Kewal Asosingh

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Pulmonary artery endothelium resident endothelial colony-forming cells in pulmonary arterial hypertension
    Heng T Duong
    Department of Pathobiology, Lerner Research Institute, Genomic Medicine Institute, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Pulm Circ 1:475-86. 2011
  2. pmc Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension
    Kewal Asosingh
    Pathobiology, Lerner Research Institute and Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Blood 120:1218-27. 2012
  3. ncbi request reprint Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, NB40, Cleveland, OH 44195, USA
    Haematologica 90:810-7. 2005
  4. pmc Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA and
    J Allergy Clin Immunol 125:918-25. 2010
  5. pmc Angioplasticity in asthma
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Biochem Soc Trans 37:805-10. 2009
  6. pmc Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
    Kewal Asosingh
    Cleveland Clinic, Department of Pathobiology, NC22, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Pathol 172:615-27. 2008
  7. pmc Effects of the menstrual cycle on lung function variables in women with asthma
    Samar Farha
    Respiratory Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Respir Crit Care Med 180:304-10. 2009
  8. pmc Nascent endothelium initiates Th2 polarization of asthma
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 190:3458-65. 2013
  9. pmc Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle
    Samar Farha
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA
    J Appl Physiol 103:1789-95. 2007
  10. pmc Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy
    Kevin Tan
    Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Exp Eye Res 91:229-37. 2010

