J N Weitzel

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network
    Jeffrey N Weitzel
    City of Hope, Duarte, CA 91010, USA
    J Clin Oncol 31:210-6. 2013
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  3. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
  4. ncbi request reprint Limited family structure and BRCA gene mutation status in single cases of breast cancer
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    JAMA 297:2587-95. 2007
  5. ncbi request reprint Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriers
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Clin Cancer Res 13:654-8. 2007
  6. ncbi request reprint Evidence for common ancestral origin of a recurring BRCA1 genomic rearrangement identified in high-risk Hispanic families
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Epidemiol Biomarkers Prev 16:1615-20. 2007
  7. ncbi request reprint Prevalence of BRCA mutations and founder effect in high-risk Hispanic families
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope Cancer Center, 1500 East Duarte Road, Mod 103, Duarte, CA 91010, USA
    Cancer Epidemiol Biomarkers Prev 14:1666-71. 2005
  8. ncbi request reprint The current social, political, and medical role of genetic testing in familial breast and ovarian carcinomas
    J N Weitzel
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Curr Opin Obstet Gynecol 11:65-70. 1999
  9. ncbi request reprint The HRAS1 minisatellite locus and risk of ovarian cancer
    J N Weitzel
    City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010 3000, USA
    Cancer Res 60:259-61. 2000
  10. ncbi request reprint Effect of genetic cancer risk assessment on surgical decisions at breast cancer diagnosis
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Arch Surg 138:1323-8; discussion 1329. 2003

Research Grants

  1. Genetic Discrimination Knowledge in Primary Care
    Jeffrey Weitzel; Fiscal Year: 2004
  2. CLINICAL CANCER GENETICS EDUCATION
    Jeffrey Weitzel; Fiscal Year: 2005
  3. Community Cancer Genetics and Research Training (Revision)
    Jeffrey Weitzel; Fiscal Year: 2007
  4. Cancer Genetics Career Development Program
    Jeffrey Weitzel; Fiscal Year: 2007

