SUNEEL APTE

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms
    Suneel S Apte
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:31493-7. 2009
  2. pmc ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells
    Bon Hun Koo
    Department of Biomedical Engineering ND20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 176:1494-504. 2010

Research Grants

  1. Biological Role of ADAMTS Proteases
    SUNEEL APTE; Fiscal Year: 2007
  2. Protease regulation of extracellular networks
    SUNEEL APTE; Fiscal Year: 2007
  3. Role of ADAMTS-3 in Procollagen Processing
    SUNEEL APTE; Fiscal Year: 2004
  4. METALLOPROTEASES IN SKELETAL DEVELOPMENT AND GROWTH
    SUNEEL APTE; Fiscal Year: 2003
  5. Protease regulation of extracellular networks
    Suneel S Apte; Fiscal Year: 2010

Collaborators

  • Bon Hun Koo
  • Daniel J Lindner
  • Lauren W Wang
  • Courtney M Nelson
  • David M Coe
  • Robert P T Somerville
  • Laura J Dixon
  • Mary Elizabeth Young

Detail Information

Publications2

  1. pmc A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms
    Suneel S Apte
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:31493-7. 2009
    ..New insights into ADAMTS mechanisms indicate significant regulatory roles for ADAMTS ancillary domains, propeptide processing, and glycosylation. ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix...
  2. pmc ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells
    Bon Hun Koo
    Department of Biomedical Engineering ND20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Pathol 176:1494-504. 2010
    ..Taken together, these data identify ADAMTS9 as a novel, constitutive, endogenous angiogenesis inhibitor that operates cell-autonomously in ECs via molecular mechanisms that are distinct from those used by ADAMTS1...

Research Grants14

  1. Biological Role of ADAMTS Proteases
    SUNEEL APTE; Fiscal Year: 2007
    ..The significance of these studies lies in improved fundamental understanding of proteolysis during development and human disease, especially arthritis. ..
  2. Protease regulation of extracellular networks
    SUNEEL APTE; Fiscal Year: 2007
    ..An understanding of how ADAMTS10 integrates with fibrillin networks may have long-term potential for disease modification in Marfan syndrome. ..
  3. Role of ADAMTS-3 in Procollagen Processing
    SUNEEL APTE; Fiscal Year: 2004
    ..In the long-term, this information may be useful for treatment of dermatosparaxis. ..
  4. METALLOPROTEASES IN SKELETAL DEVELOPMENT AND GROWTH
    SUNEEL APTE; Fiscal Year: 2003
    ..abstract_text> ..
  5. Protease regulation of extracellular networks
    Suneel S Apte; Fiscal Year: 2010
    ..An understanding of how ADAMTS10 integrates with fibrillin networks may have long-term potential for disease modification in Marfan syndrome. ..