Affiliation: City of Hope National Medical Center
Lifshitz V, Priceman S, Li W, Cherryholmes G, Lee H, Makovski Silverstein A, et al
. Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance. Mol Cancer Ther. 2017;16:2516-2527 pubmed publisher
..In summary, we identify S1PR1 as a critical target for reducing both EMDR and acquired chemoresistance in NB. Mol Cancer Ther; 16(11); 2516-27. ©2017 AACR. ..
Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9:798-809 pubmed publisher
..Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy. ..
Priceman S, Shen S, Wang L, Deng J, Yue C, Kujawski M, et al
. S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. Cell Rep. 2014;6:992-999 pubmed publisher
..Our study demonstrates a stark contrast between the consequences of S1PR1 signaling in Treg cells in the periphery versus tumors. ..
Wang T, Fahrmann J, Lee H, LI Y, Tripathi S, Yue C, et al
. JAK/STAT3-Regulated Fatty Acid ?-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance. Cell Metab. 2018;27:136-150.e5 pubmed publisher
..Blocking FAO and/or leptin re-sensitizes them to chemotherapy and inhibits BCSCs in mouse breast tumors in vivo. We identify a critical pathway for BCSC maintenance and breast cancer chemoresistance. ..