Collaborators

Detail Information

Publications42

  1. pmc Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network
    Jeffrey N Weitzel
    City of Hope, Duarte, CA 91010, USA
    J Clin Oncol 31:210-6. 2013
    ..To determine the prevalence and type of BRCA1 and BRCA2 (BRCA) mutations among Hispanics in the Southwestern United States and their potential impact on genetic cancer risk assessment (GCRA)...
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  3. pmc Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers
    Susan L Neuhausen
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA 92697, USA
    Breast Cancer Res 11:R76. 2009
    ..In this study, we investigate the association of variants in genes involved in IGF signaling and risk of breast cancer in women who carry deleterious BRCA1 and BRCA2 mutations...
  4. ncbi request reprint Limited family structure and BRCA gene mutation status in single cases of breast cancer
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    JAMA 297:2587-95. 2007
    ..An autosomal dominant pattern of hereditary breast cancer may be masked by small family size or transmission through males given sex-limited expression...
  5. ncbi request reprint Reduced mammographic density with use of a gonadotropin-releasing hormone agonist-based chemoprevention regimen in BRCA1 carriers
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Clin Cancer Res 13:654-8. 2007
    ..We evaluated the efficacy, safety, and tolerability of hormonal chemoprevention with a gonadotropin-releasing hormone agonist (GnRHA) with low-dose add-back steroids in BRCA1(mut) carriers...
  6. ncbi request reprint Evidence for common ancestral origin of a recurring BRCA1 genomic rearrangement identified in high-risk Hispanic families
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Epidemiol Biomarkers Prev 16:1615-20. 2007
    ..Large rearrangements account for 8% to 15% of deleterious BRCA mutations, although none have been characterized previously in individuals of Mexican ancestry...
  7. ncbi request reprint Prevalence of BRCA mutations and founder effect in high-risk Hispanic families
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope Cancer Center, 1500 East Duarte Road, Mod 103, Duarte, CA 91010, USA
    Cancer Epidemiol Biomarkers Prev 14:1666-71. 2005
    ..Approximately 12% of the U.S. population is Hispanic, with the majority residing in urban centers such as Los Angeles. The prevalence of BRCA mutations among high-risk Hispanic families is unknown...
  8. ncbi request reprint The current social, political, and medical role of genetic testing in familial breast and ovarian carcinomas
    J N Weitzel
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Curr Opin Obstet Gynecol 11:65-70. 1999
    ..This article will consider recent advances in the understanding of cancer genetics, and describe the state-of-the-art in terms of management of individuals with inherited susceptibility to breast and ovarian cancer...
  9. ncbi request reprint The HRAS1 minisatellite locus and risk of ovarian cancer
    J N Weitzel
    City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010 3000, USA
    Cancer Res 60:259-61. 2000
    ..Thus, the HRAS1-variable number of tandem repeats locus may function as a modifier of ovarian cancer risk in both sporadic and hereditary ovarian cancer...
  10. ncbi request reprint Effect of genetic cancer risk assessment on surgical decisions at breast cancer diagnosis
    Jeffrey N Weitzel
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Arch Surg 138:1323-8; discussion 1329. 2003
    ..Breast cancer gene (BRCA) mutation status affects patients' surgical decisions when genetic cancer risk assessment is offered at the time of breast cancer diagnosis, prior to definitive treatment...
  11. ncbi request reprint Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers
    Carey A Cullinane
    City of Hope National Medical Center, Duarte, CA, USA
    Int J Cancer 117:988-91. 2005
    ..Among BRCA2 carriers, increasing parity was associated with a significant increase in the risk of breast cancer before age 50 and this increase was greatest in the 2-year period following a pregnancy...
  12. doi request reprint Social-cognitive aspects of underserved Latinas preparing to undergo genetic cancer risk assessment for hereditary breast and ovarian cancer
    Veronica I Lagos
    Department of Clinical Cancer Genetics, City of Hope Cancer Center, Duarte, CA 91010, USA
    Psychooncology 17:774-82. 2008
    ..This study explores social, cognitive and cultural variables in Latinas prior to undergoing GCRA...
  13. ncbi request reprint Beliefs and interest in cancer risk in an underserved Latino cohort
    Charité N Ricker
    City of Hope National Medical Center, Clinical Cancer Genetics Department, Duarte, CA 91010, USA
    Prev Med 44:241-5. 2007
    ..To measure beliefs about cancer causation, cancer screening behaviors, access to information about and resources for cancer screening, and interest in cancer genetics services in two underserved predominantly Latino communities...
  14. ncbi request reprint Restriction endonuclease fingerprinting enhanced conformation sensitive gel electrophoresis (REF-CSGE) in the analysis of BRCA1 exon 11 mutations in a high-risk breast cancer cohort
    Josef S Herzog
    Department of Clinical Cancer Genetics, Beckman Research Institute and City of Hope COH Comprehensive Cancer Center, Duarte, California, USA
    Hum Mutat 19:656-63. 2002
    ..An analysis of the overall efficiency of both techniques revealed that REF-CSGE required 67% fewer confirmatory sequencing reactions, resulting in savings in both reagents and technician time...
  15. ncbi request reprint Linkage of a pedigree drawing program and database to a program for determining BRCA mutation carrier probability
    Sharon R Sand
    Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center, 1500 East Duarte Rd, Modular 103, Duarte, CA 9101, USA
    Fam Cancer 4:313-6. 2005
    ..An export module was developed for transferring primary relational pedigree data directly from a widely used pedigree program and relational database to the BRCAPRO program for calculation of BRCA gene mutation probability estimation...
