W S Baldwin

Summary

Affiliation: Clemson University
Country: USA

Publications

  1. pmc Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex
    Susanne A Thomson
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA
    BMC Genomics 10:500. 2009
  2. ncbi request reprint Incomplete ecdysis is an indicator of ecdysteroid exposure in Daphnia magna
    W S Baldwin
    Biology Department, Anderson College, Anderson, South Carolina 29621, USA
    Environ Toxicol Chem 20:1564-9. 2001
  3. pmc A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures
    William S Baldwin
    Institute of Environmental Toxicology, Clemson University, Pendleton, South Carolina 29670, USA
    Toxicol Sci 107:93-105. 2009
  4. pmc The cytochrome P450 (CYP) gene superfamily in Daphnia pulex
    William S Baldwin
    Clemson University, Biological Sciences, Institute of Environmental Toxicology, Pendleton, SC, USA
    BMC Genomics 10:169. 2009
  5. pmc Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR)
    J P Hernandez
    Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA
    Toxicology 256:53-64. 2009
  6. ncbi request reprint CAR and PXR: xenosensors of endocrine disrupters?
    Xiomara C Kretschmer
    University of Texas at El Paso, Biological Sciences, 500 W University Ave, El Paso, TX 79968, USA
    Chem Biol Interact 155:111-28. 2005
  7. ncbi request reprint Impacts of Fenholloway River water on invertebrate biodiversity and growth of Daphnia magna
    T R Kozel
    Biology Department, Anderson College, Anderson, SC, USA
    Bull Environ Contam Toxicol 71:512-9. 2003
  8. pmc Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice
    Juan P Hernandez
    Biological Sciences, University of Texas at El Paso, 500 W University Ave, El Paso, TX 79968, USA
    Toxicol Appl Pharmacol 216:186-96. 2006
  9. pmc The environmental estrogen, nonylphenol, activates the constitutive androstane receptor
    Juan P Hernandez
    Biological Sciences, The University of Texas at El Paso, El Paso, Texas 79968, USA
    Toxicol Sci 98:416-26. 2007

Research Grants

  1. Induction of breast cancer in MMTVneu mice
    William Baldwin; Fiscal Year: 2002

Collaborators

  • David R Nelson
  • P B Marko
  • David Moore
  • Juan P Hernandez
  • Xiomara C Kretschmer
  • Susanne A Thomson
  • J P Hernandez
  • Laura M Chapman
  • T R Kozel
  • Ying H Wang
  • Gerald A LeBlanc
  • W Huang
  • Gwijun Kwon
  • L C Mota
  • Steven Chua
  • Wendong Huang
  • J M Brynda
  • S C Pruitt

Detail Information

Publications9

  1. pmc Annotation, phylogenetics, and expression of the nuclear receptors in Daphnia pulex
    Susanne A Thomson
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, USA
    BMC Genomics 10:500. 2009
    ..org. Nuclear receptor expression was evaluated and receptors were subjected to phylogenetic analyses to gain insight into evolution and function...
  2. ncbi request reprint Incomplete ecdysis is an indicator of ecdysteroid exposure in Daphnia magna
    W S Baldwin
    Biology Department, Anderson College, Anderson, South Carolina 29621, USA
    Environ Toxicol Chem 20:1564-9. 2001
    ..Last, both exogenous 20-E and PoA show similar effects, including premature death associated with incomplete ecdysis, and the overall difference in toxicity is mostly likely due to receptor affinity...
  3. pmc A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures
    William S Baldwin
    Institute of Environmental Toxicology, Clemson University, Pendleton, South Carolina 29670, USA
    Toxicol Sci 107:93-105. 2009
    ..Overall, our data indicates that it is important to consider that we are exposed to a milieu of chemicals, and the efficacy of each individual chemical is not the sole factor in determining CAR's activity in mixture modeling...
  4. pmc The cytochrome P450 (CYP) gene superfamily in Daphnia pulex
    William S Baldwin
    Clemson University, Biological Sciences, Institute of Environmental Toxicology, Pendleton, SC, USA
    BMC Genomics 10:169. 2009
    ..The latter form a critical component of detoxification systems...
  5. pmc Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR)
    J P Hernandez
    Biological Sciences, The University of Texas at El Paso, El Paso, TX, USA
    Toxicology 256:53-64. 2009
    ..In summary, CAR regulates the basal and chemically inducible expression of several sexually dimorphic xenobiotic metabolizing P450s in a manner that varies depending on the ligand...
  6. ncbi request reprint CAR and PXR: xenosensors of endocrine disrupters?
    Xiomara C Kretschmer
    University of Texas at El Paso, Biological Sciences, 500 W University Ave, El Paso, TX 79968, USA
    Chem Biol Interact 155:111-28. 2005
    ....
  7. ncbi request reprint Impacts of Fenholloway River water on invertebrate biodiversity and growth of Daphnia magna
    T R Kozel
    Biology Department, Anderson College, Anderson, SC, USA
    Bull Environ Contam Toxicol 71:512-9. 2003
  8. pmc Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice
    Juan P Hernandez
    Biological Sciences, University of Texas at El Paso, 500 W University Ave, El Paso, TX 79968, USA
    Toxicol Appl Pharmacol 216:186-96. 2006
    ..In conclusion, NP causes gender-specific P450 induction and therefore exposure to NP may cause distinct pharmacological and toxicological effects in males compared to females...
  9. pmc The environmental estrogen, nonylphenol, activates the constitutive androstane receptor
    Juan P Hernandez
    Biological Sciences, The University of Texas at El Paso, El Paso, Texas 79968, USA
    Toxicol Sci 98:416-26. 2007
    ..In conclusion, NP is a CAR activator, and this was demonstrated in vitro with transactivation assays and in vivo with transgenic CAR mouse models...

Research Grants1

  1. Induction of breast cancer in MMTVneu mice
    William Baldwin; Fiscal Year: 2002
    ..Overall, the purpose of this study is to examine 4-nonylphenol's effects on breast cancer growth and its mechanism of action on the mammary tumor. ..