ROBERT BALLOCK

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling in Growth Plate Chondrocytes
    Lai Wang
    Orthopaedic and Rheumatologic Research Center, Departments of Biomedical Engineering and Orthopaedic, Surgery, A 41, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    PPAR Res 2012:756198. 2012
  2. pmc Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling
    Lai Wang
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Bone Miner Res 25:1138-46. 2010
  3. pmc Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling pathways in growth plate chondrocytes
    Lai Wang
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Bone Miner Res 24:265-73. 2009
  4. ncbi request reprint Molecular and genetic approaches to musculoskeletal diseases
    R Tracy Ballock
    Department of Orthopedic Surgery, Cleveland Clinic Foundation, OH 44195, USA
    J Pediatr Orthop 23:131-7. 2003
  5. ncbi request reprint Physiology and pathophysiology of the growth plate
    R Tracy Ballock
    Orthopaedic Research Center, Departments of Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Birth Defects Res C Embryo Today 69:123-43. 2003
  6. ncbi request reprint The biology of the growth plate
    R Tracy Ballock
    Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, OH 44195, USA
    J Bone Joint Surg Am 85:715-26. 2003
  7. ncbi request reprint Peroxisome proliferator activated receptor-gamma (PPARgamma) represses thyroid hormone signaling in growth plate chondrocytes
    Lai Wang
    Department of Orthopaedic Surgery and Biomedical Engineering, Orthopaedic Research Center, The Lerner Research Institute, A 41, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Bone 37:305-12. 2005
  8. ncbi request reprint Expression and activation of peroxisome proliferator-activated receptors in growth plate chondrocytes
    Yvonne Y Shao
    Departments of Orthopaedic Surgery and Biomedical Engineering, Orthopaedic Research Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Orthop Res 23:1139-45. 2005
  9. ncbi request reprint Thyroid hormone and the growth plate
    Yvonne Y Shao
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Rev Endocr Metab Disord 7:265-71. 2006
  10. ncbi request reprint Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation
    Matthew C Stewart
    Department of Veterinary Clinical Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    J Bone Miner Res 19:123-32. 2004

Detail Information

Publications13

  1. pmc Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling in Growth Plate Chondrocytes
    Lai Wang
    Orthopaedic and Rheumatologic Research Center, Departments of Biomedical Engineering and Orthopaedic, Surgery, A 41, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    PPAR Res 2012:756198. 2012
    ..Furthermore, leptin signaling in growth plate cells is also negatively modulated by activation of PPARγ, implying that these two signaling pathways are mutually regulated in growth plate chondrocytes...
  2. pmc Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling
    Lai Wang
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Bone Miner Res 25:1138-46. 2010
    ....
  3. pmc Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling pathways in growth plate chondrocytes
    Lai Wang
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Bone Miner Res 24:265-73. 2009
    ..These data indicate that thyroid hormone may regulate terminal differentiation of growth plate chondrocytes in part by modulating Wnt signaling pathways through the induction of CPZ and subsequent CPZ-enhanced activation of Wnt-4...
  4. ncbi request reprint Molecular and genetic approaches to musculoskeletal diseases
    R Tracy Ballock
    Department of Orthopedic Surgery, Cleveland Clinic Foundation, OH 44195, USA
    J Pediatr Orthop 23:131-7. 2003
  5. ncbi request reprint Physiology and pathophysiology of the growth plate
    R Tracy Ballock
    Orthopaedic Research Center, Departments of Orthopaedic Surgery and Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Birth Defects Res C Embryo Today 69:123-43. 2003
    ....
  6. ncbi request reprint The biology of the growth plate
    R Tracy Ballock
    Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, OH 44195, USA
    J Bone Joint Surg Am 85:715-26. 2003
  7. ncbi request reprint Peroxisome proliferator activated receptor-gamma (PPARgamma) represses thyroid hormone signaling in growth plate chondrocytes
    Lai Wang
    Department of Orthopaedic Surgery and Biomedical Engineering, Orthopaedic Research Center, The Lerner Research Institute, A 41, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Bone 37:305-12. 2005
    ..The molecular mechanism involved in this inhibition appears to be competition between PPARgamma and TRalpha for limiting amounts of the heterodimeric partner RXR...
  8. ncbi request reprint Expression and activation of peroxisome proliferator-activated receptors in growth plate chondrocytes
    Yvonne Y Shao
    Departments of Orthopaedic Surgery and Biomedical Engineering, Orthopaedic Research Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Orthop Res 23:1139-45. 2005
    ....
  9. ncbi request reprint Thyroid hormone and the growth plate
    Yvonne Y Shao
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Rev Endocr Metab Disord 7:265-71. 2006
    ....
  10. ncbi request reprint Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation
    Matthew C Stewart
    Department of Veterinary Clinical Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    J Bone Miner Res 19:123-32. 2004
    ..The phenotypic consequences of p57 expression were assessed in an in vitro model of hypertrophic differentiation. Adenoviral p57 expression was not sufficient for CollX expression but did augment induction of CollX by BMP-2...
  11. ncbi request reprint Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes
    Lai Wang
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Bone Miner Res 22:1988-95. 2007
    ..This study indicates that thyroid hormone regulates terminal differentiation of growth plate chondrocytes in part through modulating Wnt/beta-catenin signaling...
  12. ncbi request reprint Analysis of gene expression in mineralized skeletal tissues by laser capture microdissection and RT-PCR
    Yvonne Y Shao
    Orthopaedic Research Center, Department of Orthopaedic Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Lab Invest 86:1089-95. 2006
    ....

Research Grants6

  1. The Interaction of Thyroid Hormone and Wnt Signaling Pathways in the Growth Plate
    ROBERT BALLOCK; Fiscal Year: 2009
    ....
  2. PPAR ACTIVATION IN GROWTH PLATE CHONDROCYTES
    ROBERT BALLOCK; Fiscal Year: 2002
    ..abstract_text> ..
  3. The Interaction of Thyroid Hormone and Wnt Signaling Pathways in the Growth Plate
    ROBERT TRACY BALLOCK; Fiscal Year: 2010
    ....
  4. PPAR ACTIVATION IN GROWTH PLATE CHONDROCYTES
    R Ballock; Fiscal Year: 2001
    ..abstract_text> ..
  5. PPAR ACTIVATION IN GROWTH PLATE CHONDROCYTES
    ROBERT BALLOCK; Fiscal Year: 2003
    ..abstract_text> ..