Yanhong Shi

Summary

Affiliation: City of Hope National Medical Center
Country: USA

Publications

  1. pmc Induced pluripotent stem cells, new tools for drug discovery and new hope for stem cell therapies
    Yanhong Shi
    Division of Neurosciences, and the Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Curr Mol Pharmacol 2:15-8. 2009
  2. pmc MicroRNA regulation of neural stem cells and neurogenesis
    Yanhong Shi
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Neurosci 30:14931-6. 2010
  3. ncbi request reprint Nuclear receptors in stem cell biology
    Yanhong Shi
    Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Crit Rev Eukaryot Gene Expr 16:171-81. 2006
  4. ncbi request reprint Orphan nuclear receptors, excellent targets of drug discovery
    Yanhong Shi
    Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Comb Chem High Throughput Screen 9:683-9. 2006
  5. pmc Orphan nuclear receptors in drug discovery
    Yanhong Shi
    Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Drug Discov Today 12:440-5. 2007
  6. pmc Neural stem cell self-renewal
    Yanhong Shi
    Neuroscience Division, Center of Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Crit Rev Oncol Hematol 65:43-53. 2008
  7. pmc Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal
    Qiuhao Qu
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, 1500 E Duarte Road, Duarte, California 91010, USA
    Nat Cell Biol 12:31-40; sup pp 1-9. 2010
  8. pmc Wnt7a regulates multiple steps of neurogenesis
    Qiuhao Qu
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California, USA
    Mol Cell Biol 33:2551-9. 2013
  9. pmc Histone demethylase LSD1 regulates neural stem cell proliferation
    GuoQiang Sun
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Mol Cell Biol 30:1997-2005. 2010
  10. pmc miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
    GuoQiang Sun
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, California 91010, USA
    Nat Commun 2:529. 2011