  16. pmc Effects of a cancer genetics education programme on clinician knowledge and practice
    K R Blazer
    Department of Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA
    J Med Genet 41:518-22. 2004
    ..Many clinicians lack adequate knowledge about emerging standards of care related to genetic cancer risk assessment and the features of hereditary cancer needed to identify patients at risk...
  17. pmc Development and evaluation of a decision aid for BRCA carriers with breast cancer
    Julie O Culver
    Division of Clinical Cancer Genetics, Department of Population Sciences, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Genet Couns 20:294-307. 2011
    ..Stakeholders were divided as to whether the DA should be offered at-home versus only in a clinical setting. This well-received DA will be further tested to determine accessibility and effectiveness...
  18. doi request reprint Comparison of Latina and non-Latina white women's beliefs about communicating genetic cancer risk to relatives
    Deborah J MacDonald
    Cancer Screening and Prevention Program, Clinical Cancer Genetics Department, City of Hope Cancer Center, Duarte, California 91010 3000, USA
    J Health Commun 13:465-79. 2008
    ..15-5.66), Latina ethnicity (odds ratio [OR] 0.22, 95% CI, 0.09-0.53), and Spanish as primary language (OR, 0.17, 95% CI, 0.06-0.47) were independently associated with the belief that a clinician should be the informant...
  19. doi request reprint Women's perceptions of the personal and family impact of genetic cancer risk assessment: focus group findings
    Deborah J MacDonald
    Division of Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
    J Genet Couns 19:148-60. 2010
    ..Additional research is needed to extend these findings and identify interventions to support positive outcomes of GCRA...
  20. ncbi request reprint Creating tomorrow's leaders in cancer prevention: a novel interdisciplinary career development program in cancer genetics research
    Kathleen R Blazer
    City of Hope Cancer Center, Duarte, CA 91010, USA
    J Cancer Educ 21:216-22. 2006
    ..To prepare oncology, genetics and molecular medicine professionals for basic, translational and epidemiological cancer genetics research through advanced training in a novel specialized cancer genetics career development program (CGCDP)...
  21. ncbi request reprint Selection of family members for communication of cancer risk and barriers to this communication before and after genetic cancer risk assessment
    Deborah J MacDonald
    Clinical Cancer Genetics Department, City of Hope Cancer Center, Duarte, California 91010 3000, USA
    Genet Med 9:275-82. 2007
    ..We compared women's selection of family members for cancer risk communication and perceived barriers to this communication before genetic cancer risk assessment and 6 months afterward...
  22. doi request reprint Evolving perspectives on genetic discrimination in health insurance among health care providers
    Carin R Huizenga
    Division of Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Fam Cancer 9:253-60. 2010
    ..Better knowledge of GD and protective legislation, may facilitate non-genetics clinician utilization of genetics and personalized medicine...
  23. ncbi request reprint Assessing the predictive accuracy of hMLH1 and hMSH2 mutation probability models
    Kory W Jasperson
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    J Genet Couns 15:339-47. 2006
    ..616 and 0.400, respectively). The results of this study demonsrate that neither the Wijnen model nor the Myriad table are sensitive or specific enough to be used as the only indication when to offer genetic testing for HNPCC...
  24. ncbi request reprint Cancer screening and risk-reducing behaviors of women seeking genetic cancer risk assessment for breast and ovarian cancers
    Deborah J MacDonald
    Clinical Cancer Genetics Department, City of Hope Cancer Center, Duarte, CA, USA
    Oncol Nurs Forum 33:E27-35. 2006
    ..To examine breast and ovarian cancer screening and risk-reducing behaviors of women seeking genetic cancer risk assessment (GCRA)...
  25. ncbi request reprint Development of a cancer genetics education program for clinicians
    Kathleen R Blazer
    Department of Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California 91010, USA
    J Cancer Educ 17:69-73. 2002
    ..There is a gap in knowledge about hereditary cancer and genetic testing among primary care practitioners. Education is needed to enable identification and management of patients at high risk for cancer...
  26. ncbi request reprint Health beliefs of women with and without breast cancer seeking genetic cancer risk assessment
    Deborah J MacDonald
    Clinical Cancer Genetics Department, City of Hope Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Nurs 28:372-9; quiz 380-1. 2005
    ..Nurses are in a prime position to assist women seeking GCRA by providing accurate information and emotional support regarding cancer risk, risk factors, and genetic testing...
  27. pmc Contralateral risk-reducing mastectomy in young breast cancer patients with and without genetic cancer risk assessment
    Phuong L Mai
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA, USA
    Ann Surg Oncol 15:3415-21. 2008
    ..In this study, we examined the use of CRRM before versus after genetic cancer risk assessment (GCRA) in women diagnosed with breast cancer before age 50...
  28. ncbi request reprint Outcomes from intensive training in genetic cancer risk counseling for clinicians
    Kathleen R Blazer
    Department of Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center and Beckman Research Institute, Duarte, California, USA
    Genet Med 7:40-7. 2005
    ..Pre- and postcourse knowledge tests measured cancer genetics knowledge. Six month and one-year postcourse practice outcome surveys measured the impact of the program on professional self-efficacy and continued professional development...
  29. pmc Loss of five amino acids in BRCA2 is associated with ovarian cancer
