Jiehua Zhou

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition
    Jiehua Zhou
    Division of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA
    Methods 54:284-94. 2011
  2. pmc Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice
    Jiehua Zhou
    Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, California 91010, USA
    Mol Ther 19:2228-38. 2011
  3. pmc Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge
    Jiehua Zhou
    Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    Mol Ther 21:192-200. 2013
  4. doi request reprint Aptamer-targeted RNAi for HIV-1 therapy
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA, USA
    Methods Mol Biol 721:355-71. 2011
  5. pmc Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
    Jiehua Zhou
    Division of Molecular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    Nucleic Acids Res 37:3094-109. 2009
  6. pmc Therapeutic potential of aptamer-siRNA conjugates for treatment of HIV-1
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    BioDrugs 26:393-400. 2012
  7. pmc Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy
    Jiehua Zhou
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Mol Ther 16:1481-9. 2008
  8. doi request reprint Progress in RNAi-based antiviral therapeutics
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA, USA
    Methods Mol Biol 721:67-75. 2011
  9. ncbi request reprint The therapeutic potential of cell-internalizing aptamers
    Jiehua Zhou
    Division of Molecular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    Curr Top Med Chem 9:1144-57. 2009
  10. pmc Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape
    Sergey Nechaev
    Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    J Control Release 170:307-15. 2013

Collaborators

Detail Information

Publications17

  1. pmc Dual functional RNA nanoparticles containing phi29 motor pRNA and anti-gp120 aptamer for cell-type specific delivery and HIV-1 inhibition
    Jiehua Zhou
    Division of Molecular and Cellular Biology, City of Hope, Duarte, CA, USA
    Methods 54:284-94. 2011
    ..Therefore, this dual functional pRNA-aptamer not only represents a potential HIV-1 inhibitor, but also provides a cell-type specific siRNA delivery vehicle, showing promise for systemic anti-HIV therapy...
  2. pmc Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice
    Jiehua Zhou
    Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, California 91010, USA
    Mol Ther 19:2228-38. 2011
    ..The dendrimer delivery approach therefore represents a promising method for systemic delivery of combinations of siRNAs for treatment of HIV-1 infection...
  3. pmc Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge
    Jiehua Zhou
    Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    Mol Ther 21:192-200. 2013
    ..Collectively, these data demonstrate a facile, targeted approach for combinatorial delivery of antiviral and host DsiRNAs for HIV-1 therapy in vivo...
  4. doi request reprint Aptamer-targeted RNAi for HIV-1 therapy
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA, USA
    Methods Mol Biol 721:355-71. 2011
    ..Our results provide a set of novel aptamer-targeted RNAi therapeutics to combat HIV and further validate the use of anti-gp120 aptamers for delivery of Dicer substrate siRNAs...
  5. pmc Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
    Jiehua Zhou
    Division of Molecular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    Nucleic Acids Res 37:3094-109. 2009
    ..Our results provide a set of novel inhibitory agents for blocking HIV replication and further validate the use of aptamers for delivery of Dicer substrate siRNAs...
  6. pmc Therapeutic potential of aptamer-siRNA conjugates for treatment of HIV-1
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    BioDrugs 26:393-400. 2012
    ..In this review, we recapitulate recent progress and the therapeutic potential of aptamer-siRNA conjugates in the treatment of HIV infection...
  7. pmc Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy
    Jiehua Zhou
    Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California, USA
    Mol Ther 16:1481-9. 2008
    ..We also show that gp120 expressed on the surface of HIV-infected cells can be used for aptamer-mediated delivery of anti-HIV siRNAs...
  8. doi request reprint Progress in RNAi-based antiviral therapeutics
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA, USA
    Methods Mol Biol 721:67-75. 2011
    ..Therefore, the present chapter mainly focuses on the recent progress of RNAi-based anti-HIV gene therapeutics, with particular attention to molecular targets and delivery strategies of the siRNAs...
  9. ncbi request reprint The therapeutic potential of cell-internalizing aptamers
    Jiehua Zhou
    Division of Molecular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    Curr Top Med Chem 9:1144-57. 2009
    ..Specifically, several attractive aptamer-mediated cell-type specific siRNA delivery systems are highlighted, and their promise in clinical development is also discussed...
  10. pmc Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape
    Sergey Nechaev
    Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    J Control Release 170:307-15. 2013
    ..These findings suggest that the class of immunostimulatory siRNAs may benefit from activation of certain endosomal immune receptors, such as TLR9, in augmented gene silencing and therapeutic efficacy...
  11. pmc Dual functional BAFF receptor aptamers inhibit ligand-induced proliferation and deliver siRNAs to NHL cells
    Jiehua Zhou
    Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Nucleic Acids Res 41:4266-83. 2013
    ....
  12. pmc Cell-specific aptamer-mediated targeted drug delivery
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Oligonucleotides 21:1-10. 2011
    ..We also place particular emphasis on aptamers evolved against cell membrane receptors and possibilities for translation to clinical applications...
  13. pmc Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs
    Jiehua Zhou
    Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, Duarte, California, USA
    Mol Ther Nucleic Acids 1:e17. 2012
    ..These optimal design features of 3'-overhangs might provide a facile approach for rationally designing highly potent 25/27-mer DsiRNAs...
  14. pmc Current progress of RNA aptamer-based therapeutics
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope Duarte, CA, USA
    Front Genet 3:234. 2012
    ..In particular, we discuss emerging aptamer-based therapeutics that provide unique clinical opportunities for the treatment various cancers and neurological diseases...
  15. pmc Aptamer-targeted cell-specific RNA interference
    Jiehua Zhou
    Division of Molecular and Cellular Biology, Beckman Research Institute of City of Hope, City of Hope, Duarte, CA 91010, USA
    Silence 1:4. 2010
    ..The optimization and improvement of aptamer-targeted siRNAs for clinical translation are further highlighted...