Naim Alkhouri

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 59:1617-24. 2014
  2. doi request reprint Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA
    Liver Int 33:79-85. 2013
  3. doi request reprint Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, United States
    J Hepatol 57:1312-8. 2012
  4. doi request reprint Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
    Naim Alkhouri
    Digestive Disease Institute, Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Int 32:297-302. 2012
  5. pmc Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Gastroenterol Hepatol 5:201-12. 2011
  6. doi request reprint A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 9:150-5. 2011
  7. pmc Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, 9500 Euclid Avenue, Desk A 111, Cleveland, OH 44195, USA
    World J Gastroenterol 14:6863-6. 2008
  8. doi request reprint The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 55:2644-50. 2010
  9. pmc Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD
    Angela Shannon
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, USA
    J Pediatr Gastroenterol Nutr 53:190-5. 2011
  10. doi request reprint Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children s Hosptial, University of California San Diego UCSD, San Diego, CA, USA
    Am J Gastroenterol 108:1526-31. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH, 44195, USA
    Dig Dis Sci 59:1617-24. 2014
    ..The aims of this study were to assess the utility of OxNASH as a predictor of NASH and study the association between OxNASH and specific histologic features of NAFLD...
  2. doi request reprint Combined paediatric NAFLD fibrosis index and transient elastography to predict clinically significant fibrosis in children with fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA
    Liver Int 33:79-85. 2013
    ..To prospectively evaluate the performance of PNFI and TE in assessing clinically significant fibrosis in children with biopsy-proven NAFLD...
  3. doi request reprint Development and validation of a new histological score for pediatric non-alcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, United States
    J Hepatol 57:1312-8. 2012
    ..We aimed at developing a new grading score for pediatric NAFLD to be used in clinical trials that takes into account the presence of PI and the weight of histological features...
  4. doi request reprint Neutrophil to lymphocyte ratio: a new marker for predicting steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease
    Naim Alkhouri
    Digestive Disease Institute, Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Int 32:297-302. 2012
    ..The neutrophil/lymphocyte ratio (N/L) integrates information on the inflammatory milieu and physiological stress...
  5. pmc Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Gastroenterol Hepatol 5:201-12. 2011
    ..In particular, it will highlight the efforts for the development of both novel diagnostic and therapeutic strategies based on this knowledge...
  6. doi request reprint A combination of the pediatric NAFLD fibrosis index and enhanced liver fibrosis test identifies children with fibrosis
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 9:150-5. 2011
    ..We prospectively evaluated the performance of PNFI and ELF in assessing fibrosis in children with biopsy-proven NAFLD...
  7. pmc Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing
    Naim Alkhouri
    Department of Pediatric Gastroenterology and Nutrition, Cleveland Clinic, 9500 Euclid Avenue, Desk A 111, Cleveland, OH 44195, USA
    World J Gastroenterol 14:6863-6. 2008
    ..We report the case of a 7-year-old female with pancreatic insufficiency and mild phenotypic features, in whom the diagnosis of JBS was established using recently described molecular testing for the UBR1 gene...
  8. doi request reprint The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 55:2644-50. 2010
    ..Growing evidence links NAFLD to cardiovascular (CV) disease; however, the association between the histologic severity of NAFLD and CV risk remains poorly understood...
  9. pmc Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD
    Angela Shannon
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH, USA
    J Pediatr Gastroenterol Nutr 53:190-5. 2011
    ..The aim of this study was to prospectively evaluate the clinical utility of ultrasonographic quantification of hepatic steatosis...
  10. doi request reprint Serum cytokeratin-18 fragment levels are useful biomarkers for nonalcoholic steatohepatitis in children
    Ariel E Feldstein
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Rady Children s Hosptial, University of California San Diego UCSD, San Diego, CA, USA
    Am J Gastroenterol 108:1526-31. 2013
    ..The aim of this study was to evaluate the use of plasma cytokeratin-18 (CK18) fragment levels, a marker of increased hepatocyte apoptosis, as a non-invasive biomarker for pediatric NASH...
  11. pmc An apoptosis panel for nonalcoholic steatohepatitis diagnosis
    Tarek I Abu Rajab Tamimi
    Digestive Disease Institute, Sioux Falls, SD, USA
    J Hepatol 54:1224-9. 2011
    ..Our aims were to create and validate a noninvasive prediction model for NASH diagnosis based on specific circulating markers of apoptosis...
  12. ncbi request reprint Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children
    Naim Alkhouri
    Departments of aPediatric Gastroenterology and Hepatology bQuantitative Health Sciences cDepartment of Gastroenterology and Hepatology, Digestive Disease Institute dDepartment of Pathobiology, Lerner Research Institute eDepartment of Pulmonary, Allergy and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Eur J Gastroenterol Hepatol 26:82-7. 2014
    ..Nonalcoholic fatty liver disease (NAFLD) is one of the most common complications of childhood obesity. Our objective was to investigate the association of breath volatile organic compounds with the diagnosis of NAFLD in children...
  13. pmc Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic Foundation, OH 44195, USA
    J Clin Gastroenterol 43:985-9. 2009
    ..The aims of this study were to determine serum RBP4 levels in patients with biopsy proven NAFLD, and to correlate these levels with the metabolic profile and histologic features in this population...
  14. doi request reprint Health-related quality of life in children with autoimmune liver disease
    Reema Gulati
    Division of Pediatric Gastroenterology and Nutrition Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH Division of Pediatric Gastroenterology and Nutrition, UC San Diego, Rady Children s Hospital, San Diego, CA
    J Pediatr Gastroenterol Nutr 57:444-50. 2013
    ..The aim of this study was to determine HRQOL in children with AILD and the factors affecting it...
