Jean Paul Achkar

Summary

Affiliation: Cleveland Clinic Foundation
Country: USA

Publications

  1. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
  2. ncbi request reprint Medical management of postoperative complications of inflammatory bowel disease: pouchitis and Crohn's disease recurrence
    J P Achkar
    Department of Gastroenterology, The Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Gastroenterol Rep 3:484-90. 2001
  3. ncbi request reprint Differentiating risk factors for acute and chronic pouchitis
    Jean Paul Achkar
    Department of Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A30, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 3:60-6. 2005
  4. ncbi request reprint Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology and Biostatistics, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 10:339-45. 2004
  5. ncbi request reprint Ulcerative colitis: responding to the challenges
    Jean Paul Achkar
    Department of Gastroenterology and Hepatology, Cleveland Clinic, OH 44195, USA
    Cleve Clin J Med 74:657-60. 2007
  6. doi request reprint The expanding universe of inflammatory bowel disease genetics
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Curr Opin Gastroenterol 24:429-34. 2008
  7. doi request reprint Pathogenesis of postoperative recurrence in Crohn's disease
    Tasneem Ahmed
    Department of Gastroenterology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Gut 60:553-62. 2011
  8. ncbi request reprint Endoscopic balloon dilation of ileal pouch strictures
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:2340-7. 2004
  9. ncbi request reprint Treatment of rectal cuff inflammation (cuffitis) in patients with ulcerative colitis following restorative proctocolectomy and ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology, Anatomic Pathology, and Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:1527-31. 2004
  10. ncbi request reprint A cost-effectiveness analysis of diagnostic strategies for symptomatic patients with ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease Department of Gastroenterology, I H Page Center for Health Outcomes Research, Department of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 98:2460-7. 2003

