D Sliva

Summary

Affiliation: Clarian Health Partners
Country: USA

Publications

  1. ncbi Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 29:695-703. 2006
  2. ncbi Synthesis and screening of N-alkyl hydroxamates for inhibition of cancer cell proliferation
    Keith J Stanger
    Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
    Comb Chem High Throughput Screen 9:651-61. 2006
  3. ncbi Cellular and physiological effects of Ganoderma lucidum (Reishi)
    Daniel Sliva
    Methodist Research Institute, Clarian Health Partners, Inc, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 4:873-9. 2004
  4. ncbi Signaling pathways responsible for cancer cell invasion as targets for cancer therapy
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, and Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Curr Cancer Drug Targets 4:327-36. 2004
  5. ncbi Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    J Altern Complement Med 9:491-7. 2003
  6. ncbi Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 298:603-12. 2002
  7. ncbi Suppression of cancer invasiveness by dietary compounds
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 8:677-88. 2008
  8. ncbi Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling
    D Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Br J Cancer 98:1348-56. 2008
  9. ncbi Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Incorporated, 1633 North Capitol Avenue, MT 350, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 290:552-7. 2002
  10. ncbi Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator
    Daniel Sliva
    Cancer Research Laboratory, the Signal Transduction Laboratory, and the Experimental Cell Research Program, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:3150-7. 2002