Collaborators

Detail Information

Publications40

  1. pmc Pulmonary artery endothelium resident endothelial colony-forming cells in pulmonary arterial hypertension
    Heng T Duong
    Department of Pathobiology, Lerner Research Institute, Genomic Medicine Institute, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Pulm Circ 1:475-86. 2011
    ..We conclude that ECFC reside among PAEC and that PAH PAEC contain ECFC that are more proliferative than ECFC in control cultures, which likely contributes to the proliferative angiopathic process in PAH...
  2. pmc Pulmonary vascular disease in mice xenografted with human BM progenitors from patients with pulmonary arterial hypertension
    Kewal Asosingh
    Pathobiology, Lerner Research Institute and Respiratory Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Blood 120:1218-27. 2012
    ..The results of the present study suggest a causal role for hematopoietic stem cell abnormalities in vascular injury, right ventricular hypertrophy, and morbidity associated with PAH...
  3. ncbi request reprint Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, NB40, Cleveland, OH 44195, USA
    Haematologica 90:810-7. 2005
    ..BM hypoxia is crucial for normal hematopoiesis. However, how BM hypoxia and MM affect each other is unknown. We addressed this topic in the 5T2MM mouse model...
  4. pmc Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA and
    J Allergy Clin Immunol 125:918-25. 2010
    ....
  5. pmc Angioplasticity in asthma
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Biochem Soc Trans 37:805-10. 2009
    ..This mini review provides a concise synopsis of our present knowledge about vascular plasticity in adult lungs, summarizes our current view of angioplasticity in asthma and highlights yet unresolved areas of potential interest...
  6. pmc Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
    Kewal Asosingh
    Cleveland Clinic, Department of Pathobiology, NC22, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Pathol 172:615-27. 2008
    ..Thus, mobilization of high levels of proliferative bone marrow-derived proangiogenic precursors is a characteristic of IPAH and may participate in the pulmonary vascular remodeling process...
  7. pmc Effects of the menstrual cycle on lung function variables in women with asthma
    Samar Farha
    Respiratory Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Respir Crit Care Med 180:304-10. 2009
    ..One vital function modulated over the menstrual cycle in healthy women is gas transfer, and this has been related to angiogenesis and cyclic expansion of the pulmonary vascular bed...
  8. pmc Nascent endothelium initiates Th2 polarization of asthma
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 190:3458-65. 2013
    ..The results identify angiogenic responses in the origins of atopic inflammation...
  9. pmc Pulmonary gas transfer related to markers of angiogenesis during the menstrual cycle
    Samar Farha
    Department of Pulmonary, Allergy, and Critical Care Medicine, Cleveland Clinic, Cleveland, OH, USA
    J Appl Physiol 103:1789-95. 2007
    ..These findings suggest that angiogenesis in the lungs may participate in the cyclic changes in gas transfer that occur over the menstrual cycle...
  10. pmc Impaired function of circulating CD34(+) CD45(-) cells in patients with proliferative diabetic retinopathy
    Kevin Tan
    Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH 44195, USA
    Exp Eye Res 91:229-37. 2010
    ..This suggests that ECFCs may be a potential therapeutic target in the prevention and treatment of diabetic vascular complications...
  11. pmc Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension
    Micheala A Aldred
    Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Respir Crit Care Med 182:1153-60. 2010
    ..Previous studies have indicated that the endothelial cell proliferation is quasineoplastic, with evidence of monoclonality and instability of short DNA microsatellite sequences...
  12. pmc Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities
    Samar Farha
    Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Blood 117:3485-93. 2011
    ....
  13. pmc Human primary lung endothelial cells in culture
    Suzy A A Comhair
    Department of Pathobiology, Cleveland Clinic, 9500 Euclid Avenue NC22, Cleveland, OH 44195, USA
    Am J Respir Cell Mol Biol 46:723-30. 2012
    ..This detailed method provides researchers with the ability to establish cells for molecular, genetic, and biochemical investigation of human pulmonary vascular diseases...
  14. pmc Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation
    Heng T Duong
    Department of Pathobiology, NC22, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Angiogenesis 14:411-22. 2011
    ..This review focuses on current knowledge of pro-angiogenic progenitor cells in the pathogenesis of asthma and PAH...
  15. pmc Mast cell number, phenotype, and function in human pulmonary arterial hypertension
    Samar Farha
    Respiratory Institute, Cleveland, Ohio, USA
    Pulm Circ 2:220-8. 2012
    ..These results suggest that mast cells might contribute to the pulmonary vascular pathologic processes underlying PAH. More studies are needed to confirm their potential contribution to the disease...
  16. pmc Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo
    Quteba Ebrahem
    Department of Ophthalmology, Cole Eye Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Am J Pathol 176:496-503. 2010
    ..Our results suggest that MMPs act both upstream and downstream of VEGF and imply that potential combination therapies of VEGF and MMP inhibitors may be a useful therapeutic approach in diseases of pathological neovascularization...
  17. pmc Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year
    Erika L Lundgrin
    Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA
    Ann Am Thorac Soc 10:1-9. 2013
    ....
  18. ncbi request reprint Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension
    Fares A Masri
    Department of Pathobiology, Allergy and Critical Care Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Physiol Lung Cell Mol Physiol 293:L548-54. 2007
    ..Phosphorylated STAT3 was detected in endothelial cells of IPAH lesions in vivo, suggesting that STAT3 activation plays a role in the proliferative pulmonary vascular lesions in IPAH lungs...
  19. pmc Cutting edge: IFN-γR signaling in non-T cell targets regulates T cell-mediated intestinal inflammation through multiple mechanisms
    Jeong su Do
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195
    J Immunol 192:2537-41. 2014
    ..Therefore, our results suggest novel immunoregulatory functions for IFN-γ to orchestrate colitogenic T cell responses through its distinct action on different non-T cell target cells. ..
  20. pmc Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report
    Serpil Erzurum
    Department of Pathobiology, Cleveland Clinic, Cleveland, Ohio, USA
    Am J Respir Crit Care Med 182:1554-62. 2010
    ..Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes...
  21. pmc Corneal myofibroblast generation from bone marrow-derived cells
    Flavia L Barbosa
    Cole Eye Institute, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Exp Eye Res 91:92-6. 2010
    ..This model, therefore, cannot exclude the possibility of myofibroblasts also developed from keratocytes and/or corneal fibroblasts...
  22. ncbi request reprint Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma
    Kewal Asosingh
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Immunol 178:6482-94. 2007
