Marilyn L Slovak

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. ncbi request reprint Targeting multiple genetic aberrations in isolated tumor cells by spectral fluorescence in situ hybridization
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Detect Prev 26:171-9. 2002
  2. ncbi request reprint Targeting plasma cells improves detection of cytogenetic aberrations in multiple myeloma: phenotype/genotype fluorescence in situ hybridization
    Marilyn L Slovak
    Division of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 158:99-109. 2005
  3. doi request reprint International Working Group on MDS cytogenetics: October 2007 meeting report
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, United States
    Leuk Res 32:1329-32. 2008
  4. doi request reprint Does MDS with der(1;7)(q10;p10) constitute a distinct risk group? A retrospective single institutional analysis of clinical/pathologic features compared to -7/del(7q) MDS
    Marilyn L Slovak
    Cytogenetics Laboratory, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 193:78-85. 2009
  5. ncbi request reprint 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope National Medical Center, Duarte, California 91010, USA
    Genes Chromosomes Cancer 33:379-94. 2002
  6. pmc Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia
    Anthony S Stein
    Department of Hematology Hematopoietic Cell Transplantation City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Biol Blood Marrow Transplant 15:1407-14. 2009
  7. ncbi request reprint Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    Ravi Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 101:4701-7. 2003
  8. doi request reprint Detection of copy number alterations in metastatic melanoma by a DNA fluorescence in situ hybridization probe panel and array comparative genomic hybridization: a southwest oncology group study (S9431)
    Stephen R Moore
    City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 14:2927-35. 2008
  9. pmc Successful application of a direct detection slide-based sequential phenotype/genotype assay using archived bone marrow smears and paraffin embedded tissue sections
    Victoria Bedell
    Department of Cytogenetics, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    J Mol Diagn 9:589-97. 2007
  10. ncbi request reprint Value of combined morphologic, cytochemical, and immunophenotypic features in predicting recurrent cytogenetic abnormalities in acute myeloid leukemia
    Daniel A Arber
    Divisions of pathology and Biostatistics, City of Hope National Medical Center, Duatre, CA 94305 5627, USA
    Hum Pathol 34:479-83. 2003

Detail Information

Publications50

  1. ncbi request reprint Targeting multiple genetic aberrations in isolated tumor cells by spectral fluorescence in situ hybridization
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Cancer Detect Prev 26:171-9. 2002
    ..Simultaneous detection of more than three chromosomal or gene targets should increase the overall power of molecular cytogenetics by permitting detection of multiple genetic aberrations at the single cell level...
  2. ncbi request reprint Targeting plasma cells improves detection of cytogenetic aberrations in multiple myeloma: phenotype/genotype fluorescence in situ hybridization
    Marilyn L Slovak
    Division of Pathology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 158:99-109. 2005
    ....
  3. doi request reprint International Working Group on MDS cytogenetics: October 2007 meeting report
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope, 1500 East Duarte Road, Duarte, CA 91010, United States
    Leuk Res 32:1329-32. 2008
    ..The final goal discussed was how to advance cytogenetic research into the origin, progression and clinical significance of genetic anomalies associated with MDS...
  4. doi request reprint Does MDS with der(1;7)(q10;p10) constitute a distinct risk group? A retrospective single institutional analysis of clinical/pathologic features compared to -7/del(7q) MDS
    Marilyn L Slovak
    Cytogenetics Laboratory, City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 193:78-85. 2009
    ..4, 32.0, and 23.6%, respectively) did not differ significantly (P=0.94). While der(1;7) MDS is associated with some clinically distinctive features, reassignment of risk category based on these data would be premature...
  5. ncbi request reprint 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope National Medical Center, Duarte, California 91010, USA
    Genes Chromosomes Cancer 33:379-94. 2002
    ..In general, patients could be divided into two prognostic risk groups, those with t(8;21) (median OS, 19 mo) and those without t(8;21) (median OS, 7 mo) leukemia (log-rank, P = 0.0007)...
  6. pmc Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia
    Anthony S Stein
    Department of Hematology Hematopoietic Cell Transplantation City of Hope National Medical Center, Duarte, California 91010 3000, USA
    Biol Blood Marrow Transplant 15:1407-14. 2009
    ..These high survival rates for high-risk ALL patients following RIC HCT may offer a promising option for patients not eligible for a standard myeloablative transplant...