    S L Martinez
    Department of Clinical Cancer Genetics, Beckman Research Institute, CA, USA
    J Med Genet 41:e18. 2004
  30. pmc Clinical and functional properties of novel VHL mutation (X214L) consistent with Type 2A phenotype and low risk of renal cell carcinoma
    A D Sorrell
    City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Clin Genet 79:539-45. 2011
    ..In contrast, this variant, like other pVHL variants linked to Type 2A disease, fails to suppress JunB. This underscores that JunB may play a role in the pathogenesis of Type 2A VHL disease...
  31. pmc Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis
    Kory W Jasperson
    Cancer Screening and Prevention Program, City of Hope Cancer Center, Duarte, CA, USA
    Fam Cancer 9:99-107. 2010
    ..Careful attention to evolving or additional clinical features is warranted and may lead to an alternate genetic diagnosis in families with early onset CRC...
  32. doi request reprint Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations
    Kelly D Gonzalez
    Departments of Molecular Diagnosis, Molecular Genetics, Clinical Cancer Genetics, and Information Sciences, and the Bioinformatics Group, City of Hope, Duarte, CA 91010 0269, USA
    J Clin Oncol 27:1250-6. 2009
    ..A clinical testing cohort was used to gain a broader understanding of the spectrum of tumors associated with germline p53 mutations to aid clinicians in identifying high-risk families...
  33. doi request reprint Influence of genetic discrimination perceptions and knowledge on cancer genetics referral practice among clinicians
    Katrina J Lowstuter
    Department of Clinical Cancer Genetics, City of Hope, Duarte, California 91010, USA
    Genet Med 10:691-8. 2008
    ..To describe nongenetics clinicians' perceptions and knowledge of cancer genetics and laws prohibiting genetic discrimination, attitudes toward the use of cancer genetic testing, and referral practices...
  34. ncbi request reprint Genetic discrimination: the clinician perspective
    R Nedelcu
    Department of Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA
    Clin Genet 66:311-7. 2004
    ..Clinician concerns about potential genetic discrimination, and lack of information regarding protective legislation, may influence access to care...
  35. pmc Extending comprehensive cancer center expertise in clinical cancer genetics and genomics to diverse communities: the power of partnership
    Deborah J MacDonald
    Division of Clinical Cancer Genetics, City of Hope Comprehensive Cancer Center, Duarte, California 91010, USA
    J Natl Compr Canc Netw 8:615-24. 2010
    ....
  36. doi request reprint Working through a diagnostic challenge: colonic polyposis, Amsterdam criteria, and a mismatch repair mutation
    Kory W Jasperson
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, Duarte, CA, USA
    Fam Cancer 7:281-5. 2008
    ..We outline evidence supporting the pathogenicity of the identified hMSH6 mutation (arg772trp) and suggest possible etiologies for the unexplained colonic adenomatous polyposis...
  37. ncbi request reprint Microsatellite instability is a rare finding in tumors of patients with both primary renal and rectal neoplasms
    Carey A Cullinane
    Department of Clinical Cancer Genetics, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 148:163-5. 2004
    ....
  38. ncbi request reprint A comparison of bilateral breast cancers in BRCA carriers
    Jeffrey N Weitzel
    The Centre for Research in Women s Health, 790 Bay Street, Toronto, Ontario, Canada M5G 1N8
    Cancer Epidemiol Biomarkers Prev 14:1534-8. 2005
    ..It is generally believed that the two cancers represent independent events. However, the extent of concordance between the first and second tumors with respect to hormone receptor expression and other pathologic features is unknown...
  39. ncbi request reprint Genetic cancer risk assessment in the newly diagnosed breast cancer patient is useful and possible in practice
    Melanie R Palomares
    J Clin Oncol 23:3165-6; author reply 3166-7. 2005
  40. pmc Validity of models for predicting BRCA1 and BRCA2 mutations
    Giovanni Parmigiani
    The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland 21205 2011, USA
    Ann Intern Med 147:441-50. 2007
    ..At least 7 models for estimating the probabilities of having a mutation are used widely in clinical and scientific activities; however, the merits and limitations of these models are not fully understood...
  41. ncbi request reprint Screening-detected breast cancer in a man with BRCA2 mutation: case report
    R James Brenner
    Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Saint Johns Health Center, 1328 22nd St, Santa Monica, CA 90404, USA
    Radiology 230:553-5. 2004
    ..The authors discuss the clinical implications of this approach to detecting male breast cancer...
  42. ncbi request reprint Genetic/familial high-risk assessment: breast and ovarian
    Mary B Daly
    Fox Chase Cancer Center, Philadelphia, PA, USA
    J Natl Compr Canc Netw 4:156-76. 2006

Research Grants6

  1. Genetic Discrimination Knowledge in Primary Care
    Jeffrey Weitzel; Fiscal Year: 2004
    ..Because genetic testing for hereditary cancer represents a new paradigm for predictive genetic testing in other adult onset disorders, the results of the proposed study will potentially have broad-based implications. ..
  2. CLINICAL CANCER GENETICS EDUCATION
    Jeffrey Weitzel; Fiscal Year: 2005
    ..abstract_text> ..
  3. Community Cancer Genetics and Research Training (Revision)
    Jeffrey Weitzel; Fiscal Year: 2007
    ..The curriculum and delivery design may serve as a model for dissemination to other cancer centers to help address NCI priorities such as augmentation of familial registries (e.g. Cooperative Family Studies) ..
  4. Cancer Genetics Career Development Program
    Jeffrey Weitzel; Fiscal Year: 2007
    ..The graduates of this program will reduce the burden of cancer among those at highest risk by translating cancer genetic epidemiology to individual risk assessment tools and acceptable interventions. ..