A M Wu

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment
    A M Wu
    Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 97:8495-500. 2000
  2. ncbi request reprint Designer genes: recombinant antibody fragments for biological imaging
    A M Wu
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Q J Nucl Med 44:268-83. 2000
  3. ncbi request reprint Numerical selection of optimal tumor imaging agents with application to engineered antibodies
    L E Williams
    Division of Radiology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA
    Cancer Biother Radiopharm 16:25-35. 2001
  4. ncbi request reprint Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments
    P J Yazaki
    Department of Molecular Biology and Division of Immunology of the Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Bioconjug Chem 12:220-8. 2001
  5. ncbi request reprint Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies
    L E Williams
    Division of Radiology, City of Hope National Medical Center, Beckman Research Institute, Duarte, California 91010, USA
    Med Phys 27:988-94. 2000
  6. ncbi request reprint Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications
    P J Yazaki
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, 91010, Duarte, CA, USA
    J Immunol Methods 253:195-208. 2001
  7. ncbi request reprint Human T lymphocyte genetic modification with naked DNA
    M C Jensen
    City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010 3000, USA
    Mol Ther 1:49-55. 2000
  8. ncbi request reprint Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange
    A M Wu
    Department of Molecular Biology, Divison of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Protein Eng 14:1025-33. 2001
  9. ncbi request reprint Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo
    J J Ye
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Horm Metab Res 35:836-42. 2003
  10. ncbi request reprint Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy
    M C Jensen
    Division of Pediatric Hematology Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Cytotherapy 5:131-8. 2003

Collaborators

Detail Information

Publications10

  1. pmc High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment
    A M Wu
    Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 97:8495-500. 2000
    ..Average target/background ratios relative to neighboring tissue were 3-4:1. Engineered antibody fragments labeled with positron-emitting isotopes such as copper-64 provide a new class of agents for PET imaging of tumors...
  2. ncbi request reprint Designer genes: recombinant antibody fragments for biological imaging
    A M Wu
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Q J Nucl Med 44:268-83. 2000
    ..Ease of engineering and expression, combined with novel specificities that will arise from advances in genomic and combinatorial approaches to target discovery, will usher in a new era of recombinant antibodies for biological imaging...
  3. ncbi request reprint Numerical selection of optimal tumor imaging agents with application to engineered antibodies
    L E Williams
    Division of Radiology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA
    Cancer Biother Radiopharm 16:25-35. 2001
    ..The diabody had the largest impulse response function, but renal uptake may limit its present usefulness...
  4. ncbi request reprint Tumor targeting of radiometal labeled anti-CEA recombinant T84.66 diabody and t84.66 minibody: comparison to radioiodinated fragments
    P J Yazaki
    Department of Molecular Biology and Division of Immunology of the Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Bioconjug Chem 12:220-8. 2001
    ..Development of alternative blocking strategies or new metabolizable chelates are under investigation to enhance the utility of the radiometal form of these and other promising recombinant antibody fragments...
  5. ncbi request reprint Truncation of blood curves to enhance imaging and therapy with monoclonal antibodies
    L E Williams
    Division of Radiology, City of Hope National Medical Center, Beckman Research Institute, Duarte, California 91010, USA
    Med Phys 27:988-94. 2000
    ..Use of such convolution techniques to assess truncation of the perfused material is probably also applicable to multistep processes as well as to lesion targeting with other tumor-specific pharmaceuticals...
  6. ncbi request reprint Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications
    P J Yazaki
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, 91010, Duarte, CA, USA
    J Immunol Methods 253:195-208. 2001
    ..4 g of the T84.66 minibody in the harvest. A portion of this material was purified yielding 180 mg of highly purified T84.66 minibody intended for pilot radioimmunoscintigraphy studies of carcinoembryonic antigen (CEA) positive disease...
  7. ncbi request reprint Human T lymphocyte genetic modification with naked DNA
    M C Jensen
    City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010 3000, USA
    Mol Ther 1:49-55. 2000
    ..This T lymphocyte genetic modification strategy is currently being piloted in a FDA-sanctioned adoptive therapy trial for recurrent lymphoma...
  8. ncbi request reprint Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange
    A M Wu
    Department of Molecular Biology, Divison of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Protein Eng 14:1025-33. 2001
    ..Thus, domain exchange or cross-pairing appears to be the basis of the observed multimerization...
  9. ncbi request reprint Combined effects of tamoxifen and a chimeric humanized single chain antibody against the type I IGF receptor on breast tumor growth in vivo
    J J Ye
    Department of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Horm Metab Res 35:836-42. 2003
    ..scFv-Fc treatment down-regulated IGF-IR which appears to contribute to tumor growth inhibition. This study provides evidence that simultaneous targeting of IGF-IR and the estrogen receptor may enhance the therapeutic effect...
  10. ncbi request reprint Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy
    M C Jensen
    Division of Pediatric Hematology Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA
    Cytotherapy 5:131-8. 2003
    ..Strategies to invoke or augment cellular anti-lymphoma immune responses may also have considerable therapeutic potential and serve to further augment the clinical efficacy of MAbs...