  7. ncbi request reprint Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    Ravi Bhatia
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 101:4701-7. 2003
    ..Patients in CCR with imatinib mesylate treatment need to be followed carefully to assess for risk of relapse...
  8. doi request reprint Detection of copy number alterations in metastatic melanoma by a DNA fluorescence in situ hybridization probe panel and array comparative genomic hybridization: a southwest oncology group study (S9431)
    Stephen R Moore
    City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 14:2927-35. 2008
    ..The concordance between molecular cytogenetic techniques used to determine CNA has not been evaluated on a large set of loci in malignant melanoma...
  9. pmc Successful application of a direct detection slide-based sequential phenotype/genotype assay using archived bone marrow smears and paraffin embedded tissue sections
    Victoria Bedell
    Department of Cytogenetics, City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    J Mol Diagn 9:589-97. 2007
    ..Furthermore, the method has proved reliable and reproducible on test samples regardless of specimen age, tissue type, or referring institution...
  10. ncbi request reprint Value of combined morphologic, cytochemical, and immunophenotypic features in predicting recurrent cytogenetic abnormalities in acute myeloid leukemia
    Daniel A Arber
    Divisions of pathology and Biostatistics, City of Hope National Medical Center, Duatre, CA 94305 5627, USA
    Hum Pathol 34:479-83. 2003
    ..Cytogenetic studies are still needed on all cases to identify the small proportion of cases that will be missed by these methods and to identify other significant cytogenetic abnormalities in AML...
  11. ncbi request reprint Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on survival
    Daniel A Arber
    Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
    Am J Clin Pathol 119:672-80. 2003
    ..These findings suggest that the detection of recurring cytogenetic abnormalities and multilineage dysplasia are the most significant features of current AML classification...
  12. pmc Impact of cytogenetics on the outcome of adult acute lymphoblastic leukemia: results of Southwest Oncology Group 9400 study
    Vinod Pullarkat
    Division of Hematology and Hematopoietic Cell Transplantation, Department of Cytogenetics, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Blood 111:2563-72. 2008
    ..This trial was registered at www.ClinicalTrials.gov as #NCT00002665...
  13. ncbi request reprint Clinical and pathologic analysis of 16 cases of relapsed chronic myeloid leukemia after stem cell transplantation
    Qin Huang
    Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Clin Pathol 128:565-70. 2007
    ..Disease mortality in patients with relapsed CML after HCT was closely associated with advanced disease and HCT-related complications...
  14. ncbi request reprint An interphase fluorescence in situ hybridisation assay for the detection of 3q26.2/EVI1 rearrangements in myeloid malignancies
    Dolores Bobadilla
    Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Br J Haematol 136:806-13. 2007
    ..This study demonstrated that, despite the extensive breakpoint heterogeneity observed with 3q26.2 aberrations, this FISH strategy is effective for the detection of 3q26.2 abnormalities in myeloid malignancies...
  15. pmc Screening for clonal hematopoiesis as a predictive marker for development of therapy-related myeloid neoplasia (t-MN) following neoadjuvant therapy for breast cancer: a Southwest Oncology Group study (S0012)
    Marilyn L Slovak
    Department of Cytogenetics, City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Breast Cancer Res Treat 119:391-8. 2010
    ..Longer clinical follow-up will be necessary to define better the positive predictive value of detecting clonal hematopoiesis in the HUMARA+/MSI- cases...
  16. ncbi request reprint Neoplastic mast cells in systemic mastocytosis associated with t(8;21) acute myeloid leukemia are derived from the leukemic clone
    Vinod Pullarkat
    Division of Hematology and Hematopoietic Cell Transplantation, Department of Cytogenetics, Division of Pathology, City of Hope Comprehensive Cancer Center, 1500 East Duarte Road, Duarte, CA 91010, United States
    Leuk Res 31:261-5. 2007
    ..We also show that after successful allogeneic hematopoietic stem cell transplantation, these neoplastic bone marrow mast cells can persist without adverse consequences and gradually decline with time...
  17. ncbi request reprint Detection of NPM/MLF1 fusion in t(3;5)-positive acute myeloid leukemia and myelodysplasia
    Daniel A Arber
    Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
    Hum Pathol 34:809-13. 2003
    ..These findings suggest that an NPM/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS and AML with multilineage dysplasia, and also that cases with NPM/MLF1 may be clinically distinct from other MDS-associated disease...
