Josephine Clare Adams

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. ncbi request reprint Regulation of protrusive and contractile cell-matrix contacts
    Josephine Clare Adams
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 115:257-65. 2002
  2. pmc The thrombospondins
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, NC1 110, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:961-8. 2004
  3. ncbi request reprint Functions of the conserved thrombospondin carboxy-terminal cassette in cell-extracellular matrix interactions and signaling
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, NC1 110, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:1102-14. 2004
  4. ncbi request reprint Roles of fascin in cell adhesion and motility
    Josephine C Adams
    Dept of Cell Biology, NC1 110, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Curr Opin Cell Biol 16:590-6. 2004
  5. doi request reprint Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Sci 121:784-95. 2008
  6. pmc Neuronal expression of muskelin in the rodent central nervous system
    Nadia Tagnaouti
    Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, Universitat Hamburg, Germany
    BMC Neurosci 8:28. 2007
  7. pmc Comparative genomics of the syndecans defines an ancestral genomic context associated with matrilins in vertebrates
    Ritu Chakravarti
    Dept of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    BMC Genomics 7:83. 2006
  8. pmc Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage
    R P Tucker
    Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
    BMC Evol Biol 6:60. 2006
  9. pmc Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation
    Patrick McKenzie
    Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    BMC Evol Biol 6:33. 2006
  10. pmc Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Cancer 6:241. 2006

Research Grants

  1. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2007
  2. Modulatory Adhesion Molecules in Tissue Organization
    Josephine Adams; Fiscal Year: 2004

