Steven D Billings

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variants
    Steven D Billings
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Dermatopathol 29:437-42. 2007
  2. doi request reprint Molecular diagnostics complementing morphology in superficial mesenchymal tumors
    Alison L Cheah
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Semin Diagn Pathol 30:95-109. 2013
  3. doi request reprint The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens
    Karen J Fritchie
    Dept of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Clin Pathol 137:229-39. 2012
  4. ncbi request reprint STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics
    Alison L Cheah
    Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, United States
    Pathology 46:389-95. 2014
  5. doi request reprint The role of molecular testing in the diagnosis of cutaneous soft tissue tumors
    Alison L Cheah
    Department of Anatomic Pathology, Cleveland Clinic, L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Semin Cutan Med Surg 31:221-33. 2012
  6. doi request reprint FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations
    Anthony P Fernandez
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 39:234-42. 2012
  7. doi request reprint Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience
    Munir R Tanas
    Department of Pathology, Cleveland Clinic, Ohio, USA
    Arch Pathol Lab Med 134:1797-803. 2010
  8. ncbi request reprint Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005
  9. ncbi request reprint Fully automated dual-color dual-hapten silver in situ hybridization staining for MYC amplification: a diagnostic tool for discriminating secondary angiosarcoma
    Jennifer S Ko
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    J Cutan Pathol 41:286-92. 2014
  10. doi request reprint Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum
    Summer L Bohman
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, United States
    Pathology 46:199-204. 2014

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Diagnostically challenging spindle cell lipomas: a report of 34 "low-fat" and "fat-free" variants
    Steven D Billings
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Dermatopathol 29:437-42. 2007
    ..CD34 was diffusely positive (10/11). A high index of suspicion based on clinical context and identification of other typical features of SCL are key features to the diagnosis of low-fat and fat-free SCL...
  2. doi request reprint Molecular diagnostics complementing morphology in superficial mesenchymal tumors
    Alison L Cheah
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Semin Diagn Pathol 30:95-109. 2013
    ..This review will focus on mesenchymal tumors with specific cytogenetic abnormalities that may present as a superficial tumor of the dermis or subcutis...
  3. doi request reprint The expanded histologic spectrum of myxoid liposarcoma with an emphasis on newly described patterns: implications for diagnosis on small biopsy specimens
    Karen J Fritchie
    Dept of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Clin Pathol 137:229-39. 2012
    ..Awareness of the variety of histologic patterns is critical to avoid misdiagnosis, especially in small biopsy specimens...
  4. ncbi request reprint STAT6 rabbit monoclonal antibody is a robust diagnostic tool for the distinction of solitary fibrous tumour from its mimics
    Alison L Cheah
    Robert J Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, United States
    Pathology 46:389-95. 2014
    ..Our study further supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of solitary fibrous tumour...
  5. doi request reprint The role of molecular testing in the diagnosis of cutaneous soft tissue tumors
    Alison L Cheah
    Department of Anatomic Pathology, Cleveland Clinic, L25, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Semin Cutan Med Surg 31:221-33. 2012
    ..This review will focus on the application of molecular diagnostic testing in select mesenchymal tumors of the dermis and subcutis...
  6. doi request reprint FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations
    Anthony P Fernandez
    Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA
    J Cutan Pathol 39:234-42. 2012
    ....
  7. doi request reprint Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience
    Munir R Tanas
    Department of Pathology, Cleveland Clinic, Ohio, USA
    Arch Pathol Lab Med 134:1797-803. 2010
    ..Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH)...
  8. ncbi request reprint Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005
    ..PAF signaling may participate in the cutaneous inflammation that occurs during photo-aggravated dermatoses...
  9. ncbi request reprint Fully automated dual-color dual-hapten silver in situ hybridization staining for MYC amplification: a diagnostic tool for discriminating secondary angiosarcoma
    Jennifer S Ko
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA
    J Cutan Pathol 41:286-92. 2014
    ....
  10. doi request reprint Angiomatoid fibrous histiocytoma: an expansion of the clinical and histological spectrum
    Summer L Bohman
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, United States
    Pathology 46:199-204. 2014
    ..Thirteen of 16 (81%) had a rearrangement of EWSR1; none had a FUS rearrangement.This series expands the spectrum of angiomatoid fibrous histiocytoma...
