Min Booki

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival
    Tao Shen
    Department of Immunology NB30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int Immunol 20:1201-9. 2008
  2. pmc Basophils induce Th2 immunity: is this final answer?
    Booki Min
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Virulence 1:399-401. 2010
  3. ncbi request reprint Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 37:1916-23. 2007
  4. ncbi request reprint Basophils: a potential liaison between innate and adaptive immunity
    Booki Min
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Allergol Int 55:99-104. 2006
  5. doi request reprint Basophils: what they 'can do' versus what they 'actually do'
    Booki Min
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Immunol 9:1333-9. 2008
  6. ncbi request reprint Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6039-44. 2005
  7. ncbi request reprint Endogenous proliferation: burst-like CD4 T cell proliferation in lymphopenic settings
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Immunol 17:201-7. 2005
  8. pmc Mice that "conditionally" lack basophils, AT LAST
    Booki Min
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 120:2648-51. 2010
  9. ncbi request reprint Neonates support lymphopenia-induced proliferation
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:131-40. 2003
  10. pmc IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo
    Jeong su Do
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Blood 113:6361-71. 2009

Research Grants

  1. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2009
  2. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2010
  3. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint T cell-derived IL-3 plays key role in parasite infection-induced basophil production but is dispensable for in vivo basophil survival
    Tao Shen
    Department of Immunology NB30, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int Immunol 20:1201-9. 2008
    ..Collectively, these results highlight a novel mechanism by which activation of adaptive immune components induces basophil production but not basophil survival via IL-3 production...
  2. pmc Basophils induce Th2 immunity: is this final answer?
    Booki Min
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Virulence 1:399-401. 2010
    ..In this review, how basophils may (and may not) contribute to the development of Th2 immunity in vivo is discussed...
  3. ncbi request reprint Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 37:1916-23. 2007
    ..Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg...
  4. ncbi request reprint Basophils: a potential liaison between innate and adaptive immunity
    Booki Min
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Allergol Int 55:99-104. 2006
    ....
  5. doi request reprint Basophils: what they 'can do' versus what they 'actually do'
    Booki Min
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Nat Immunol 9:1333-9. 2008
    ..In this review, the functions of basophils determined on the basis of analysis of in vitro and in vivo systems and their potential involvement in clinical settings are discussed...
  6. ncbi request reprint Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6039-44. 2005
    ..Our results reveal the complexity and heterogeneity of lymphopenia-driven T cell proliferation and suggest that they may have fundamentally distinct roles in the maintenance of CD4 T cell homeostasis...
  7. ncbi request reprint Endogenous proliferation: burst-like CD4 T cell proliferation in lymphopenic settings
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Semin Immunol 17:201-7. 2005
    ..We argue that it is regulated not by the absolute number of memory cells present but by the range of specificities of those cells. We discuss the physiologic significance of endogenous proliferation and outline goals for future studies...
  8. pmc Mice that "conditionally" lack basophils, AT LAST
    Booki Min
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Clin Invest 120:2648-51. 2010
    ..Using this model, they then uncover a nonredundant role for basophils in acquired immunity against tick infection...
  9. ncbi request reprint Neonates support lymphopenia-induced proliferation
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:131-40. 2003
    ..CD44(bright) CD4 T cells in neonates have a wide repertoire as judged by the distribution of Vbeta expression. Thus, lymphopenia-induced T cell proliferation is a physiologic process that occurs during the early postnatal period...
  10. pmc IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo
    Jeong su Do
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, OH 44195, USA
    Blood 113:6361-71. 2009
    ....
  11. ncbi request reprint Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils
    Keunhee Oh
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, OH, USA
    Blood 109:2921-7. 2007
    ..Taken together, our results suggest that basophils may provide an important link for the development of Th2 immunity...
  12. pmc Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Proc Natl Acad Sci U S A 101:3874-9. 2004
    ..This finding suggests that the immune system has evolved mechanisms to attain a memory cell repertoire of great diversity independently of foreign antigens...
  13. doi request reprint Basophils can directly present or cross-present antigen to CD8 lymphocytes and alter CD8 T cell differentiation into IL-10-producing phenotypes
    Sohee Kim
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 183:3033-9. 2009
    ..Collectively, these results suggest a novel function of basophils that act as professional APCs to present Ag to CD8 T cells, thus inducing IL-10 production...
  14. pmc Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo
    Jeong su Do
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 106:20394-8. 2009
    ..These results suggest that depending on the T-cell lineages, as well as the differentiation status, different mechanisms control endogenous proliferation, revealing in vivo complexity of T-cell proliferation under lymphopenic conditions...
  15. pmc Repertoire-dependent immunopathology
    Joshua Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Autoimmun 29:257-61. 2007
    ..Limited repertoire complexity of Tregs may lead to a failure to control immunopathologic responses and limited repertoire complexity of conventional cells may be responsible for the Th2 phenotype...
  16. pmc Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism
    Jeong su Do
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 184:1675-9. 2010