  18. ncbi request reprint Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma. Report of two cases and concise review of the literature
    David S Snyder
    Division of Hematology, City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Hematol 78:74-8. 2005
    ..We report herein two cases of young adult patients who were both diagnosed with Ph+ ALL 19 years after successful treatment for ES with combined modality therapy. A review of the relevant literature follows the case reports...
  19. pmc Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma
    Marilyn L Slovak
    Cytogenetics Laboratory, Department of Hematology Stem Cell Transplantation, City of Hope, Duarte, California 91010, USA
    Clin Cancer Res 17:3443-54. 2011
    ..To determine the recurring DNA copy number alterations (CNA) in classical Hodgkin lymphoma (HL) by microarray-based comparative genomic hybridization (aCGH) using laser capture microdissected CD30(+) Hodgkin and Reed-Sternberg (HRS) cells...
  20. pmc Therapy-related, mixed-lineage leukaemia translocation-positive, monoblastic myeloid sarcoma of the uterus
    Vinod Pullarkat
    Division of Haematology, City of Hope National Medical Center, Duarte, California 91010, USA
    J Clin Pathol 60:562-4. 2007
    ..This case illustrates that t-AML can rarely present as isolated extramedullary tumours, and the detection of specific chromosomal abnormalities in these myeloid sarcomas can be useful for risk assessment and guiding definitive therapy...
  21. ncbi request reprint Human marrow-derived mesodermal progenitor cells generate insulin-secreting islet-like clusters in vivo
    Cuiwei Ai
    Division of Hematology Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
    Stem Cells Dev 16:757-70. 2007
    ..Insulin secretion from these ISILCs is regulated by glucose concentration in vitro, and transplantation of purified ISILCs normalizes hyperglycemia in streptozocin (STZ)- induced nonobese diabetic (NOD)/SCID mice...
  22. ncbi request reprint Longitudinal assessment of hematopoietic abnormalities after autologous hematopoietic cell transplantation for lymphoma
    Ravi Bhatia
    Division of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010, USA
    J Clin Oncol 23:6699-711. 2005
    ..The phenomenon of hematopoietic reconstitution after autologous HCT and the role of proliferative stress in the pathogenesis of t-MDS/AML are poorly understood...
  23. ncbi request reprint Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma
    Lijun Zhu
    Department of Medical Oncology and Therapeutic Research, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    Mol Cancer Ther 4:787-98. 2005
    ..Our observations indicate that shRNAs can specifically and effectively inhibit FGFR3 expression. This targeted approach may be worth testing in multiple myeloma patients with t(4;14) and FGFR3 overexpression in the future...
  24. ncbi request reprint Chronic myeloid leukemia with an e13a3 BCR-ABL fusion: benign course responsive to imatinib with an RT-PCR advisory
    David S Snyder
    Division of Hematology Bone Marrow Transplantation, City of Hope National Medical Center, Duarte, California 91010, USA
    Am J Hematol 75:92-5. 2004
    ..The patient responded well to imatinib and achieved a complete cytogenetic response...
  25. ncbi request reprint Therapy-related acute myeloid leukemia/myelodysplasia with balanced 21q22 translocations
    Daniel A Arber
    City of Hope National Medical Center, Duarte, CA 91010, USA
    Am J Clin Pathol 117:306-13. 2002
    ....
  26. ncbi request reprint Diagnostic utility of bilateral bone marrow examination: significance of morphologic and ancillary technique study in malignancy
    Jun Wang
    Division of Pathology, City of Hope National Medical Center, Duarte, California 91010, USA
    Cancer 94:1522-31. 2002
    ..To retrospectively evaluate the significance of morphologic examination and ancillary studies performed on bilateral bone marrow biopsy specimens, 1864 bone marrow samples were studied...
  27. ncbi request reprint Interleukin-2 after autologous stem-cell transplantation for adult patients with acute myeloid leukemia in first complete remission
    Anthony S Stein
    Division of Hematology and Bone Marrow Transplantation, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA
    J Clin Oncol 21:615-23. 2003
    ....