Collaborators

Detail Information

Publications32

  1. ncbi Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 29:695-703. 2006
    ..lucidum as a suitable herb for chemoprevention and chemotherapy of breast cancer...
  2. ncbi Synthesis and screening of N-alkyl hydroxamates for inhibition of cancer cell proliferation
    Keith J Stanger
    Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, IN 46556, USA
    Comb Chem High Throughput Screen 9:651-61. 2006
    ..The most active compound 4317 inhibited cell growth at IC(50) 30 microM. N-alkylation of N-H hydroxamate-based MMP inhibitors, a modification known to eliminate MMP activity, enhanced cell proliferation inhibition potency...
  3. ncbi Cellular and physiological effects of Ganoderma lucidum (Reishi)
    Daniel Sliva
    Methodist Research Institute, Clarian Health Partners, Inc, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 4:873-9. 2004
    ..This review summarizes the biological effects of Ganoderma lucidum upon specific signaling molecules and pathways, which are responsible for its therapeutic effects...
  4. ncbi Signaling pathways responsible for cancer cell invasion as targets for cancer therapy
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, and Department of Medicine, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Curr Cancer Drug Targets 4:327-36. 2004
    ..This review will summarize different approaches to targeting distinct signaling molecules involved in cancer invasion and metastasis...
  5. ncbi Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    J Altern Complement Med 9:491-7. 2003
    ..Because the dried powder of ganoderma is commercially available as a dietary supplement itself, the purpose of this study was to evaluate the biologic activity of samples of Ganoderma lucidum from different sources...
  6. ncbi Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 298:603-12. 2002
    ..Our data suggest that spores and unpurified fruiting body of G. lucidum inhibit invasion of breast and prostate cancer cells by a common mechanism and could have potential therapeutic use for cancer treatment...
  7. ncbi Suppression of cancer invasiveness by dietary compounds
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 8:677-88. 2008
    ....
  8. ncbi Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling
    D Sliva
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Br J Cancer 98:1348-56. 2008
    ..Taken together, our study suggests potential therapeutic effect of PL against invasive breast cancer...
  9. ncbi Protein kinase C induces motility of breast cancers by upregulating secretion of urokinase-type plasminogen activator through activation of AP-1 and NF-kappaB
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Incorporated, 1633 North Capitol Avenue, MT 350, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 290:552-7. 2002
    ..The disruption of PKC, AP- 1, and NF-kappaB signaling in breast cancer may be used to develop therapies for breast cancer prevention and intervention by reducing the secretion of uPA...
  10. ncbi Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator
    Daniel Sliva
    Cancer Research Laboratory, the Signal Transduction Laboratory, and the Experimental Cell Research Program, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, Indiana 46202, USA
    J Biol Chem 277:3150-7. 2002
    ..Thus, constitutively active PI 3-kinase controls cell motility by the regulation of expression of uPA through the activation of NF-kappaB...
  11. ncbi Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
    Anita Thyagarajan
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 18:657-64. 2006
    ..In summary, our results suggest that G. lucidum inhibits the oxidative stress-induced invasive behavior of breast cancer cells by modulating Erk1/2 signaling and can be potentially considered as an antioxidant in adjuvant cancer therapy...
  12. ncbi Aspirin inhibits highly invasive prostate cancer cells
    Frank P Lloyd
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    Int J Oncol 23:1277-83. 2003
    ..These results indicate that aspirin may contribute directly to reducing invasion and metastasis of prostate cancers by inhibiting cell migration and invasion...
  13. ncbi 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor
    D Sliva
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, and Indiana Cancer Research Institute, 1044 W Walnut Street, R4 272, Indianapolis, IN 46202, USA
    Biochem J 345:741-7. 2000
    ..This is the first demonstration that 14-3-3 can interact with a non-tyrosine kinase receptor. The interaction between 14-3-3 and IL-9Ralpha but not IL-4Ralpha also suggests a potential role for 14-3-3 in determining cytokine specificity...
  14. ncbi Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
    ..In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers...
  15. ncbi Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 49:209-16. 2004
    ..Our results suggest that Ganoderma lucidum inhibits the growth of MDA-MB-231 breast cancer cells by modulating Akt/NF-kappaB signaling and could have potential therapeutic use for the treatment of breast cancer...
  16. ncbi Effect of phosphatidic acid on human breast cancer cells exposed to doxorubicin
    D Sliva
    Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, Indiana 46202, USA
    Cancer Invest 19:783-90. 2001
    ..Thus, PA is able to increase the apoptotic potential of doxorubicin, and may regulate the effects of doxorubicin used for chemotherapy...
  17. ncbi Green tea polyphenols modulate secretion of urokinase plasminogen activator (uPA) and inhibit invasive behavior of breast cancer cells
    Veronika Slivova
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 52:66-73. 2005
    ..Our results indicate that GTP may contribute to the anticancer effects of green tea by inhibiting the invasive behavior of cancer cells...
  18. ncbi Soy isoflavones suppress invasiveness of breast cancer cells by the inhibition of NF-kappaB/AP-1-dependent and -independent pathways
    Tatiana Valachovicova
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, 1800 N. Capitol Avenue, Indianapolis, IN 46202, USA
    Int J Oncol 25:1389-95. 2004
    ..Taken together, our results suggest that dietary soy isoflavones inhibit adhesion and motility of highly invasive breast cancer cells by distinct signaling pathways...
  19. ncbi Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells
    Anita Thyagarajan
    Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
    Int J Oncol 30:963-9. 2007
    ..Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers...
  20. ncbi Ganoderma lucidum (Reishi) in cancer treatment
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 2:358-64. 2003
    ..However, because of the availability of Ganoderma lucidum from different sources, it is advisable to test its biologic activity...
  21. ncbi Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
    Int J Oncol 24:1093-9. 2004
    ..Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer...
  22. ncbi Cellular and physiological effects of soy flavonoids
    Tatiana Valachovicova
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    Mini Rev Med Chem 4:881-7. 2004
    ..Recent studies suggest beneficial health effects of soy and recommend increasing the intake of isoflavone-rich soy protein to the level of intake commonly used in Asian countries...
  23. ncbi Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells
    Gwenaelle Stanley
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 330:46-52. 2005
    ..In summary, our results suggest that G. lucidum inhibits prostate cancer-dependent angiogenesis by modulating MAPK and Akt signaling and could have potential therapeutic use for the treatment of prostate cancer...
  24. ncbi Activated macrophages induce metastatic behavior of colon cancer cells
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Immunobiology 215:242-9. 2010
    ..In conclusion, the interruption of signaling between activated macrophages and colon cancer cells could be considered as a new therapeutic strategy...
  25. ncbi Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
    Shailesh Dudhgaonkar
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Int Immunopharmacol 9:1272-80. 2009
    ..In conclusion, the anti-inflammatory and anti-proliferative effects of GLT on macrophages are mediated through the inhibition of NF-kappaB and AP-1 signaling pathways...
  26. ncbi Tip60 interacts with human interleukin-9 receptor alpha-chain
    D Sliva
    Department of Medicine Hematology Oncology, Indiana University School of Medicine, and Indiana Cancer Research Institute, 1044 W Walnut Street, R4 272, Indianapolis, Indiana 46202, USA
    Biochem Biophys Res Commun 263:149-55. 1999
    ..Our results therefore suggest that Tip60 may act as a cofactor of Stat3 or as an adaptor protein for molecules that are important for IL-9 signaling...
  27. ncbi Phospholipids released from activated platelets improve platelet aggregation and endothelial cell migration
    H Xiao
    The Methodist Research Institute, Clarian Health Partners, Inc, Indianapolis 46202, IN, USA
    Platelets 12:163-70. 2001
    ..These observations suggest that activated platelets release biologically active phospholipids into the blood stream, where they may play an important role in thrombosis and angiogenesis...
  28. ncbi Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 33:1307-13. 2008
    ..In conclusion, our results indicated that the edible oyster mushroom has potential therapeutic/preventive effects on breast and colon cancer...
  29. ncbi Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
    Anita Thyagarajan
    Methodist Research Institute, Indianapolis, Indiana, USA
    Nutr Cancer 62:630-40. 2010
    ..Taken together, our data demonstrate a novel mechanism responsible for the inhibition of colon cancer cells by G. lucidum and suggest GLT as natural product for the treatment of colon cancer...
  30. ncbi Serum factors involved in human microvascular endothelial cell morphogenesis
    Kevin Harvey
    Methodist Research Institute, the Department of Biology of Indiana University-Purdue University, Indianapolis, 46202, USA
    J Lab Clin Med 140:188-98. 2002
    ..Lipid and protein growth factors apparently exert complementary roles in the angiogenic response, as demonstrated by their ability to promote chemotaxis, angiogenic differentiation, and angiogenesis in vivo...
  31. ncbi Migration of vascular smooth muscle cells induced by sphingosine 1-phosphate and related lipids: potential role in the angiogenic response
    George Boguslawski
    Experimental Cell Research Laboratory, Methodist Research Institute, Indianapolis, Indiana 46202, USA
    Exp Cell Res 274:264-74. 2002
    ..SPP and related lipids may play a key role in angiogenesis by coordinating the migration of both endothelial cells and vascular smooth muscle cells in response to the changing gradients of these bioactive lipid messengers...
  32. ncbi Ganoderma lucidum in cancer research
    Daniel Sliva
    Leuk Res 30:767-8. 2006