  11. doi request reprint Morphologic mimickers of Cryptococcus occurring within inflammatory infiltrates in the setting of neutrophilic dermatitis: a series of three cases highlighting clinical dilemmas associated with a novel histopathologic pitfall
    Jennifer S Ko
    Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Cutan Pathol 40:38-45. 2013
    ..We believe recognition of this microscopic pitfall will be useful to dermatopathologists faced with similar findings in the future, and may prevent unnecessary delay of appropriate therapy in acutely ill patients...
  12. doi request reprint Acral soft tissue tumors: a review
    Dipti Mahajan
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Adv Anat Pathol 18:103-19. 2011
    ..Clinical, histologic, and immunohistochemical features are discussed along with prognosis and differential diagnosis...
  13. doi request reprint Initial presentation of stasis dermatitis mimicking solitary lesions: a previously unrecognized clinical scenario
    Joshua Weaver
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Am Acad Dermatol 61:1028-32. 2009
    ..Early recognition of signs and appropriate diagnosis can lead to timely treatment that can prevent painful complications, such as leg ulcers which are at risk for development of squamous cell carcinoma...
  14. doi request reprint Cutaneous collagenous vasculopathy: a rare cutaneous microangiopathy
    Laura M Burdick
    Cleveland Clinic Anatomic Pathology and Dermatology, Cleveland, OH, USA
    J Cutan Pathol 39:741-6. 2012
    ..The amorphous pink material is periodic acid-Schiff-positive and resistant to diastase. We describe a series of four patients with cutaneous collagenous vasculopathy and highlight its clinical and histopathologic features...
  15. doi request reprint Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases
    Munir R Tanas
    Department of Anatomic Pathology, Pathology and Laboratory Medicine Institute, The Cleveland Clinic and The Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA
    Mod Pathol 23:93-7. 2010
    ..Finally, we discuss some of the potential pitfalls of this technique, including confusion with other mesenchymal neoplasms containing rearrangement of EWSR1, in particular Ewing's sarcoma/PNET...
  16. ncbi request reprint Primary cutaneous epithelioid rhabdomyosarcoma: a rare, recently described entity with review of the literature
    Patrick C Feasel
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    J Cutan Pathol 41:588-91. 2014
    ..No evidence of a deep soft tissue primary lesion was identified. In summary, epithelioid rhabdomyosarcoma can present as a primary cutaneous lesion and dermatopathologists should be aware of this entity. ..
  17. ncbi request reprint Clinicopathological analysis of basal cell carcinoma of the anal region and its distinction from basaloid squamous cell carcinoma
    Deepa T Patil
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    Mod Pathol 26:1382-9. 2013
    ..Immunostains are extremely helpful as diffuse Ber-EP4 and BCL2 expression is a feature of basal cell carcinoma and basaloid squamous cell carcinoma is typified by diffuse CDKN2A and SOX2 expression. ..
  18. doi request reprint Primary cutaneous rhabdomyosarcoma: a clinicopathologic review of 11 cases
    Trent B Marburger
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA
    J Cutan Pathol 39:987-95. 2012
    ..Rhabdomyosarcoma is a malignant mesenchymal tumor with skeletal muscle differentiation. Primary cutaneous rhabdomyosarcoma is rare. We report a series of 11 cases of primary cutaneous rhabdomyosarcoma...
  19. doi request reprint Cutaneous soft tissue tumors that make you say, "oh $*&%!"
    Rajiv M Patel
    Department of Pathology and Dermatology, University of Michigan, Ann Arbor, MI, USA
    Adv Anat Pathol 19:320-30. 2012
    ..The clinical, histologic, immunohistochemical, and where appropriate, molecular features of these entities are discussed along with their prognosis and differential diagnosis...
  20. doi request reprint Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26
    Jerad M Gardner
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Am J Surg Pathol 36:1047-51. 2012
    ..The low incidence of MDM2 gene amplification in our series indicates that most superficial PLs are unrelated to WDL/DL. PL likely evolves by way of more than 1 molecular pathway...
  21. ncbi request reprint Postradiation cutaneous vascular tumors of the breast: a review
    Joshua Weaver
    Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Semin Diagn Pathol 26:141-9. 2009
    ..Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL...
