SUNEEL APTE

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Metalloproteinases: A parade of functions in matrix biology and an outlook for the future
    Suneel S Apte
    Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA Electronic address
    Matrix Biol 44:1-6. 2015
  2. doi request reprint Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis
    Suneel S Apte
    Department of Biomedical Engineering ND20, Cleveland Clinic Lerner Research Institute and the Orthopaedic and Rheumatologic Research Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, U S A
    Biochem J 473:e1-4. 2016
  3. pmc A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms
    Suneel S Apte
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:31493-7. 2009
  4. pmc ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells
    Bon Hun Koo
    Department of Biomedical Engineering ND20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 176:1494-504. 2010

Research Grants

  1. METALLOPROTEASES IN SKELETAL DEVELOPMENT AND GROWTH
    SUNEEL APTE; Fiscal Year: 2003
  2. Role of ADAMTS-3 in Procollagen Processing
    SUNEEL APTE; Fiscal Year: 2004
  3. Biological Role of ADAMTS Proteases
    SUNEEL APTE; Fiscal Year: 2007

Collaborators

  • Bon Hun Koo
  • Daniel J Lindner
  • Lauren W Wang
  • Mary Elizabeth Young
  • Courtney M Nelson
  • Robert P T Somerville
  • Laura J Dixon
  • David M Coe

Detail Information

Publications4

  1. doi request reprint Metalloproteinases: A parade of functions in matrix biology and an outlook for the future
    Suneel S Apte
    Cleveland Clinic Lerner Research Institute, Cleveland, OH, USA Electronic address
    Matrix Biol 44:1-6. 2015
    ..Attempts to inhibit metalloproteinases in human diseases thus require continuing appraisal of their biological roles and cautious evaluation of potential new therapeutic opportunities. ..
  2. doi request reprint Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis
    Suneel S Apte
    Department of Biomedical Engineering ND20, Cleveland Clinic Lerner Research Institute and the Orthopaedic and Rheumatologic Research Center, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, U S A
    Biochem J 473:e1-4. 2016
    ....
  3. pmc A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms
    Suneel S Apte
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:31493-7. 2009
    ..New insights into ADAMTS mechanisms indicate significant regulatory roles for ADAMTS ancillary domains, propeptide processing, and glycosylation. ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix...
  4. pmc ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells
    Bon Hun Koo
    Department of Biomedical Engineering ND20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 176:1494-504. 2010
    ..Taken together, these data identify ADAMTS9 as a novel, constitutive, endogenous angiogenesis inhibitor that operates cell-autonomously in ECs via molecular mechanisms that are distinct from those used by ADAMTS1...

Research Grants3

  1. METALLOPROTEASES IN SKELETAL DEVELOPMENT AND GROWTH
    SUNEEL APTE; Fiscal Year: 2003
    ..abstract_text> ..
  2. Role of ADAMTS-3 in Procollagen Processing
    SUNEEL APTE; Fiscal Year: 2004
    ..In the long-term, this information may be useful for treatment of dermatosparaxis. ..
  3. Biological Role of ADAMTS Proteases
    SUNEEL APTE; Fiscal Year: 2007
    ..The significance of these studies lies in improved fundamental understanding of proteolysis during development and human disease, especially arthritis. [unreadable] [unreadable]..