  28. ncbi request reprint Telomerase activity and proliferation index in aggressive mature B-cell lymphoma: comparison to germinal center phenotypic markers
    Katharine C Chiu
    Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
    Hum Pathol 34:1259-64. 2003
    ..With the exception of FLC, the tumors exhibited poor correlation between telomerase activity and Ki-67 proliferation index. These tests did show some correlation with expression of GC cell phenotypic markers, however...
  29. ncbi request reprint Coexistence of inversion 16 and the Philadelphia chromosome in acute and chronic myeloid leukemias : report of six cases and review of literature
    Yaping Wu
    Division of Pathology, City of Hope National Medical Center, Duarte, CA, USA
    Am J Clin Pathol 125:260-6. 2006
    ..Of 5 patients with CML, 4 had a rapid transformation to myeloid accelerated phase of blast crisis. The coexistence of t(9;22) and inv(16) in CML seems to correlate with more rapid transformation...
  30. ncbi request reprint Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation
    Melissa S Holtz
    Division of Hematology and Bone Marrow Transplantation and the Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA 91010, USA
    Blood 99:3792-800. 2002
    ..These results suggest that inhibition of Bcr-Abl tyrosine kinase by imatinib mesylate restores normal hematopoiesis by removing the proliferative advantage of CML progenitors but that elimination of all CML progenitors may not occur...
  31. ncbi request reprint Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas
    Warren A Chow
    Department of Medical Oncology and Therapeutics Research, City of Hope Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Cancer Genet Cytogenet 166:95-100. 2006
    ..The present study led to development by the Intergroup Coalition Against Sarcomas of a phase II trial of pemetrexed, a multitargeted anti-folate, for advanced chondrosarcomas...
  32. ncbi request reprint Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia
    David A Sweetser
    Department of Pediatrics, Massachusetts General Hospital, 55 Fruit Street Jackson 904, Boston, MA 02114, USA
    Genes Chromosomes Cancer 44:279-91. 2005
    ..The results of our studies are consistent with a model of tumor suppression mediated by haploinsufficiency of critical genes in del(9q) AML...
  33. ncbi request reprint Impact of trisomy 8 (+8) on clinical presentation, treatment response, and survival in acute myeloid leukemia: a Southwest Oncology Group study
    Sandra R Wolman
    Wayne State University, Detroit, MI, USA
    Blood 100:29-35. 2002
    ..36). Thus, the trisomy 8 group as a whole had poor survival, which was largely attributable to worsened outcomes among patients whose trisomy 8 was associated with other unfavorable cytogenetic abnormalities...
  34. pmc Long-term remission of Philadelphia chromosome-positive acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen
    Ginna G Laport
    Division of Blood and Marrow Transplantation, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5623, USA
    Blood 112:903-9. 2008
    ..Our results indicate that FTBI/VP16 with or without cyclophosphamide confers long-term survival in Ph(+) ALL patients and that disease status at the time of HCT is an important predictor of outcome...
  35. pmc Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction
    Carla S Wilson
    Department of Pathology, University of New Mexico UNM, Albuquerque, 87131, USA
    Blood 108:685-96. 2006
    ..These gene expression signatures provide insights into novel groups of AML not predicted by traditional studies that impact prognosis and potential therapy...
  36. doi request reprint Megakaryocytic blast crisis as a presenting manifestation of chronic myeloid leukemia
    Sheeja T Pullarkat
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    Leuk Res 32:1770-5. 2008
    ..Blast crisis as a presenting manifestation of CML is rare and detecting clonal evolution of acute leukemia by specialized cytogenetic techniques may have important diagnostic and therapeutic implications...
  37. ncbi request reprint Identification of novel Runx1 (AML1) translocation partner genes SH3D19, YTHDf2, and ZNF687 in acute myeloid leukemia
    TuDung T Nguyen
    Department of Pathology, Stanford University, Stanford, CA, USA
    Genes Chromosomes Cancer 45:918-32. 2006
    ..Future studies would be useful to further characterize these novel fusion protein products...
  38. ncbi request reprint The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations
    Frederick R Appelbaum
    Southwest Oncology Group Statistical Center, Seattle, WA, USA
    Br J Haematol 135:165-73. 2006
    ..021), and in patients with t(8;21) (P = 0.025). OS was superior in patients who received regimens with high-dose cytarabine, a combination of fludarabine and intermediate-dose cytarabine, or haematopoietic cell transplantation...