    ..Thus, a Th1- and Th2-dependent angiogenic switch with EPC mobilization, recruitment, and increased lung vessel formation occurs early but becomes a sustained and cumulative component of the allergen-induced asthmatic response...
  23. pmc Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis
    Anja Schirbel
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Gastroenterology 144:613-623.e9. 2013
    ..We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis...
  24. pmc Small-animal imaging using clinical positron emission tomography/computed tomography and super-resolution
    Frank P DiFilippo
    Department of Nuclear Medicine, Cleveland Clinic, 9500 Euclid Avenue Jb3, Cleveland, OH 44195, USA
    Mol Imaging 11:210-9. 2012
    ..Although not a perfect substitute for a state-of-the-art small-animal PET/CT scanner, a clinical PET/CT scanner with super-resolution produces acceptable small-animal image quality for many preclinical research studies...
  25. doi request reprint Epigenetic silencing of the tetraspanin CD9 during disease progression in multiple myeloma cells and correlation with survival
    Elke De Bruyne
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Clin Cancer Res 14:2918-26. 2008
    ..The purpose of this study was to investigate expression and epigenetic regulation of CD9 in multiple myeloma (MM) cells during disease progression...
  26. ncbi request reprint Multiple myeloma tumor progression in the 5T2MM murine model is a multistage and dynamic process of differentiation, proliferation, invasion, and apoptosis
    Kewal Asosingh
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Blood 101:3136-41. 2003
    ..These data suggest that myeloma disease progression is a multistage and dynamic process of differentiation, proliferation, invasion, and apoptosis...
  27. ncbi request reprint Delayed in vivo disease progression is associated with high proportions of CD45+ myeloma cells in the 5T2MM murine model
    Kewal Asosingh
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, B 1090 Brussels, Belgium
    Cancer Res 63:3019-20. 2003
    ..These animals had typically a bowed back and never got paralyzed. The MM cells in the BM of these mice were predominantly CD45(+). These data indicate that CD45 subsets are associated with the final outcome of myeloma disease...
  28. ncbi request reprint Multiple myeloma biology: lessons from the 5TMM models
    Karin Vanderkerken
    Vrije Universiteit Brussel, Department of Hematology and Immunology, Brussels, Belgium
    Immunol Rev 194:196-206. 2003
    ..These different studies demonstrate the strength of these models, not only in unraveling basic biological processes but also in the testing of potentially new therapeutic targets...
  29. ncbi request reprint Angiogenic switch during 5T2MM murine myeloma tumorigenesis: role of CD45 heterogeneity
    Kewal Asosingh
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Blood 103:3131-7. 2004
    ..These data suggest that, like in solid tumors, angiogenic switch and angiogenic heterogeneity exist in MM...
  30. ncbi request reprint The involvement of stromal derived factor 1alpha in homing and progression of multiple myeloma in the 5TMM model
    Eline Menu
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Haematologica 91:605-12. 2006
    ..Stromal cell derived factor 1a (SDF1alpha) or CXCL12 is known to play an important role as a chemokine for hematopoietic progenitor cells and human MM cells. We studied the effects of SDF1a in the 5TMM murine model...
  31. ncbi request reprint Myeloma cells (5TMM) and their interactions with the marrow microenvironment
    Eline Menu
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, 1090 Brussels, Belgium
    Blood Cells Mol Dis 33:111-9. 2004
    ..Furthermore, studies targeting the marrow with inhibitors will be highlighted. These studies show that the 5TMM models are useful for unraveling basic biological processes and for identifying new therapeutic targets...
  32. ncbi request reprint Upregulation of matrix metalloproteinase-9 in murine 5T33 multiple myeloma cells by interaction with bone marrow endothelial cells
    Els Van Valckenborgh
    Department of Hematology and Immunology, Free University Brussels, Brussels, Belgium
    Int J Cancer 101:512-8. 2002
    ..In conclusion, our results demonstrate that MMP-9 production by MM cells is upregulated in vivo by the interaction of MM cells with BMECs...
  33. ncbi request reprint Mechanisms involved in the differential bone marrow homing of CD45 subsets in 5T murine models of myeloma
    Kewal Asosingh
    Department of Hematology and Immunology, Vrije Universiteit Brussel VUB, Brussels, Belgium
    Clin Exp Metastasis 19:583-91. 2002
    ..Our results indicate that CD45+ and CD45- 5T myeloma cells have a differential BM homing attributable to differential migratory and invasive capacities...
  34. ncbi request reprint Selective in vivo growth of lymphocyte function- associated antigen-1-positive murine myeloma cells. Involvement of function-associated antigen-1-mediated homotypic cell-cell adhesion
    Kewal Asosingh
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Exp Hematol 31:48-55. 2003
    ..In this study we used the 5T experimental mouse model to analyze the involvement of LFA-1 in myeloma cell bone marrow homing, survival, and growth...
  35. ncbi request reprint Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    Karin Vanderkerken
    Department of Hematology and Immunology, Free University Brussels, Brussels, Belgium
    Cancer Res 63:287-9. 2003
    ....
  36. ncbi request reprint Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model
    Eline Menu
    Department of Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Blood 107:655-60. 2006
    ..These data suggest that the IGF-1RTK inhibitor PPP possesses a marked antitumor activity and strongly points to the possibility of using IGF-1R inhibitors in the treatment of MM...
  37. ncbi request reprint The 5T2MM murine model of multiple myeloma: maintenance and analysis
    Karin Vanderkerken
    Department of Hematology and Immunology, Free University Brussels, Brussels, Belgium
    Methods Mol Med 113:191-205. 2005
    ..The combination of these different techniques in these models not only helps in unraveling basic biological processes but also in the testing of potentially new therapeutic targets...
  38. pmc Multifunctional role of matrix metalloproteinases in multiple myeloma: a study in the 5T2MM mouse model
    Els Van Valckenborgh
    Department Hematology and Immunology, Vrije Universiteit Brussel, Brussels, Belgium
    Am J Pathol 165:869-78. 2004
    ..The direct role of MMPs in these different processes was confirmed by in vitro experiments. All these results support the multifunctional role of MMPs in the development of multiple myeloma...
  39. ncbi request reprint Part of the multiple myeloma-associated microvessels is functionally connected to the systemic circulation: a study in the murine 5T33MM model
    Hendrik R De Raeve
    Department of Pathology, University of Antwerp, Wilrijkstraat 10, B 2650 Edegem, Belgium
    Virchows Arch 445:389-95. 2004
    ....
  40. ncbi request reprint Monocyte chemoattractant protein-1 (MCP-1), secreted by bone marrow endothelial cells, induces chemoattraction of 5T multiple myeloma cells
    Karin Vanderkerken
    Department of Hematology and Immunology, Free University Brussels VUB, Belgium
    Clin Exp Metastasis 19:87-90. 2002
    ..In conclusion, MM cells express CCR2 and are attracted by MCP-1 secreted by BMEC. We suggest that local MCP-1 production by BMEC is one of the mechanisms involved in homing of myeloma cells to the BM...