Collaborators

Detail Information

Publications25

  1. pmc Induced pluripotent stem cells, new tools for drug discovery and new hope for stem cell therapies
    Yanhong Shi
    Division of Neurosciences, and the Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Curr Mol Pharmacol 2:15-8. 2009
    ..The cellular models created will provide valuable tools for drug discovery. Furthermore, this reprogramming system provides great potential to design customized patient-specific stem cell therapies with economic feasibility...
  2. pmc MicroRNA regulation of neural stem cells and neurogenesis
    Yanhong Shi
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Neurosci 30:14931-6. 2010
    ..This is a summary of the topics covered in the mini-symposium on microRNA regulation of neural stem cells and neurogenesis in SFN 2010 and is not meant to be a comprehensive review of the subject...
  3. ncbi request reprint Nuclear receptors in stem cell biology
    Yanhong Shi
    Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of the City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Crit Rev Eukaryot Gene Expr 16:171-81. 2006
    ..These studies not only facilitate an understanding of stem cell biology but also provide a basis for the development of therapeutic drugs for the treatment of a variety of diseases...
  4. ncbi request reprint Orphan nuclear receptors, excellent targets of drug discovery
    Yanhong Shi
    Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA 91010, USA
    Comb Chem High Throughput Screen 9:683-9. 2006
    ..With rapid advances in combinatorial chemistry and high throughput screening, along with other modern technologies, this field promises a bountiful harvest...
  5. pmc Orphan nuclear receptors in drug discovery
    Yanhong Shi
    Division of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Drug Discov Today 12:440-5. 2007
    ..Here, I highlight recent advances in the use of orphan nuclear receptors and their potential as targets for drug discovery in diabetes, obesity, neurodegenerative diseases and other related disorders...
  6. pmc Neural stem cell self-renewal
    Yanhong Shi
    Neuroscience Division, Center of Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Road, Duarte, CA 91010, USA
    Crit Rev Oncol Hematol 65:43-53. 2008
    ..Unraveling the mechanisms by which neural stem cells renew themselves will provide insights into both basic neurosciences and clinical applications of stem cell-based cell replacement therapies for neurodegenerative diseases...
  7. pmc Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal
    Qiuhao Qu
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, 1500 E Duarte Road, Duarte, California 91010, USA
    Nat Cell Biol 12:31-40; sup pp 1-9. 2010
    ..Moreover, this study suggests that neural stem cells can promote their own self-renewal by secreting signalling molecules that act in an autocrine/paracrine mode...
  8. pmc Wnt7a regulates multiple steps of neurogenesis
    Qiuhao Qu
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, California, USA
    Mol Cell Biol 33:2551-9. 2013
    ..Thus, Wnt7a exercised critical control over multiple steps of neurogenesis by regulating genes involved in both cell cycle control and neuronal differentiation...
  9. pmc Histone demethylase LSD1 regulates neural stem cell proliferation
    GuoQiang Sun
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Mol Cell Biol 30:1997-2005. 2010
    ..These findings revealed a novel role for LSD1 in neural stem cell proliferation and uncovered a mechanism for neural stem cell proliferation through recruitment of LSD1 to modulate TLX activity...
  10. pmc miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells
    GuoQiang Sun
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, California 91010, USA
    Nat Commun 2:529. 2011
    ..Thus, miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development...
  11. pmc MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling
    Chunnian Zhao
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 107:1876-81. 2010
    ..Let-7b, by targeting TLX and cyclin D1, establishes an efficient strategy to control neural stem cell proliferation and differentiation...
  12. pmc Characterization of TLX expression in neural stem cells and progenitor cells in adult brains
    Shengxiu Li
    Department of Neurosciences, Cancer Center, Beckman Research Institute of City of Hope, Duarte, California, United States of America
    PLoS ONE 7:e43324. 2012
    ..Understanding the cellular distribution of TLX and its function in specific cell types may provide insights into the development of therapeutic tools for neurodegenerative diseases by targeting TLX in neural stem/progenitors cells...
  13. pmc A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination
    Chunnian Zhao
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, Duarte, California, USA
    Nat Struct Mol Biol 16:365-71. 2009
    ..Moreover, TLX represses expression of the miR-9 pri-miRNA. By forming a negative regulatory loop with TLX, miR-9 provides a model for controlling the balance between neural stem cell proliferation and differentiation...
  14. pmc Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation
    GuoQiang Sun
    Neuroscience Division, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 104:15282-7. 2007
    ..Taken together, these findings demonstrate a mechanism for neural stem cell proliferation through transcriptional repression of p21 and pten gene expression by TLX-HDAC interactions...
  15. pmc MicroRNA let-7d regulates the TLX/microRNA-9 cascade to control neural cell fate and neurogenesis
    Chunnian Zhao
    Department of Neurosciences, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Sci Rep 3:1329. 2013
    ..Therefore, manipulating let-7d and its downstream targets could be a novel strategy to unravel neurogenic signaling pathways and identify potential interventions for relevant neurological disorders...
  16. pmc Identification of Oct4-activating compounds that enhance reprogramming efficiency
    Wendong Li
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 109:20853-8. 2012
    ..OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation...
  17. pmc Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells
    Ming Fei Lang
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Cancer Center, Beckman Research Institute of City of Hope, Duarte, California, USA
    PLoS ONE 7:e36248. 2012
    ..Characterizing the role of these miRNAs in glioblastoma stem cells may lead to the development of miRNA-based therapies that specifically target tumor stem cells, but spare normal stem cells...
  18. pmc Nuclear receptor TLX regulates cell cycle progression in neural stem cells of the developing brain
    Wenwu Li
    Neuroscience Division, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    Mol Endocrinol 22:56-64. 2008
    ..Together these results indicate that TLX plays an important role in neural development by regulating cell cycle progression and exit of neural stem cells in the developing brain...
  19. pmc Neural stem cells in the developing and adult brains
    Qiuhao Qu
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, Duarte, California 91010, USA
    J Cell Physiol 221:5-9. 2009
    ..The aim of this review is to summarize our current understanding of neural stem cell regulation through these important stem cell regulators...
  20. pmc Nuclear receptors in stem cells and their therapeutic potential
    GuoQiang Sun
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Beckman Research Institute of City of Hope, 1500 E Duarte Rd, Duarte, CA 91010, USA
    Adv Drug Deliv Rev 62:1299-306. 2010
    ..These studies not only uncover molecular mechanisms of stem cell regulation, but also provide unique opportunities for drug discovery...
  21. pmc Histone deacetylases in neural stem cells and induced pluripotent stem cells
    GuoQiang Sun
    Department of Neurosciences, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA
    J Biomed Biotechnol 2011:835968. 2011
    ..It promises to be an active area of future research...
  22. pmc Dynamic Roles of microRNAs in Neurogenesis
    Ming Fei Lang
    Department of Neurosciences, Center for Gene Expression and Drug Discovery, Cancer Center, Beckman Research Institute of City of Hope Duarte, CA, USA
    Front Neurosci 6:71. 2012
    ..This review summarizes our current state of knowledge on the dynamic roles that miRNAs play in neural stem cells and neurogenesis...
  23. ncbi request reprint Expression and function of orphan nuclear receptor TLX in adult neural stem cells
    Yanhong Shi
    Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 427:78-83. 2004
    ..TLX can silence glia-specific expression of the astrocyte marker GFAP in neural stem cells, suggesting that transcriptional repression may be crucial in maintaining the undifferentiated state of these cells...
  24. pmc Retinoic acid is required early during adult neurogenesis in the dentate gyrus
    Sharoni Jacobs
    Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:3902-7. 2006
    ..Our results reveal RA as a crucial contributor to early stages of adult neurogenesis and survival in vivo...
  25. pmc The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling
    Yanhong Shi
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:2613-8. 2002
    ....

Research Grants6

  1. Orphan nuclear receptor TLX signaling in neural stem cells
    Yanhong Shi; Fiscal Year: 2010
    ..Each component of the TLX signaling network, either downstream target genes or upstream regulators, will be novel molecular targets for intervening neurodegenerative diseases. ..
  2. TLX Ligands in Neural Stem Cells & Neurodegeneration
    Yanhong Shi; Fiscal Year: 2007
    ..Thus, these studies are directly responsive to the NINDS Collaborative Research in Stem Cell Biology. ..
  3. Orphan nuclear receptor TLX signaling in neural stem cells
    Yanhong Shi; Fiscal Year: 2007
    ..Each component of the TLX signaling network, either downstream target genes or upstream regulators, will be novel molecular targets for intervening neurodegenerative diseases. ..