs may have nearly comparable results... - Use of platelet glycoprotein IIb/IIIa inhibitors in saphenous vein graft percutaneous coronary intervention and clinical outcomesJuhana Karha
The Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 98:906-10. 2006..92, 95% confidence interval 0.69 to 1.23, p = 0.59). In conclusion, adjunctive use of platelet GP IIb/IIIa inhibitors in saphenous vein graft PCI does not appear to be associated with less myonecrosis or improved survival... - Relation of C-reactive protein level and long-term risk of death or myocardial infarction following percutaneous coronary intervention with a sirolimus-eluting stentJuhana Karha
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Am J Cardiol 98:616-8. 2006..This finding was present in the BMS and SES groups and highlights the need for aggressive risk-factor modification after PCI... - Safety of abciximab during percutaneous coronary intervention in patients with chronic renal insufficiencyAllen Jeremias
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 89:1209-11. 2002 - Long-term impact of drug-eluting stents versus bare-metal stents on all-cause mortalityMehdi H Shishehbor
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA
J Am Coll Cardiol 52:1041-8. 2008..Our purpose was to examine the incidence of all-cause mortality among drug-eluting stents (DES) and bare-metal stents (BMS) while adjusting for many confounding factors generally not considered in prior studies... - Reperfusion after primary angioplasty for ST-elevation myocardial infarction: predictors of success and relationship to clinical outcomes in the APEX-AMI angiographic studySorin J Brener
Cleveland Clinic Foundation, Cleveland, OH, USA
Eur Heart J 29:1127-35. 2008.... - Safety and efficacy of overlapping sirolimus-eluting versus paclitaxel-eluting stentsMehdi H Shishehbor
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
Am Heart J 155:1075-80. 2008..The short-term and long-term safety and efficacy of paclitaxel versus sirolimus-overlapping drug-eluting stents (DES) is unknown. We sought to examine the clinical consequences of overlapping sirolimus versus paclitaxel DES... - GuardWire emboli protection device is associated with improved myocardial perfusion grade in saphenous vein graft interventionJose E Exaire
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am Heart J 148:1003-6. 2004..5 or 3 had a statistically significant reduction in MACE (OR 0.36, 95% CI 0.14-0.87, P = .02). CONCLUSIONS: Compared with SVG-PCI without emboli protection, EPD significantly improved TMP and trended towards a reduction in MACE... - Early invasive strategies for acute coronary syndromesMartin J Quinn
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Desk F25, 9500 Euclid Avenue, OH 44195, USA
Curr Cardiol Rep 4:334-40. 2002..Initial costs are higher with an early invasive strategy; however, these are offset by reductions in rehospitalizations and later ischemic complications... - Relation of myocardial perfusion to mortality after primary percutaneous coronary interventionJuhana Karha
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Am J Cardiol 95:980-2. 2005..This observation has important implications for the methods of evaluating primary PCI results and the strategies used to improve myocardial reperfusion... - Prevalence of conventional risk factors in patients with coronary heart diseaseUmesh N Khot
Department of Cardiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
JAMA 290:898-904. 2003..This claim implies that other factors play a significant role in CHD and has led to considerable interest in nontraditional risk factors and genetic causes of CHD... - Primary percutaneous coronary intervention for acute MI: improving access and outcomesJuhana Karha
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, OH 44195, USA
Cleve Clin J Med 72:559-60, 562, 565-6 passim. 2005..Multiple clinical trials in the past 10 years have addressed ways to improve PCI as primary therapy for acute MI. Logistic strategies to improve access to PCI are being studied... - Images in cardiovascular medicine. Tako-tsubo--like transient left ventricular dysfunctionJohn P Girod
Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, Ohio 44195, USA
Circulation 107:e120-1. 2003 - Flow-dependent changes resulting in restoration of patency of the left internal mammary artery graft after documented atresiaRaja Nawaz
Department of Cardiology, New York Methodist Hospital, 476 6th Street, Brooklyn, NY 11215, USA
J Invasive Cardiol 23:207-10. 2011..We report a patient in whom the LIMA was occluded 2 years after CABG, but was found to be completely patent 5 years later, after worsening of the left anterior descending artery disease... - Improved clinical outcomes with abciximab therapy in acute myocardial infarction: a systematic overview of randomized clinical trialsDavid E Kandzari
Division of Cardiology, Department of Medicine, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27715, USA
Am Heart J 147:457-62. 2004.... - The relation between extent of coronary artery disease measured by quantitative coronary angiography and changes in lipid profile: insights from trials of atherosclerosis regressionSorin J Brener
Division of Cardiology, New York Methodist Hospital, Brooklyn, NY 11215, USA
J Invasive Cardiol 20:261-5. 2008..While favorable changes in atherogenic lipids are indisputably associated with improved clinical outcomes, a similar correlation with quantitative coronary angiography (QCA) parameters is more difficult to document... - Effect of uncoated stenting versus balloon angioplasty alone of long coronary (>20 mm) versus shorter narrowings on one-year event-free survivalFernando A Cura
Department of Cardiology, Instituto Cardiovascular de Buenos Aires, Argentina
Am J Cardiol 91:587-90. 2003 - The influence of peripheral arterial disease on outcomes: a pooled analysis of mortality in eight large randomized percutaneous coronary intervention trialsJacqueline Saw
Department of Medicine, Division of Cardiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada
J Am Coll Cardiol 48:1567-72. 2006..31 to 2.37; p < 0.001), and 1 year (HR 1.46, 95% CI 1.08 to 1.96; p = 0.013). CONCLUSIONS: The presence of PAD is associated with higher rates of post-PCI death and MI, and is an independent predictor of short- and long-term mortality... - Impaired myocardial perfusion score and inflammatory markers in patients undergoing primary angioplasty for acute myocardial infarctionJ Emilio Exaire
Instituto Nacional de Cardiologia, Mexico City, Mexico
Arch Cardiol Mex 76:376-82. 2006.... - Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burdenChristie M Ballantyne
Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart and Vascular Center, Houston, Tex 77030, USA
Circulation 117:2458-66. 2008..Intravascular ultrasound showed atheroma volume regression in a single coronary artery with <50% angiographic luminal narrowing... - Wish list and REALITY: choice of stents and end points for treatment of de novo coronary artery lesionsSorin J Brener
JAMA 295:937-8. 2006 - CABG or PCI? An interventional cardiologist's perspective. To stent or to operate: is this the question?Sorin J Brener
Cleve Clin J Med 73:340, 343. 2006