  39. pmc Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia
    Olga Sala-Torra
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 109:3080-3. 2007
    ..36, for each 10-fold increase in expression; P = .019). Further studies are ongoing to confirm the prognostic value of CTGF expression in ALL and to investigate its role in normal and abnormal lymphocyte biology...
  40. ncbi request reprint MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene
    Clelia Tiziana Storlazzi
    Department of Genetics and Microbiology, University of Bari, Via Amendola 165 A, 70126 Bari, Italy
    Hum Mol Genet 15:933-42. 2006
    ..The present study, therefore, strongly suggests that MYC is not the target gene of the 8q24 amplifications...
  41. ncbi request reprint Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials
    Nataliya Kuptsova
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Blood 109:3936-44. 2007
    ..With validation of results in larger samples, these findings could lead to optimizing individual chemotherapy options...
  42. pmc Transvection mediated by the translocated cyclin D1 locus in mantle cell lymphoma
    Hui Liu
    Center for Hematologic Malignancies, Oregon Cancer Institute, Portland, OR 97239, USA
    J Exp Med 205:1843-58. 2008
    ..Furthermore, NPM short hairpin RNA produces a specific growth arrest in these cells. Our data demonstrate transvection in human cancer and suggest a functional role for CTCF and NPM...
  43. ncbi request reprint Comments on editorial entitled "ISCN (2005) is not acceptable for describing clonal evolution in cancer"
    Lynda J Campbell
    Genes Chromosomes Cancer 46:514-5; author reply 516. 2007
  44. pmc Age and acute myeloid leukemia
    Frederick R Appelbaum
    Southwest Oncology Group, Operations Office, 14980 Omicron Dr, San Antonio, TX 78245 3217, USA
    Blood 107:3481-5. 2006
    ..The distinct biology and clinical responses seen argue for age-specific assessments when evaluating therapies for AML...
  45. ncbi request reprint Cyclosporine inhibition of P-glycoprotein in chronic myeloid leukemia blast phase
    Alan F List
    Arizona Cancer Center, Tucson, USA
    Blood 100:1910-2. 2002
    ..025). We conclude that Pgp has prognostic relevance in CML-BP but that the modulation of Pgp function with CsA as applied in this trial is ineffective...
  46. ncbi request reprint Aneusomy for detection of bladder cancer recurrence: a Southwest Oncology Group study
    Sandra R Wolman
    George Washington School of Medicine, 2300 Eye St NW Washington, DC 20037, USA
    Cancer Genet Cytogenet 176:22-7. 2007
    ..A short-term survival advantage was noted anecdotally with gain of chromosome 9...
  47. pmc Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia
    Derek L Stirewalt
    Fred Hutchinson Cancer Research Center, D5 380, 1100 Fairview Ave N Seattle, WA 98109, USA
    Blood 107:3724-6. 2006
    ..072) and RFS (estimated 5-year RFS: large = 13%, small = 27%, and no ITD = 34%, P = .017). These studies suggest that ITD size may have prognostic significance...
  48. ncbi request reprint Challenges in array comparative genomic hybridization for the analysis of cancer samples
    Norma J Nowak
    New York State Center of Excellence in Bioinformatics and Life Sciences and Department of Biochemistry, University at Buffalo, Buffalo, New York 14203, USA
    Genet Med 9:585-95. 2007
    ....
  49. ncbi request reprint Acute promyelocytic leukaemia in patients originating in Latin America is associated with an increased frequency of the bcr1 subtype of the PML/RARalpha fusion gene
    Dan Douer
    Division of Haematology, University of Southern California Keck School of Medicine, Norris Comprehensive Cancer Centre, 14421 Eastlake Avenue, Room 4360, Los Angeles, CA 90033, USA
    Br J Haematol 122:563-70. 2003
    ....
  50. ncbi request reprint AML1-FOG2 fusion protein in myelodysplasia
    Edward M Chan
    Division of Hematology Oncology, Department of Medicine, Indiana University School of Medicine, 1044 W Walnut St, R4 202, Indianapolis, IN 46202 5254, USA
    Blood 105:4523-6. 2005
    ..These results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of the AML1 and GATAdevelopmental programs in the pathogenesis of myelodysplasia...