  22. doi request reprint Low-fat and fat-free pleomorphic lipomas: a diagnostic challenge
    Mandi P Sachdeva
    Department of Dermatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Dermatopathol 31:423-6. 2009
    ..When fat is absent or present in reduced amounts, clinical context and identification of classic nonlipogenic components are essential for the diagnosis of pleomorphic lipomas...
  23. pmc Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor
    Qiwei Zhang
    Department of Dermatology, H B Wells Center for Pedoatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 115:2855-61. 2005
    ..These findings show a novel mechanism by which staphylococcal infections can inhibit Th1 reactions and thus worsen Th2 skin diseases, such as atopic dermatitis...
  24. pmc Amphiregulin overexpression results in rapidly growing keratinocytic tumors: an in vivo xenograft model of keratoacanthoma
    Steven D Billings
    Departments of Pathology and Laboratory Medicine and Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Pathol 163:2451-8. 2003
    ..The HaCaT-NIE cells formed thin tumors resembling conventional SCC. The HaCaT-AR cells formed rapidly growing tumors with AR expression similar to KA. HaCaT-AR cells may represent a new system for the further evaluation of KA...
  25. ncbi request reprint Immunolocalization of low-affinity prostaglandin E receptors, EP and EP, in adult human epidermis
    Raymond L Konger
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Invest Dermatol 124:965-70. 2005
    ..In cultured primary human keratinocytes, we also verified the presence of functional EP(1) receptor coupled to intracellular calcium mobilization and EP(2) receptor coupled to cAMP production...
  26. pmc Trafficking pathways and characterization of CD4 and CD8 cells recruited to the skin of humans experimentally infected with Haemophilus ducreyi
    Tricia L Humphreys
    Department of Medicine, Indiana University, Indianapolis, Indiana 46202, USA
    Infect Immun 73:3896-902. 2005
    ..Soler, T. L. Humphreys, S. M. Spinola, and J. J. Campbell, Blood 101:1677-1683, 2003), these studies led us to propose a model of memory T-cell trafficking to skin in response to experimental H. ducreyi infection...
  27. ncbi request reprint Genetically heterogeneous and clonally unrelated metastases may arise in patients with cutaneous melanoma
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1029-37. 2007
    ....
  28. doi request reprint Widespread cutaneous metastases from acinic cell carcinoma 20 years after primary presentation
    Mary F Varsegi
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    J Cutan Pathol 35:591-3. 2008
    ..To our knowledge, is the first report of widespread cutaneous metastasis from acinic cell carcinoma...
  29. ncbi request reprint Cutaneous and subcutaneous fibrohistiocytic tumors of intermediate malignancy: an update
    Steven D Billings
    Department of Pathology, Indiana University, Indianapolis, IN, USA
    Am J Dermatopathol 26:141-55. 2004
    ..The differential diagnosis of these tumors with a variety of benign and fully malignant cutaneous soft tissue neoplasms is discussed...
  30. ncbi request reprint Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 cases
    Steven D Billings
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 28:781-8. 2004
    ..The median interval to death was 33.5 months. All 4 patients with disease have documented metastasis. CPRASB differs from Stewart-Treves AS by its shorter latency period and lack of association with lymphedema...
  31. ncbi request reprint Langerhans cell histiocytosis associated with myelodysplastic syndrome in adults
    Steven D Billings
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Cutan Pathol 33:171-4. 2006
    ..Langerhans cell histiocytosis (LCH) is primarily a pediatric disease, and rarely LCH has been described in association with pediatric MDS. We are aware of only a single case report of LCH associated with MDS in an adult...
  32. ncbi request reprint Spindle cell lipoma of the oral cavity
    Steven D Billings
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Dermatopathol 28:28-31. 2006
    ..The combination of the histologic features and the immunoreactivity for CD34 confirmed the diagnosis. Spindle cell lipoma should be considered in the differential diagnosis of oral cavity mesenchymal tumors...
  33. ncbi request reprint Abdominal plaque in a 10-day-old boy
    Ernest Lee
    Indiana University School of Medicine, Indianapolis, USA
    Arch Dermatol 142:641-6. 2006
  34. ncbi request reprint Fungating forehead plaque: angiosarcoma
    Benjamin N Lockshin
    Case Western Reserve School of Medicine, Silver Spring, MD, USA
    Arch Dermatol 142:1059-64. 2006
  35. ncbi request reprint Histological evaluation of acute mucocutaneous graft-versus-host disease in nonmyeloablative hematologic stem cell transplants with an observation predicting an increased risk of progression to chronic graft-versus-host disease
    Andrew T Bridge
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Dermatopathol 29:1-6. 2007
    ..Patients with composite skin GVHD may benefit from an earlier, more aggressive immunosuppressive interventional strategy...
