Xingzhi Xu

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi Chk2 activation and phosphorylation-dependent oligomerization
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Mol Cell Biol 22:4419-32. 2002
  2. ncbi NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, 310 Cedar St, BML342, New Haven, Connecticut 06510, USA
    FASEB J 17:1842-8. 2003
  3. ncbi 53BP1 is a positive regulator of the BRCA1 promoter
    Tibor Rauch
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Cell Cycle 4:1078-83. 2005
  4. ncbi A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication
    Dipanjan Chowdhury
    Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 31:33-46. 2008
  5. ncbi Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, 310 Cedar Street, New Haven, CT 06510, USA
    J Biol Chem 279:34091-4. 2004
  6. ncbi The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2
    Lyuben M Tsvetkov
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Cell Cycle 4:609-17. 2005
  7. ncbi Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
    Lyuben Tsvetkov
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06511, USA
    J Biol Chem 278:8468-75. 2003
  8. ncbi NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Biol Chem 278:8795-803. 2003
  9. ncbi Establishment of a cell-free system to study the activation of Chk2
    Xingzhi Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 280:165-74. 2004
  10. ncbi The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein
    Xueyan Zhong
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Cell Cycle 4:1227-9. 2005

Collaborators

Detail Information

Publications12

  1. ncbi Chk2 activation and phosphorylation-dependent oligomerization
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Mol Cell Biol 22:4419-32. 2002
    ..These results suggest that Chk2 oligomerization regulates Chk2 activation, signal amplification, and transduction in DNA damage checkpoint pathways...
  2. ncbi NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, 310 Cedar St, BML342, New Haven, Connecticut 06510, USA
    FASEB J 17:1842-8. 2003
    ..These results suggest that NFBD1 is an ATM/ATR-dependent organizer that recruits DNA checkpoint signaling and repair proteins to the sites of DNA damage...
  3. ncbi 53BP1 is a positive regulator of the BRCA1 promoter
    Tibor Rauch
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Cell Cycle 4:1078-83. 2005
    ..These findings establish a positive regulation of the BRCA1 promoter by 53BP1. Disruption of this regulation in cancer cells may provide a molecular mechanistic basis for sporadic breast and ovarian tumor formation...
  4. ncbi A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication
    Dipanjan Chowdhury
    Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 31:33-46. 2008
    ..Therefore, gamma-H2AX elimination at DNA damage foci is required for DNA damage repair, but accomplishing this task involves distinct phosphatases with potentially overlapping roles...
  5. ncbi Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, 310 Cedar Street, New Haven, CT 06510, USA
    J Biol Chem 279:34091-4. 2004
    ..We conclude that Mcph1 is involved in DNA damage-induced cellular responses, and we propose that regulation of Brca1 and/or Chk1 by Mcph1 may contribute to these cellular responses...
  6. ncbi The Plk1 Polo box domain mediates a cell cycle and DNA damage regulated interaction with Chk2
    Lyuben M Tsvetkov
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    Cell Cycle 4:609-17. 2005
    ..These results identify potential mechanisms for interaction and inter-regulation of these two protein kinases...
  7. ncbi Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
    Lyuben Tsvetkov
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06511, USA
    J Biol Chem 278:8468-75. 2003
    ..These findings suggest lateral communication between the DNA damage and mitotic checkpoints...
  8. ncbi NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
    Xingzhi Xu
    Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA
    J Biol Chem 278:8795-803. 2003
    ..IR-induced NFBD1 foci also colocalized with 53BP1 and MRE11/RAD50 foci. Taken together, these results suggest that NFBD1 is a mediator of DNA damage-dependent signaling...
  9. ncbi Establishment of a cell-free system to study the activation of Chk2
    Xingzhi Xu
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Methods Mol Biol 280:165-74. 2004
    ..This method will be useful for identification of cofactors required for activation of Chk2...
  10. ncbi The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein
    Xueyan Zhong
    Division of Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA
    Cell Cycle 4:1227-9. 2005
    ..ASPM localizes to the centrosome in interphase and to the spindle poles from prophase through telophase. These findings indicate that ASPM may be involved in mitotic spindle function, possibly, through regulation of BRCA1...
  11. ncbi Microcephalin encodes a centrosomal protein
    Xueyan Zhong
    Cell Cycle 5:457-8. 2006
  12. ncbi The spindle function of CDCA4
    Limin Wang
    Key Laboratory for Cell Proliferation and Regulation of the Ministry of Education, Beijing Normal University, Beijing China
    Cell Motil Cytoskeleton 65:581-93. 2008
    ..When anaphase begins, CDCA4 may play a different role as a midzone factor involved in chromosome segregation or cytokinesis...