    ..Our findings identify a novel developmental pathway during which IL-17-competent gammadelta T cells arise in the thymus by a TGF-beta1-dependent mechanism...
  17. pmc The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
    Muhammet F Gulen
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Immunity 32:54-66. 2010
    ..Our results demonstrate an important mechanism by which SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signaling pathway...
  18. ncbi request reprint Neonates support "homeostatic" proliferation
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    Adv Exp Med Biol 512:91-5. 2002
  19. pmc Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    Booki Min
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr, Bldg 10, Bethesda, MD 20892, USA
    J Exp Med 200:507-17. 2004
    ..Thus, infection with a parasite that induces a "Th2-type response" resulted in accumulation of tissue basophils, and these cells, stimulated by a non-FcR cross-linking mechanism, are a principal source of in vivo IL-4 production...
  20. ncbi request reprint Blimp-1 induced by IL-4 plays a critical role in suppressing IL-2 production in activated CD4 T cells
    Lu Wang
    Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 181:5249-56. 2008
    ..Taken together, our results demonstrate a potential link with IL-4, Blimp-1, and IL-2 production, suggesting that Blimp-1 may play an important role in controlling IL-2 production in activated T cells and in adaptive T cell immunity...
  21. pmc Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3
    Sohee Kim
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 184:1143-7. 2010
    ..Our results reveal a previously unknown role of IL-3 in recruiting basophils to the LN and demonstrate that basophils are not necessarily associated with the development of Th2 immunity during parasite infection...
  22. pmc Basophils and type 2 immunity
    Booki Min
    Department of Immunology NB30, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Curr Opin Hematol 15:59-63. 2008
    ..Mechanisms involved in the development of in-vivo type 2 immunity are poorly defined. Basophils are potent IL-4-producing cells and may contribute to the process of polarizing immune responses...
  23. pmc Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells
    Nobuki Hayashi
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:6187-91. 2002
    ..Thus, antigenic challenge of mice possessing resting memory TH1 CD4 T cells leads to the unanticipated loss of most of the specific cells and an apparent depletion rather than enhancement of immunologic memory...
  24. ncbi request reprint Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 16:733-44. 2002
    ..The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion...
  25. ncbi request reprint Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 5:1157-65. 2004
    ..Thus, GATA-3 serves as a principal switch in determining T(H)1-T(H)2 responses...
  26. pmc A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity
    Tae Whan Kim
    Department of Immunology, Cleveland Clinic Foundation, Indianapolis, IN 46285, USA
    J Exp Med 204:1025-36. 2007
    ..Collectively, our results indicate that IRAK4 kinase activity plays a critical role in TLR-dependent immune responses...
  27. pmc Jak3 negatively regulates dendritic-cell cytokine production and survival
    Kunihiro Yamaoka
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bldg 10, 9N256, 10 Center Dr, Bethesda, MD 20892 1820, USA
    Blood 106:3227-33. 2005
    ..These results may be relevant clinically for patients with SCID who have undergone hematopoietic stem cell transplantation and for patients who might be treated with a Jak3 inhibitor...
  28. pmc The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response
    Katarzyna Bulek
    Immunology Department, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 182:2601-9. 2009
    ..Taken together, our results suggest that SIGIRR plays an important role in the regulation of Th2 response in vivo, possibly through its impact on IL-33-ST2-mediated signaling...
  29. ncbi request reprint Concomitant regulation of T-cell activation and homeostasis
    Zvi Grossman
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Nat Rev Immunol 4:387-95. 2004
  30. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells...
  31. pmc Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection
    Aiping Zhao
    Department of Medicine and the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 175:2563-9. 2005
    ..N. brasiliensis-induced changes in PAR-1 function and expression were seen in IL-4-deficient mice, but not in IL-13- or STAT6-deficient mice, indicating the dependence of IL-13 on the STAT6 signaling pathway independent of IL-4...
  32. ncbi request reprint Break of neonatal Th1 tolerance and exacerbation of experimental allergic encephalomyelitis by interference with B7 costimulation
    J Jeremiah Bell
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 171:1801-8. 2003
    ..Thus, recovery from neonatally induced T cell anergy requires B7 molecules to serve double functions, namely, costimulation and induction of cytokine production by APCs...
  33. ncbi request reprint neonatally primed lymph node, but not splenic T cells, display a Gly-Gly motif within the TCR beta-chain complementarity-determining region 3 that controls affinity and may affect lymphoid organ retention
    Jacque C Caprio-Young
    Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Immunol 176:357-64. 2006
    ..Also, it is suggested that a higher TCR affinity may be a contributing factor for the development of the neonatal Th1 response in the spleen...
  34. doi request reprint Basophils: in the spotlight at last
    Booki Min
    Nat Immunol 9:223-5. 2008

Research Grants3

  1. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2009
    ..The current proposal aims to investigate underlying cellular mechanism, and the results will aid our understanding of the immune mechanism and facilitate therapeutic strategies to treat disorders caused by the dysregulation. ..
  2. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2010
    ..The current proposal aims to investigate underlying cellular mechanism, and the results will aid our understanding of the immune mechanism and facilitate therapeutic strategies to treat disorders caused by the dysregulation. ..
  3. Homeostatic Regulation of T Lymphocytes
    Booki Min; Fiscal Year: 2011
    ..The current proposal aims to investigate underlying cellular mechanism, and the results will aid our understanding of the immune mechanism and facilitate therapeutic strategies to treat disorders caused by the dysregulation. ..