John Bright

Summary

Affiliation: Clarian Health Partners
Country: USA

Publications

  1. ncbi request reprint Curcumin and autoimmune disease
    John J Bright
    Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA
    Adv Exp Med Biol 595:425-51. 2007
  2. pmc PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes
    Saravanan Kanakasabai
    Neuroscience Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e50500. 2012
  3. pmc Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
    S Chakraborty
    Neuroscience Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue, Noyes Bldg E504C, Indianapolis, IN 46202, USA
    Br J Cancer 104:448-59. 2011
  4. pmc PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells
    W Chearwae
    Neuroscience Research Laboratory, Methodist Research Institute at Clarian Health, Indianapolis, IN, USA
    Br J Cancer 99:2044-53. 2008
  5. pmc PPAR Regulation of Inflammatory Signaling in CNS Diseases
    John J Bright
    Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA
    PPAR Res 2008:658520. 2008
  6. ncbi request reprint Targeting PPAR as a therapy to treat multiple sclerosis
    John J Bright
    Methodist Research Institute, Neuroscience Research Laboratory, 1800 N Capitol Avenue, Noyes Bldg E 504C, Indianapolis, IN 46202, USA
    Expert Opin Ther Targets 12:1565-75. 2008
  7. ncbi request reprint 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte
    Wanida Chearwae
    Neuroscience Research Laboratory, Methodist Research Institute at Clarian Health, 1800 North Capitol Avenue, Noyes Building E 504C, Indianapolis, IN 46202, USA
    J Clin Immunol 28:558-70. 2008
  8. pmc Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis
    Caiqing Mo
    Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    J Immunol 181:5681-90. 2008
  9. ncbi request reprint Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia
    Johnson Rajasingh
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Biochem Biophys Res Commun 340:359-68. 2006
  10. ncbi request reprint Targeting autoimmune diseases through nutraceuticals
    John J Bright
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Nutrition 20:39-43. 2004

Research Grants

Collaborators

  • Wanida Chearwae
  • Saravanan Kanakasabai
  • S Chakraborty
  • W Chearwae
  • Caiqing Mo
  • Johnson Rajasingh
  • Chandramohan Natarajan
  • Sushil K Gupta
  • Saif Ansari
  • Ecaterina Pestereva
  • S Kanakasabai
  • John T O'Malley
  • Suzanne M Adams
  • Seth R Good
  • Mark H Kaplan
  • Gretta L Stritesky
  • Narayanan B Perumal
  • Crystal C Walline
  • Caroline Johnson
  • Himanshu P Raikwar
  • Gladson Muthian

Detail Information

Publications11

  1. ncbi request reprint Curcumin and autoimmune disease
    John J Bright
    Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA
    Adv Exp Med Biol 595:425-51. 2007
    ..A precise understanding of effective dose, safe regiment, and mechanism of action is required for the use of curcumin in the treatment of human autoimmune diseases...
  2. pmc PPARγ agonists promote oligodendrocyte differentiation of neural stem cells by modulating stemness and differentiation genes
    Saravanan Kanakasabai
    Neuroscience Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e50500. 2012
    ..These findings highlight the influence of PPARγ agonists in promoting neuro-glial differentiation of NSCs and its significance in the treatment of neurodegenerative diseases...
  3. pmc Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
    S Chakraborty
    Neuroscience Research Laboratory, Methodist Research Institute, 1800 N Capitol Avenue, Noyes Bldg E504C, Indianapolis, IN 46202, USA
    Br J Cancer 104:448-59. 2011
    ..In this study, we examined the effect of CAR agonist, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehydeO-(3,4-dichlorobenzyl)oxime (CITCO) on BTSCs...
  4. pmc PPARgamma agonists inhibit growth and expansion of CD133+ brain tumour stem cells
    W Chearwae
    Neuroscience Research Laboratory, Methodist Research Institute at Clarian Health, Indianapolis, IN, USA
    Br J Cancer 99:2044-53. 2008
    ..These findings demonstrate that PPARgamma agonists regulate growth and expansion of BTSCs and extend their use to target BTSCs in the treatment of brain tumour...
  5. pmc PPAR Regulation of Inflammatory Signaling in CNS Diseases
    John J Bright
    Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA
    PPAR Res 2008:658520. 2008
    ..In this manuscript, we review the current knowledge on how PPARs regulate neuroinflammatory signaling networks in CNS diseases...
  6. ncbi request reprint Targeting PPAR as a therapy to treat multiple sclerosis
    John J Bright
    Methodist Research Institute, Neuroscience Research Laboratory, 1800 N Capitol Avenue, Noyes Bldg E 504C, Indianapolis, IN 46202, USA
    Expert Opin Ther Targets 12:1565-75. 2008
    ..The etiology of MS is not known but it is generally viewed as an autoimmune inflammatory disease of the CNS. Over the past decade, several anti-inflammatory drugs have been developed to control MS symptoms but there is no medical cure...
  7. ncbi request reprint 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte
    Wanida Chearwae
    Neuroscience Research Laboratory, Methodist Research Institute at Clarian Health, 1800 North Capitol Avenue, Noyes Building E 504C, Indianapolis, IN 46202, USA
    J Clin Immunol 28:558-70. 2008
    ..T lymphocytes also express TLRs and function as costimulatory receptors to upregulate proliferation and cytokine production in response to specific agonists...
  8. pmc Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis
    Caiqing Mo
    Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    J Immunol 181:5681-90. 2008
    ..This study demonstrates that Stat4 isoforms differentially regulate inflammatory cytokines in association with distinct effects on the onset and severity of EAE...
  9. ncbi request reprint Curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active JAK-STAT pathway in T cell leukemia
    Johnson Rajasingh
    Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Biochem Biophys Res Commun 340:359-68. 2006
    ..The induction of growth-arrest and apoptosis in association with the blockade of constitutively active JAK-STAT pathway suggests this be a mechanism by which curcumin induces antitumor activity in T cell leukemia...
  10. ncbi request reprint Targeting autoimmune diseases through nutraceuticals
    John J Bright
    Department of Neurology, Vanderbilt University School of Medicine, Nashville, Tennessee 37212, USA
    Nutrition 20:39-43. 2004
  11. ncbi request reprint Curcumin inhibits experimental allergic encephalomyelitis by blocking IL-12 signaling through Janus kinase-STAT pathway in T lymphocytes
    Chandramohan Natarajan
    Division of Neuroimmunology, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    J Immunol 168:6506-13. 2002
    ..These findings highlight the fact that curcumin inhibits EAE by blocking IL-12 signaling in T cells and suggest its use in the treatment of MS and other Th1 cell-mediated inflammatory diseases...

Research Grants6

  1. PPAR-gamma regulation of IL-12 in CNS demyelination
    John Bright; Fiscal Year: 2003
    ....
  2. Curcumin inhibition of growth signaling in leukemia
    John Bright; Fiscal Year: 2004
    ..abstract_text> ..