ALEXANDRU ALMASAN ALMASAN

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. doi request reprint Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)
    Kamini Singh
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cancer 13:70. 2014
  2. pmc Microarray gene expression profiling and analysis in renal cell carcinoma
    Louis S Liou
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, USA
    BMC Urol 4:9. 2004
  3. ncbi request reprint Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
    Alexandru Almasan
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cytokine Growth Factor Rev 14:337-48. 2003
  4. ncbi request reprint APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy
    Octavian Bucur
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Front Biosci 11:1549-68. 2006
  5. ncbi request reprint Proteolytic cleavage of the p65-RelA subunit of NF-kappaB during poliovirus infection
    Nickolay Neznanov
    Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:24153-8. 2005
  6. pmc Effects of resveratrol on gene expression in renal cell carcinoma
    Ting Shi
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Biol Ther 3:882-8. 2004
  7. ncbi request reprint Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells
    Erica L DuPree
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Res 64:4390-3. 2004
  8. pmc Role of Apo2L/TRAIL and Bcl-2-family proteins in apoptosis of multiple myeloma
    Quan Chen
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Leuk Lymphoma 44:1209-14. 2003
  9. ncbi request reprint S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells
    Subrata Ray
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Mol Cancer Ther 6:1368-78. 2007
  10. pmc A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron
    Dragos Plesca
    Department of Cancer Biology, Lerner Research Institute, Cleveland, OH, USA
    J Biol Chem 283:30796-803. 2008

Research Grants

  1. Signals for Commitment to Radiation Induces Apoptosis
    Alexandru Almasan; Fiscal Year: 2007
  2. Cdk-2 Independent role of cyclin E in Cell survival
    ALEXANDRU ALMASAN ALMASAN; Fiscal Year: 2010
  3. SIGNALS FOR COMMITMENT TO RADIATION INDUCED APOPTOSIS
    Alexandru Almasan; Fiscal Year: 2002
  4. Cdk-2 Independent role of cyclin E in Cell survival
    ALEXANDRU ALMASAN ALMASAN; Fiscal Year: 2011

Collaborators

Detail Information

Publications14

  1. doi request reprint Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)
    Kamini Singh
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Cancer 13:70. 2014
    ....
  2. pmc Microarray gene expression profiling and analysis in renal cell carcinoma
    Louis S Liou
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, USA
    BMC Urol 4:9. 2004
    ..To better understand the genetics and biology of RCC, we profiled the expression of 7,129 genes in both clear cell RCC tissue and cell lines using oligonucleotide arrays...
  3. ncbi request reprint Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
    Alexandru Almasan
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cytokine Growth Factor Rev 14:337-48. 2003
    ..In this review, we focus on the apoptosis signaling pathways stimulated by Apo2L/TRAIL, summarize what is known to date about the physiological role of this ligand and the potential for its application to cancer therapy...
  4. ncbi request reprint APO2 ligand/tumor necrosis factor-related apoptosis-inducing ligand in prostate cancer therapy
    Octavian Bucur
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Front Biosci 11:1549-68. 2006
    ....
  5. ncbi request reprint Proteolytic cleavage of the p65-RelA subunit of NF-kappaB during poliovirus infection
    Nickolay Neznanov
    Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:24153-8. 2005
    ....
  6. pmc Effects of resveratrol on gene expression in renal cell carcinoma
    Ting Shi
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Biol Ther 3:882-8. 2004
    ..This study provides a general understanding of the overall genetic response of RCC54 to RE treatment and yields insights into the understanding of the cancer preventive mechanism of RE in RCC...
  7. ncbi request reprint Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells
    Erica L DuPree
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Res 64:4390-3. 2004
    ..The E2F4/p130 pocket protein complex emerges as a new target of radiation in prostate carcinoma cells...
  8. pmc Role of Apo2L/TRAIL and Bcl-2-family proteins in apoptosis of multiple myeloma
    Quan Chen
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, USA
    Leuk Lymphoma 44:1209-14. 2003
    ..This review is focused on the apoptotic signaling pathways regulated by Apo2L and Bcl-2-family proteins and summarizes what is known about their clinical role...
  9. ncbi request reprint S-phase checkpoints regulate Apo2 ligand/TRAIL and CPT-11-induced apoptosis of prostate cancer cells
    Subrata Ray
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Mol Cancer Ther 6:1368-78. 2007
    ..Combinations with S-phase arrest-inducing chemotherapeutic drugs may represent promising avenues for clinical development of Apo2L/TRAIL...
  10. pmc A C-terminal fragment of Cyclin E, generated by caspase-mediated cleavage, is degraded in the absence of a recognizable phosphodegron
    Dragos Plesca
    Department of Cancer Biology, Lerner Research Institute, Cleveland, OH, USA
    J Biol Chem 283:30796-803. 2008
    ..By preventing its proteasomal degradation, p18-Cyclin E, but not Cyclin E, may become an effective therapeutic target for Bortezomib and apoptotic effectors in hematopoietic malignancies...
  11. doi request reprint IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression
    Yan Zhou
    Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA
    J Interferon Cytokine Res 28:65-72. 2008
    ..This study thus provides the basis for additional research to uncover the molecular mechanism by which IFN-gamma regulates the expression of Bcl-2 family members in various cell types...
  12. pmc Opposing roles of E2Fs in cell proliferation and death
    Meredith E Crosby
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Biol Ther 3:1208-11. 2004
    ..The balance between the activities of these two proteins in tumor cells is of great interest. Directed control of E2F1 and E2F4 action may lead to better diagnosis of disease and improved therapeutic modalities...
  13. pmc Apoptosis of multiple myeloma
    Marcela Oancea
    Department of Cancer Biology, Lerner Research Institute, Cleveland, Ohio 44195, USA
    Int J Hematol 80:224-31. 2004
    ..This review focuses on the key concepts and some of the most recent studies of signaling pathways regulated in MM and summarizes what is known about the clinical role of these pathways...
  14. pmc Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells
    Suparna Mazumder
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Mol Cell Biol 22:2398-409. 2002
    ....

Research Grants21

  1. Signals for Commitment to Radiation Induces Apoptosis
    Alexandru Almasan; Fiscal Year: 2007
    ....
  2. Cdk-2 Independent role of cyclin E in Cell survival
    ALEXANDRU ALMASAN ALMASAN; Fiscal Year: 2010
    ....
  3. SIGNALS FOR COMMITMENT TO RADIATION INDUCED APOPTOSIS
    Alexandru Almasan; Fiscal Year: 2002
    ..abstract_text> ..
  4. Cdk-2 Independent role of cyclin E in Cell survival
    ALEXANDRU ALMASAN ALMASAN; Fiscal Year: 2011
    ....