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Regulation of protrusive and contractile cell-matrix contacts
    Josephine Clare Adams
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 115:257-65. 2002
    ..I describe contexts for the formation of protrusive or contractile contacts and discuss recent information on the molecular processes by which these contacts are specified, coordinated and regulated at a cellular level...
  2. pmc The thrombospondins
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, NC1 110, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:961-8. 2004
    ..In this article, we give the 2004 view on TSPs and our perspectives on the significant challenges that remain. Other articles in this issue discuss the functions of vertebrate TSPs in depth...
  3. ncbi request reprint Functions of the conserved thrombospondin carboxy-terminal cassette in cell-extracellular matrix interactions and signaling
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, NC1 110, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:1102-14. 2004
    ..The strong conservation of the TSP-CTC suggests that it may mediate ancestral functions that are shared by all TSPs. This review summarizes the current knowledge of the TSP-CTC and areas of future interest...
  4. ncbi request reprint Roles of fascin in cell adhesion and motility
    Josephine C Adams
    Dept of Cell Biology, NC1 110, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Curr Opin Cell Biol 16:590-6. 2004
    ..Recent developments advance our understanding of the multifaceted regulation of fascin and the roles of fascin-containing structures in cell adhesion, motility and invasion in the life of vertebrate organisms...
  5. doi request reprint Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Sci 121:784-95. 2008
    ..CD47 and beta1 integrins are dispensable for ECM retention, but beta1 integrins enhance activity. These novel data advance concepts of the molecular processes that lead to ECM retention of TSP1...
  6. pmc Neuronal expression of muskelin in the rodent central nervous system
    Nadia Tagnaouti
    Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, Universitat Hamburg, Germany
    BMC Neurosci 8:28. 2007
    ..Since little is known about muskelin in neuronal tissues, we here analysed the tissue distribution of muskelin in rodent brain and analysed its subcellular localization using cultured neurons from multiple life stages...
  7. pmc Comparative genomics of the syndecans defines an ancestral genomic context associated with matrilins in vertebrates
    Ritu Chakravarti
    Dept of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    BMC Genomics 7:83. 2006
    ..Here, we develop a new level of knowledge for the whole syndecan family, by combining molecular phylogeny of syndecan protein sequences with analysis of the genomic contexts of syndecan genes in multiple vertebrate organisms...
  8. pmc Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage
    R P Tucker
    Department of Cell Biology and Human Anatomy, University of California at Davis, Davis, CA 95616, USA
    BMC Evol Biol 6:60. 2006
    ....
  9. pmc Phylogenomic analysis of vertebrate thrombospondins reveals fish-specific paralogues, ancestral gene relationships and a tetrapod innovation
    Patrick McKenzie
    Lerner College of Medicine, Case Western Reserve University, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    BMC Evol Biol 6:33. 2006
    ..In general the zebrafish is proving an excellent model organism for vertebrate biology, therefore we set out to evaluate the status of TSPs in zebrafish and two species of pufferfish...
  10. pmc Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    BMC Cancer 6:241. 2006
    ..Here, we report on the prevalence and potential clinical significance of fascin expression in relation to the progression of colorectal adenocarcinoma and to tumor cell proliferation as measured by Ki67 index...
  11. pmc Association of loss of epithelial syndecan-1 with stage and local metastasis of colorectal adenocarcinomas: an immunohistochemical study of clinically annotated tumors
    Yosuke Hashimoto
    Dept of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA
    BMC Cancer 8:185. 2008
    ..Here we have examined syndecan-1 expression and its potential prognostic value with reference to a clinically annotated tissue microarray for human colon adenocarcinomas...
  12. pmc Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals
    Soren Prag
    Dept of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    BMC Bioinformatics 4:42. 2003
    ....
  13. ncbi request reprint Fascin protrusions in cell interactions
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Trends Cardiovasc Med 14:221-6. 2004
    ..This review discusses current knowledge of the molecular and cellular properties and functions of fascin, the roles of fascin-based protrusions in the cardiovascular system in health and disease, and areas of future interest...
  14. ncbi request reprint Characterization of a Drosophila melanogaster orthologue of muskelin
    Josephine C Adams
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Gene 297:69-78. 2002
    ..These findings provide new information on the modular structure of muskelin and indicate potential for conserved mechanisms of function...
  15. ncbi request reprint Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins
    Josephine C Adams
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, Gower St, London WC1E 6BT, UK
    J Mol Biol 328:479-94. 2003
    ..These novel results establish TSPs as highly conserved ECM components in both invertebrates and vertebrates and open fresh perspectives on the conservation of structure and biological function within this family...
  16. ncbi request reprint Molecular organisation of cell-matrix contacts: essential multiprotein assemblies in cell and tissue function
    Josephine Clare Adams
    Department of Cell Biology, NC1 12, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Expert Rev Mol Med 4:1-24. 2002
    ....
  17. pmc Functional role of syndecan-1 cytoplasmic V region in lamellipodial spreading, actin bundling, and cell migration
    Ritu Chakravarti
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mol Biol Cell 16:3678-91. 2005
    ..These data identify for the first time specific cell behaviors that depend on signaling through the V region of syndecan-1...
  18. ncbi request reprint Trimeric assembly of the C-terminal region of thrombospondin-1 or thrombospondin-2 is necessary for cell spreading and fascin spike organisation
    Narayanapanicker Anilkumar
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London, WC1E 6BT, UK
    J Cell Sci 115:2357-66. 2002
    ..We conclude that trimeric assembly of the highly conserved TSP C-terminal region is necessary for organisation of the fascin-based cytoskeletal structures that are needed for thrombospondin-induced cell motility...
  19. pmc Interaction of fascin and protein kinase Calpha: a novel intersection in cell adhesion and motility
    N Anilkumar
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London, London WC1E 6BT, UK
    EMBO J 22:5390-402. 2003
    ..These results identify the fascin-PKCalpha interaction as an important novel intersection in the regulation and networking of cell-matrix contacts...
  20. ncbi request reprint Fascins, and their roles in cell structure and function
    Nina Kureishy
    MRC Laboratory for Molecular Cell Biology and Department of Biochemistry and Molecular Biology, University College London
    Bioessays 24:350-61. 2002
    ..The supplementary material referred to in this section can be found at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/2002/v24.350.html..
  21. pmc Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association
    Soren Prag
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Biochem J 381:547-59. 2004
    ..We obtained evidence for cis- and trans-interactions between the two domains. These studies provide evidence that muskelin self-associates through a head-to-tail mechanism involving the discoidin-like domain...
  22. ncbi request reprint Bioinformatic analysis of adhesion proteins
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA
    Methods Mol Biol 370:147-72. 2007
    ....
  23. ncbi request reprint The expression of fascin, an actin-bundling motility protein, correlates with hormone receptor-negative breast cancer and a more aggressive clinical course
    Brian J Yoder
    Department of Anatomic Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Cancer Res 11:186-92. 2005
    ..If so, then fascin may represent a new molecular target for therapeutic intervention in patients with ER-negative breast cancer...
  24. pmc Fascin-1 promoter activity is regulated by CREB and the aryl hydrocarbon receptor in human carcinoma cells
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    PLoS ONE 4:e5130. 2009
    ..The question is important because of the clinical significance of fascin expression in human carcinomas...
  25. pmc Dual actin-bundling and protein kinase C-binding activities of fascin regulate carcinoma cell migration downstream of Rac and contribute to metastasis
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH 44195, USA
    Mol Biol Cell 18:4591-602. 2007
    ..Thus, fascin contributes to carcinoma migration and metastasis through dual pathways that impact on multiple subcellular structures needed for cell migration...
  26. pmc Novel role of the muskelin-RanBP9 complex as a nucleocytoplasmic mediator of cell morphology regulation
    Manojkumar Valiyaveettil
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    J Cell Biol 182:727-39. 2008
    ..Knockdown of RanBP9 resulted in equivalent morphological alterations. These novel findings identify a role for muskelin-RanBP9 complex in pathways that integrate cell morphology regulation and nucleocytoplasmic communication...
  27. ncbi request reprint Regulation of post-translational modifications of muskelin by protein kinase C
    Soren Prag
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 39:366-78. 2007
    ..Interestingly, both sites are predicted to lie in surface-exposed loops on the same side of the beta-propeller, implicating a common binding interface...
  28. ncbi request reprint Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?
    Yosuke Hashimoto
    Department of Cell Biology, Lerner Research Institute, NC1 10, Cleveland Clinic Foundation, OH 44195, USA
    Int J Biochem Cell Biol 37:1787-804. 2005
    ..Here, we discuss the evidence that fascin is upregulated in carcinomas, its contributions to carcinoma cell behaviour and its potential as a candidate novel biomarker or therapeutic target...
  29. pmc The evolution of thrombospondins and their ligand-binding activities
    Amber A Bentley
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Mol Biol Evol 27:2187-97. 2010
    ..In contrast, the neofunctions of vertebrate TSPs likely include interactions suitable for therapeutic targeting without general disruption of ECM...
  30. ncbi request reprint Methods in cell-matrix adhesion. Introduction
    Josephine C Adams
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Methods Cell Biol 69:3-5. 2002
  31. ncbi request reprint Coronary artery disease and the thrombospondin single nucleotide polymorphisms
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology NB50, Cleveland Clinic Foundation Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:1013-30. 2004
    ....

Research Grants6

  1. Fascin Protrusions in ECM-Cytoskeletal Networking
    Josephine Adams; Fiscal Year: 2007
    ....
  2. Modulatory Adhesion Molecules in Tissue Organization
    Josephine Adams; Fiscal Year: 2004
    ..abstract_text> ..