  36. ncbi request reprint Expression of androgen receptor by fibroepithelioma of Pinkus: evidence supporting classification as a basal cell carcinoma variant?
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Dermatopathol 29:7-12. 2007
    ..In small, partial biopsy specimens, coexpression of androgen receptor and cytokeratin 20 may aid in the diagnosis of fibroepithelioma of Pinkus...
  37. ncbi request reprint CD4+ CD56+ hematodermic neoplasm
    Thomas L Cibull
    Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
    Am J Dermatopathol 29:59-61. 2007
    ..CD4+CD56+ hematodermic neoplasms are rare and commonly present as cutaneous lesions. This is an important diagnosis in the differential diagnosis of cutaneous hematologic malignancies because of the extremely poor prognosis...
  38. ncbi request reprint Cutaneous malignant ossifying fibromyxoid tumor
    Thomas L Cibull
    Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202 5126, USA
    Am J Dermatopathol 29:156-9. 2007
    ..Given the histologic features, this tumor was considered a malignant OFMT. The patient had a wide excision. The patient died secondary to unrelated comorbidities without evidence of recurrence or metastasis...
  39. ncbi request reprint Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity?
    Torsten Ehrig
    Dermatopathology Laboratory of New England, Meriden, CT 06450, USA
    Ann Diagn Pathol 11:153-9. 2007
    ..0 years). Cutaneous PN/ES is a superficial round cell tumor in older women, with better prognosis than deep PN/ES. These may have a hitherto unrecognized variant genetic abnormality...
  40. ncbi request reprint Clonal relationships between epidermotropic metastatic melanomas and their primary lesions: a loss of heterozygosity and X-chromosome inactivation-based analysis
    Soon Bahrami
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Mod Pathol 20:821-7. 2007
    ..Our data also indicated that some cases diagnosed as epidermotropic metastatic melanoma might be divergent clones or new primaries rather than metastatic disease...
  41. ncbi request reprint Loss of heterozygosity analysis identifies genetic abnormalities in mycosis fungoides and specific loci associated with disease progression
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Surg Pathol 31:1552-6. 2007
    ..Further, in this series, several loci associated with the tumor suppressor gene PTEN on chromosome 10 appear to be associated with progression from plaque to tumor stage...
  42. ncbi request reprint Leiomyosarcoma of the penis presenting as a cutaneous lesion
    Thomas L Cibull
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA
    J Cutan Pathol 35:585-7. 2008
    ..This is an important diagnosis in the differential diagnosis of cutaneous spindle cell neoplasms of the male genital tract...
  43. ncbi request reprint Expression of OCT4 transcription factor in cutaneous neoplasia
    Terrence M Katona
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA
    Appl Immunohistochem Mol Morphol 15:359-62. 2007
    ..In contrast to previous studies, our data indicate that the OCT4 expression is not retained in cutaneous neoplasms derived from basal epidermis or related adnexal neoplasms, including lesions of the scalp...
  44. doi request reprint Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma?
    Terrence M Katona
    Department of Pathology, Indiana University School of Medicine, Indianapolis, IN 46259, USA
    J Cutan Pathol 35:174-9. 2008
    ..We investigated whether AR and CK20 immunostains may distinguish between mBCC and DTE...
  45. doi request reprint Myeloid leukemia cutis: a histologic and immunohistochemical review
    Thomas L Cibull
    Department of Pathology and Laboratory Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    J Cutan Pathol 35:180-5. 2008
    ..The histologic diagnosis of myeloid leukemia cutis (LC) can be difficult, requiring confirmatory immunohistochemical stains...
  46. ncbi request reprint Subungual pleomorphic fibroma
    Ya Ju Hsieh
    Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan
    J Cutan Pathol 30:569-71. 2003
    ..These cytologic features may lead to an incorrect diagnosis of malignancy. Most cases reported in the literature are located on trunk or extremities; the presentation as a subungual mass is rare...