HUA E YU

..Consequently, STAT3 has emerged as a promising target for cancer immunotherapy...

..Consequently, STAT3 is a promising target to redirect inflammation for cancer therapy...

..With these and other biological systems and reagents, the proposed studies will define whether Stat3 is an effective target for modulating tumor microenvironment and inhibiting angiogenesis. ..

..If our hypothesis is correct, inhibiting Stat3 in these subsets of immune cells will disrupt the immune suppressive networks, thereby enhancing the efficacy of DC and T-cell based immunotherapies. ..

..With these and other biological systems and reagents, the proposed studies will define whether Stat3 is an effective target for modulating tumor microenvironment and inhibiting angiogenesis. ..

..With these and other biological systems and reagents, the proposed studies will define whether Stat3 is an effective target for modulating tumor microenvironment and inhibiting angiogenesis. ..

..If our hypothesis is correct, inhibiting Stat3 in these subsets of immune cells will disrupt the immune suppressive networks, thereby enhancing the efficacy of DC and T-cell based immunotherapies. ..

....

..Collectively, these studies may lead to development of more potent VEGF inhibitors for cancer therapy. ..

..Finally, we will define the cellular and molecular mechanisms by which innate immune responses triggered by tumor-released pro-inflammatory factors impact on tumor-specific adaptive immune responses. ..