Costel C Darie

Summary

Affiliation: Clarkson University
Country: USA

Publications

  1. pmc Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells
    Izabela Sokolowska
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Proteome Sci 10:47. 2012
  2. pmc Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometry
    Costel C Darie
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York, NY, USA
    Proteomics 11:4514-28. 2011
  3. ncbi request reprint Identification of tumor differentiation factor (TDF) in select CNS neurons
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Brain Struct Funct 219:1333-42. 2014
  4. doi request reprint Protein-protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches
    Armand G Ngounou Wetie
    Department of Chemistry and Biomolecular Science, Biochemistry and Proteomics Group, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Cell Mol Life Sci 71:205-28. 2014
  5. ncbi request reprint Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF)
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:509-23. 2014
  6. ncbi request reprint Utility of computational structural biology in mass spectrometry
    Urmi Roy
    Department of Chemistry and Biomolecular Science, Biochemistry and Proteomics Group, Structural Biology and Molecular Modeling Unit, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:107-28. 2014
  7. ncbi request reprint Mass Spectrometric Analysis of Post-translational Modifications (PTMs) and Protein-Protein Interactions (PPIs)
    Armand G Ngounou Wetie
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:205-35. 2014
  8. ncbi request reprint Mass spectrometry for the study of autism and neurodevelopmental disorders
    Armand G Ngounou Wetie
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:525-44. 2014
  9. ncbi request reprint Mass spectrometry for proteomics-based investigation
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:1-32. 2014
  10. ncbi request reprint Cancer secretomes and their place in supplementing other hallmarks of cancer
    Sapan Patel
    Memorial Sloan Kettering Cancer Center, Molecular Pharmacology and Chemistry Program, 415 East 68th Street, New York, NY, 10065, USA
    Adv Exp Med Biol 806:409-42. 2014

Collaborators

  • Alisa G Woods
  • Thomas A Neubert
  • Armand G Ngounou Wetie
  • Izabela Sokolowska
  • Urmi Roy
  • Cristinel Sandu
  • Reshica Baral
  • Sapan Patel
  • Katrin Deinhardt
  • Daniel S Spellman
  • Devon A Shipp
  • Bayard D Clarkson
  • Kenneth N Wallace
  • Robert M Dekroon
  • Jeanne P Ryan
  • Mihaela Mocanu
  • Hermann Steller
  • Norica Branza-Nichita
  • Alina Macovei
  • Cristina Dorobantu
  • Moses V Chao

Detail Information

Publications15

  1. pmc Proteomic analysis of plasma membranes isolated from undifferentiated and differentiated HepaRG cells
    Izabela Sokolowska
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Proteome Sci 10:47. 2012
    ....
  2. pmc Identifying transient protein-protein interactions in EphB2 signaling by blue native PAGE and mass spectrometry
    Costel C Darie
    Kimmel Center for Biology and Medicine at the Skirball Institute, New York, NY, USA
    Proteomics 11:4514-28. 2011
    ..These data led us to investigate the roles of proteins such as FAK, WAVEs and Nischarin in EphB2 signaling...
  3. ncbi request reprint Identification of tumor differentiation factor (TDF) in select CNS neurons
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Brain Struct Funct 219:1333-42. 2014
    ..This is the first report of any cellular localization of TDF. TDF may have specific roles as a pituitary-derived hormone and in the CNS, and appears to be produced by distinct CNS neurons, not astroglia. ..
  4. doi request reprint Protein-protein interactions: switch from classical methods to proteomics and bioinformatics-based approaches
    Armand G Ngounou Wetie
    Department of Chemistry and Biomolecular Science, Biochemistry and Proteomics Group, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Cell Mol Life Sci 71:205-28. 2014
    ..Finally, we point out the limitations of these methods and the need to set up a standard for the validation of PPI experiments. ..
  5. ncbi request reprint Investigating a Novel Protein Using Mass Spectrometry: The Example of Tumor Differentiation Factor (TDF)
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:509-23. 2014
    ..These studies have combined directed protein identification techniques with mass spectrometry to increase our understanding of a novel protein that may have distinct actions as a hormone in the body and as a growth factor in the brain. ..
  6. ncbi request reprint Utility of computational structural biology in mass spectrometry
    Urmi Roy
    Department of Chemistry and Biomolecular Science, Biochemistry and Proteomics Group, Structural Biology and Molecular Modeling Unit, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:107-28. 2014
    ..To investigate possible protein conformation we will describe two proteins, lysozyme and myoglobin. ..
  7. ncbi request reprint Mass Spectrometric Analysis of Post-translational Modifications (PTMs) and Protein-Protein Interactions (PPIs)
    Armand G Ngounou Wetie
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:205-35. 2014
    ..Our goal is to provide a thorough understanding of these proteins and their isoforms, PTMs and PPIs and to shed light on the biological significance of these factors. ..
  8. ncbi request reprint Mass spectrometry for the study of autism and neurodevelopmental disorders
    Armand G Ngounou Wetie
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:525-44. 2014
    ..Other neurodevelopmental disorders have been investigated using this technique, including genetic syndromes associated with autism such as fragile X syndrome and Smith-Lemli-Opitz syndrome. ..
  9. ncbi request reprint Mass spectrometry for proteomics-based investigation
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:1-32. 2014
    ..Other chapters will also touch upon areas that expand beyond proteomics, such as lipidomics and metabolomics. ..
  10. ncbi request reprint Cancer secretomes and their place in supplementing other hallmarks of cancer
    Sapan Patel
    Memorial Sloan Kettering Cancer Center, Molecular Pharmacology and Chemistry Program, 415 East 68th Street, New York, NY, 10065, USA
    Adv Exp Med Biol 806:409-42. 2014
    ..In this review, we highlight the role of the altered secretome in contributing to already recognized and emerging hallmarks of cancer and we discuss new challenges in the field of secretome analysis. ..
  11. pmc Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signaling
    Daniel S Spellman
    Department of Pharmacology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Proteomics 7:1067-76. 2008
    ..These results demonstrate that the combination of primary neuronal cell culture and SILAC can be a powerful tool for the study of the proteomes of neuronal molecular and cellular dynamics...
  12. ncbi request reprint Thiostrepton, a natural compound that triggers heat shock response and apoptosis in human cancer cells: a proteomics investigation
    Cristinel Sandu
    Howard Hughes Medical Institute, Strang Laboratory of Apoptosis and Cancer Biology, The Rockefeller University, New York, NY, 10065, USA
    Adv Exp Med Biol 806:443-51. 2014
    ..We propose a model where Thiostrepton-induced proteasome inhibition leads to accumulation of protein aggregates that trigger a heat shock response and apoptosis in human cancer cells. ..
  13. ncbi request reprint Mass spectrometry for proteomics-based investigation using the zebrafish vertebrate model system
    Reshica Baral
    Department of Biology, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:331-40. 2014
    ..This review highlights studies that have already been performed using proteomic techniques and as well as our initial proteomic work comparing changes to the proteome between the ascl1a-/- and WT intestine. ..
  14. ncbi request reprint Biomarkers in major depressive disorder: the role of mass spectrometry
    Alisa G Woods
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:545-60. 2014
    ....
  15. ncbi request reprint Bottlenecks in proteomics
    Armand G Ngounou Wetie
    Biochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, NY, 13699 5810, USA
    Adv Exp Med Biol 806:581-93. 2014
    ..Here we discuss some of the problems that researchers should be aware of when performing a proteomic experiment. ..