Research Grants

  1. Genetic Studies in Crohn's Disease
    Jean Paul Achkar; Fiscal Year: 2007

Detail Information

Publications38

  1. pmc Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    Mark S Silverberg
    Mount Sinai Hospital Inflammatory Bowel Disease Group, University of Toronto, 600 University Avenue, Toronto, ON M5G1X5, Canada
    Nat Genet 41:216-20. 2009
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)...
  2. ncbi request reprint Medical management of postoperative complications of inflammatory bowel disease: pouchitis and Crohn's disease recurrence
    J P Achkar
    Department of Gastroenterology, The Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Curr Gastroenterol Rep 3:484-90. 2001
    ..Increasing evidence suggests that postoperative medical therapy has the potential to decrease the risk of postoperative Crohn's disease recurrence...
  3. ncbi request reprint Differentiating risk factors for acute and chronic pouchitis
    Jean Paul Achkar
    Department of Gastroenterology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Desk A30, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 3:60-6. 2005
    ..The clinical course and medical therapy are different between acute pouchitis and chronic pouchitis. The aim of this study was to determine if there are predictors of risk for acute vs. chronic pouchitis...
  4. ncbi request reprint Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology and Biostatistics, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 10:339-45. 2004
    ..The purpose of this study was to assess the relation between clinical response, 6-mercaptopurine metabolite levels, relative leukopenia, and drug dose...
  5. ncbi request reprint Ulcerative colitis: responding to the challenges
    Jean Paul Achkar
    Department of Gastroenterology and Hepatology, Cleveland Clinic, OH 44195, USA
    Cleve Clin J Med 74:657-60. 2007
    ....
  6. doi request reprint The expanding universe of inflammatory bowel disease genetics
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Curr Opin Gastroenterol 24:429-34. 2008
    ..In this review, we will provide an update on the rapid advances in the discovery of inflammatory bowel disease, primarily Crohn's disease, associated genes...
  7. doi request reprint Pathogenesis of postoperative recurrence in Crohn's disease
    Tasneem Ahmed
    Department of Gastroenterology, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Gut 60:553-62. 2011
    ..This paper reviews the postoperative disease outcome and evolution based on defining the combination of the patient's microbial flora, environmental exposure history, immune response and genetic make-up...
  8. ncbi request reprint Endoscopic balloon dilation of ileal pouch strictures
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:2340-7. 2004
    ..Endoscopic balloon dilation has been successfully used in patients with Crohn's strictures at the small intestine and colon. There are no published trials on endoscopic balloon therapy of ileal pouch strictures...
  9. ncbi request reprint Treatment of rectal cuff inflammation (cuffitis) in patients with ulcerative colitis following restorative proctocolectomy and ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology, Anatomic Pathology, and Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:1527-31. 2004
    ..Despite its advantages, the procedure normally leaves a 1-2 cm of anal transitional zone or rectal cuff, which is susceptible to recurrence of residual UC or cuffitis. Cuffitis can cause symptoms mimicking pouchitis...
  10. ncbi request reprint A cost-effectiveness analysis of diagnostic strategies for symptomatic patients with ileal pouch-anal anastomosis
    Bo Shen
    Center for Inflammatory Bowel Disease Department of Gastroenterology, I H Page Center for Health Outcomes Research, Department of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 98:2460-7. 2003
    ..Cost-effectiveness of these strategies has not been compared. The aim of this study was to compare cost-effectiveness of different clinical approaches for patients with symptoms suggestive of pouchitis...
  11. ncbi request reprint Modified pouchitis disease activity index: a simplified approach to the diagnosis of pouchitis
    Bo Shen
    Center for Inflammatory Bowel Disease, Cleveland, Ohio, USA
    Dis Colon Rectum 46:748-53. 2003
    ..The aim of the present study was to determine whether omitting histologic evaluation from the pouchitis disease activity index significantly affects the sensitivity and specificity of diagnostic criteria for pouchitis...
  12. ncbi request reprint Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolectomy for ulcerative colitis
    Bo Shen
    Department of Gastroenterology Hepatology, Center for Inflammatory Bowel Disease, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Clin Gastroenterol Hepatol 4:81-9; quiz 2-3. 2006
    ..The aim of this study was to assess risk factors for inflammatory and noninflammatory diseases of IPAA in a tertiary care setting...
  13. ncbi request reprint Afferent limb ulcers predict Crohn's disease in patients with ileal pouch-anal anastomosis
    Jason M Wolf
    Department of Gastroenterology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastroenterology 126:1686-91. 2004
    ..Making the diagnosis of CD in patients with IPAA can be difficult, but it is important for prognostic and therapeutic purposes. The aim of this study was to identify diagnostic features of CD in patients with IPAA...
  14. ncbi request reprint Predictors of response to infliximab in patients with Crohn's disease
    Mansour A Parsi
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Gastroenterology 123:707-13. 2002
    ..Identifying predictors of response to infliximab in Crohn's disease may lead to better selection of patients for this therapy...
  15. ncbi request reprint Irritable pouch syndrome: a new category of diagnosis for symptomatic patients with ileal pouch-anal anastomosis
    Bo Shen
    Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:972-7. 2002
    ..This study was designed to assess the etiology of bowel symptoms using the Pouchitis Disease Activity Index (PDAI)...
  16. pmc Gene-gene and gene-environment interactions in ulcerative colitis
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A31, Cleveland, OH, 44195, USA
    Hum Genet 133:547-58. 2014
    ..UC risk can be predicted by a 133 loci and improved by adding gene-gene and gene-environment interactions. ..
  17. ncbi request reprint Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis
    Mansour A Parsi
    Department of Gastroenterology, Center for Inflammatory Bowel Disease, Cleveland Clinic Foundation, Desk A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Gastroenterology 126:1280-6. 2004
    ..Distinction among these entities requires pouch endoscopy and biopsy. Noninvasive means of diagnosis are preferable...
  18. doi request reprint Long-term outcomes with ileal pouch-anal anastomosis and Crohn's disease: pouch retention and implications of delayed diagnosis
    Genevieve B Melton
    Digestive Disease Institute, Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Surg 248:608-16. 2008
    ..To assess long-term outcomes after ileal pouch-anal anastomosis (IPAA) in Crohn's disease (CD)...
  19. ncbi request reprint Type of fistula determines response to infliximab in patients with fistulous Crohn's disease