  15. pmc Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Gastroenterol Hepatol 3:445-51. 2009
    ....
  16. doi request reprint Hepatitis B immunity and response to booster vaccination in children with inflammatory bowel disease treated with infliximab
    Jonathan Moses
    Department of Pediatric Gastroenterology, Cleveland Clinic, Ohio, USA
    Am J Gastroenterol 107:133-8. 2012
    ..The objectives of this study were to determine HBV immunity in children with IBD on infliximab therapy and to determine response to a booster dose of the HBV vaccine in patients who were found to be non-immune...
  17. doi request reprint Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease
    Christine Carter-Kent
    Department of Pathology, Cleveland Clinic, USA
    J Pediatr Gastroenterol Nutr 52:190-7. 2011
    ..The aims of the present study were to establish associations between steatosis amount, type, and distribution in a well-characterized group of children with biopsy-proven nonalcoholic fatty liver disease (NAFLD)...
  18. doi request reprint Monitoring peripheral blood CD4+ adenosine triphosphate activity in recurrent hepatitis C and its correlation to fibrosis progression
    Naim Alkhouri
    Department of Pediatric Gastroenterology, Cleveland Clinic, Cleveland, OH 44195, USA
    Liver Transpl 16:155-62. 2010
    ..Post-OLT monitoring of CD4+ ATP activity may identify a subset of patients at greatest risk for early fibrosis progression...
  19. pmc Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis
    Naim Alkhouri
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 285:3428-38. 2010
    ..Inhibition of adipocyte apoptosis may be a new therapeutic strategy for the treatment of obesity-associated metabolic complications...
  20. pmc The breathprints in patients with liver disease identify novel breath biomarkers in alcoholic hepatitis
    Ibrahim A Hanouneh
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio
    Clin Gastroenterol Hepatol 12:516-23. 2014
    ..We investigated whether concentrations of volatile compounds in breath samples correlate with the diagnosis of alcoholic hepatitis (AH) and the severity of liver disease in patients with AH...
  21. ncbi request reprint Autoimmune hepatitis in children--impact of cirrhosis at presentation on natural history and long-term outcome
    Kadakkal R Radhakrishnan
    Department of Pediatric Gastroenterology, Cleveland Clinic, 9500 Euclid Avenue, A 111, Cleveland, OH 44195, United States
    Dig Liver Dis 42:724-8. 2010
    ..The aims of this longitudinal cohort study were to determine the long-term prognosis of children with autoimmune hepatitis and to determine the effect of cirrhosis at presentation on survival...
  22. doi request reprint A122: metabolomic analysis of breath volatile organic compounds reveals unique breathprints in children with juvenile idiopathic arthritis
    Andrew Zeft
    The Cleveland Clinic, Cleveland, OH
    Arthritis Rheumatol 66:S159. 2014
    ..The aim of this study was to analyze exhaled volatile organic compounds (VOCs) to evaluate for the presence of a unique breath pattern to differentiate pediatric patients with JIA from healthy controls...
  23. ncbi request reprint Serum bilirubin level is inversely associated with nonalcoholic steatohepatitis in children
    Kanika Puri
    Department of Pediatrics, SUNY Downstate, Brooklyn, NY, USA
    J Pediatr Gastroenterol Nutr 57:114-8. 2013
    ..We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD...
  24. doi request reprint Novel therapeutic targets for nonalcoholic fatty liver disease
    Akiko Eguchi
    Rady Children s Hospital, Department of Pediatric Gastroenterology, University of California San Diego, CA 92123, USA
    Expert Opin Ther Targets 17:773-9. 2013
    ..It is now estimated to affect 30% of adults and about 10% of children in the U.S. Hispanics are disproportionably affected with not only higher rates of NAFLD but also more severe disease. Treatment options are currently limited...
  25. doi request reprint Changes in body composition after transjugular intrahepatic portosystemic stent in cirrhosis: a critical review of literature
    Jaividhya Dasarathy
    Department of Family Medicine, MetroHealth Medical Center, Cleveland, OH 44195, USA
    Liver Int 31:1250-8. 2011
    ..The mechanism of these is unclear, but its clinical implication is that this may contribute to the improved survival after TIPS...
  26. doi request reprint Ileoscopy via stoma after diverting ileostomy: a safe and effective tool to evaluate for Crohn's recurrence of neoterminal ileum
    Narendra Vadlamudi
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Dig Dis Sci 56:866-70. 2011
    ..Retrograde ileoscopy via stoma is also a valuable tool for recognition of CD recurrence; however, this technique has not been formally studied...
  27. ncbi request reprint Short bowel syndrome in children: current and potential therapies
    Victor Uko
    Department of Pediatric Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Paediatr Drugs 14:179-88. 2012
    ..Intestinal transplantation is a last resort option when the process of adaptation is unsuccessful. This review article is intended to provide an overview of the conventional and emerging therapies for pediatric SBS...
  28. doi request reprint Chronic constipation due to delayed diagnosis of a congenital anal web
    Neilendu Kundu
    Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH, USA
    J Gastrointest Surg 16:1429-32. 2012
    ..To our best knowledge, this is the first report of an anal web in a patient with Down's syndrome presenting with severe chronic constipation...
  29. doi request reprint Protease inhibitors: silver bullets for chronic hepatitis C infection?
    Naim Alkhouri
    Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH 44195, USA
    Cleve Clin J Med 79:213-22. 2012
    ..These drugs open the door for triple therapy and other new therapies involving combinations of other direct-acting antiviral agents to become the new standard of care for this population...