    Mansour A Parsi
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 99:445-9. 2004
    ..Infliximab has been shown to be efficacious for treating perianal fistulae in patients with Crohn's disease. There is limited information regarding response to infliximab in patients with other types of fistulae...
  20. ncbi request reprint Phenotype-stratified genetic linkage study demonstrates that IBD2 is an extensive ulcerative colitis locus
    Jean Paul Achkar
    Center for Inflammatory Bowel Disease, Department of Gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Am J Gastroenterol 101:572-80. 2006
    ..The purpose of this study was to assess phenotypic subsets that contribute to the major IBD susceptibility loci...
  21. doi request reprint Effect of altering automatic exposure control settings and quality reference mAs on radiation dose, image quality, and diagnostic efficacy in MDCT enterography of active inflammatory Crohn's disease
    Brian C Allen
    Imaging Institute, Cleveland Clinic, OH 44195, USA
    AJR Am J Roentgenol 195:89-100. 2010
    ....
  22. ncbi request reprint Comprehensive evaluation of inflammatory and noninflammatory sequelae of ileal pouch-anal anastomoses
    Bo Shen
    Center for Inflammatory Bowel Disease, Departments of Gastroenterology Hepatology, The Cleveland Clinic Foundation, Cleveland, Ohio
    Am J Gastroenterol 100:93-101. 2005
    ..Symptomatology, endoscopy, histology, and the Cleveland Global QOL and the Irritable Bowel Syndrome-QOL scores were compared among the groups...
  23. pmc How patients view probiotics: findings from a multicenter study of patients with inflammatory bowel disease and irritable bowel syndrome
    MaryBeth Mercer
    Department of Bioethics, Cleveland Clinic, Cleveland, OH 44195, USA
    J Clin Gastroenterol 46:138-44. 2012
    ..Understanding patients' knowledge, attitudes and expectations of probiotics may help gastroenterologists engage patients in collaborative discussions about probiotics...
  24. ncbi request reprint Perinuclear neutrophil antibodies are not markers for genetic susceptibility or indicators of genetic heterogeneity in familial ulcerative colitis
    Jean Paul Achkar
    Department of Gastroenterology, The Cleveland Clinic Foundation, Ohio 44195, USA
    Am J Gastroenterol 97:2343-9. 2002
    ..To address this discrepancy, we assayed perinuclear neutrophil antibodies in the UC-affected members of 53 families with at least one relative pair affected with UC...
  25. pmc Helping patients make informed choices about probiotics: a need for research
    Richard R Sharp
    Department of Bioethics, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Am J Gastroenterol 104:809-13. 2009
    ..Considerable effort may be required to help patients make informed choices about probiotic therapies...
  26. pmc A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 19:1799-808. 2013
    ..The value of genetic variants in clinical practice is not defined because of limited explained heritability...
  27. doi request reprint Mural attenuation in normal small bowel and active inflammatory Crohn's disease on CT enterography: location, absolute attenuation, relative attenuation, and the effect of wall thickness
    Mark E Baker
    Imaging Institute, Department of Quantitative Health Sciences and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    AJR Am J Roentgenol 192:417-23. 2009
    ....
  28. doi request reprint Molecular pathways underlying IBD-associated colorectal neoplasia: therapeutic implications
    Gati A Goel
    Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA
    Am J Gastroenterol 106:719-30. 2011
    ....
  29. pmc ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    Craig R Homer
    Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Gastroenterology 139:1630-41, 1641.e1-2. 2010
    ..We examined the functional interaction between the CD risk genes ATG16L1 and NOD2 to identify an autophagy-dependent pathway that is altered by disease-associated variants...
  30. doi request reprint Using technology to promote gastrointestinal outcomes research: a case for electronic health records
    Ashish Atreja
    Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Gastroenterol 103:2171-8. 2008
    ....
  31. ncbi request reprint Assessment of reliability and validity of IBD phenotyping within the National Institutes of Diabetes and Digestive and Kidney Diseases (NIDDK) IBD Genetics Consortium (IBDGC)
    Themistocles Dassopoulos
    Johns Hopkins University Meyerhoff Inflammatory Bowel Disease Center, Baltimore MD, USA
    Inflamm Bowel Dis 13:975-83. 2007
    ..Our aim was to determine the reliability and validity of these phenotypic assessments...
  32. ncbi request reprint Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
    Steven R Brant
    The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Dept of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, U S A
    Inflamm Bowel Dis 9:281-9. 2003
    ..Multiple factors, particularly IBD family history, tobacco use, age at diagnosis and recently, NOD2 mutant genotypes may influence Crohn's disease (CD) heterogeneity...
  33. doi request reprint IL23R and ATG16L1 SNPs in IBD: alphabet soup or something more?
    Jean Paul Achkar
    Am J Gastroenterol 103:628-30. 2008
    ..These findings highlight the importance of the immune system and interactions with intestinal microflora in the pathogenesis of IBD...
  34. ncbi request reprint A genome scan in 260 inflammatory bowel disease-affected relative pairs
    M Michael Barmada
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Inflamm Bowel Dis 10:513-20. 2004
    ....
  35. ncbi request reprint A genome scan in 260 inflammatory bowel disease-affected relative pairs
    M Michael Barmada
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Inflamm Bowel Dis 10:15-22. 2004
    ....
  36. ncbi request reprint Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis
    Amir S Karban
    Johns Hopkins University School of Medicine, 1503 E Jefferson Street, Room B136, Baltimore, MD 21231, USA
    Hum Mol Genet 13:35-45. 2004
    ..Therefore, we have identified the first potentially functional polymorphism of NFKB1 and demonstrated its genetic association with a common human disease, ulcerative colitis...
  37. ncbi request reprint Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage
    Richard H Duerr
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
    Hum Mol Genet 11:2599-606. 2002
    ..12). Thus, the existence of an inflammatory bowel disease locus on chromosome 3p26 is supported by significant linkage, transmission/disequilibrium and partitioning of linkage evidence...
  38. pmc MDR1 Ala893 polymorphism is associated with inflammatory bowel disease
    Steven R Brant
    The Harvey M and Lyn P Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Hum Genet 73:1282-92. 2003
    ..Taken together, these data support the association of the common Ala893 polymorphism with IBD specifically and, more broadly, provides additional support for its contribution to interindividual pharmacogenetic variation...

Research Grants2

  1. Genetic Studies in Crohn's Disease
    Jean Paul Achkar; Fiscal Year: 2007
    ..The PI will continue to recruit patients and controls for an IBD DMA bank that he recently started. This collection will then be used to pursue a case-control, haplotype-based analysis of Paneth cell candidate genes. ..